PMC:7172841 / 1069-1279 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T12","span":{"begin":106,"end":109},"obj":"Body_part"},{"id":"T13","span":{"begin":167,"end":175},"obj":"Body_part"}],"attributes":[{"id":"A12","pred":"fma_id","subj":"T12","obj":"http://purl.org/sig/ont/fma/fma84795"},{"id":"A13","pred":"fma_id","subj":"T13","obj":"http://purl.org/sig/ont/fma/fma84050"}],"text":"Thus, the unique pattern of immune dysregulation in severe COVID-19 is characterized by IL-6-mediated low HLA-DR expression and lymphopenia, associated with sustained cytokine production and hyper-inflammation."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T15","span":{"begin":59,"end":67},"obj":"Disease"},{"id":"T16","span":{"begin":128,"end":139},"obj":"Disease"},{"id":"T17","span":{"begin":197,"end":209},"obj":"Disease"}],"attributes":[{"id":"A15","pred":"mondo_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A16","pred":"mondo_id","subj":"T16","obj":"http://purl.obolibrary.org/obo/MONDO_0003783"},{"id":"A17","pred":"mondo_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"}],"text":"Thus, the unique pattern of immune dysregulation in severe COVID-19 is characterized by IL-6-mediated low HLA-DR expression and lymphopenia, associated with sustained cytokine production and hyper-inflammation."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T9","span":{"begin":88,"end":90},"obj":"Chemical"},{"id":"T11","span":{"begin":110,"end":112},"obj":"Chemical"}],"attributes":[{"id":"A9","pred":"chebi_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A10","pred":"chebi_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A11","pred":"chebi_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/CHEBI_73445"}],"text":"Thus, the unique pattern of immune dysregulation in severe COVID-19 is characterized by IL-6-mediated low HLA-DR expression and lymphopenia, associated with sustained cytokine production and hyper-inflammation."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T9","span":{"begin":167,"end":186},"obj":"http://purl.obolibrary.org/obo/GO_0001816"},{"id":"T10","span":{"begin":197,"end":209},"obj":"http://purl.obolibrary.org/obo/GO_0006954"}],"text":"Thus, the unique pattern of immune dysregulation in severe COVID-19 is characterized by IL-6-mediated low HLA-DR expression and lymphopenia, associated with sustained cytokine production and hyper-inflammation."}

{"project":"LitCovid-sentences","denotations":[{"id":"T10","span":{"begin":0,"end":210},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Thus, the unique pattern of immune dysregulation in severe COVID-19 is characterized by IL-6-mediated low HLA-DR expression and lymphopenia, associated with sustained cytokine production and hyper-inflammation."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T6","span":{"begin":28,"end":48},"obj":"Phenotype"},{"id":"T7","span":{"begin":128,"end":139},"obj":"Phenotype"}],"attributes":[{"id":"A6","pred":"hp_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/HP_0002958"},{"id":"A7","pred":"hp_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/HP_0001888"}],"text":"Thus, the unique pattern of immune dysregulation in severe COVID-19 is characterized by IL-6-mediated low HLA-DR expression and lymphopenia, associated with sustained cytokine production and hyper-inflammation."}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T38","span":{"begin":28,"end":34},"obj":"UBERON:0002405"},{"id":"T39","span":{"begin":35,"end":48},"obj":"GO:0065007"},{"id":"T40","span":{"begin":59,"end":67},"obj":"SP_7"},{"id":"T41","span":{"begin":88,"end":92},"obj":"PR:000001393"},{"id":"T42","span":{"begin":106,"end":109},"obj":"PR:000029150"},{"id":"T43","span":{"begin":113,"end":123},"obj":"GO:0010467"},{"id":"T2958","span":{"begin":28,"end":34},"obj":"UBERON:0002405"},{"id":"T86620","span":{"begin":35,"end":48},"obj":"GO:0065007"},{"id":"T3195","span":{"begin":59,"end":67},"obj":"SP_7"},{"id":"T88472","span":{"begin":88,"end":92},"obj":"PR:000001393"},{"id":"T6458","span":{"begin":106,"end":109},"obj":"PR:000029150"},{"id":"T72315","span":{"begin":113,"end":123},"obj":"GO:0010467"}],"text":"Thus, the unique pattern of immune dysregulation in severe COVID-19 is characterized by IL-6-mediated low HLA-DR expression and lymphopenia, associated with sustained cytokine production and hyper-inflammation."}

{"project":"LitCovid-PubTator","denotations":[{"id":"43","span":{"begin":88,"end":92},"obj":"Gene"},{"id":"63","span":{"begin":59,"end":67},"obj":"Disease"},{"id":"64","span":{"begin":128,"end":139},"obj":"Disease"},{"id":"65","span":{"begin":191,"end":209},"obj":"Disease"}],"attributes":[{"id":"A43","pred":"tao:has_database_id","subj":"43","obj":"Gene:3569"},{"id":"A63","pred":"tao:has_database_id","subj":"63","obj":"MESH:C000657245"},{"id":"A64","pred":"tao:has_database_id","subj":"64","obj":"MESH:D008231"},{"id":"A65","pred":"tao:has_database_id","subj":"65","obj":"MESH:D007249"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Thus, the unique pattern of immune dysregulation in severe COVID-19 is characterized by IL-6-mediated low HLA-DR expression and lymphopenia, associated with sustained cytokine production and hyper-inflammation."}