PMC:7170415 / 25806-27330 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7170415","sourcedb":"PMC","sourceid":"7170415","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7170415","text":"Although excellent tools exist for the diagnosis of symptomatic patients in well-equipped laboratories, important gaps remain in screening asymptomatic persons in the incubation phase, as well as for the accurate determination of live viral shedding among patients in the convalescence phase to inform de-isolation decisions (Figure 2). Further, it is critical to advance solutions that require less well-equipped laboratories to curb the pandemic globally. The Foundation for Innovative New Diagnostics (FIND) and others have created online resources to collate the rapidly evolving set of assays at various stages of development, from proof of concept to full regulatory approval (20, 53). Simple antigen-based tests, if sensitive enough, might be useful in lower-resource and home settings to inform quarantine and spatial distancing measures for patients without severe illness and their contacts. Novel technologies, such as Clustered Regularly Interspersed Short Palindromic Repeats (CRISPR)-based diagnostics are being used to develop rapid, simple, low-cost, portable, temperature-stable assays for deployment in the field in nontraditional and resource-limited settings, such as airports and border crossings (20, 51, 54). Other technologies might be deployed to lower-resource settings if they can be standardized. For example, it might be possible to leverage existing loop-mediated isothermal amplification testing networks established for other diseases, such as human African trypanosomiasis surveillance (66).","tracks":[{"project":"LitCovid-PubTator","denotations":[{"id":"366","span":{"begin":64,"end":72},"obj":"Species"},{"id":"367","span":{"begin":152,"end":159},"obj":"Species"},{"id":"368","span":{"begin":256,"end":264},"obj":"Species"},{"id":"369","span":{"begin":850,"end":858},"obj":"Species"},{"id":"370","span":{"begin":1476,"end":1481},"obj":"Species"},{"id":"371","span":{"begin":1490,"end":1505},"obj":"Disease"}],"attributes":[{"id":"A366","pred":"tao:has_database_id","subj":"366","obj":"Tax:9606"},{"id":"A367","pred":"tao:has_database_id","subj":"367","obj":"Tax:9606"},{"id":"A368","pred":"tao:has_database_id","subj":"368","obj":"Tax:9606"},{"id":"A369","pred":"tao:has_database_id","subj":"369","obj":"Tax:9606"},{"id":"A370","pred":"tao:has_database_id","subj":"370","obj":"Tax:9606"},{"id":"A371","pred":"tao:has_database_id","subj":"371","obj":"MESH:D014352"},{"subj":"366","pred":"source","obj":"LitCovid-PubTator"},{"subj":"367","pred":"source","obj":"LitCovid-PubTator"},{"subj":"368","pred":"source","obj":"LitCovid-PubTator"},{"subj":"369","pred":"source","obj":"LitCovid-PubTator"},{"subj":"370","pred":"source","obj":"LitCovid-PubTator"},{"subj":"371","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T105","span":{"begin":1476,"end":1505},"obj":"Disease"},{"id":"T106","span":{"begin":1490,"end":1505},"obj":"Disease"}],"attributes":[{"id":"A105","pred":"mondo_id","subj":"T105","obj":"http://purl.obolibrary.org/obo/MONDO_0005459"},{"id":"A106","pred":"mondo_id","subj":"T106","obj":"http://purl.obolibrary.org/obo/MONDO_0000940"},{"subj":"T105","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T106","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T236","span":{"begin":713,"end":718},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T237","span":{"begin":1125,"end":1130},"obj":"http://purl.obolibrary.org/obo/UBERON_0007688"},{"id":"T238","span":{"begin":1419,"end":1426},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T239","span":{"begin":1476,"end":1481},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"}],"attributes":[{"subj":"T236","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T237","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T238","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T239","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T42","span":{"begin":699,"end":706},"obj":"Chemical"}],"attributes":[{"id":"A42","pred":"chebi_id","subj":"T42","obj":"http://purl.obolibrary.org/obo/CHEBI_59132"},{"subj":"T42","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T28","span":{"begin":235,"end":249},"obj":"http://purl.obolibrary.org/obo/GO_0019076"}],"attributes":[{"subj":"T28","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T180","span":{"begin":0,"end":336},"obj":"Sentence"},{"id":"T181","span":{"begin":337,"end":457},"obj":"Sentence"},{"id":"T182","span":{"begin":458,"end":691},"obj":"Sentence"},{"id":"T183","span":{"begin":692,"end":901},"obj":"Sentence"},{"id":"T184","span":{"begin":902,"end":1231},"obj":"Sentence"},{"id":"T185","span":{"begin":1232,"end":1324},"obj":"Sentence"},{"id":"T186","span":{"begin":1325,"end":1524},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T180","pred":"source","obj":"LitCovid-sentences"},{"subj":"T181","pred":"source","obj":"LitCovid-sentences"},{"subj":"T182","pred":"source","obj":"LitCovid-sentences"},{"subj":"T183","pred":"source","obj":"LitCovid-sentences"},{"subj":"T184","pred":"source","obj":"LitCovid-sentences"},{"subj":"T185","pred":"source","obj":"LitCovid-sentences"},{"subj":"T186","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PubTator","color":"#9eec93","default":true},{"id":"LitCovid-PD-MONDO","color":"#ec93b9"},{"id":"LitCovid-PD-CLO","color":"#93d3ec"},{"id":"LitCovid-PD-CHEBI","color":"#eceb93"},{"id":"LitCovid-PD-GO-BP","color":"#d193ec"},{"id":"LitCovid-sentences","color":"#93ecb7"}]}]}}