PMC:7195088 / 67202-68210 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"1952","span":{"begin":255,"end":263},"obj":"Species"},{"id":"1953","span":{"begin":311,"end":319},"obj":"Species"},{"id":"1954","span":{"begin":740,"end":748},"obj":"Species"},{"id":"1955","span":{"begin":935,"end":943},"obj":"Species"},{"id":"1956","span":{"begin":956,"end":964},"obj":"Species"},{"id":"1957","span":{"begin":20,"end":31},"obj":"Chemical"},{"id":"1958","span":{"begin":32,"end":50},"obj":"Chemical"},{"id":"1959","span":{"begin":438,"end":456},"obj":"Chemical"},{"id":"1960","span":{"begin":617,"end":624},"obj":"Chemical"},{"id":"1961","span":{"begin":828,"end":835},"obj":"Chemical"},{"id":"1962","span":{"begin":275,"end":301},"obj":"Disease"},{"id":"1963","span":{"begin":331,"end":357},"obj":"Disease"},{"id":"1964","span":{"begin":715,"end":729},"obj":"Disease"},{"id":"1965","span":{"begin":735,"end":739},"obj":"Disease"},{"id":"1966","span":{"begin":930,"end":934},"obj":"Disease"},{"id":"1967","span":{"begin":951,"end":955},"obj":"Disease"}],"attributes":[{"id":"A1952","pred":"tao:has_database_id","subj":"1952","obj":"Tax:9606"},{"id":"A1953","pred":"tao:has_database_id","subj":"1953","obj":"Tax:9606"},{"id":"A1954","pred":"tao:has_database_id","subj":"1954","obj":"Tax:9606"},{"id":"A1955","pred":"tao:has_database_id","subj":"1955","obj":"Tax:9606"},{"id":"A1956","pred":"tao:has_database_id","subj":"1956","obj":"Tax:9606"},{"id":"A1957","pred":"tao:has_database_id","subj":"1957","obj":"MESH:D002738"},{"id":"A1958","pred":"tao:has_database_id","subj":"1958","obj":"MESH:D006886"},{"id":"A1959","pred":"tao:has_database_id","subj":"1959","obj":"MESH:D006886"},{"id":"A1960","pred":"tao:has_database_id","subj":"1960","obj":"MESH:D013256"},{"id":"A1961","pred":"tao:has_database_id","subj":"1961","obj":"MESH:D013256"},{"id":"A1962","pred":"tao:has_database_id","subj":"1962","obj":"MESH:D012140"},{"id":"A1963","pred":"tao:has_database_id","subj":"1963","obj":"MESH:D012140"},{"id":"A1964","pred":"tao:has_database_id","subj":"1964","obj":"MESH:D016638"},{"id":"A1965","pred":"tao:has_database_id","subj":"1965","obj":"MESH:D012128"},{"id":"A1966","pred":"tao:has_database_id","subj":"1966","obj":"MESH:D012128"},{"id":"A1967","pred":"tao:has_database_id","subj":"1967","obj":"MESH:D012128"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"The optimal time of chloroquine/hydroxychloroquine and corticosteroids initiation still remains unknown. Although based on low-level evidence, the positive effect of virus clearance observed by Gautret et al. [41] was observed in a mixed group of non-ICU patients with upper respiratory tract symptoms, non-ICU patients with lower respiratory tract symptoms and asymptomatic subjects, which overall may support a positive effect of early hydroxychloroquine initiation in non-ICU settings (although information on the exact time of treatment initiation with respect to symptoms onset was not provided). With regard to steroid treatment, there is currently no evidence of a positive impact of early initiation in non–critically ill, non-ARDS patients. Although lack of evidence is not a synonym of lack of effect, in our opinion, steroid treatment, considering also its potential detrimental effects, should currently be limited to ARDS patients or non-ARDS patients with worsening conditions (see question 5)."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T116","span":{"begin":269,"end":292},"obj":"Body_part"},{"id":"T117","span":{"begin":325,"end":348},"obj":"Body_part"}],"attributes":[{"id":"A116","pred":"fma_id","subj":"T116","obj":"http://purl.org/sig/ont/fma/fma45661"},{"id":"A117","pred":"fma_id","subj":"T117","obj":"http://purl.org/sig/ont/fma/fma45662"}],"text":"The optimal time of chloroquine/hydroxychloroquine and corticosteroids initiation still remains unknown. Although based on low-level evidence, the positive effect of virus clearance observed by Gautret et al. [41] was observed in a mixed group of non-ICU patients with upper respiratory tract symptoms, non-ICU patients with lower respiratory tract symptoms and asymptomatic subjects, which overall may support a positive effect of early hydroxychloroquine initiation in non-ICU settings (although information on the exact time of treatment initiation with respect to symptoms onset was not provided). With regard to steroid treatment, there is currently no evidence of a positive impact of early initiation in non–critically ill, non-ARDS patients. Although lack of evidence is not a synonym of lack of effect, in our opinion, steroid treatment, considering also its potential detrimental effects, should currently be limited to ARDS patients or non-ARDS patients with worsening conditions (see question 5)."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T51","span":{"begin":269,"end":292},"obj":"Body_part"},{"id":"T52","span":{"begin":275,"end":292},"obj":"Body_part"},{"id":"T53","span":{"begin":325,"end":348},"obj":"Body_part"},{"id":"T54","span":{"begin":331,"end":348},"obj":"Body_part"}],"attributes":[{"id":"A51","pred":"uberon_id","subj":"T51","obj":"http://purl.obolibrary.org/obo/UBERON_0001557"},{"id":"A52","pred":"uberon_id","subj":"T52","obj":"http://purl.obolibrary.org/obo/UBERON_0000065"},{"id":"A53","pred":"uberon_id","subj":"T53","obj":"http://purl.obolibrary.org/obo/UBERON_0001558"},{"id":"A54","pred":"uberon_id","subj":"T54","obj":"http://purl.obolibrary.org/obo/UBERON_0000065"}],"text":"The optimal time of chloroquine/hydroxychloroquine and corticosteroids initiation still remains unknown. Although based on low-level evidence, the positive effect of virus clearance observed by Gautret et al. [41] was observed in a mixed group of non-ICU patients with upper respiratory tract symptoms, non-ICU patients with lower respiratory tract symptoms and asymptomatic subjects, which overall may support a positive effect of early hydroxychloroquine initiation in non-ICU settings (although information on the exact time of treatment initiation with respect to symptoms onset was not provided). With regard to steroid treatment, there is currently no evidence of a positive impact of early initiation in non–critically ill, non-ARDS patients. Although lack of evidence is not a synonym of lack of effect, in our opinion, steroid treatment, considering also its potential detrimental effects, should currently be limited to ARDS patients or non-ARDS patients with worsening conditions (see question 5)."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T383","span":{"begin":735,"end":739},"obj":"Disease"},{"id":"T384","span":{"begin":930,"end":934},"obj":"Disease"},{"id":"T385","span":{"begin":951,"end":955},"obj":"Disease"}],"attributes":[{"id":"A383","pred":"mondo_id","subj":"T383","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"},{"id":"A384","pred":"mondo_id","subj":"T384","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"},{"id":"A385","pred":"mondo_id","subj":"T385","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"}],"text":"The optimal time of chloroquine/hydroxychloroquine and corticosteroids initiation still remains unknown. Although based on low-level evidence, the positive effect of virus clearance observed by Gautret et al. [41] was observed in a mixed group of non-ICU patients with upper respiratory tract symptoms, non-ICU patients with lower respiratory tract symptoms and asymptomatic subjects, which overall may support a positive effect of early hydroxychloroquine initiation in non-ICU settings (although information on the exact time of treatment initiation with respect to symptoms onset was not provided). With regard to steroid treatment, there is currently no evidence of a positive impact of early initiation in non–critically ill, non-ARDS patients. Although lack of evidence is not a synonym of lack of effect, in our opinion, steroid treatment, considering also its potential detrimental effects, should currently be limited to ARDS patients or non-ARDS patients with worsening conditions (see question 5)."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T369","span":{"begin":166,"end":171},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T370","span":{"begin":210,"end":212},"obj":"http://purl.obolibrary.org/obo/CLO_0053794"},{"id":"T371","span":{"begin":230,"end":231},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T372","span":{"begin":325,"end":348},"obj":"http://purl.obolibrary.org/obo/UBERON_0001558"},{"id":"T373","span":{"begin":411,"end":412},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T374","span":{"begin":670,"end":671},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T375","span":{"begin":783,"end":784},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"The optimal time of chloroquine/hydroxychloroquine and corticosteroids initiation still remains unknown. Although based on low-level evidence, the positive effect of virus clearance observed by Gautret et al. [41] was observed in a mixed group of non-ICU patients with upper respiratory tract symptoms, non-ICU patients with lower respiratory tract symptoms and asymptomatic subjects, which overall may support a positive effect of early hydroxychloroquine initiation in non-ICU settings (although information on the exact time of treatment initiation with respect to symptoms onset was not provided). With regard to steroid treatment, there is currently no evidence of a positive impact of early initiation in non–critically ill, non-ARDS patients. Although lack of evidence is not a synonym of lack of effect, in our opinion, steroid treatment, considering also its potential detrimental effects, should currently be limited to ARDS patients or non-ARDS patients with worsening conditions (see question 5)."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T87596","span":{"begin":20,"end":31},"obj":"Chemical"},{"id":"T51549","span":{"begin":32,"end":50},"obj":"Chemical"},{"id":"T54232","span":{"begin":55,"end":70},"obj":"Chemical"},{"id":"T33985","span":{"begin":238,"end":243},"obj":"Chemical"},{"id":"T99","span":{"begin":438,"end":456},"obj":"Chemical"},{"id":"T38634","span":{"begin":617,"end":624},"obj":"Chemical"},{"id":"T95699","span":{"begin":828,"end":835},"obj":"Chemical"}],"attributes":[{"id":"A92552","pred":"chebi_id","subj":"T87596","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A25302","pred":"chebi_id","subj":"T51549","obj":"http://purl.obolibrary.org/obo/CHEBI_5801"},{"id":"A86934","pred":"chebi_id","subj":"T54232","obj":"http://purl.obolibrary.org/obo/CHEBI_50858"},{"id":"A75104","pred":"chebi_id","subj":"T33985","obj":"http://purl.obolibrary.org/obo/CHEBI_24433"},{"id":"A45839","pred":"chebi_id","subj":"T99","obj":"http://purl.obolibrary.org/obo/CHEBI_5801"},{"id":"A69747","pred":"chebi_id","subj":"T38634","obj":"http://purl.obolibrary.org/obo/CHEBI_35341"},{"id":"A88242","pred":"chebi_id","subj":"T95699","obj":"http://purl.obolibrary.org/obo/CHEBI_35341"}],"text":"The optimal time of chloroquine/hydroxychloroquine and corticosteroids initiation still remains unknown. Although based on low-level evidence, the positive effect of virus clearance observed by Gautret et al. [41] was observed in a mixed group of non-ICU patients with upper respiratory tract symptoms, non-ICU patients with lower respiratory tract symptoms and asymptomatic subjects, which overall may support a positive effect of early hydroxychloroquine initiation in non-ICU settings (although information on the exact time of treatment initiation with respect to symptoms onset was not provided). With regard to steroid treatment, there is currently no evidence of a positive impact of early initiation in non–critically ill, non-ARDS patients. Although lack of evidence is not a synonym of lack of effect, in our opinion, steroid treatment, considering also its potential detrimental effects, should currently be limited to ARDS patients or non-ARDS patients with worsening conditions (see question 5)."}

{"project":"LitCovid-sentences","denotations":[{"id":"T473","span":{"begin":0,"end":104},"obj":"Sentence"},{"id":"T474","span":{"begin":105,"end":601},"obj":"Sentence"},{"id":"T475","span":{"begin":602,"end":749},"obj":"Sentence"},{"id":"T476","span":{"begin":750,"end":1008},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"The optimal time of chloroquine/hydroxychloroquine and corticosteroids initiation still remains unknown. Although based on low-level evidence, the positive effect of virus clearance observed by Gautret et al. [41] was observed in a mixed group of non-ICU patients with upper respiratory tract symptoms, non-ICU patients with lower respiratory tract symptoms and asymptomatic subjects, which overall may support a positive effect of early hydroxychloroquine initiation in non-ICU settings (although information on the exact time of treatment initiation with respect to symptoms onset was not provided). With regard to steroid treatment, there is currently no evidence of a positive impact of early initiation in non–critically ill, non-ARDS patients. Although lack of evidence is not a synonym of lack of effect, in our opinion, steroid treatment, considering also its potential detrimental effects, should currently be limited to ARDS patients or non-ARDS patients with worsening conditions (see question 5)."}