PMC:7195088 / 58842-59734
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7195088","sourcedb":"PMC","sourceid":"7195088","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7195088","text":"Data on the use of corticosteroids in critically ill patients with SARS-CoV-1 and MERS-CoV infection are available, albeit with conflicting results. In a retrospective observational study of 152 SARS-CoV-1–infected, critically ill patients, corticosteroid therapy was found to reduce mortality and shorten the length of hospital stay (odds ratio 0.08, 95% confidence intervals 0.01–0.97, p 0.046). The study did not report increased secondary infections or other complications with corticosteroid administration [64]. Conversely, in a retrospective observational study on 309 critically ill patients with MERS-CoV, the administration of a median hydrocortisone equivalent dose of 300 mg per day was not associated with a difference in 90-day mortality. In addition, corticosteroid administration was associated with delayed clearance of MERS-CoV RNA from the patients' respiratory tract 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