PMC:7195088 / 8864-9886 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7195088","sourcedb":"PMC","sourceid":"7195088","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7195088","text":"Question 5. Should steroids be administered? So far, no definitive efficacy or effectiveness data are available on the benefit of corticosteroid administration in patients with SARS-CoV-2 infection. As the WHO underlines, there is an important need for efficacy data from RCT for supporting corticosteroid therapy in patients with SARS-Cov-2. However, considering that overwhelming inflammation and cytokine-related lung injury might be responsible for rapidly progressive pneumonia and clinical deterioration in COVID-19 patients, we suggest (expert opinion only) to consider administration of corticosteroids in critically ill COVID-19 patients with ARDS or with worsening of non-ARDS respiratory failure in the absence of bacterial/fungal superinfections (independent of ICU admission). Yet in the absence of convincing evidence, the following cannot currently be supported: (1) steroid administration stratified according to inflammatory markers; and (b) steroid administration in non–critically ill COVID-19 patients.","divisions":[{"label":"td","span":{"begin":0,"end":44}}],"tracks":[{"project":"LitCovid-PubTator","denotations":[{"id":"164","span":{"begin":163,"end":171},"obj":"Species"},{"id":"165","span":{"begin":317,"end":325},"obj":"Species"},{"id":"166","span":{"begin":331,"end":341},"obj":"Species"},{"id":"167","span":{"begin":522,"end":530},"obj":"Species"},{"id":"168","span":{"begin":638,"end":646},"obj":"Species"},{"id":"169","span":{"begin":1013,"end":1021},"obj":"Species"},{"id":"201","span":{"begin":19,"end":27},"obj":"Chemical"},{"id":"202","span":{"begin":882,"end":889},"obj":"Chemical"},{"id":"203","span":{"begin":959,"end":966},"obj":"Chemical"},{"id":"231","span":{"begin":177,"end":197},"obj":"Disease"},{"id":"232","span":{"begin":382,"end":394},"obj":"Disease"},{"id":"233","span":{"begin":416,"end":427},"obj":"Disease"},{"id":"234","span":{"begin":473,"end":482},"obj":"Disease"},{"id":"235","span":{"begin":513,"end":521},"obj":"Disease"},{"id":"236","span":{"begin":614,"end":628},"obj":"Disease"},{"id":"237","span":{"begin":629,"end":637},"obj":"Disease"},{"id":"238","span":{"begin":652,"end":656},"obj":"Disease"},{"id":"239","span":{"begin":682,"end":706},"obj":"Disease"},{"id":"240","span":{"begin":985,"end":1003},"obj":"Disease"},{"id":"241","span":{"begin":1004,"end":1012},"obj":"Disease"}],"attributes":[{"id":"A164","pred":"tao:has_database_id","subj":"164","obj":"Tax:9606"},{"id":"A165","pred":"tao:has_database_id","subj":"165","obj":"Tax:9606"},{"id":"A166","pred":"tao:has_database_id","subj":"166","obj":"Tax:2697049"},{"id":"A167","pred":"tao:has_database_id","subj":"167","obj":"Tax:9606"},{"id":"A168","pred":"tao:has_database_id","subj":"168","obj":"Tax:9606"},{"id":"A169","pred":"tao:has_database_id","subj":"169","obj":"Tax:9606"},{"id":"A201","pred":"tao:has_database_id","subj":"201","obj":"MESH:D013256"},{"id":"A202","pred":"tao:has_database_id","subj":"202","obj":"MESH:D013256"},{"id":"A203","pred":"tao:has_database_id","subj":"203","obj":"MESH:D013256"},{"id":"A231","pred":"tao:has_database_id","subj":"231","obj":"MESH:C000657245"},{"id":"A232","pred":"tao:has_database_id","subj":"232","obj":"MESH:D007249"},{"id":"A233","pred":"tao:has_database_id","subj":"233","obj":"MESH:D055370"},{"id":"A234","pred":"tao:has_database_id","subj":"234","obj":"MESH:D011014"},{"id":"A235","pred":"tao:has_database_id","subj":"235","obj":"MESH:C000657245"},{"id":"A236","pred":"tao:has_database_id","subj":"236","obj":"MESH:D016638"},{"id":"A237","pred":"tao:has_database_id","subj":"237","obj":"MESH:C000657245"},{"id":"A238","pred":"tao:has_database_id","subj":"238","obj":"MESH:D012128"},{"id":"A239","pred":"tao:has_database_id","subj":"239","obj":"MESH:D012131"},{"id":"A240","pred":"tao:has_database_id","subj":"240","obj":"MESH:D016638"},{"id":"A241","pred":"tao:has_database_id","subj":"241","obj":"MESH:C000657245"},{"subj":"164","pred":"source","obj":"LitCovid-PubTator"},{"subj":"165","pred":"source","obj":"LitCovid-PubTator"},{"subj":"166","pred":"source","obj":"LitCovid-PubTator"},{"subj":"167","pred":"source","obj":"LitCovid-PubTator"},{"subj":"168","pred":"source","obj":"LitCovid-PubTator"},{"subj":"169","pred":"source","obj":"LitCovid-PubTator"},{"subj":"201","pred":"source","obj":"LitCovid-PubTator"},{"subj":"202","pred":"source","obj":"LitCovid-PubTator"},{"subj":"203","pred":"source","obj":"LitCovid-PubTator"},{"subj":"231","pred":"source","obj":"LitCovid-PubTator"},{"subj":"232","pred":"source","obj":"LitCovid-PubTator"},{"subj":"233","pred":"source","obj":"LitCovid-PubTator"},{"subj":"234","pred":"source","obj":"LitCovid-PubTator"},{"subj":"235","pred":"source","obj":"LitCovid-PubTator"},{"subj":"236","pred":"source","obj":"LitCovid-PubTator"},{"subj":"237","pred":"source","obj":"LitCovid-PubTator"},{"subj":"238","pred":"source","obj":"LitCovid-PubTator"},{"subj":"239","pred":"source","obj":"LitCovid-PubTator"},{"subj":"240","pred":"source","obj":"LitCovid-PubTator"},{"subj":"241","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T1","span":{"begin":399,"end":407},"obj":"Body_part"},{"id":"T2","span":{"begin":416,"end":420},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"fma_id","subj":"T1","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A2","pred":"fma_id","subj":"T2","obj":"http://purl.org/sig/ont/fma/fma7195"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T1","span":{"begin":416,"end":420},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid-PD-HP","denotations":[{"id":"T8","span":{"begin":473,"end":482},"obj":"Phenotype"},{"id":"T9","span":{"begin":687,"end":706},"obj":"Phenotype"}],"attributes":[{"id":"A8","pred":"hp_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/HP_0002090"},{"id":"A9","pred":"hp_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/HP_0002878"},{"subj":"T8","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T9","pred":"source","obj":"LitCovid-PD-HP"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T39","span":{"begin":177,"end":185},"obj":"Disease"},{"id":"T40","span":{"begin":188,"end":197},"obj":"Disease"},{"id":"T41","span":{"begin":331,"end":335},"obj":"Disease"},{"id":"T42","span":{"begin":382,"end":394},"obj":"Disease"},{"id":"T43","span":{"begin":421,"end":427},"obj":"Disease"},{"id":"T44","span":{"begin":473,"end":482},"obj":"Disease"},{"id":"T45","span":{"begin":513,"end":521},"obj":"Disease"},{"id":"T46","span":{"begin":629,"end":637},"obj":"Disease"},{"id":"T47","span":{"begin":652,"end":656},"obj":"Disease"},{"id":"T48","span":{"begin":682,"end":686},"obj":"Disease"},{"id":"T49","span":{"begin":687,"end":706},"obj":"Disease"},{"id":"T50","span":{"begin":1004,"end":1012},"obj":"Disease"}],"attributes":[{"id":"A39","pred":"mondo_id","subj":"T39","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A40","pred":"mondo_id","subj":"T40","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A41","pred":"mondo_id","subj":"T41","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A42","pred":"mondo_id","subj":"T42","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"},{"id":"A43","pred":"mondo_id","subj":"T43","obj":"http://purl.obolibrary.org/obo/MONDO_0021178"},{"id":"A44","pred":"mondo_id","subj":"T44","obj":"http://purl.obolibrary.org/obo/MONDO_0005249"},{"id":"A45","pred":"mondo_id","subj":"T45","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A46","pred":"mondo_id","subj":"T46","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A47","pred":"mondo_id","subj":"T47","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"},{"id":"A48","pred":"mondo_id","subj":"T48","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"},{"id":"A49","pred":"mondo_id","subj":"T49","obj":"http://purl.obolibrary.org/obo/MONDO_0021113"},{"id":"A50","pred":"mondo_id","subj":"T50","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"subj":"T39","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T40","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T41","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T42","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T43","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T44","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T45","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T46","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T47","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T48","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T49","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T50","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T29","span":{"begin":416,"end":420},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T30","span":{"begin":416,"end":420},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T31","span":{"begin":956,"end":957},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"}],"attributes":[{"subj":"T29","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T30","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T31","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T38","span":{"begin":19,"end":27},"obj":"Chemical"},{"id":"T39","span":{"begin":130,"end":144},"obj":"Chemical"},{"id":"T40","span":{"begin":291,"end":305},"obj":"Chemical"},{"id":"T41","span":{"begin":595,"end":610},"obj":"Chemical"},{"id":"T42","span":{"begin":882,"end":889},"obj":"Chemical"},{"id":"T43","span":{"begin":959,"end":966},"obj":"Chemical"}],"attributes":[{"id":"A38","pred":"chebi_id","subj":"T38","obj":"http://purl.obolibrary.org/obo/CHEBI_35341"},{"id":"A39","pred":"chebi_id","subj":"T39","obj":"http://purl.obolibrary.org/obo/CHEBI_50858"},{"id":"A40","pred":"chebi_id","subj":"T40","obj":"http://purl.obolibrary.org/obo/CHEBI_50858"},{"id":"A41","pred":"chebi_id","subj":"T41","obj":"http://purl.obolibrary.org/obo/CHEBI_50858"},{"id":"A42","pred":"chebi_id","subj":"T42","obj":"http://purl.obolibrary.org/obo/CHEBI_35341"},{"id":"A43","pred":"chebi_id","subj":"T43","obj":"http://purl.obolibrary.org/obo/CHEBI_35341"},{"subj":"T38","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T39","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T40","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T41","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T42","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T43","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T1","span":{"begin":382,"end":394},"obj":"http://purl.obolibrary.org/obo/GO_0006954"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T61","span":{"begin":0,"end":11},"obj":"Sentence"},{"id":"T62","span":{"begin":12,"end":44},"obj":"Sentence"},{"id":"T63","span":{"begin":45,"end":198},"obj":"Sentence"},{"id":"T64","span":{"begin":199,"end":342},"obj":"Sentence"},{"id":"T65","span":{"begin":343,"end":789},"obj":"Sentence"},{"id":"T66","span":{"begin":790,"end":1022},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T61","pred":"source","obj":"LitCovid-sentences"},{"subj":"T62","pred":"source","obj":"LitCovid-sentences"},{"subj":"T63","pred":"source","obj":"LitCovid-sentences"},{"subj":"T64","pred":"source","obj":"LitCovid-sentences"},{"subj":"T65","pred":"source","obj":"LitCovid-sentences"},{"subj":"T66","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PubTator","color":"#9395ec","default":true},{"id":"LitCovid-PD-FMA-UBERON","color":"#afec93"},{"id":"LitCovid-PD-UBERON","color":"#ec93c9"},{"id":"LitCovid-PD-HP","color":"#93e3ec"},{"id":"LitCovid-PD-MONDO","color":"#ecdb93"},{"id":"LitCovid-PD-CLO","color":"#c193ec"},{"id":"LitCovid-PD-CHEBI","color":"#93eca7"},{"id":"LitCovid-PD-GO-BP","color":"#ec9398"},{"id":"LitCovid-sentences","color":"#93b2ec"}]}]}}