PMC:7195088 / 22469-22874 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"644","span":{"begin":84,"end":90},"obj":"Gene"},{"id":"679","span":{"begin":215,"end":223},"obj":"Species"},{"id":"810","span":{"begin":0,"end":9},"obj":"Chemical"},{"id":"811","span":{"begin":10,"end":30},"obj":"Chemical"},{"id":"812","span":{"begin":113,"end":122},"obj":"Chemical"},{"id":"946","span":{"begin":229,"end":247},"obj":"Disease"}],"attributes":[{"id":"A644","pred":"tao:has_database_id","subj":"644","obj":"Gene:1576"},{"id":"A679","pred":"tao:has_database_id","subj":"679","obj":"Tax:9606"},{"id":"A810","pred":"tao:has_database_id","subj":"810","obj":"MESH:D000069454"},{"id":"A812","pred":"tao:has_database_id","subj":"812","obj":"MESH:D000069454"},{"id":"A946","pred":"tao:has_database_id","subj":"946","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Darunavir/cobicistat Darunavir is an HIV type 1 protease inhibitor. Cobicistat is a CYP3A4 inhibitor that boosts darunavir concentrations • Not available • Comparison of darunavir/cobicistat vs. standard of care in patients with COVID-19 pneumonia. Open-label RCT (NCT04252274, recruiting). Primary endpoint: virologic clearance rate of throat swabs, sputum or lower respiratory tract secretions at day 7."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T16","span":{"begin":37,"end":40},"obj":"Body_part"},{"id":"T17","span":{"begin":337,"end":343},"obj":"Body_part"},{"id":"T18","span":{"begin":351,"end":357},"obj":"Body_part"},{"id":"T19","span":{"begin":361,"end":384},"obj":"Body_part"}],"attributes":[{"id":"A16","pred":"fma_id","subj":"T16","obj":"http://purl.org/sig/ont/fma/fma278683"},{"id":"A17","pred":"fma_id","subj":"T17","obj":"http://purl.org/sig/ont/fma/fma228738"},{"id":"A18","pred":"fma_id","subj":"T18","obj":"http://purl.org/sig/ont/fma/fma312401"},{"id":"A19","pred":"fma_id","subj":"T19","obj":"http://purl.org/sig/ont/fma/fma45662"}],"text":"Darunavir/cobicistat Darunavir is an HIV type 1 protease inhibitor. Cobicistat is a CYP3A4 inhibitor that boosts darunavir concentrations • Not available • Comparison of darunavir/cobicistat vs. standard of care in patients with COVID-19 pneumonia. Open-label RCT (NCT04252274, recruiting). Primary endpoint: virologic clearance rate of throat swabs, sputum or lower respiratory tract secretions at day 7."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T15","span":{"begin":337,"end":343},"obj":"Body_part"},{"id":"T16","span":{"begin":351,"end":357},"obj":"Body_part"},{"id":"T17","span":{"begin":361,"end":384},"obj":"Body_part"},{"id":"T18","span":{"begin":367,"end":384},"obj":"Body_part"}],"attributes":[{"id":"A15","pred":"uberon_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/UBERON_0000341"},{"id":"A16","pred":"uberon_id","subj":"T16","obj":"http://purl.obolibrary.org/obo/UBERON_0007311"},{"id":"A17","pred":"uberon_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/UBERON_0001558"},{"id":"A18","pred":"uberon_id","subj":"T18","obj":"http://purl.obolibrary.org/obo/UBERON_0000065"}],"text":"Darunavir/cobicistat Darunavir is an HIV type 1 protease inhibitor. Cobicistat is a CYP3A4 inhibitor that boosts darunavir concentrations • Not available • Comparison of darunavir/cobicistat vs. standard of care in patients with COVID-19 pneumonia. Open-label RCT (NCT04252274, recruiting). Primary endpoint: virologic clearance rate of throat swabs, sputum or lower respiratory tract secretions at day 7."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T26","span":{"begin":238,"end":247},"obj":"Phenotype"}],"attributes":[{"id":"A26","pred":"hp_id","subj":"T26","obj":"http://purl.obolibrary.org/obo/HP_0002090"}],"text":"Darunavir/cobicistat Darunavir is an HIV type 1 protease inhibitor. Cobicistat is a CYP3A4 inhibitor that boosts darunavir concentrations • Not available • Comparison of darunavir/cobicistat vs. standard of care in patients with COVID-19 pneumonia. Open-label RCT (NCT04252274, recruiting). Primary endpoint: virologic clearance rate of throat swabs, sputum or lower respiratory tract secretions at day 7."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T109","span":{"begin":229,"end":237},"obj":"Disease"},{"id":"T110","span":{"begin":238,"end":247},"obj":"Disease"}],"attributes":[{"id":"A109","pred":"mondo_id","subj":"T109","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A110","pred":"mondo_id","subj":"T110","obj":"http://purl.obolibrary.org/obo/MONDO_0005249"}],"text":"Darunavir/cobicistat Darunavir is an HIV type 1 protease inhibitor. Cobicistat is a CYP3A4 inhibitor that boosts darunavir concentrations • Not available • Comparison of darunavir/cobicistat vs. standard of care in patients with COVID-19 pneumonia. Open-label RCT (NCT04252274, recruiting). Primary endpoint: virologic clearance rate of throat swabs, sputum or lower respiratory tract secretions at day 7."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T109","span":{"begin":82,"end":83},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T110","span":{"begin":254,"end":259},"obj":"http://purl.obolibrary.org/obo/CLO_0007225"},{"id":"T111","span":{"begin":361,"end":384},"obj":"http://purl.obolibrary.org/obo/UBERON_0001558"}],"text":"Darunavir/cobicistat Darunavir is an HIV type 1 protease inhibitor. Cobicistat is a CYP3A4 inhibitor that boosts darunavir concentrations • Not available • Comparison of darunavir/cobicistat vs. standard of care in patients with COVID-19 pneumonia. Open-label RCT (NCT04252274, recruiting). Primary endpoint: virologic clearance rate of throat swabs, sputum or lower respiratory tract secretions at day 7."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T258","span":{"begin":0,"end":9},"obj":"Chemical"},{"id":"T259","span":{"begin":10,"end":20},"obj":"Chemical"},{"id":"T260","span":{"begin":21,"end":30},"obj":"Chemical"},{"id":"T261","span":{"begin":48,"end":66},"obj":"Chemical"},{"id":"T263","span":{"begin":57,"end":66},"obj":"Chemical"},{"id":"T264","span":{"begin":84,"end":100},"obj":"Chemical"},{"id":"T265","span":{"begin":91,"end":100},"obj":"Chemical"},{"id":"T266","span":{"begin":113,"end":122},"obj":"Chemical"},{"id":"T267","span":{"begin":170,"end":179},"obj":"Chemical"},{"id":"T268","span":{"begin":180,"end":190},"obj":"Chemical"},{"id":"T269","span":{"begin":254,"end":259},"obj":"Chemical"}],"attributes":[{"id":"A258","pred":"chebi_id","subj":"T258","obj":"http://purl.obolibrary.org/obo/CHEBI_367163"},{"id":"A259","pred":"chebi_id","subj":"T259","obj":"http://purl.obolibrary.org/obo/CHEBI_72291"},{"id":"A260","pred":"chebi_id","subj":"T260","obj":"http://purl.obolibrary.org/obo/CHEBI_367163"},{"id":"A261","pred":"chebi_id","subj":"T261","obj":"http://purl.obolibrary.org/obo/CHEBI_37670"},{"id":"A262","pred":"chebi_id","subj":"T261","obj":"http://purl.obolibrary.org/obo/CHEBI_60258"},{"id":"A263","pred":"chebi_id","subj":"T263","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A264","pred":"chebi_id","subj":"T264","obj":"http://purl.obolibrary.org/obo/CHEBI_86501"},{"id":"A265","pred":"chebi_id","subj":"T265","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A266","pred":"chebi_id","subj":"T266","obj":"http://purl.obolibrary.org/obo/CHEBI_367163"},{"id":"A267","pred":"chebi_id","subj":"T267","obj":"http://purl.obolibrary.org/obo/CHEBI_367163"},{"id":"A268","pred":"chebi_id","subj":"T268","obj":"http://purl.obolibrary.org/obo/CHEBI_72291"},{"id":"A269","pred":"chebi_id","subj":"T269","obj":"http://purl.obolibrary.org/obo/CHEBI_35209"}],"text":"Darunavir/cobicistat Darunavir is an HIV type 1 protease inhibitor. Cobicistat is a CYP3A4 inhibitor that boosts darunavir concentrations • Not available • Comparison of darunavir/cobicistat vs. standard of care in patients with COVID-19 pneumonia. Open-label RCT (NCT04252274, recruiting). Primary endpoint: virologic clearance rate of throat swabs, sputum or lower respiratory tract secretions at day 7."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T5","span":{"begin":385,"end":395},"obj":"http://purl.obolibrary.org/obo/GO_0046903"}],"text":"Darunavir/cobicistat Darunavir is an HIV type 1 protease inhibitor. Cobicistat is a CYP3A4 inhibitor that boosts darunavir concentrations • Not available • Comparison of darunavir/cobicistat vs. standard of care in patients with COVID-19 pneumonia. Open-label RCT (NCT04252274, recruiting). Primary endpoint: virologic clearance rate of throat swabs, sputum or lower respiratory tract secretions at day 7."}

{"project":"LitCovid-sentences","denotations":[{"id":"T166","span":{"begin":0,"end":67},"obj":"Sentence"},{"id":"T167","span":{"begin":68,"end":248},"obj":"Sentence"},{"id":"T168","span":{"begin":249,"end":290},"obj":"Sentence"},{"id":"T169","span":{"begin":291,"end":405},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Darunavir/cobicistat Darunavir is an HIV type 1 protease inhibitor. Cobicistat is a CYP3A4 inhibitor that boosts darunavir concentrations • Not available • Comparison of darunavir/cobicistat vs. standard of care in patients with COVID-19 pneumonia. Open-label RCT (NCT04252274, recruiting). Primary endpoint: virologic clearance rate of throat swabs, sputum or lower respiratory tract secretions at day 7."}