> top > docs > PMC:7170368 > spans > 5085-9307 > annotations

PMC:7170368 / 5085-9307 JSONTXT

Annnotations TAB JSON ListView MergeView

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
187 32-40 Species denotes patients Tax:9606
188 77-83 Species denotes People Tax:9606
189 131-139 Species denotes patients Tax:9606
190 176-184 Species denotes patients Tax:9606
191 342-350 Species denotes patients Tax:9606
192 444-452 Species denotes patients Tax:9606
193 542-550 Species denotes patients Tax:9606
194 561-569 Species denotes patients Tax:9606
195 633-641 Species denotes patients Tax:9606
196 652-660 Species denotes patients Tax:9606
197 779-787 Species denotes patients Tax:9606
198 826-834 Species denotes patients Tax:9606
199 988-996 Species denotes patients Tax:9606
200 1116-1124 Species denotes patients Tax:9606
201 714-721 Chemical denotes calcium MESH:D002118
202 23-31 Disease denotes COVID-19 MESH:C000657245
203 157-169 Disease denotes hypertension MESH:D006973
204 898-913 Disease denotes type 2 diabetes MESH:D003924
205 924-946 Disease denotes coronary heart disease MESH:D003324
206 948-951 Disease denotes CHD
207 975-987 Disease denotes hypertensive MESH:D006973
209 1451-1463 Disease denotes hypertension MESH:D006973
215 3807-3810 Gene denotes ACE Gene:1636
216 3920-3924 Gene denotes IL-6 Gene:3569
217 3929-3932 Gene denotes CRP Gene:1401
218 3984-3987 Gene denotes CD4 Gene:920
219 3994-3997 Gene denotes CD8 Gene:925
235 2853-2857 Gene denotes IL-6 Gene:3569
236 2925-2943 Gene denotes C-reactive protein Gene:1401
237 2945-2948 Gene denotes CRP Gene:1401
238 3033-3036 Gene denotes CD8 Gene:925
239 3167-3170 Gene denotes CD4 Gene:920
240 2246-2254 Species denotes patients Tax:9606
241 2334-2341 Species denotes patient Tax:9606
242 2391-2399 Species denotes patients Tax:9606
243 2454-2462 Species denotes patients Tax:9606
244 2769-2777 Species denotes patients Tax:9606
245 2868-2876 Species denotes patients Tax:9606
246 2342-2346 Disease denotes died MESH:D003643
247 2463-2467 Disease denotes died MESH:D003643
248 2760-2768 Disease denotes COVID-19 MESH:C000657245
249 2783-2795 Disease denotes hypertension MESH:D006973

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T11 933-938 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T12 1098-1103 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T13 1893-1898 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T14 2017-2022 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T15 2936-2943 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T16 3040-3045 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T17 3174-3178 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T18 3500-3516 Body_part denotes white blood cell http://purl.org/sig/ont/fma/fma62852
T19 3512-3516 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T20 3525-3535 Body_part denotes neutrophil http://purl.org/sig/ont/fma/fma62860
T21 3544-3552 Body_part denotes platelet http://purl.org/sig/ont/fma/fma62851
T22 3947-3952 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T23 4001-4006 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T24 4021-4026 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T14 933-938 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T15 1098-1103 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T16 1893-1898 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T17 2017-2022 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T18 3506-3511 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T19 3947-3952 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T20 4021-4026 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T41 23-31 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T42 157-169 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T43 528-531 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T44 591-594 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T45 619-622 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T46 810-813 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T47 855-858 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T48 898-913 Disease denotes type 2 diabetes http://purl.obolibrary.org/obo/MONDO_0005148
T49 905-913 Disease denotes diabetes http://purl.obolibrary.org/obo/MONDO_0005015
T50 915-918 Disease denotes T2D http://purl.obolibrary.org/obo/MONDO_0005148
T51 924-946 Disease denotes coronary heart disease http://purl.obolibrary.org/obo/MONDO_0005010
T52 933-946 Disease denotes heart disease http://purl.obolibrary.org/obo/MONDO_0005267
T53 948-951 Disease denotes CHD http://purl.obolibrary.org/obo/MONDO_0005010
T54 1451-1463 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T55 1502-1505 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T56 1529-1532 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T57 1686-1689 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T58 1716-1719 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T59 1835-1838 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T60 1871-1874 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T61 1943-1946 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T62 2067-2070 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T63 2271-2274 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T64 2373-2376 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T65 2526-2529 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T66 2573-2576 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T67 2724-2727 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T68 2760-2768 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T69 2783-2795 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T70 2891-2894 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T71 3058-3061 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T72 3119-3122 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T73 3380-3383 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T74 3440-3443 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T75 3789-3792 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T76 3811-3814 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T32 8-9 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T33 933-938 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T34 933-938 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T35 933-938 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T36 933-938 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T37 1072-1074 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T38 1098-1103 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T39 1098-1103 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T40 1308-1310 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T41 1308-1310 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T42 1414-1419 http://purl.obolibrary.org/obo/UBERON_0003101 denotes males
T43 1414-1419 http://www.ebi.ac.uk/efo/EFO_0000970 denotes males
T44 1893-1898 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T45 1893-1898 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T46 1893-1898 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T47 1893-1898 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T48 2017-2022 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T49 2017-2022 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T50 2017-2022 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T51 2017-2022 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T52 2159-2161 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T53 2159-2161 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T54 2282-2284 http://purl.obolibrary.org/obo/CLO_0001382 denotes 48
T55 2478-2479 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T56 2818-2819 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T57 2832-2833 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T58 2996-2997 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T59 3024-3027 http://purl.obolibrary.org/obo/CLO_0052882 denotes CD3
T60 3024-3027 http://purl.obolibrary.org/obo/CLO_0053434 denotes CD3
T61 3033-3036 http://purl.obolibrary.org/obo/CLO_0053438 denotes CD8
T62 3038-3045 http://purl.obolibrary.org/obo/CL_0000084 denotes T cells
T63 3167-3170 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T64 3172-3178 http://purl.obolibrary.org/obo/CL_0000084 denotes T cell
T65 3506-3511 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T66 3512-3516 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T67 3823-3824 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T68 3903-3904 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T69 3947-3952 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T70 3947-3952 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T71 3978-3981 http://purl.obolibrary.org/obo/CLO_0052882 denotes CD3
T72 3978-3981 http://purl.obolibrary.org/obo/CLO_0053434 denotes CD3
T73 3984-3987 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T74 3994-3997 http://purl.obolibrary.org/obo/CLO_0053438 denotes CD8
T75 3999-4006 http://purl.obolibrary.org/obo/CL_0000084 denotes T cells
T76 4021-4026 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T77 4021-4026 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T78 4167-4175 http://purl.obolibrary.org/obo/UBERON_0000473 denotes test was

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T50 235-257 Chemical denotes antihypertensive drugs http://purl.obolibrary.org/obo/CHEBI_35674
T51 252-257 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T52 369-385 Chemical denotes antihypertensive http://purl.obolibrary.org/obo/CHEBI_35674
T53 491-507 Chemical denotes antihypertensive http://purl.obolibrary.org/obo/CHEBI_35674
T54 532-537 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T55 595-600 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T56 623-628 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T57 680-702 Chemical denotes antihypertensive drugs http://purl.obolibrary.org/obo/CHEBI_35674
T58 697-702 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T59 714-738 Chemical denotes calcium channel blockers http://purl.obolibrary.org/obo/CHEBI_38215
T60 714-721 Chemical denotes calcium http://purl.obolibrary.org/obo/CHEBI_22984|http://purl.obolibrary.org/obo/CHEBI_29320
T62 762-771 Chemical denotes diuretics http://purl.obolibrary.org/obo/CHEBI_35498
T63 814-819 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T64 859-864 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T65 1308-1310 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T66 1506-1511 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T67 1533-1538 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T68 1690-1695 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T69 1720-1725 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T70 1839-1844 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T71 1875-1880 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T72 1947-1952 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T73 2071-2076 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T74 2159-2161 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T75 2275-2280 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T76 2377-2382 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T77 2530-2535 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T78 2577-2582 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T79 2728-2733 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T80 2853-2855 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T82 2895-2900 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T83 2936-2943 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T84 3062-3067 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T85 3123-3128 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T86 3384-3389 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T87 3444-3449 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T88 3565-3572 Chemical denotes lactate http://purl.obolibrary.org/obo/CHEBI_24996
T89 3621-3623 Chemical denotes S3 http://purl.obolibrary.org/obo/CHEBI_29388
T90 3793-3798 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T91 3815-3820 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T92 3920-3922 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T45 0-7 Sentence denotes Results
T46 8-118 Sentence denotes A total of 417 COVID-19 patients were admitted to the Shenzhen Third People’s Hospital as of 23 February 2020.
T47 119-170 Sentence denotes Among these patients, 51 (12.23%) had hypertension.
T48 171-328 Sentence denotes Nine patients (17.6%) with Grade 1hypertension did not take any antihypertensive drugs during hospitalization and were excluded from the subsequent analysis.
T49 329-427 Sentence denotes The other 42 patients (82.4%) receiving antihypertensive therapy were included in further studies.
T50 428-772 Sentence denotes The 42 analyzed patients were divided into two groups based on antihypertensive therapies: the ACEI/ARB group (17 patients) included patients treated with ACEI or ARB drugs, and the non-ACEI/ARB group (25 patients) included patients treated with other antihypertensive drugs, including calcium channel blockers (CCBs), β-blockers and diuretics.
T51 773-953 Sentence denotes Eight patients (32%) in the non-ACEI/ARB group and 5 patients (29.41%)in the ACEI/ARB group had other comorbidities, such as type 2 diabetes (T2D) and coronary heart disease (CHD).
T52 954-1093 Sentence denotes The vast majority of hypertensive patients had received the current therapeutic regimens shown in supplementary Table S1 for over one year.
T53 1094-1204 Sentence denotes The blood pressure of patients was well-controlled with the above therapeutic regimens during hospitalization.
T54 1205-1311 Sentence denotes The comparison of baseline characteristics between the two groups is summarized in supplementary Table S2.
T55 1312-1420 Sentence denotes The median age of the analyzed subjects was 64.5 years (IQR, 55.8–69.0 years), and 57.1% of them were males.
T56 1421-1539 Sentence denotes No significant differences in hypertension grades were observed between the ACEI/ARB group and the non-ACEI/ARB group.
T57 1540-1586 Sentence denotes Both groups showed similar signs and symptoms.
T58 1587-1726 Sentence denotes The median number of days from the onset of symptoms to hospital admission was 2.0 in the non-ACEI/ARB group and 3.0 in the ACEI/ARB group.
T59 1727-1881 Sentence denotes Meanwhile, the median number of days from symptom onset to hospital discharge was 16.5 days in the non-ACEI/ARB group and 20.0 days in the ACEI/ARB group.
T60 1882-1990 Sentence denotes The median heart rate and respiratory rate from the non-ACEI/ARB group were 90.5 bpm and 20.0, respectively.
T61 1991-2114 Sentence denotes In comparison, the median heart rate and respiratory rate from the non-ACEI/ARB group were 80.0 bmp and 20.0, respectively.
T62 2115-2218 Sentence denotes All baseline characteristics shown in Table S2 were not significantly different between the two groups.
T63 2219-2347 Sentence denotes During hospitalization, 12 patients in the non-ACEI/ARB group (48%) were categorized into severe subgroups and one patient died.
T64 2348-2482 Sentence denotes In contrast, in the ACEI/ARB group, only 4 patients (23.5%) were categorized into severe subgroups and no patients died (Figure 1(A)).
T65 2483-2676 Sentence denotes The percentage of severe cases in the ACEI/ARB group was higher than that in the non-ACEI/ARB group, but this difference was not significant, possibly due to the small number of clinical cases.
T66 2677-2796 Sentence denotes We next examined the effects of taking ACEI or ARB drugs on laboratory findings of COVID-19 patients with hypertension.
T67 2797-2901 Sentence denotes As shown in Figure 1(B), there was a trend toward lower IL-6 levels in patients from the ACEI/ARB group.
T68 2902-3000 Sentence denotes No marked variation in C-reactive protein (CRP) was observed between the two groups (Figure 1(B)).
T69 3001-3129 Sentence denotes The absolute number of CD3+ and CD8+ T cells in the ACEI/ARB group was significantly higher than that in the non-ACEI/ARB group.
T70 3130-3223 Sentence denotes There were no significant changes in CD4+ T cell counts between the two groups (Figure 1(C)).
T71 3224-3464 Sentence denotes In addition, although the viral load was not different between the two groups at hospital admission, the peak viral load during hospitalization in the ACEI/ARB group was significantly lower than that in the non-ACEI/ARB group (Figure 1(D)).
T72 3465-3693 Sentence denotes Other laboratory findings, such as white blood cell counts, neutrophil counts, platelet counts, and lactate dehydrogenase, are shown in supplementary Table S3, and no significant differences were observed between the two groups.
T73 3694-3703 Sentence denotes Figure 1.
T74 3704-4106 Sentence denotes Summarized clinical, inflammatory, immunological, and viral findings in the non-ACEI/ARB group and the ACE/ARB group. (A) The disease severity distribution of the two groups during hospitalization. (B) The levels of IL-6 and CRP in peripheral blood. (C) Absolute numbers of CD3+, CD4+, and CD8+ T cells in peripheral blood. (D) Viral load on hospital admission and maximum value during hospitalization.
T75 4107-4152 Sentence denotes The data are expressed as the median and IQR.
T76 4153-4222 Sentence denotes An unpaired t test was used, and P < 0.05 was considered significant.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T15 157-169 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T16 898-913 Phenotype denotes type 2 diabetes http://purl.obolibrary.org/obo/HP_0005978
T17 1451-1463 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T18 2783-2795 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822