PMC:7195088 / 8864-9886 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue	tao:has_database_id
164	163-171	Species	denotes	patients	Tax:9606
165	317-325	Species	denotes	patients	Tax:9606
166	331-341	Species	denotes	SARS-Cov-2	Tax:2697049
167	522-530	Species	denotes	patients	Tax:9606
168	638-646	Species	denotes	patients	Tax:9606
169	1013-1021	Species	denotes	patients	Tax:9606
201	19-27	Chemical	denotes	steroids	MESH:D013256
202	882-889	Chemical	denotes	steroid	MESH:D013256
203	959-966	Chemical	denotes	steroid	MESH:D013256
231	177-197	Disease	denotes	SARS-CoV-2 infection	MESH:C000657245
232	382-394	Disease	denotes	inflammation	MESH:D007249
233	416-427	Disease	denotes	lung injury	MESH:D055370
234	473-482	Disease	denotes	pneumonia	MESH:D011014
235	513-521	Disease	denotes	COVID-19	MESH:C000657245
236	614-628	Disease	denotes	critically ill	MESH:D016638
237	629-637	Disease	denotes	COVID-19	MESH:C000657245
238	652-656	Disease	denotes	ARDS	MESH:D012128
239	682-706	Disease	denotes	ARDS respiratory failure	MESH:D012131
240	985-1003	Disease	denotes	non–critically ill	MESH:D016638
241	1004-1012	Disease	denotes	COVID-19	MESH:C000657245

Id	Subject	Object	Predicate	Lexical cue	fma_id
T1	399-407	Body_part	denotes	cytokine	http://purl.org/sig/ont/fma/fma84050
T2	416-420	Body_part	denotes	lung	http://purl.org/sig/ont/fma/fma7195

Id	Subject	Object	Predicate	Lexical cue	uberon_id
T1	416-420	Body_part	denotes	lung	http://purl.obolibrary.org/obo/UBERON_0002048

Id	Subject	Object	Predicate	Lexical cue	hp_id
T8	473-482	Phenotype	denotes	pneumonia	http://purl.obolibrary.org/obo/HP_0002090
T9	687-706	Phenotype	denotes	respiratory failure	http://purl.obolibrary.org/obo/HP_0002878

Id	Subject	Object	Predicate	Lexical cue	mondo_id
T39	177-185	Disease	denotes	SARS-CoV	http://purl.obolibrary.org/obo/MONDO_0005091
T40	188-197	Disease	denotes	infection	http://purl.obolibrary.org/obo/MONDO_0005550
T41	331-335	Disease	denotes	SARS	http://purl.obolibrary.org/obo/MONDO_0005091
T42	382-394	Disease	denotes	inflammation	http://purl.obolibrary.org/obo/MONDO_0021166
T43	421-427	Disease	denotes	injury	http://purl.obolibrary.org/obo/MONDO_0021178
T44	473-482	Disease	denotes	pneumonia	http://purl.obolibrary.org/obo/MONDO_0005249
T45	513-521	Disease	denotes	COVID-19	http://purl.obolibrary.org/obo/MONDO_0100096
T46	629-637	Disease	denotes	COVID-19	http://purl.obolibrary.org/obo/MONDO_0100096
T47	652-656	Disease	denotes	ARDS	http://purl.obolibrary.org/obo/MONDO_0006502
T48	682-686	Disease	denotes	ARDS	http://purl.obolibrary.org/obo/MONDO_0006502
T49	687-706	Disease	denotes	respiratory failure	http://purl.obolibrary.org/obo/MONDO_0021113
T50	1004-1012	Disease	denotes	COVID-19	http://purl.obolibrary.org/obo/MONDO_0100096

Id	Subject	Object	Predicate	Lexical cue
T29	416-420	http://purl.obolibrary.org/obo/UBERON_0002048	denotes	lung
T30	416-420	http://www.ebi.ac.uk/efo/EFO_0000934	denotes	lung
T31	956-957	http://purl.obolibrary.org/obo/CLO_0001021	denotes	b

Id	Subject	Object	Predicate	Lexical cue	chebi_id
T38	19-27	Chemical	denotes	steroids	http://purl.obolibrary.org/obo/CHEBI_35341
T39	130-144	Chemical	denotes	corticosteroid	http://purl.obolibrary.org/obo/CHEBI_50858
T40	291-305	Chemical	denotes	corticosteroid	http://purl.obolibrary.org/obo/CHEBI_50858
T41	595-610	Chemical	denotes	corticosteroids	http://purl.obolibrary.org/obo/CHEBI_50858
T42	882-889	Chemical	denotes	steroid	http://purl.obolibrary.org/obo/CHEBI_35341
T43	959-966	Chemical	denotes	steroid	http://purl.obolibrary.org/obo/CHEBI_35341

Id	Subject	Object	Predicate	Lexical cue
T1	382-394	http://purl.obolibrary.org/obo/GO_0006954	denotes	inflammation

Id	Subject	Object	Predicate	Lexical cue
T61	0-11	Sentence	denotes	Question 5.
T62	12-44	Sentence	denotes	Should steroids be administered?
T63	45-198	Sentence	denotes	So far, no definitive efficacy or effectiveness data are available on the benefit of corticosteroid administration in patients with SARS-CoV-2 infection.
T64	199-342	Sentence	denotes	As the WHO underlines, there is an important need for efficacy data from RCT for supporting corticosteroid therapy in patients with SARS-Cov-2.
T65	343-789	Sentence	denotes	However, considering that overwhelming inflammation and cytokine-related lung injury might be responsible for rapidly progressive pneumonia and clinical deterioration in COVID-19 patients, we suggest (expert opinion only) to consider administration of corticosteroids in critically ill COVID-19 patients with ARDS or with worsening of non-ARDS respiratory failure in the absence of bacterial/fungal superinfections (independent of ICU admission).
T66	790-1022	Sentence	denotes	Yet in the absence of convincing evidence, the following cannot currently be supported: (1) steroid administration stratified according to inflammatory markers; and (b) steroid administration in non–critically ill COVID-19 patients.