PMC:7195088 / 12800-13894
Annnotations
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 182 | 264-272 | Species | denotes | patients | Tax:9606 |
| 183 | 831-838 | Species | denotes | patient | Tax:9606 |
| 210 | 0-30 | Chemical | denotes | Chloroquine/hydroxychloroquine | |
| 211 | 453-463 | Chemical | denotes | remdesivir | MESH:C000606551 |
| 212 | 915-922 | Chemical | denotes | steroid | MESH:D013256 |
| 256 | 255-263 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 257 | 384-425 | Disease | denotes | QT prolongation or hepatic/renal toxicity | MESH:D056486 |
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T6 | 879-883 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T4 | 879-883 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T64 | 255-263 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T43 | 750-751 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T44 | 879-883 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T45 | 879-883 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
| T46 | 987-988 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T55 | 0-11 | Chemical | denotes | Chloroquine | http://purl.obolibrary.org/obo/CHEBI_3638 |
| T56 | 12-30 | Chemical | denotes | hydroxychloroquine | http://purl.obolibrary.org/obo/CHEBI_5801 |
| T57 | 453-463 | Chemical | denotes | remdesivir | http://purl.obolibrary.org/obo/CHEBI_145994 |
| T58 | 709-724 | Chemical | denotes | corticosteroids | http://purl.obolibrary.org/obo/CHEBI_50858 |
| T59 | 915-922 | Chemical | denotes | steroid | http://purl.obolibrary.org/obo/CHEBI_35341 |
| T60 | 1006-1020 | Chemical | denotes | corticosteroid | http://purl.obolibrary.org/obo/CHEBI_50858 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T82 | 0-299 | Sentence | denotes | Chloroquine/hydroxychloroquine treatment should be continued for at least 5 days, and possibly up to 20 days, according to some expert opinions, although it should be noted that data regarding the relative safety of different lengths of administration in COVID-19 patients are currently unavailable. |
| T83 | 300-427 | Sentence | denotes | Early discontinuation should be considered in the presence of adverse effects (e.g. QT prolongation or hepatic/renal toxicity). |
| T84 | 428-705 | Sentence | denotes | If the administration of remdesivir is approved within compassionate-use/expanded-access programmes, treatment duration should follow compassionate or expanded access protocols (e.g. up to 10 days according to the most recent compassionate protocol at the time of this review). |
| T85 | 706-823 | Sentence | denotes | If corticosteroids are provided, we suggest a total treatment duration of 7–10 days, with progressive dose reduction. |
| T86 | 824-1094 | Sentence | denotes | If the patient's condition deteriorates with worsening lung physiology after withdrawal of steroid treatment in the absence of bacterial or fungal superinfection, a second course of corticosteroid treatment may be considered, followed by slow tapering after improvement. |