PMC:7170415 / 6249-8395 JSONTXT

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    LitCovid-PubTator

    {"project":"LitCovid-PubTator","denotations":[{"id":"109","span":{"begin":38,"end":48},"obj":"Species"},{"id":"115","span":{"begin":171,"end":178},"obj":"Species"},{"id":"116","span":{"begin":416,"end":423},"obj":"Species"},{"id":"117","span":{"begin":532,"end":542},"obj":"Species"},{"id":"118","span":{"begin":583,"end":590},"obj":"Species"},{"id":"119","span":{"begin":391,"end":399},"obj":"Disease"},{"id":"128","span":{"begin":625,"end":635},"obj":"Species"},{"id":"129","span":{"begin":1000,"end":1007},"obj":"Species"},{"id":"130","span":{"begin":1189,"end":1196},"obj":"Species"},{"id":"131","span":{"begin":1249,"end":1257},"obj":"Species"},{"id":"132","span":{"begin":1355,"end":1363},"obj":"Species"},{"id":"133","span":{"begin":1180,"end":1188},"obj":"Disease"},{"id":"134","span":{"begin":1263,"end":1272},"obj":"Disease"},{"id":"135","span":{"begin":1387,"end":1393},"obj":"Disease"},{"id":"137","span":{"begin":1874,"end":1882},"obj":"Species"}],"attributes":[{"id":"A109","pred":"tao:has_database_id","subj":"109","obj":"Tax:2697049"},{"id":"A115","pred":"tao:has_database_id","subj":"115","obj":"Tax:9606"},{"id":"A116","pred":"tao:has_database_id","subj":"116","obj":"Tax:9606"},{"id":"A117","pred":"tao:has_database_id","subj":"117","obj":"Tax:2697049"},{"id":"A118","pred":"tao:has_database_id","subj":"118","obj":"Tax:9606"},{"id":"A119","pred":"tao:has_database_id","subj":"119","obj":"MESH:D007239"},{"id":"A128","pred":"tao:has_database_id","subj":"128","obj":"Tax:2697049"},{"id":"A129","pred":"tao:has_database_id","subj":"129","obj":"Tax:9606"},{"id":"A130","pred":"tao:has_database_id","subj":"130","obj":"Tax:9606"},{"id":"A131","pred":"tao:has_database_id","subj":"131","obj":"Tax:9606"},{"id":"A132","pred":"tao:has_database_id","subj":"132","obj":"Tax:9606"},{"id":"A133","pred":"tao:has_database_id","subj":"133","obj":"MESH:D007239"},{"id":"A134","pred":"tao:has_database_id","subj":"134","obj":"MESH:D011014"},{"id":"A135","pred":"tao:has_database_id","subj":"135","obj":"MESH:D003643"},{"id":"A137","pred":"tao:has_database_id","subj":"137","obj":"Tax:9606"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"The Role of Diagnostic Testing in the SARS–CoV-2 Pandemic\nThe primary goal of epidemic containment is to reduce disease transmission by reducing the number of susceptible persons in the population or by reducing the basic reproductive number (R0). This number is modulated by such factors as the duration of viral shedding, the infectiousness of the organism, and the contact matrix between infected and susceptible persons (18). Given the lack of effective vaccines or treatments (19), the only currently available lever to reduce SARS–CoV-2 transmission is to identify and isolate persons who are contagious.\nDeployment of SARS–CoV-2 testing has varied widely across the globe. A few Asian countries have illustrated the power of preparedness, flexible isolation systems, and intensive case finding. South Korea dramatically slowed the epidemic by implementing an unprecedented testing effort (20). Using innovative measures, South Korea performed more than 300 000 tests (5828.6 tests per million persons) in the 9 weeks after the first case was identified (20, 21). Singapore used a broad case definition, aggressive contact tracing, and isolation (10). Moreover, to identify infected persons not meeting the case definition, Singapore screened patients with pneumonia and influenza-like illnesses in hospitals and primary care settings, severely ill patients in intensive care, and deaths with a possible infectious cause (10). Taiwan and Hong Kong used similar approaches (22). These countries rapidly deployed resource-intensive strategies that prioritized aggressive testing and isolation to interrupt transmission (20, 22).\nIn the face of widespread transmission, the role of diagnostic testing is contingent on the type of testing available, the resources required for testing, and time to obtain results. For example, rapidly identifying cases among hospitalized patients remains a high priority to properly allocate personal protective equipment and to prevent nosocomial spread with subsequent community transmission (23, 24). Likewise, specific treatment decisions and enrollment in ongoing clinical trials require prompt diagnosis."}

    LitCovid-PD-FMA-UBERON

    {"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T7","span":{"begin":1640,"end":1644},"obj":"Body_part"}],"attributes":[{"id":"A7","pred":"fma_id","subj":"T7","obj":"http://purl.org/sig/ont/fma/fma24728"}],"text":"The Role of Diagnostic Testing in the SARS–CoV-2 Pandemic\nThe primary goal of epidemic containment is to reduce disease transmission by reducing the number of susceptible persons in the population or by reducing the basic reproductive number (R0). This number is modulated by such factors as the duration of viral shedding, the infectiousness of the organism, and the contact matrix between infected and susceptible persons (18). Given the lack of effective vaccines or treatments (19), the only currently available lever to reduce SARS–CoV-2 transmission is to identify and isolate persons who are contagious.\nDeployment of SARS–CoV-2 testing has varied widely across the globe. A few Asian countries have illustrated the power of preparedness, flexible isolation systems, and intensive case finding. South Korea dramatically slowed the epidemic by implementing an unprecedented testing effort (20). Using innovative measures, South Korea performed more than 300 000 tests (5828.6 tests per million persons) in the 9 weeks after the first case was identified (20, 21). Singapore used a broad case definition, aggressive contact tracing, and isolation (10). Moreover, to identify infected persons not meeting the case definition, Singapore screened patients with pneumonia and influenza-like illnesses in hospitals and primary care settings, severely ill patients in intensive care, and deaths with a possible infectious cause (10). Taiwan and Hong Kong used similar approaches (22). These countries rapidly deployed resource-intensive strategies that prioritized aggressive testing and isolation to interrupt transmission (20, 22).\nIn the face of widespread transmission, the role of diagnostic testing is contingent on the type of testing available, the resources required for testing, and time to obtain results. For example, rapidly identifying cases among hospitalized patients remains a high priority to properly allocate personal protective equipment and to prevent nosocomial spread with subsequent community transmission (23, 24). Likewise, specific treatment decisions and enrollment in ongoing clinical trials require prompt diagnosis."}

    LitCovid-PD-UBERON

    {"project":"LitCovid-PD-UBERON","denotations":[{"id":"T3","span":{"begin":1640,"end":1644},"obj":"Body_part"}],"attributes":[{"id":"A3","pred":"uberon_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/UBERON_0001456"}],"text":"The Role of Diagnostic Testing in the SARS–CoV-2 Pandemic\nThe primary goal of epidemic containment is to reduce disease transmission by reducing the number of susceptible persons in the population or by reducing the basic reproductive number (R0). This number is modulated by such factors as the duration of viral shedding, the infectiousness of the organism, and the contact matrix between infected and susceptible persons (18). Given the lack of effective vaccines or treatments (19), the only currently available lever to reduce SARS–CoV-2 transmission is to identify and isolate persons who are contagious.\nDeployment of SARS–CoV-2 testing has varied widely across the globe. A few Asian countries have illustrated the power of preparedness, flexible isolation systems, and intensive case finding. South Korea dramatically slowed the epidemic by implementing an unprecedented testing effort (20). Using innovative measures, South Korea performed more than 300 000 tests (5828.6 tests per million persons) in the 9 weeks after the first case was identified (20, 21). Singapore used a broad case definition, aggressive contact tracing, and isolation (10). Moreover, to identify infected persons not meeting the case definition, Singapore screened patients with pneumonia and influenza-like illnesses in hospitals and primary care settings, severely ill patients in intensive care, and deaths with a possible infectious cause (10). Taiwan and Hong Kong used similar approaches (22). These countries rapidly deployed resource-intensive strategies that prioritized aggressive testing and isolation to interrupt transmission (20, 22).\nIn the face of widespread transmission, the role of diagnostic testing is contingent on the type of testing available, the resources required for testing, and time to obtain results. For example, rapidly identifying cases among hospitalized patients remains a high priority to properly allocate personal protective equipment and to prevent nosocomial spread with subsequent community transmission (23, 24). Likewise, specific treatment decisions and enrollment in ongoing clinical trials require prompt diagnosis."}

    LitCovid-PD-MONDO

    {"project":"LitCovid-PD-MONDO","denotations":[{"id":"T34","span":{"begin":38,"end":42},"obj":"Disease"},{"id":"T35","span":{"begin":328,"end":342},"obj":"Disease"},{"id":"T36","span":{"begin":532,"end":536},"obj":"Disease"},{"id":"T37","span":{"begin":625,"end":629},"obj":"Disease"},{"id":"T38","span":{"begin":1263,"end":1272},"obj":"Disease"},{"id":"T39","span":{"begin":1277,"end":1286},"obj":"Disease"},{"id":"T40","span":{"begin":1410,"end":1420},"obj":"Disease"}],"attributes":[{"id":"A34","pred":"mondo_id","subj":"T34","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A35","pred":"mondo_id","subj":"T35","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A36","pred":"mondo_id","subj":"T36","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A37","pred":"mondo_id","subj":"T37","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A38","pred":"mondo_id","subj":"T38","obj":"http://purl.obolibrary.org/obo/MONDO_0005249"},{"id":"A39","pred":"mondo_id","subj":"T39","obj":"http://purl.obolibrary.org/obo/MONDO_0005812"},{"id":"A40","pred":"mondo_id","subj":"T40","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"}],"text":"The Role of Diagnostic Testing in the SARS–CoV-2 Pandemic\nThe primary goal of epidemic containment is to reduce disease transmission by reducing the number of susceptible persons in the population or by reducing the basic reproductive number (R0). This number is modulated by such factors as the duration of viral shedding, the infectiousness of the organism, and the contact matrix between infected and susceptible persons (18). Given the lack of effective vaccines or treatments (19), the only currently available lever to reduce SARS–CoV-2 transmission is to identify and isolate persons who are contagious.\nDeployment of SARS–CoV-2 testing has varied widely across the globe. A few Asian countries have illustrated the power of preparedness, flexible isolation systems, and intensive case finding. South Korea dramatically slowed the epidemic by implementing an unprecedented testing effort (20). Using innovative measures, South Korea performed more than 300 000 tests (5828.6 tests per million persons) in the 9 weeks after the first case was identified (20, 21). Singapore used a broad case definition, aggressive contact tracing, and isolation (10). Moreover, to identify infected persons not meeting the case definition, Singapore screened patients with pneumonia and influenza-like illnesses in hospitals and primary care settings, severely ill patients in intensive care, and deaths with a possible infectious cause (10). Taiwan and Hong Kong used similar approaches (22). These countries rapidly deployed resource-intensive strategies that prioritized aggressive testing and isolation to interrupt transmission (20, 22).\nIn the face of widespread transmission, the role of diagnostic testing is contingent on the type of testing available, the resources required for testing, and time to obtain results. For example, rapidly identifying cases among hospitalized patients remains a high priority to properly allocate personal protective equipment and to prevent nosocomial spread with subsequent community transmission (23, 24). Likewise, specific treatment decisions and enrollment in ongoing clinical trials require prompt diagnosis."}

    LitCovid-PD-CLO

    {"project":"LitCovid-PD-CLO","denotations":[{"id":"T45","span":{"begin":23,"end":30},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T46","span":{"begin":350,"end":358},"obj":"http://purl.obolibrary.org/obo/OBI_0100026"},{"id":"T47","span":{"begin":350,"end":358},"obj":"http://purl.obolibrary.org/obo/UBERON_0000468"},{"id":"T48","span":{"begin":425,"end":427},"obj":"http://purl.obolibrary.org/obo/CLO_0050510"},{"id":"T49","span":{"begin":636,"end":643},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T50","span":{"begin":644,"end":647},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T51","span":{"begin":680,"end":681},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T52","span":{"begin":880,"end":887},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T53","span":{"begin":968,"end":973},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T54","span":{"begin":982,"end":987},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T55","span":{"begin":1085,"end":1086},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T56","span":{"begin":1399,"end":1400},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T57","span":{"begin":1479,"end":1481},"obj":"http://purl.obolibrary.org/obo/CLO_0050507"},{"id":"T58","span":{"begin":1575,"end":1582},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T59","span":{"begin":1628,"end":1630},"obj":"http://purl.obolibrary.org/obo/CLO_0050507"},{"id":"T60","span":{"begin":1640,"end":1644},"obj":"http://purl.obolibrary.org/obo/UBERON_0001456"},{"id":"T61","span":{"begin":1696,"end":1706},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T62","span":{"begin":1733,"end":1740},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T63","span":{"begin":1779,"end":1786},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T64","span":{"begin":1891,"end":1892},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"The Role of Diagnostic Testing in the SARS–CoV-2 Pandemic\nThe primary goal of epidemic containment is to reduce disease transmission by reducing the number of susceptible persons in the population or by reducing the basic reproductive number (R0). This number is modulated by such factors as the duration of viral shedding, the infectiousness of the organism, and the contact matrix between infected and susceptible persons (18). Given the lack of effective vaccines or treatments (19), the only currently available lever to reduce SARS–CoV-2 transmission is to identify and isolate persons who are contagious.\nDeployment of SARS–CoV-2 testing has varied widely across the globe. A few Asian countries have illustrated the power of preparedness, flexible isolation systems, and intensive case finding. South Korea dramatically slowed the epidemic by implementing an unprecedented testing effort (20). Using innovative measures, South Korea performed more than 300 000 tests (5828.6 tests per million persons) in the 9 weeks after the first case was identified (20, 21). Singapore used a broad case definition, aggressive contact tracing, and isolation (10). Moreover, to identify infected persons not meeting the case definition, Singapore screened patients with pneumonia and influenza-like illnesses in hospitals and primary care settings, severely ill patients in intensive care, and deaths with a possible infectious cause (10). Taiwan and Hong Kong used similar approaches (22). These countries rapidly deployed resource-intensive strategies that prioritized aggressive testing and isolation to interrupt transmission (20, 22).\nIn the face of widespread transmission, the role of diagnostic testing is contingent on the type of testing available, the resources required for testing, and time to obtain results. For example, rapidly identifying cases among hospitalized patients remains a high priority to properly allocate personal protective equipment and to prevent nosocomial spread with subsequent community transmission (23, 24). Likewise, specific treatment decisions and enrollment in ongoing clinical trials require prompt diagnosis."}

    LitCovid-PD-GO-BP

    {"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T8","span":{"begin":308,"end":322},"obj":"http://purl.obolibrary.org/obo/GO_0019076"}],"text":"The Role of Diagnostic Testing in the SARS–CoV-2 Pandemic\nThe primary goal of epidemic containment is to reduce disease transmission by reducing the number of susceptible persons in the population or by reducing the basic reproductive number (R0). This number is modulated by such factors as the duration of viral shedding, the infectiousness of the organism, and the contact matrix between infected and susceptible persons (18). Given the lack of effective vaccines or treatments (19), the only currently available lever to reduce SARS–CoV-2 transmission is to identify and isolate persons who are contagious.\nDeployment of SARS–CoV-2 testing has varied widely across the globe. A few Asian countries have illustrated the power of preparedness, flexible isolation systems, and intensive case finding. South Korea dramatically slowed the epidemic by implementing an unprecedented testing effort (20). Using innovative measures, South Korea performed more than 300 000 tests (5828.6 tests per million persons) in the 9 weeks after the first case was identified (20, 21). Singapore used a broad case definition, aggressive contact tracing, and isolation (10). Moreover, to identify infected persons not meeting the case definition, Singapore screened patients with pneumonia and influenza-like illnesses in hospitals and primary care settings, severely ill patients in intensive care, and deaths with a possible infectious cause (10). Taiwan and Hong Kong used similar approaches (22). These countries rapidly deployed resource-intensive strategies that prioritized aggressive testing and isolation to interrupt transmission (20, 22).\nIn the face of widespread transmission, the role of diagnostic testing is contingent on the type of testing available, the resources required for testing, and time to obtain results. For example, rapidly identifying cases among hospitalized patients remains a high priority to properly allocate personal protective equipment and to prevent nosocomial spread with subsequent community transmission (23, 24). Likewise, specific treatment decisions and enrollment in ongoing clinical trials require prompt diagnosis."}

    LitCovid-sentences

    {"project":"LitCovid-sentences","denotations":[{"id":"T47","span":{"begin":0,"end":57},"obj":"Sentence"},{"id":"T48","span":{"begin":58,"end":247},"obj":"Sentence"},{"id":"T49","span":{"begin":248,"end":429},"obj":"Sentence"},{"id":"T50","span":{"begin":430,"end":610},"obj":"Sentence"},{"id":"T51","span":{"begin":611,"end":679},"obj":"Sentence"},{"id":"T52","span":{"begin":680,"end":801},"obj":"Sentence"},{"id":"T53","span":{"begin":802,"end":900},"obj":"Sentence"},{"id":"T54","span":{"begin":901,"end":1069},"obj":"Sentence"},{"id":"T55","span":{"begin":1070,"end":1157},"obj":"Sentence"},{"id":"T56","span":{"begin":1158,"end":1432},"obj":"Sentence"},{"id":"T57","span":{"begin":1433,"end":1483},"obj":"Sentence"},{"id":"T58","span":{"begin":1484,"end":1632},"obj":"Sentence"},{"id":"T59","span":{"begin":1633,"end":1815},"obj":"Sentence"},{"id":"T60","span":{"begin":1816,"end":2039},"obj":"Sentence"},{"id":"T61","span":{"begin":2040,"end":2146},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"The Role of Diagnostic Testing in the SARS–CoV-2 Pandemic\nThe primary goal of epidemic containment is to reduce disease transmission by reducing the number of susceptible persons in the population or by reducing the basic reproductive number (R0). This number is modulated by such factors as the duration of viral shedding, the infectiousness of the organism, and the contact matrix between infected and susceptible persons (18). Given the lack of effective vaccines or treatments (19), the only currently available lever to reduce SARS–CoV-2 transmission is to identify and isolate persons who are contagious.\nDeployment of SARS–CoV-2 testing has varied widely across the globe. A few Asian countries have illustrated the power of preparedness, flexible isolation systems, and intensive case finding. South Korea dramatically slowed the epidemic by implementing an unprecedented testing effort (20). Using innovative measures, South Korea performed more than 300 000 tests (5828.6 tests per million persons) in the 9 weeks after the first case was identified (20, 21). Singapore used a broad case definition, aggressive contact tracing, and isolation (10). Moreover, to identify infected persons not meeting the case definition, Singapore screened patients with pneumonia and influenza-like illnesses in hospitals and primary care settings, severely ill patients in intensive care, and deaths with a possible infectious cause (10). Taiwan and Hong Kong used similar approaches (22). These countries rapidly deployed resource-intensive strategies that prioritized aggressive testing and isolation to interrupt transmission (20, 22).\nIn the face of widespread transmission, the role of diagnostic testing is contingent on the type of testing available, the resources required for testing, and time to obtain results. For example, rapidly identifying cases among hospitalized patients remains a high priority to properly allocate personal protective equipment and to prevent nosocomial spread with subsequent community transmission (23, 24). Likewise, specific treatment decisions and enrollment in ongoing clinical trials require prompt diagnosis."}

    LitCovid-PD-HP

    {"project":"LitCovid-PD-HP","denotations":[{"id":"T2","span":{"begin":1263,"end":1272},"obj":"Phenotype"}],"attributes":[{"id":"A2","pred":"hp_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/HP_0002090"}],"text":"The Role of Diagnostic Testing in the SARS–CoV-2 Pandemic\nThe primary goal of epidemic containment is to reduce disease transmission by reducing the number of susceptible persons in the population or by reducing the basic reproductive number (R0). This number is modulated by such factors as the duration of viral shedding, the infectiousness of the organism, and the contact matrix between infected and susceptible persons (18). Given the lack of effective vaccines or treatments (19), the only currently available lever to reduce SARS–CoV-2 transmission is to identify and isolate persons who are contagious.\nDeployment of SARS–CoV-2 testing has varied widely across the globe. A few Asian countries have illustrated the power of preparedness, flexible isolation systems, and intensive case finding. South Korea dramatically slowed the epidemic by implementing an unprecedented testing effort (20). Using innovative measures, South Korea performed more than 300 000 tests (5828.6 tests per million persons) in the 9 weeks after the first case was identified (20, 21). Singapore used a broad case definition, aggressive contact tracing, and isolation (10). Moreover, to identify infected persons not meeting the case definition, Singapore screened patients with pneumonia and influenza-like illnesses in hospitals and primary care settings, severely ill patients in intensive care, and deaths with a possible infectious cause (10). Taiwan and Hong Kong used similar approaches (22). These countries rapidly deployed resource-intensive strategies that prioritized aggressive testing and isolation to interrupt transmission (20, 22).\nIn the face of widespread transmission, the role of diagnostic testing is contingent on the type of testing available, the resources required for testing, and time to obtain results. For example, rapidly identifying cases among hospitalized patients remains a high priority to properly allocate personal protective equipment and to prevent nosocomial spread with subsequent community transmission (23, 24). Likewise, specific treatment decisions and enrollment in ongoing clinical trials require prompt diagnosis."}