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PMC:7195088 / 69460-71557 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
2017 433-444 Chemical denotes chloroquine MESH:D002738
2018 445-463 Chemical denotes hydroxychloroquine MESH:D006886
2019 831-838 Chemical denotes steroid MESH:D013256
2020 908-915 Chemical denotes steroid MESH:D013256
2021 744-753 Disease denotes mortality MESH:D003643
2030 1266-1274 Species denotes patients Tax:9606
2031 1849-1856 Species denotes patient Tax:9606
2032 994-1005 Chemical denotes Chloroquine MESH:D002738
2033 1006-1024 Chemical denotes hydroxychloroquine MESH:D006886
2034 1464-1474 Chemical denotes remdesivir MESH:C000606551
2035 1918-1925 Chemical denotes steroid MESH:D013256
2036 1257-1265 Disease denotes COVID-19 MESH:C000657245
2037 1386-1427 Disease denotes QT prolongation or hepatic/renal toxicity MESH:D056486

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T119 1885-1889 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T57 1885-1889 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T394 1257-1265 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T379 283-284 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T380 311-319 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T381 417-418 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T382 1765-1766 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T383 1885-1889 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T384 1885-1889 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T385 1990-1991 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T57203 255-260 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T40359 433-444 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T32607 445-463 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T12702 831-838 Chemical denotes steroid http://purl.obolibrary.org/obo/CHEBI_35341
T60327 908-915 Chemical denotes steroid http://purl.obolibrary.org/obo/CHEBI_35341
T70825 994-1005 Chemical denotes Chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T55266 1006-1024 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T80885 1464-1474 Chemical denotes remdesivir http://purl.obolibrary.org/obo/CHEBI_145994
T73747 1720-1735 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T40348 1918-1925 Chemical denotes steroid http://purl.obolibrary.org/obo/CHEBI_35341
T52269 2009-2023 Chemical denotes corticosteroid http://purl.obolibrary.org/obo/CHEBI_50858

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T482 0-51 Sentence denotes Question 8. what is the optimal treatment duration?
T483 52-355 Sentence denotes In the absence of proven effective treatment, treatment duration also remains unclear; it is currently based on expert opinion which is based on treatment durations in other approved indications for the drugs provided and aimed at a balance between potential activity and risk of undesired side effects.
T484 356-403 Sentence denotes Nonetheless, suggested durations vary markedly.
T485 404-809 Sentence denotes For example, a wide range of chloroquine/hydroxychloroquine treatment durations (from 5 to 20 days) have been recommended/provided in different centres/studies, making it impossible to provide an univocal recommendation in the absence of direct comparisons of different lengths of treatment with regard to relevant clinical endpoints (e.g. mortality, ICU admission) and safety [33,40,41,[83], [84], [85]].
T486 810-971 Sentence denotes There is no standard steroid treatment duration, with different consensus/study groups suggesting steroid administration for no longer than 7 to 10 days [54,85].
T487 973-993 Sentence denotes Question 8 statement
T488 994-1301 Sentence denotes Chloroquine/hydroxychloroquine treatment should be continued for at least 5 days and possibly prolonged up to 20 days according to some expert opinions, although it should be noted that data regarding the relative safety of different lengths of administration in COVID-19 patients are currently unavailable.
T489 1302-1438 Sentence denotes Early discontinuation should be considered in the presence of adverse effects (e.g. QT prolongation or hepatic/renal toxicity; Table 3).
T490 1439-1716 Sentence denotes If the administration of remdesivir is approved within compassionate-use/expanded-access programmes, treatment duration should follow compassionate or expanded access protocols (e.g. up to 10 days according to the most recent compassionate protocol at the time of this review).
T491 1717-1841 Sentence denotes If corticosteroids are administered, we suggest a total treatment duration of 7 to 10 days, with progressive dose reduction.
T492 1842-2097 Sentence denotes If the patient deteriorates with worsening lung physiology after removal of steroid treatment in the absence of bacterial or fungal superinfection, a second course of corticosteroid treatment may be considered, followed by slow tapering after improvement.

2_test

Id Subject Object Predicate Lexical cue
32360444-32164085-22369824 798-800 32164085 denotes 84
32360444-32122468-22369825 964-966 32122468 denotes 54