PMC:7172841 / 14447-15651 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T77","span":{"begin":13,"end":17},"obj":"Body_part"},{"id":"T78","span":{"begin":22,"end":29},"obj":"Body_part"},{"id":"T79","span":{"begin":25,"end":29},"obj":"Body_part"},{"id":"T80","span":{"begin":121,"end":138},"obj":"Body_part"},{"id":"T81","span":{"begin":152,"end":169},"obj":"Body_part"},{"id":"T82","span":{"begin":189,"end":206},"obj":"Body_part"},{"id":"T83","span":{"begin":232,"end":237},"obj":"Body_part"},{"id":"T84","span":{"begin":252,"end":269},"obj":"Body_part"},{"id":"T85","span":{"begin":549,"end":566},"obj":"Body_part"},{"id":"T86","span":{"begin":580,"end":597},"obj":"Body_part"},{"id":"T87","span":{"begin":617,"end":634},"obj":"Body_part"},{"id":"T88","span":{"begin":660,"end":665},"obj":"Body_part"},{"id":"T89","span":{"begin":680,"end":697},"obj":"Body_part"}],"attributes":[{"id":"A77","pred":"fma_id","subj":"T77","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A78","pred":"fma_id","subj":"T78","obj":"http://purl.org/sig/ont/fma/fma63147"},{"id":"A79","pred":"fma_id","subj":"T79","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A80","pred":"fma_id","subj":"T80","obj":"http://purl.org/sig/ont/fma/fma0326135"},{"id":"A81","pred":"fma_id","subj":"T81","obj":"http://purl.org/sig/ont/fma/fma0326135"},{"id":"A82","pred":"fma_id","subj":"T82","obj":"http://purl.org/sig/ont/fma/fma0326135"},{"id":"A83","pred":"fma_id","subj":"T83","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A84","pred":"fma_id","subj":"T84","obj":"http://purl.org/sig/ont/fma/fma0326135"},{"id":"A85","pred":"fma_id","subj":"T85","obj":"http://purl.org/sig/ont/fma/fma0326135"},{"id":"A86","pred":"fma_id","subj":"T86","obj":"http://purl.org/sig/ont/fma/fma0326135"},{"id":"A87","pred":"fma_id","subj":"T87","obj":"http://purl.org/sig/ont/fma/fma0326135"},{"id":"A88","pred":"fma_id","subj":"T88","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A89","pred":"fma_id","subj":"T89","obj":"http://purl.org/sig/ont/fma/fma0326135"}],"text":"Figure 2 CD4 Cell and NK Cell Cytopenias Are Characteristics of Infection by SARS-CoV-2\n(A–E) Absolute counts of CD3+CD4+CD45+ lymphocytes (A), CD3+CD8+CD45+ lymphocytes (B), CD3+CD16+CD56+CD45+ lymphocytes (C), CD3−CD16+CD56+CD45+ cells (D), and CD19+CD45+ lymphocytes (E) among healthy volunteers, patients with CAP caused by the 2009H1N1 influenza virus, and patients with CAP caused by COVID-19. Patients with COVID-19 are classified into three states of immune activation: intermediate, dysregulation, and MAS.\n(F–J) absolute counts of CD3+CD4+CD45+ lymphocytes (F), CD3+CD8+CD45+ lymphocytes (G), CD3+CD16+CD56+CD45+ lymphocytes (H), CD3−CD16+CD56+CD45+ cells (I), and CD19+CD45+ lymphocytes (J) among patients with severe respiratory failure developing in the field of CAP caused by the 2009H1N1 influenza virus and COVID-19.\n(K) IL-17 production by PBMCs after stimulation with heat-killed Candida albicans.\nBars in each graphic represent mean values and standard errors. Statistical comparisons are indicated by the arrows; ns: non-significant; ∗p \u003c 0.05; ∗∗p \u003c 0.01; ∗∗∗p \u003c 0.001; ∗∗∗∗p \u003c 0.0001. Comparisons were done by the Mann-Whitney U test followed by correction for multiple comparisons."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T142","span":{"begin":64,"end":73},"obj":"Disease"},{"id":"T143","span":{"begin":77,"end":85},"obj":"Disease"},{"id":"T144","span":{"begin":77,"end":81},"obj":"Disease"},{"id":"T145","span":{"begin":341,"end":350},"obj":"Disease"},{"id":"T146","span":{"begin":390,"end":398},"obj":"Disease"},{"id":"T147","span":{"begin":414,"end":422},"obj":"Disease"},{"id":"T148","span":{"begin":511,"end":514},"obj":"Disease"},{"id":"T149","span":{"begin":729,"end":748},"obj":"Disease"},{"id":"T150","span":{"begin":803,"end":812},"obj":"Disease"},{"id":"T151","span":{"begin":823,"end":831},"obj":"Disease"}],"attributes":[{"id":"A142","pred":"mondo_id","subj":"T142","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A143","pred":"mondo_id","subj":"T143","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A144","pred":"mondo_id","subj":"T144","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A145","pred":"mondo_id","subj":"T145","obj":"http://purl.obolibrary.org/obo/MONDO_0005812"},{"id":"A146","pred":"mondo_id","subj":"T146","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A147","pred":"mondo_id","subj":"T147","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A148","pred":"mondo_id","subj":"T148","obj":"http://purl.obolibrary.org/obo/MONDO_0015545"},{"id":"A149","pred":"mondo_id","subj":"T149","obj":"http://purl.obolibrary.org/obo/MONDO_0021113"},{"id":"A150","pred":"mondo_id","subj":"T150","obj":"http://purl.obolibrary.org/obo/MONDO_0005812"},{"id":"A151","pred":"mondo_id","subj":"T151","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"}],"text":"Figure 2 CD4 Cell and NK Cell Cytopenias Are Characteristics of Infection by SARS-CoV-2\n(A–E) Absolute counts of CD3+CD4+CD45+ lymphocytes (A), CD3+CD8+CD45+ lymphocytes (B), CD3+CD16+CD56+CD45+ lymphocytes (C), CD3−CD16+CD56+CD45+ cells (D), and CD19+CD45+ lymphocytes (E) among healthy volunteers, patients with CAP caused by the 2009H1N1 influenza virus, and patients with CAP caused by COVID-19. Patients with COVID-19 are classified into three states of immune activation: intermediate, dysregulation, and MAS.\n(F–J) absolute counts of CD3+CD4+CD45+ lymphocytes (F), CD3+CD8+CD45+ lymphocytes (G), CD3+CD16+CD56+CD45+ lymphocytes (H), CD3−CD16+CD56+CD45+ cells (I), and CD19+CD45+ lymphocytes (J) among patients with severe respiratory failure developing in the field of CAP caused by the 2009H1N1 influenza virus and COVID-19.\n(K) IL-17 production by PBMCs after stimulation with heat-killed Candida albicans.\nBars in each graphic represent mean values and standard errors. Statistical comparisons are indicated by the arrows; ns: non-significant; ∗p \u003c 0.05; ∗∗p \u003c 0.01; ∗∗∗p \u003c 0.001; ∗∗∗∗p \u003c 0.0001. Comparisons were done by the Mann-Whitney U test followed by correction for multiple comparisons."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T122","span":{"begin":9,"end":12},"obj":"http://purl.obolibrary.org/obo/PR_000001004"},{"id":"T123","span":{"begin":13,"end":17},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T124","span":{"begin":22,"end":29},"obj":"http://purl.obolibrary.org/obo/CL_0000623"},{"id":"T125","span":{"begin":89,"end":92},"obj":"http://purl.obolibrary.org/obo/CLO_0051456"},{"id":"T126","span":{"begin":113,"end":116},"obj":"http://purl.obolibrary.org/obo/CLO_0052882"},{"id":"T127","span":{"begin":113,"end":116},"obj":"http://purl.obolibrary.org/obo/CLO_0053434"},{"id":"T128","span":{"begin":117,"end":120},"obj":"http://purl.obolibrary.org/obo/PR_000001004"},{"id":"T129","span":{"begin":140,"end":141},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T130","span":{"begin":144,"end":147},"obj":"http://purl.obolibrary.org/obo/CLO_0052882"},{"id":"T131","span":{"begin":144,"end":147},"obj":"http://purl.obolibrary.org/obo/CLO_0053434"},{"id":"T132","span":{"begin":148,"end":151},"obj":"http://purl.obolibrary.org/obo/CLO_0053438"},{"id":"T133","span":{"begin":171,"end":172},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T134","span":{"begin":175,"end":178},"obj":"http://purl.obolibrary.org/obo/CLO_0052882"},{"id":"T135","span":{"begin":175,"end":178},"obj":"http://purl.obolibrary.org/obo/CLO_0053434"},{"id":"T136","span":{"begin":212,"end":215},"obj":"http://purl.obolibrary.org/obo/CLO_0052882"},{"id":"T137","span":{"begin":212,"end":215},"obj":"http://purl.obolibrary.org/obo/CLO_0053434"},{"id":"T138","span":{"begin":232,"end":237},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T139","span":{"begin":247,"end":251},"obj":"http://purl.obolibrary.org/obo/CLO_0053432"},{"id":"T140","span":{"begin":351,"end":356},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T141","span":{"begin":466,"end":476},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T142","span":{"begin":541,"end":544},"obj":"http://purl.obolibrary.org/obo/CLO_0052882"},{"id":"T143","span":{"begin":541,"end":544},"obj":"http://purl.obolibrary.org/obo/CLO_0053434"},{"id":"T144","span":{"begin":545,"end":548},"obj":"http://purl.obolibrary.org/obo/PR_000001004"},{"id":"T145","span":{"begin":572,"end":575},"obj":"http://purl.obolibrary.org/obo/CLO_0052882"},{"id":"T146","span":{"begin":572,"end":575},"obj":"http://purl.obolibrary.org/obo/CLO_0053434"},{"id":"T147","span":{"begin":576,"end":579},"obj":"http://purl.obolibrary.org/obo/CLO_0053438"},{"id":"T148","span":{"begin":603,"end":606},"obj":"http://purl.obolibrary.org/obo/CLO_0052882"},{"id":"T149","span":{"begin":603,"end":606},"obj":"http://purl.obolibrary.org/obo/CLO_0053434"},{"id":"T150","span":{"begin":640,"end":643},"obj":"http://purl.obolibrary.org/obo/CLO_0052882"},{"id":"T151","span":{"begin":640,"end":643},"obj":"http://purl.obolibrary.org/obo/CLO_0053434"},{"id":"T152","span":{"begin":660,"end":665},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T153","span":{"begin":675,"end":679},"obj":"http://purl.obolibrary.org/obo/CLO_0053432"},{"id":"T154","span":{"begin":767,"end":772},"obj":"http://purl.obolibrary.org/obo/UBERON_0007688"},{"id":"T155","span":{"begin":813,"end":818},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T156","span":{"begin":1151,"end":1155},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"}],"text":"Figure 2 CD4 Cell and NK Cell Cytopenias Are Characteristics of Infection by SARS-CoV-2\n(A–E) Absolute counts of CD3+CD4+CD45+ lymphocytes (A), CD3+CD8+CD45+ lymphocytes (B), CD3+CD16+CD56+CD45+ lymphocytes (C), CD3−CD16+CD56+CD45+ cells (D), and CD19+CD45+ lymphocytes (E) among healthy volunteers, patients with CAP caused by the 2009H1N1 influenza virus, and patients with CAP caused by COVID-19. Patients with COVID-19 are classified into three states of immune activation: intermediate, dysregulation, and MAS.\n(F–J) absolute counts of CD3+CD4+CD45+ lymphocytes (F), CD3+CD8+CD45+ lymphocytes (G), CD3+CD16+CD56+CD45+ lymphocytes (H), CD3−CD16+CD56+CD45+ cells (I), and CD19+CD45+ lymphocytes (J) among patients with severe respiratory failure developing in the field of CAP caused by the 2009H1N1 influenza virus and COVID-19.\n(K) IL-17 production by PBMCs after stimulation with heat-killed Candida albicans.\nBars in each graphic represent mean values and standard errors. Statistical comparisons are indicated by the arrows; ns: non-significant; ∗p \u003c 0.05; ∗∗p \u003c 0.01; ∗∗∗p \u003c 0.001; ∗∗∗∗p \u003c 0.0001. Comparisons were done by the Mann-Whitney U test followed by correction for multiple comparisons."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T64","span":{"begin":837,"end":839},"obj":"Chemical"}],"attributes":[{"id":"A64","pred":"chebi_id","subj":"T64","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A65","pred":"chebi_id","subj":"T64","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"}],"text":"Figure 2 CD4 Cell and NK Cell Cytopenias Are Characteristics of Infection by SARS-CoV-2\n(A–E) Absolute counts of CD3+CD4+CD45+ lymphocytes (A), CD3+CD8+CD45+ lymphocytes (B), CD3+CD16+CD56+CD45+ lymphocytes (C), CD3−CD16+CD56+CD45+ cells (D), and CD19+CD45+ lymphocytes (E) among healthy volunteers, patients with CAP caused by the 2009H1N1 influenza virus, and patients with CAP caused by COVID-19. Patients with COVID-19 are classified into three states of immune activation: intermediate, dysregulation, and MAS.\n(F–J) absolute counts of CD3+CD4+CD45+ lymphocytes (F), CD3+CD8+CD45+ lymphocytes (G), CD3+CD16+CD56+CD45+ lymphocytes (H), CD3−CD16+CD56+CD45+ cells (I), and CD19+CD45+ lymphocytes (J) among patients with severe respiratory failure developing in the field of CAP caused by the 2009H1N1 influenza virus and COVID-19.\n(K) IL-17 production by PBMCs after stimulation with heat-killed Candida albicans.\nBars in each graphic represent mean values and standard errors. Statistical comparisons are indicated by the arrows; ns: non-significant; ∗p \u003c 0.05; ∗∗p \u003c 0.01; ∗∗∗p \u003c 0.001; ∗∗∗∗p \u003c 0.0001. Comparisons were done by the Mann-Whitney U test followed by correction for multiple comparisons."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T21","span":{"begin":837,"end":853},"obj":"http://purl.obolibrary.org/obo/GO_0032620"}],"text":"Figure 2 CD4 Cell and NK Cell Cytopenias Are Characteristics of Infection by SARS-CoV-2\n(A–E) Absolute counts of CD3+CD4+CD45+ lymphocytes (A), CD3+CD8+CD45+ lymphocytes (B), CD3+CD16+CD56+CD45+ lymphocytes (C), CD3−CD16+CD56+CD45+ cells (D), and CD19+CD45+ lymphocytes (E) among healthy volunteers, patients with CAP caused by the 2009H1N1 influenza virus, and patients with CAP caused by COVID-19. Patients with COVID-19 are classified into three states of immune activation: intermediate, dysregulation, and MAS.\n(F–J) absolute counts of CD3+CD4+CD45+ lymphocytes (F), CD3+CD8+CD45+ lymphocytes (G), CD3+CD16+CD56+CD45+ lymphocytes (H), CD3−CD16+CD56+CD45+ cells (I), and CD19+CD45+ lymphocytes (J) among patients with severe respiratory failure developing in the field of CAP caused by the 2009H1N1 influenza virus and COVID-19.\n(K) IL-17 production by PBMCs after stimulation with heat-killed Candida albicans.\nBars in each graphic represent mean values and standard errors. Statistical comparisons are indicated by the arrows; ns: non-significant; ∗p \u003c 0.05; ∗∗p \u003c 0.01; ∗∗∗p \u003c 0.001; ∗∗∗∗p \u003c 0.0001. Comparisons were done by the Mann-Whitney U test followed by correction for multiple comparisons."}

{"project":"LitCovid-sentences","denotations":[{"id":"T114","span":{"begin":0,"end":87},"obj":"Sentence"},{"id":"T115","span":{"begin":88,"end":399},"obj":"Sentence"},{"id":"T116","span":{"begin":400,"end":515},"obj":"Sentence"},{"id":"T117","span":{"begin":516,"end":832},"obj":"Sentence"},{"id":"T118","span":{"begin":833,"end":915},"obj":"Sentence"},{"id":"T119","span":{"begin":916,"end":979},"obj":"Sentence"},{"id":"T120","span":{"begin":980,"end":1106},"obj":"Sentence"},{"id":"T121","span":{"begin":1107,"end":1204},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Figure 2 CD4 Cell and NK Cell Cytopenias Are Characteristics of Infection by SARS-CoV-2\n(A–E) Absolute counts of CD3+CD4+CD45+ lymphocytes (A), CD3+CD8+CD45+ lymphocytes (B), CD3+CD16+CD56+CD45+ lymphocytes (C), CD3−CD16+CD56+CD45+ cells (D), and CD19+CD45+ lymphocytes (E) among healthy volunteers, patients with CAP caused by the 2009H1N1 influenza virus, and patients with CAP caused by COVID-19. Patients with COVID-19 are classified into three states of immune activation: intermediate, dysregulation, and MAS.\n(F–J) absolute counts of CD3+CD4+CD45+ lymphocytes (F), CD3+CD8+CD45+ lymphocytes (G), CD3+CD16+CD56+CD45+ lymphocytes (H), CD3−CD16+CD56+CD45+ cells (I), and CD19+CD45+ lymphocytes (J) among patients with severe respiratory failure developing in the field of CAP caused by the 2009H1N1 influenza virus and COVID-19.\n(K) IL-17 production by PBMCs after stimulation with heat-killed Candida albicans.\nBars in each graphic represent mean values and standard errors. Statistical comparisons are indicated by the arrows; ns: non-significant; ∗p \u003c 0.05; ∗∗p \u003c 0.01; ∗∗∗p \u003c 0.001; ∗∗∗∗p \u003c 0.0001. Comparisons were done by the Mann-Whitney U test followed by correction for multiple comparisons."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T61","span":{"begin":729,"end":748},"obj":"Phenotype"}],"attributes":[{"id":"A61","pred":"hp_id","subj":"T61","obj":"http://purl.obolibrary.org/obo/HP_0002878"}],"text":"Figure 2 CD4 Cell and NK Cell Cytopenias Are Characteristics of Infection by SARS-CoV-2\n(A–E) Absolute counts of CD3+CD4+CD45+ lymphocytes (A), CD3+CD8+CD45+ lymphocytes (B), CD3+CD16+CD56+CD45+ lymphocytes (C), CD3−CD16+CD56+CD45+ cells (D), and CD19+CD45+ lymphocytes (E) among healthy volunteers, patients with CAP caused by the 2009H1N1 influenza virus, and patients with CAP caused by COVID-19. Patients with COVID-19 are classified into three states of immune activation: intermediate, dysregulation, and MAS.\n(F–J) absolute counts of CD3+CD4+CD45+ lymphocytes (F), CD3+CD8+CD45+ lymphocytes (G), CD3+CD16+CD56+CD45+ lymphocytes (H), CD3−CD16+CD56+CD45+ cells (I), and CD19+CD45+ lymphocytes (J) among patients with severe respiratory failure developing in the field of CAP caused by the 2009H1N1 influenza virus and COVID-19.\n(K) IL-17 production by PBMCs after stimulation with heat-killed Candida albicans.\nBars in each graphic represent mean values and standard errors. Statistical comparisons are indicated by the arrows; ns: non-significant; ∗p \u003c 0.05; ∗∗p \u003c 0.01; ∗∗∗p \u003c 0.001; ∗∗∗∗p \u003c 0.0001. Comparisons were done by the Mann-Whitney U test followed by correction for multiple comparisons."}

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