PMC:7195088 / 73851-74320 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"2061","span":{"begin":110,"end":123},"obj":"Species"},{"id":"2062","span":{"begin":129,"end":137},"obj":"Species"},{"id":"2063","span":{"begin":288,"end":296},"obj":"Species"},{"id":"2064","span":{"begin":460,"end":468},"obj":"Species"},{"id":"2065","span":{"begin":53,"end":60},"obj":"Chemical"},{"id":"2066","span":{"begin":440,"end":447},"obj":"Chemical"},{"id":"2067","span":{"begin":451,"end":459},"obj":"Disease"}],"attributes":[{"id":"A2061","pred":"tao:has_database_id","subj":"2061","obj":"Tax:11118"},{"id":"A2062","pred":"tao:has_database_id","subj":"2062","obj":"Tax:9606"},{"id":"A2063","pred":"tao:has_database_id","subj":"2063","obj":"Tax:9606"},{"id":"A2064","pred":"tao:has_database_id","subj":"2064","obj":"Tax:9606"},{"id":"A2065","pred":"tao:has_database_id","subj":"2065","obj":"MESH:C558899"},{"id":"A2066","pred":"tao:has_database_id","subj":"2066","obj":"MESH:C558899"},{"id":"A2067","pred":"tao:has_database_id","subj":"2067","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Notably, this is what, in our opinion, happened with LPV/RTV: (a) preclinical data supported activity against coronaviruses; (b) patients were enrolled onto RCT whenever possible, and otherwise they were offered off-label administration when not spontaneously improving; (c) because many patients were rapidly enrolled onto the first RCT, evidence rapidly become available that in our opinion discouraged a universal off-label provision of LPV/RTV in COVID-19 patients."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T397","span":{"begin":451,"end":459},"obj":"Disease"}],"attributes":[{"id":"A397","pred":"mondo_id","subj":"T397","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"}],"text":"Notably, this is what, in our opinion, happened with LPV/RTV: (a) preclinical data supported activity against coronaviruses; (b) patients were enrolled onto RCT whenever possible, and otherwise they were offered off-label administration when not spontaneously improving; (c) because many patients were rapidly enrolled onto the first RCT, evidence rapidly become available that in our opinion discouraged a universal off-label provision of LPV/RTV in COVID-19 patients."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T390","span":{"begin":63,"end":64},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T391","span":{"begin":93,"end":101},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T392","span":{"begin":126,"end":127},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T393","span":{"begin":216,"end":221},"obj":"http://purl.obolibrary.org/obo/CLO_0007225"},{"id":"T394","span":{"begin":405,"end":406},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T395","span":{"begin":421,"end":426},"obj":"http://purl.obolibrary.org/obo/CLO_0007225"}],"text":"Notably, this is what, in our opinion, happened with LPV/RTV: (a) preclinical data supported activity against coronaviruses; (b) patients were enrolled onto RCT whenever possible, and otherwise they were offered off-label administration when not spontaneously improving; (c) because many patients were rapidly enrolled onto the first RCT, evidence rapidly become available that in our opinion discouraged a universal off-label provision of LPV/RTV in COVID-19 patients."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T22983","span":{"begin":216,"end":221},"obj":"Chemical"},{"id":"T82876","span":{"begin":421,"end":426},"obj":"Chemical"}],"attributes":[{"id":"A73415","pred":"chebi_id","subj":"T22983","obj":"http://purl.obolibrary.org/obo/CHEBI_35209"},{"id":"A59992","pred":"chebi_id","subj":"T82876","obj":"http://purl.obolibrary.org/obo/CHEBI_35209"}],"text":"Notably, this is what, in our opinion, happened with LPV/RTV: (a) preclinical data supported activity against coronaviruses; (b) patients were enrolled onto RCT whenever possible, and otherwise they were offered off-label administration when not spontaneously improving; (c) because many patients were rapidly enrolled onto the first RCT, evidence rapidly become available that in our opinion discouraged a universal off-label provision of LPV/RTV in COVID-19 patients."}

{"project":"LitCovid-sentences","denotations":[{"id":"T502","span":{"begin":0,"end":469},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Notably, this is what, in our opinion, happened with LPV/RTV: (a) preclinical data supported activity against coronaviruses; (b) patients were enrolled onto RCT whenever possible, and otherwise they were offered off-label administration when not spontaneously improving; (c) because many patients were rapidly enrolled onto the first RCT, evidence rapidly become available that in our opinion discouraged a universal off-label provision of LPV/RTV in COVID-19 patients."}