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PMC:7195088 / 22469-22874 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
644 84-90 Gene denotes CYP3A4 Gene:1576
679 215-223 Species denotes patients Tax:9606
810 0-9 Chemical denotes Darunavir MESH:D000069454
811 10-30 Chemical denotes cobicistat Darunavir
812 113-122 Chemical denotes darunavir MESH:D000069454
946 229-247 Disease denotes COVID-19 pneumonia MESH:C000657245

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T16 37-40 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T17 337-343 Body_part denotes throat http://purl.org/sig/ont/fma/fma228738
T18 351-357 Body_part denotes sputum http://purl.org/sig/ont/fma/fma312401
T19 361-384 Body_part denotes lower respiratory tract http://purl.org/sig/ont/fma/fma45662

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T15 337-343 Body_part denotes throat http://purl.obolibrary.org/obo/UBERON_0000341
T16 351-357 Body_part denotes sputum http://purl.obolibrary.org/obo/UBERON_0007311
T17 361-384 Body_part denotes lower respiratory tract http://purl.obolibrary.org/obo/UBERON_0001558
T18 367-384 Body_part denotes respiratory tract http://purl.obolibrary.org/obo/UBERON_0000065

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T26 238-247 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T109 229-237 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T110 238-247 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T109 82-83 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T110 254-259 http://purl.obolibrary.org/obo/CLO_0007225 denotes label
T111 361-384 http://purl.obolibrary.org/obo/UBERON_0001558 denotes lower respiratory tract

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T258 0-9 Chemical denotes Darunavir http://purl.obolibrary.org/obo/CHEBI_367163
T259 10-20 Chemical denotes cobicistat http://purl.obolibrary.org/obo/CHEBI_72291
T260 21-30 Chemical denotes Darunavir http://purl.obolibrary.org/obo/CHEBI_367163
T261 48-66 Chemical denotes protease inhibitor http://purl.obolibrary.org/obo/CHEBI_37670|http://purl.obolibrary.org/obo/CHEBI_60258
T263 57-66 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T264 84-100 Chemical denotes CYP3A4 inhibitor http://purl.obolibrary.org/obo/CHEBI_86501
T265 91-100 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T266 113-122 Chemical denotes darunavir http://purl.obolibrary.org/obo/CHEBI_367163
T267 170-179 Chemical denotes darunavir http://purl.obolibrary.org/obo/CHEBI_367163
T268 180-190 Chemical denotes cobicistat http://purl.obolibrary.org/obo/CHEBI_72291
T269 254-259 Chemical denotes label http://purl.obolibrary.org/obo/CHEBI_35209

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T5 385-395 http://purl.obolibrary.org/obo/GO_0046903 denotes secretions

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T166 0-67 Sentence denotes Darunavir/cobicistat Darunavir is an HIV type 1 protease inhibitor.
T167 68-248 Sentence denotes Cobicistat is a CYP3A4 inhibitor that boosts darunavir concentrations • Not available • Comparison of darunavir/cobicistat vs. standard of care in patients with COVID-19 pneumonia.
T168 249-290 Sentence denotes Open-label RCT (NCT04252274, recruiting).
T169 291-405 Sentence denotes Primary endpoint: virologic clearance rate of throat swabs, sputum or lower respiratory tract secretions at day 7.