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PMC:7170368 / 9958-11712 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
308 61-75 Gene denotes Angiotensin II Gene:183
309 133-147 Gene denotes Angiotensin II Gene:183
310 307-321 Gene denotes Angiotensin II Gene:183
311 410-414 Gene denotes AT1R Gene:185
312 874-878 Gene denotes IL-6 Gene:3569
313 37-45 Species denotes patients Tax:9606
314 96-102 Species denotes people Tax:9606
315 281-289 Species denotes patients Tax:9606
316 511-519 Species denotes patients Tax:9606
317 579-587 Species denotes patients Tax:9606
318 721-729 Species denotes patients Tax:9606
319 1001-1009 Species denotes patients Tax:9606
320 962-965 Chemical denotes LPS MESH:D008070
321 1425-1433 Chemical denotes ACEI/ARB
322 28-36 Disease denotes COVID-19 MESH:C000657245
323 163-175 Disease denotes hypertension MESH:D006973
324 180-192 Disease denotes lung failure MESH:D012131
325 268-277 Disease denotes mortality MESH:D003643
326 295-301 Disease denotes sepsis MESH:D018805
327 502-510 Disease denotes COVID-19 MESH:C000657245
328 570-578 Disease denotes COVID-19 MESH:C000657245
329 712-720 Disease denotes COVID-19 MESH:C000657245
330 735-747 Disease denotes hypertension MESH:D006973
331 974-990 Disease denotes pneumonic injury MESH:D011014
332 1015-1036 Disease denotes chronic heart failure MESH:D006333
333 1382-1393 Disease denotes lung injury MESH:D055370

MyTest

Id Subject Object Predicate Lexical cue
32228222-31838905-27780685 303-304 31838905 denotes 9
32228222-31805278-27780686 992-994 31805278 denotes 11
32228222-15067208-27780687 1167-1169 15067208 denotes 12

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T27 180-184 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T28 374-383 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T29 461-470 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T30 1023-1028 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T31 1113-1121 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T32 1146-1154 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T33 1250-1263 Body_part denotes immune system http://purl.org/sig/ont/fma/fma9825
T34 1289-1293 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T35 1382-1386 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T27 180-184 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T28 207-210 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T29 621-624 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T30 1023-1028 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T31 1250-1263 Body_part denotes immune system http://purl.obolibrary.org/obo/UBERON_0002405
T32 1382-1386 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T33 1492-1495 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T88 28-36 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T89 163-175 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T90 502-510 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T91 570-578 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T92 712-720 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T93 735-747 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T94 786-789 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T95 939-942 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T96 984-990 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T97 1023-1036 Disease denotes heart failure http://purl.obolibrary.org/obo/MONDO_0005252
T98 1207-1210 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T99 1387-1393 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T100 1430-1433 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T86 180-184 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T87 180-184 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T88 396-406 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T89 677-680 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T90 992-994 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T91 1023-1028 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T92 1023-1028 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T93 1023-1028 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T94 1023-1028 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T95 1041-1044 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T96 1223-1224 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T97 1250-1263 http://purl.obolibrary.org/obo/UBERON_0002405 denotes immune system
T98 1287-1293 http://purl.obolibrary.org/obo/CL_0000084 denotes T cell
T99 1382-1386 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T100 1382-1386 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T102 61-75 Chemical denotes Angiotensin II http://purl.obolibrary.org/obo/CHEBI_2719
T103 73-75 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T104 133-147 Chemical denotes Angiotensin II http://purl.obolibrary.org/obo/CHEBI_2719
T105 145-147 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T106 207-210 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T107 211-221 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T108 307-321 Chemical denotes Angiotensin II http://purl.obolibrary.org/obo/CHEBI_2719
T109 319-321 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T110 595-600 Chemical denotes ACEIs http://purl.obolibrary.org/obo/CHEBI_35457
T111 621-624 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T112 874-876 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T114 962-965 Chemical denotes LPS http://purl.obolibrary.org/obo/CHEBI_16412|http://purl.obolibrary.org/obo/CHEBI_52603|http://purl.obolibrary.org/obo/CHEBI_89981
T117 1492-1495 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T118 1496-1506 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T119 1580-1589 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T2 813-834 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory response
T3 1146-1165 http://purl.obolibrary.org/obo/GO_0001816 denotes cytokine production
T4 1523-1548 http://purl.obolibrary.org/obo/GO_1903901 denotes inhibit viral replication
T5 1531-1548 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T6 1531-1548 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T7 1629-1671 http://purl.obolibrary.org/obo/GO_0050728 denotes inhibiting inflammatory responses, and the
T8 1640-1662 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory responses

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T84 0-107 Sentence denotes Studies have suggested that COVID-19 patients have increased Angiotensin II compared to healthy people [8].
T85 108-193 Sentence denotes The abnormal increase in Angiotensin II was related to hypertension and lung failure.
T86 194-306 Sentence denotes In addition, RAS inhibitors have been shown to be associated with reduced mortality in patients with sepsis [9].
T87 307-420 Sentence denotes Angiotensin II positively regulates the expression of inflammatory cytokines through the activation of AT1R [10].
T88 421-520 Sentence denotes Excessively high levels of inflammatory cytokines are harmful to the outcomes of COVID-19 patients.
T89 521-625 Sentence denotes Thus, it was suggested that it is beneficial for COVID-19 patients to use ACEIs/ARBs to inhibit the RAS.
T90 626-696 Sentence denotes However, until now, no confirmed clinical evidence has been available.
T91 697-996 Sentence denotes In this study, COVID-19 patients with hypertension were enrolled, and we found that ACEI/ARB therapy attenuated the inflammatory response, potentially through the inhibition of IL-6 levels, which is consistent with the findings that ACEI and ARB therapy alleviated LPS-induced pneumonic injury [11].
T92 997-1171 Sentence denotes For patients with chronic heart failure, it has been proven that ACEI therapy was associated with decreased Th1/Th2 cytokine ratios and inflammatory cytokine production [12].
T93 1172-1304 Sentence denotes This study also suggests that ACEI/ARB therapy had a beneficial effect on the immune system by avoiding peripheral T cell depletion.
T94 1305-1398 Sentence denotes Furthermore, the viral load was reported to be highly correlated with severe lung injury [8].
T95 1399-1754 Sentence denotes It was also observed that ACEI/ARB therapy decreased the viral load, but we hypothesize that RAS inhibitors do not directly inhibit viral replication; rather, they play an indirect antiviral role by regulating immune function and inhibiting inflammatory responses, and the mechanism needs to be clarified through in vitro and in vivostudies in the future.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T24 163-175 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T25 295-301 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T26 735-747 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T27 1015-1036 Phenotype denotes chronic heart failure http://purl.obolibrary.org/obo/HP_0001635

2_test

Id Subject Object Predicate Lexical cue
32228222-31838905-27780685 303-304 31838905 denotes 9
32228222-31805278-27780686 992-994 31805278 denotes 11
32228222-15067208-27780687 1167-1169 15067208 denotes 12