PMC:7170368 / 161-1062
Annnotations
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
18 | 547-551 | Gene | denotes | IL-6 | Gene:3569 |
19 | 624-627 | Gene | denotes | CD8 | Gene:925 |
20 | 125-133 | Species | denotes | patients | Tax:9606 |
21 | 336-344 | Species | denotes | patients | Tax:9606 |
22 | 436-444 | Species | denotes | patients | Tax:9606 |
23 | 874-882 | Species | denotes | patients | Tax:9606 |
24 | 84-105 | Disease | denotes | coronavirus infection | MESH:D018352 |
25 | 115-123 | Disease | denotes | COVID-19 | MESH:C000657245 |
26 | 327-335 | Disease | denotes | COVID-19 | MESH:C000657245 |
27 | 350-362 | Disease | denotes | hypertension | MESH:D006973 |
28 | 865-873 | Disease | denotes | COVID-19 | MESH:C000657245 |
29 | 888-900 | Disease | denotes | hypertension | MESH:D006973 |
LitCovid-PD-FMA-UBERON
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T1 | 566-571 | Body_part | denotes | blood | http://purl.org/sig/ont/fma/fma9670 |
T2 | 630-634 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T3 | 656-661 | Body_part | denotes | blood | http://purl.org/sig/ont/fma/fma9670 |
LitCovid-PD-UBERON
Id | Subject | Object | Predicate | Lexical cue | uberon_id |
---|---|---|---|---|---|
T2 | 32-56 | Body_part | denotes | renin-angiotensin system | http://purl.obolibrary.org/obo/UBERON_0018229 |
T3 | 58-61 | Body_part | denotes | RAS | http://purl.obolibrary.org/obo/UBERON_0018229 |
T4 | 147-150 | Body_part | denotes | RAS | http://purl.obolibrary.org/obo/UBERON_0018229 |
T5 | 403-406 | Body_part | denotes | RAS | http://purl.obolibrary.org/obo/UBERON_0018229 |
T6 | 566-571 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
T7 | 656-661 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
LitCovid-PD-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T3 | 96-105 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
T4 | 115-123 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T5 | 327-335 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T6 | 350-362 | Disease | denotes | hypertension | http://purl.obolibrary.org/obo/MONDO_0005044 |
T7 | 463-466 | Disease | denotes | ARB | http://purl.obolibrary.org/obo/MONDO_0012733 |
T8 | 594-597 | Disease | denotes | ARB | http://purl.obolibrary.org/obo/MONDO_0012733 |
T9 | 865-873 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T10 | 888-900 | Disease | denotes | hypertension | http://purl.obolibrary.org/obo/MONDO_0005044 |
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 63-66 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
T2 | 479-480 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T3 | 515-516 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T4 | 530-531 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T5 | 566-571 | http://purl.obolibrary.org/obo/UBERON_0000178 | denotes | blood |
T6 | 566-571 | http://www.ebi.ac.uk/efo/EFO_0000296 | denotes | blood |
T7 | 616-619 | http://purl.obolibrary.org/obo/CLO_0052882 | denotes | CD3 |
T8 | 616-619 | http://purl.obolibrary.org/obo/CLO_0053434 | denotes | CD3 |
T9 | 624-627 | http://purl.obolibrary.org/obo/CLO_0053438 | denotes | CD8 |
T10 | 628-634 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T cell |
T11 | 656-661 | http://purl.obolibrary.org/obo/UBERON_0000178 | denotes | blood |
T12 | 656-661 | http://www.ebi.ac.uk/efo/EFO_0000296 | denotes | blood |
LitCovid-PD-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T3 | 38-49 | Chemical | denotes | angiotensin | http://purl.obolibrary.org/obo/CHEBI_48433 |
T4 | 58-61 | Chemical | denotes | RAS | http://purl.obolibrary.org/obo/CHEBI_63620 |
T5 | 147-150 | Chemical | denotes | RAS | http://purl.obolibrary.org/obo/CHEBI_63620 |
T6 | 151-161 | Chemical | denotes | inhibitors | http://purl.obolibrary.org/obo/CHEBI_35222 |
T7 | 171-211 | Chemical | denotes | angiotensin-converting enzyme inhibitors | http://purl.obolibrary.org/obo/CHEBI_35457 |
T8 | 171-182 | Chemical | denotes | angiotensin | http://purl.obolibrary.org/obo/CHEBI_48433 |
T9 | 194-211 | Chemical | denotes | enzyme inhibitors | http://purl.obolibrary.org/obo/CHEBI_23924 |
T10 | 201-211 | Chemical | denotes | inhibitors | http://purl.obolibrary.org/obo/CHEBI_35222 |
T11 | 213-218 | Chemical | denotes | ACEIs | http://purl.obolibrary.org/obo/CHEBI_35457 |
T12 | 224-238 | Chemical | denotes | angiotensin II | http://purl.obolibrary.org/obo/CHEBI_2719|http://purl.obolibrary.org/obo/CHEBI_48432|http://purl.obolibrary.org/obo/CHEBI_58506 |
T15 | 224-235 | Chemical | denotes | angiotensin | http://purl.obolibrary.org/obo/CHEBI_48433 |
T16 | 236-238 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
T17 | 403-406 | Chemical | denotes | RAS | http://purl.obolibrary.org/obo/CHEBI_63620 |
T18 | 407-417 | Chemical | denotes | inhibitors | http://purl.obolibrary.org/obo/CHEBI_35222 |
T19 | 547-549 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
T21 | 714-736 | Chemical | denotes | antihypertensive drugs | http://purl.obolibrary.org/obo/CHEBI_35674 |
T22 | 731-736 | Chemical | denotes | drugs | http://purl.obolibrary.org/obo/CHEBI_23888 |
T23 | 782-787 | Chemical | denotes | ACEIs | http://purl.obolibrary.org/obo/CHEBI_35457 |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T6 | 0-8 | Sentence | denotes | ABSTRACT |
T7 | 9-326 | Sentence | denotes | The dysfunction of the renin-angiotensin system (RAS) has been observed in coronavirus infection disease (COVID-19) patients, but whether RAS inhibitors, such as angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II type 1 receptor blockers (ARBs), are associated with clinical outcomes remains unknown. |
T8 | 327-418 | Sentence | denotes | COVID-19 patients with hypertension were enrolled to evaluate the effect of RAS inhibitors. |
T9 | 419-572 | Sentence | denotes | We observed that patients receiving ACEI or ARB therapy had a lower rate of severe diseases and a trend toward a lower level of IL-6 in peripheral blood. |
T10 | 573-737 | Sentence | denotes | In addition, ACEI or ARB therapy increased CD3 and CD8 T cell counts in peripheral blood and decreased the peak viral load compared to other antihypertensive drugs. |
T11 | 738-901 | Sentence | denotes | This evidence supports the benefit of using ACEIs or ARBs to potentially contribute to the improvement of clinical outcomes of COVID-19 patients with hypertension. |
LitCovid-PD-HP
Id | Subject | Object | Predicate | Lexical cue | hp_id |
---|---|---|---|---|---|
T2 | 350-362 | Phenotype | denotes | hypertension | http://purl.obolibrary.org/obo/HP_0000822 |
T3 | 888-900 | Phenotype | denotes | hypertension | http://purl.obolibrary.org/obo/HP_0000822 |