PMC:7190487 / 1355-1928 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T8","span":{"begin":193,"end":197},"obj":"Body_part"},{"id":"T9","span":{"begin":480,"end":494},"obj":"Body_part"},{"id":"T10","span":{"begin":495,"end":512},"obj":"Body_part"},{"id":"T11","span":{"begin":507,"end":512},"obj":"Body_part"},{"id":"T12","span":{"begin":542,"end":548},"obj":"Body_part"},{"id":"T13","span":{"begin":563,"end":568},"obj":"Body_part"}],"attributes":[{"id":"A8","pred":"fma_id","subj":"T8","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A9","pred":"fma_id","subj":"T9","obj":"http://purl.org/sig/ont/fma/fma70317"},{"id":"A10","pred":"fma_id","subj":"T10","obj":"http://purl.org/sig/ont/fma/fma66772"},{"id":"A11","pred":"fma_id","subj":"T11","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A12","pred":"fma_id","subj":"T12","obj":"http://purl.org/sig/ont/fma/fma7203"},{"id":"A13","pred":"fma_id","subj":"T13","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"Acute Respiratory Distress Syndrome (ARDS) is one of the commonest complications developing in patients with COVID-19 [6]. There have been animal studies that have implicated ACE2 in the acute lung injury (ALI) caused due to SARS-CoV [4]. It has been hypothesized that ACE2 causes ALI by bringing about autophagy through the AMPK/mTOR pathway [7]. AMPK has been shown to increase the expression of ACE2 as well as to increase its stability by phosphorylating ACE2 Ser680 in human umbilical vein endothelial cells (HUVECs) and human embryonic kidney 293 (HEK293T) cells [8]."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T1","span":{"begin":193,"end":197},"obj":"Body_part"},{"id":"T2","span":{"begin":480,"end":494},"obj":"Body_part"},{"id":"T3","span":{"begin":490,"end":494},"obj":"Body_part"},{"id":"T4","span":{"begin":542,"end":548},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"A2","pred":"uberon_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/UBERON_0002066"},{"id":"A3","pred":"uberon_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/UBERON_0001638"},{"id":"A4","pred":"uberon_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/UBERON_0002113"}],"text":"Acute Respiratory Distress Syndrome (ARDS) is one of the commonest complications developing in patients with COVID-19 [6]. There have been animal studies that have implicated ACE2 in the acute lung injury (ALI) caused due to SARS-CoV [4]. It has been hypothesized that ACE2 causes ALI by bringing about autophagy through the AMPK/mTOR pathway [7]. AMPK has been shown to increase the expression of ACE2 as well as to increase its stability by phosphorylating ACE2 Ser680 in human umbilical vein endothelial cells (HUVECs) and human embryonic kidney 293 (HEK293T) cells [8]."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T7","span":{"begin":0,"end":35},"obj":"Disease"},{"id":"T8","span":{"begin":6,"end":35},"obj":"Disease"},{"id":"T9","span":{"begin":37,"end":41},"obj":"Disease"},{"id":"T10","span":{"begin":109,"end":117},"obj":"Disease"},{"id":"T11","span":{"begin":187,"end":204},"obj":"Disease"},{"id":"T13","span":{"begin":198,"end":204},"obj":"Disease"},{"id":"T14","span":{"begin":206,"end":209},"obj":"Disease"},{"id":"T15","span":{"begin":225,"end":233},"obj":"Disease"},{"id":"T16","span":{"begin":281,"end":284},"obj":"Disease"}],"attributes":[{"id":"A7","pred":"mondo_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"},{"id":"A8","pred":"mondo_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/MONDO_0009971"},{"id":"A9","pred":"mondo_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"},{"id":"A10","pred":"mondo_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A11","pred":"mondo_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"},{"id":"A12","pred":"mondo_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/MONDO_0015796"},{"id":"A13","pred":"mondo_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/MONDO_0021178"},{"id":"A14","pred":"mondo_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"},{"id":"A15","pred":"mondo_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A16","pred":"mondo_id","subj":"T16","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"}],"text":"Acute Respiratory Distress Syndrome (ARDS) is one of the commonest complications developing in patients with COVID-19 [6]. There have been animal studies that have implicated ACE2 in the acute lung injury (ALI) caused due to SARS-CoV [4]. It has been hypothesized that ACE2 causes ALI by bringing about autophagy through the AMPK/mTOR pathway [7]. AMPK has been shown to increase the expression of ACE2 as well as to increase its stability by phosphorylating ACE2 Ser680 in human umbilical vein endothelial cells (HUVECs) and human embryonic kidney 293 (HEK293T) cells [8]."}

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{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T10","span":{"begin":303,"end":312},"obj":"http://purl.obolibrary.org/obo/GO_0016236"},{"id":"T11","span":{"begin":303,"end":312},"obj":"http://purl.obolibrary.org/obo/GO_0006914"},{"id":"T12","span":{"begin":325,"end":329},"obj":"http://purl.obolibrary.org/obo/GO_0050405"},{"id":"T13","span":{"begin":325,"end":329},"obj":"http://purl.obolibrary.org/obo/GO_0047322"},{"id":"T14","span":{"begin":325,"end":329},"obj":"http://purl.obolibrary.org/obo/GO_0004691"},{"id":"T15","span":{"begin":348,"end":352},"obj":"http://purl.obolibrary.org/obo/GO_0050405"},{"id":"T16","span":{"begin":348,"end":352},"obj":"http://purl.obolibrary.org/obo/GO_0047322"},{"id":"T17","span":{"begin":348,"end":352},"obj":"http://purl.obolibrary.org/obo/GO_0004691"},{"id":"T18","span":{"begin":443,"end":458},"obj":"http://purl.obolibrary.org/obo/GO_0016310"}],"text":"Acute Respiratory Distress Syndrome (ARDS) is one of the commonest complications developing in patients with COVID-19 [6]. There have been animal studies that have implicated ACE2 in the acute lung injury (ALI) caused due to SARS-CoV [4]. It has been hypothesized that ACE2 causes ALI by bringing about autophagy through the AMPK/mTOR pathway [7]. AMPK has been shown to increase the expression of ACE2 as well as to increase its stability by phosphorylating ACE2 Ser680 in human umbilical vein endothelial cells (HUVECs) and human embryonic kidney 293 (HEK293T) cells [8]."}

{"project":"LitCovid-sentences","denotations":[{"id":"T16","span":{"begin":0,"end":122},"obj":"Sentence"},{"id":"T17","span":{"begin":123,"end":238},"obj":"Sentence"},{"id":"T18","span":{"begin":239,"end":347},"obj":"Sentence"},{"id":"T19","span":{"begin":348,"end":573},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Acute Respiratory Distress Syndrome (ARDS) is one of the commonest complications developing in patients with COVID-19 [6]. There have been animal studies that have implicated ACE2 in the acute lung injury (ALI) caused due to SARS-CoV [4]. It has been hypothesized that ACE2 causes ALI by bringing about autophagy through the AMPK/mTOR pathway [7]. AMPK has been shown to increase the expression of ACE2 as well as to increase its stability by phosphorylating ACE2 Ser680 in human umbilical vein endothelial cells (HUVECs) and human embryonic kidney 293 (HEK293T) cells [8]."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T1","span":{"begin":6,"end":26},"obj":"Phenotype"},{"id":"T2","span":{"begin":187,"end":204},"obj":"Phenotype"},{"id":"T3","span":{"begin":206,"end":209},"obj":"Phenotype"},{"id":"T4","span":{"begin":281,"end":284},"obj":"Phenotype"}],"attributes":[{"id":"A1","pred":"hp_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/HP_0002098"},{"id":"A2","pred":"hp_id","subj":"T2","obj":"http://www.orpha.net/ORDO/Orphanet_178320"},{"id":"A3","pred":"hp_id","subj":"T3","obj":"http://www.orpha.net/ORDO/Orphanet_178320"},{"id":"A4","pred":"hp_id","subj":"T4","obj":"http://www.orpha.net/ORDO/Orphanet_178320"}],"text":"Acute Respiratory Distress Syndrome (ARDS) is one of the commonest complications developing in patients with COVID-19 [6]. There have been animal studies that have implicated ACE2 in the acute lung injury (ALI) caused due to SARS-CoV [4]. It has been hypothesized that ACE2 causes ALI by bringing about autophagy through the AMPK/mTOR pathway [7]. AMPK has been shown to increase the expression of ACE2 as well as to increase its stability by phosphorylating ACE2 Ser680 in human umbilical vein endothelial cells (HUVECs) and human embryonic kidney 293 (HEK293T) cells [8]."}

{"project":"2_test","denotations":[{"id":"32360697-31986264-25244885","span":{"begin":119,"end":120},"obj":"31986264"},{"id":"32360697-31356776-25244886","span":{"begin":344,"end":345},"obj":"31356776"}],"text":"Acute Respiratory Distress Syndrome (ARDS) is one of the commonest complications developing in patients with COVID-19 [6]. There have been animal studies that have implicated ACE2 in the acute lung injury (ALI) caused due to SARS-CoV [4]. It has been hypothesized that ACE2 causes ALI by bringing about autophagy through the AMPK/mTOR pathway [7]. AMPK has been shown to increase the expression of ACE2 as well as to increase its stability by phosphorylating ACE2 Ser680 in human umbilical vein endothelial cells (HUVECs) and human embryonic kidney 293 (HEK293T) cells [8]."}

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