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PMC:7170368 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
3 78-86 Species denotes patients Tax:9606
4 69-77 Disease denotes COVID-19 MESH:C000657245
5 92-104 Disease denotes hypertension MESH:D006973
18 708-712 Gene denotes IL-6 Gene:3569
19 785-788 Gene denotes CD8 Gene:925
20 286-294 Species denotes patients Tax:9606
21 497-505 Species denotes patients Tax:9606
22 597-605 Species denotes patients Tax:9606
23 1035-1043 Species denotes patients Tax:9606
24 245-266 Disease denotes coronavirus infection MESH:D018352
25 276-284 Disease denotes COVID-19 MESH:C000657245
26 488-496 Disease denotes COVID-19 MESH:C000657245
27 511-523 Disease denotes hypertension MESH:D006973
28 1026-1034 Disease denotes COVID-19 MESH:C000657245
29 1049-1061 Disease denotes hypertension MESH:D006973
76 1865-1868 Gene denotes ACE Gene:1636
77 1869-1872 Gene denotes Ang Gene:283
78 1876-1880 Gene denotes AT1R Gene:185
79 1897-1901 Gene denotes ACE2 Gene:59272
80 1902-1910 Gene denotes Ang (1–7 Gene:284
81 1997-2000 Gene denotes ACE Gene:1636
82 2001-2004 Gene denotes Ang Gene:283
83 2008-2012 Gene denotes AT1R Gene:185
84 2026-2030 Gene denotes ACE2 Gene:59272
85 2031-2039 Gene denotes Ang (1–7 Gene:284
86 2247-2251 Gene denotes ACE2 Gene:59272
87 2284-2288 Gene denotes ACE2 Gene:59272
88 2339-2342 Gene denotes ACE Gene:1636
89 2343-2346 Gene denotes Ang Gene:283
90 2350-2354 Gene denotes AT1R Gene:185
91 2368-2372 Gene denotes ACE2 Gene:59272
92 2373-2381 Gene denotes Ang (1–7 Gene:284
93 2420-2423 Gene denotes ACE Gene:1636
94 2424-2427 Gene denotes Ang Gene:283
95 2431-2435 Gene denotes AT1R Gene:185
96 2527-2530 Gene denotes ACE Gene:1636
97 2531-2534 Gene denotes Ang Gene:283
98 2538-2542 Gene denotes AT1R Gene:185
99 2573-2577 Gene denotes ACE2 Gene:59272
100 2578-2586 Gene denotes Ang (1–7 Gene:284
101 1109-1156 Species denotes severe acute respiratory syndrome coronavirus 2 Tax:2697049
102 1158-1168 Species denotes SARS-CoV-2 Tax:2697049
103 1423-1429 Species denotes people Tax:9606
104 1625-1631 Species denotes people Tax:9606
105 2173-2183 Species denotes SARS-CoV-2 Tax:2697049
106 2730-2738 Species denotes patients Tax:9606
107 3020-3028 Species denotes patients Tax:9606
108 1081-1089 Disease denotes COVID-19 MESH:C000657245
109 1385-1393 Disease denotes COVID-19 MESH:C000657245
110 1435-1456 Disease denotes SARS-CoV-2 infections MESH:C000657245
111 1461-1484 Disease denotes cardiovascular diseases MESH:D002318
112 1496-1508 Disease denotes hypertension MESH:D006973
113 1556-1568 Disease denotes hypertension MESH:D006973
114 1653-1665 Disease denotes hypertension MESH:D006973
115 1693-1705 Disease denotes hypertension MESH:D006973
116 2257-2276 Disease denotes SARS-CoV infections MESH:C000657245
117 2477-2489 Disease denotes hypertension MESH:D006973
118 2689-2710 Disease denotes coronavirus infection MESH:D018352
119 2720-2728 Disease denotes COVID-19 MESH:C000657245
120 3008-3016 Disease denotes COVID-19 MESH:C000657245
121 3034-3046 Disease denotes hypertension MESH:D006973
144 3103-3109 Species denotes People Tax:9606
145 3186-3194 Species denotes patients Tax:9606
146 3198-3206 Species denotes patients Tax:9606
147 3297-3305 Species denotes patients Tax:9606
148 3351-3357 Species denotes People Tax:9606
149 3425-3433 Species denotes patients Tax:9606
150 3493-3501 Species denotes patients Tax:9606
151 3723-3733 Species denotes SARS-CoV-2 Tax:2697049
152 4205-4211 Species denotes People Tax:9606
153 4267-4275 Species denotes patients Tax:9606
154 4354-4360 Species denotes People Tax:9606
155 4531-4539 Species denotes patients Tax:9606
156 4666-4674 Species denotes patients Tax:9606
157 3311-3319 Disease denotes COVID-19 MESH:C000657245
158 3439-3451 Disease denotes hypertension MESH:D006973
159 3484-3492 Disease denotes COVID-19 MESH:C000657245
160 4074-4082 Disease denotes COVID-19 MESH:C000657245
161 4258-4266 Disease denotes COVID-19 MESH:C000657245
162 4382-4394 Disease denotes Hypertension MESH:D006973
163 4498-4510 Disease denotes Hypertension MESH:D006973
164 4518-4530 Disease denotes Hypertensive MESH:D006973
165 4545-4553 Disease denotes COVID-19 MESH:C000657245
187 5117-5125 Species denotes patients Tax:9606
188 5162-5168 Species denotes People Tax:9606
189 5216-5224 Species denotes patients Tax:9606
190 5261-5269 Species denotes patients Tax:9606
191 5427-5435 Species denotes patients Tax:9606
192 5529-5537 Species denotes patients Tax:9606
193 5627-5635 Species denotes patients Tax:9606
194 5646-5654 Species denotes patients Tax:9606
195 5718-5726 Species denotes patients Tax:9606
196 5737-5745 Species denotes patients Tax:9606
197 5864-5872 Species denotes patients Tax:9606
198 5911-5919 Species denotes patients Tax:9606
199 6073-6081 Species denotes patients Tax:9606
200 6201-6209 Species denotes patients Tax:9606
201 5799-5806 Chemical denotes calcium MESH:D002118
202 5108-5116 Disease denotes COVID-19 MESH:C000657245
203 5242-5254 Disease denotes hypertension MESH:D006973
204 5983-5998 Disease denotes type 2 diabetes MESH:D003924
205 6009-6031 Disease denotes coronary heart disease MESH:D003324
206 6033-6036 Disease denotes CHD
207 6060-6072 Disease denotes hypertensive MESH:D006973
209 6536-6548 Disease denotes hypertension MESH:D006973
215 8892-8895 Gene denotes ACE Gene:1636
216 9005-9009 Gene denotes IL-6 Gene:3569
217 9014-9017 Gene denotes CRP Gene:1401
218 9069-9072 Gene denotes CD4 Gene:920
219 9079-9082 Gene denotes CD8 Gene:925
235 7938-7942 Gene denotes IL-6 Gene:3569
236 8010-8028 Gene denotes C-reactive protein Gene:1401
237 8030-8033 Gene denotes CRP Gene:1401
238 8118-8121 Gene denotes CD8 Gene:925
239 8252-8255 Gene denotes CD4 Gene:920
240 7331-7339 Species denotes patients Tax:9606
241 7419-7426 Species denotes patient Tax:9606
242 7476-7484 Species denotes patients Tax:9606
243 7539-7547 Species denotes patients Tax:9606
244 7854-7862 Species denotes patients Tax:9606
245 7953-7961 Species denotes patients Tax:9606
246 7427-7431 Disease denotes died MESH:D003643
247 7548-7552 Disease denotes died MESH:D003643
248 7845-7853 Disease denotes COVID-19 MESH:C000657245
249 7868-7880 Disease denotes hypertension MESH:D006973
266 9673-9676 Gene denotes ACE Gene:1636
267 9677-9680 Gene denotes Ang Gene:283
268 9684-9688 Gene denotes AT1R Gene:185
269 9456-9460 Species denotes H7N9 Tax:333278
270 9738-9746 Species denotes patients Tax:9606
271 9800-9808 Species denotes patients Tax:9606
272 9930-9938 Species denotes patients Tax:9606
273 9385-9397 Disease denotes hypertension MESH:D006973
274 9408-9419 Disease denotes lung injury MESH:D055370
275 9527-9539 Disease denotes hypertension MESH:D006973
276 9544-9569 Disease denotes inflammatory lung disease MESH:D011014
277 9725-9737 Disease denotes hypertensive MESH:D006973
278 9778-9790 Disease denotes hypertensive MESH:D006973
279 9791-9799 Disease denotes COVID-19 MESH:C000657245
280 9921-9929 Disease denotes COVID-19 MESH:C000657245
281 9944-9956 Disease denotes hypertension MESH:D006973
308 10019-10033 Gene denotes Angiotensin II Gene:183
309 10091-10105 Gene denotes Angiotensin II Gene:183
310 10265-10279 Gene denotes Angiotensin II Gene:183
311 10368-10372 Gene denotes AT1R Gene:185
312 10832-10836 Gene denotes IL-6 Gene:3569
313 9995-10003 Species denotes patients Tax:9606
314 10054-10060 Species denotes people Tax:9606
315 10239-10247 Species denotes patients Tax:9606
316 10469-10477 Species denotes patients Tax:9606
317 10537-10545 Species denotes patients Tax:9606
318 10679-10687 Species denotes patients Tax:9606
319 10959-10967 Species denotes patients Tax:9606
320 10920-10923 Chemical denotes LPS MESH:D008070
321 11383-11391 Chemical denotes ACEI/ARB
322 9986-9994 Disease denotes COVID-19 MESH:C000657245
323 10121-10133 Disease denotes hypertension MESH:D006973
324 10138-10150 Disease denotes lung failure MESH:D012131
325 10226-10235 Disease denotes mortality MESH:D003643
326 10253-10259 Disease denotes sepsis MESH:D018805
327 10460-10468 Disease denotes COVID-19 MESH:C000657245
328 10528-10536 Disease denotes COVID-19 MESH:C000657245
329 10670-10678 Disease denotes COVID-19 MESH:C000657245
330 10693-10705 Disease denotes hypertension MESH:D006973
331 10932-10948 Disease denotes pneumonic injury MESH:D011014
332 10973-10994 Disease denotes chronic heart failure MESH:D006333
333 11340-11351 Disease denotes lung injury MESH:D055370
338 11841-11849 Species denotes patients Tax:9606
339 11891-11899 Species denotes patients Tax:9606
340 11832-11840 Disease denotes COVID-19 MESH:C000657245
341 11855-11867 Disease denotes hypertension MESH:D006973

MyTest

Id Subject Object Predicate Lexical cue
32228222-25194138-27780682 1934-1935 25194138 denotes 3
32228222-16007097-27780683 2402-2403 16007097 denotes 5
32228222-16007097-27780684 9462-9463 16007097 denotes 5
32228222-31838905-27780685 10261-10262 31838905 denotes 9
32228222-31805278-27780686 10950-10952 31805278 denotes 11
32228222-15067208-27780687 11125-11127 15067208 denotes 12

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T1 727-732 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T2 791-795 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T3 817-822 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T4 1818-1823 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T5 2013-2017 Body_part denotes axis http://purl.org/sig/ont/fma/fma12520
T6 2054-2058 Body_part denotes axis http://purl.org/sig/ont/fma/fma12520
T7 2227-2231 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T8 2355-2359 Body_part denotes axis http://purl.org/sig/ont/fma/fma12520
T9 2396-2400 Body_part denotes axis http://purl.org/sig/ont/fma/fma12520
T10 2436-2440 Body_part denotes axis http://purl.org/sig/ont/fma/fma12520
T11 6018-6023 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T12 6183-6188 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T13 6978-6983 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T14 7102-7107 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T15 8021-8028 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T16 8125-8130 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T17 8259-8263 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T18 8585-8601 Body_part denotes white blood cell http://purl.org/sig/ont/fma/fma62852
T19 8597-8601 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T20 8610-8620 Body_part denotes neutrophil http://purl.org/sig/ont/fma/fma62860
T21 8629-8637 Body_part denotes platelet http://purl.org/sig/ont/fma/fma62851
T22 9032-9037 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T23 9086-9091 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T24 9106-9111 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T25 9408-9412 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T26 9557-9561 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T27 10138-10142 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T28 10332-10341 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T29 10419-10428 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T30 10981-10986 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T31 11071-11079 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T32 11104-11112 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T33 11208-11221 Body_part denotes immune system http://purl.org/sig/ont/fma/fma9825
T34 11247-11251 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T35 11340-11344 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 0-24 Body_part denotes Renin-angiotensin system http://purl.obolibrary.org/obo/UBERON_0018229
T2 193-217 Body_part denotes renin-angiotensin system http://purl.obolibrary.org/obo/UBERON_0018229
T3 219-222 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T4 308-311 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T5 564-567 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T6 727-732 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T7 817-822 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T8 1752-1755 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T9 1818-1823 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T10 2637-2661 Body_part denotes renin-angiotensin system http://purl.obolibrary.org/obo/UBERON_0018229
T11 2663-2666 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T12 2752-2755 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T13 2974-2977 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T14 6018-6023 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T15 6183-6188 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T16 6978-6983 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T17 7102-7107 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T18 8591-8596 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T19 9032-9037 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T20 9106-9111 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T21 9345-9348 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T22 9408-9412 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T23 9479-9482 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T24 9557-9561 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T25 9581-9584 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T26 9903-9906 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T27 10138-10142 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T28 10165-10168 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T29 10579-10582 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T30 10981-10986 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T31 11208-11221 Body_part denotes immune system http://purl.obolibrary.org/obo/UBERON_0002405
T32 11340-11344 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T33 11450-11453 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T34 11784-11787 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 69-77 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T2 92-104 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T3 257-266 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T4 276-284 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T5 488-496 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T6 511-523 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T7 624-627 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T8 755-758 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T9 1026-1034 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T10 1049-1061 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T11 1081-1089 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T12 1109-1156 Disease denotes severe acute respiratory syndrome coronavirus 2 http://purl.obolibrary.org/obo/MONDO_0100096
T13 1109-1142 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T14 1158-1166 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T15 1385-1393 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T16 1435-1443 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T17 1446-1456 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T18 1461-1484 Disease denotes cardiovascular diseases http://purl.obolibrary.org/obo/MONDO_0004995
T19 1496-1508 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T20 1556-1568 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T21 1653-1665 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T22 1693-1705 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T23 2167-2171 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T24 2173-2181 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T25 2257-2265 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T26 2266-2276 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T27 2477-2489 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T28 2701-2710 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T29 2720-2728 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T30 3008-3016 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T31 3034-3046 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T32 3311-3319 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T33 3439-3451 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T34 3484-3492 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T35 3723-3731 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T36 4074-4082 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T37 4258-4266 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T38 4382-4394 Disease denotes Hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T39 4498-4510 Disease denotes Hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T40 4545-4553 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T41 5108-5116 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T42 5242-5254 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T43 5613-5616 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T44 5676-5679 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T45 5704-5707 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T46 5895-5898 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T47 5940-5943 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T48 5983-5998 Disease denotes type 2 diabetes http://purl.obolibrary.org/obo/MONDO_0005148
T49 5990-5998 Disease denotes diabetes http://purl.obolibrary.org/obo/MONDO_0005015
T50 6000-6003 Disease denotes T2D http://purl.obolibrary.org/obo/MONDO_0005148
T51 6009-6031 Disease denotes coronary heart disease http://purl.obolibrary.org/obo/MONDO_0005010
T52 6018-6031 Disease denotes heart disease http://purl.obolibrary.org/obo/MONDO_0005267
T53 6033-6036 Disease denotes CHD http://purl.obolibrary.org/obo/MONDO_0005010
T54 6536-6548 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T55 6587-6590 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T56 6614-6617 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T57 6771-6774 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T58 6801-6804 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T59 6920-6923 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T60 6956-6959 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T61 7028-7031 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T62 7152-7155 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T63 7356-7359 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T64 7458-7461 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T65 7611-7614 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T66 7658-7661 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T67 7809-7812 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T68 7845-7853 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T69 7868-7880 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T70 7976-7979 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T71 8143-8146 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T72 8204-8207 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T73 8465-8468 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T74 8525-8528 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T75 8874-8877 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T76 8896-8899 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T77 9385-9397 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T78 9402-9419 Disease denotes acute lung injury http://purl.obolibrary.org/obo/MONDO_0006502|http://purl.obolibrary.org/obo/MONDO_0015796
T80 9413-9419 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T81 9447-9451 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T82 9527-9539 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T83 9557-9569 Disease denotes lung disease http://purl.obolibrary.org/obo/MONDO_0005275
T84 9650-9653 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T85 9791-9799 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T86 9921-9929 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T87 9944-9956 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T88 9986-9994 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T89 10121-10133 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T90 10460-10468 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T91 10528-10536 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T92 10670-10678 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T93 10693-10705 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T94 10744-10747 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T95 10897-10900 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T96 10942-10948 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T97 10981-10994 Disease denotes heart failure http://purl.obolibrary.org/obo/MONDO_0005252
T98 11165-11168 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T99 11345-11351 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T100 11388-11391 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T101 11832-11840 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T102 11855-11867 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T103 11964-11967 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1 224-227 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T2 640-641 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T3 676-677 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T4 691-692 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T5 727-732 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T6 727-732 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T7 777-780 http://purl.obolibrary.org/obo/CLO_0052882 denotes CD3
T8 777-780 http://purl.obolibrary.org/obo/CLO_0053434 denotes CD3
T9 785-788 http://purl.obolibrary.org/obo/CLO_0053438 denotes CD8
T10 789-795 http://purl.obolibrary.org/obo/CL_0000084 denotes T cell
T11 817-822 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T12 817-822 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T13 1554-1555 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T14 1633-1635 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T15 1818-1823 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T16 1818-1823 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T17 1981-1989 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T18 2066-2067 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T19 2227-2231 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T20 2444-2445 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T21 2668-2671 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T22 3237-3238 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T23 3374-3376 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T24 3636-3637 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T25 3873-3874 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T26 4053-4056 http://purl.obolibrary.org/obo/CL_0000990 denotes CDC
T27 4455-4459 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018
T28 4707-4709 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T29 4917-4921 http://purl.obolibrary.org/obo/UBERON_0000473 denotes test
T30 5002-5008 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested
T31 5027-5031 http://purl.obolibrary.org/obo/UBERON_0000473 denotes test
T32 5093-5094 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T33 6018-6023 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T34 6018-6023 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T35 6018-6023 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T36 6018-6023 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T37 6157-6159 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T38 6183-6188 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T39 6183-6188 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T40 6393-6395 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T41 6393-6395 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T42 6499-6504 http://purl.obolibrary.org/obo/UBERON_0003101 denotes males
T43 6499-6504 http://www.ebi.ac.uk/efo/EFO_0000970 denotes males
T44 6978-6983 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T45 6978-6983 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T46 6978-6983 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T47 6978-6983 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T48 7102-7107 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T49 7102-7107 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T50 7102-7107 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T51 7102-7107 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T52 7244-7246 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T53 7244-7246 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T54 7367-7369 http://purl.obolibrary.org/obo/CLO_0001382 denotes 48
T55 7563-7564 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T56 7903-7904 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T57 7917-7918 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T58 8081-8082 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T59 8109-8112 http://purl.obolibrary.org/obo/CLO_0052882 denotes CD3
T60 8109-8112 http://purl.obolibrary.org/obo/CLO_0053434 denotes CD3
T61 8118-8121 http://purl.obolibrary.org/obo/CLO_0053438 denotes CD8
T62 8123-8130 http://purl.obolibrary.org/obo/CL_0000084 denotes T cells
T63 8252-8255 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T64 8257-8263 http://purl.obolibrary.org/obo/CL_0000084 denotes T cell
T65 8591-8596 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T66 8597-8601 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T67 8908-8909 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T68 8988-8989 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T69 9032-9037 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T70 9032-9037 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T71 9063-9066 http://purl.obolibrary.org/obo/CLO_0052882 denotes CD3
T72 9063-9066 http://purl.obolibrary.org/obo/CLO_0053434 denotes CD3
T73 9069-9072 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T74 9079-9082 http://purl.obolibrary.org/obo/CLO_0053438 denotes CD8
T75 9084-9091 http://purl.obolibrary.org/obo/CL_0000084 denotes T cells
T76 9106-9111 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T77 9106-9111 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T78 9252-9260 http://purl.obolibrary.org/obo/UBERON_0000473 denotes test was
T79 9355-9356 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T80 9408-9412 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T81 9408-9412 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T82 9430-9437 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T83 9483-9491 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T84 9557-9561 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T85 9557-9561 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T86 10138-10142 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T87 10138-10142 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T88 10354-10364 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T89 10635-10638 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T90 10950-10952 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T91 10981-10986 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T92 10981-10986 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T93 10981-10986 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T94 10981-10986 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T95 10999-11002 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T96 11181-11182 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T97 11208-11221 http://purl.obolibrary.org/obo/UBERON_0002405 denotes immune system
T98 11245-11251 http://purl.obolibrary.org/obo/CL_0000084 denotes T cell
T99 11340-11344 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T100 11340-11344 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1 6-17 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T2 25-35 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T3 199-210 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T4 219-222 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T5 308-311 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T6 312-322 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T7 332-372 Chemical denotes angiotensin-converting enzyme inhibitors http://purl.obolibrary.org/obo/CHEBI_35457
T8 332-343 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T9 355-372 Chemical denotes enzyme inhibitors http://purl.obolibrary.org/obo/CHEBI_23924
T10 362-372 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T11 374-379 Chemical denotes ACEIs http://purl.obolibrary.org/obo/CHEBI_35457
T12 385-399 Chemical denotes angiotensin II http://purl.obolibrary.org/obo/CHEBI_2719|http://purl.obolibrary.org/obo/CHEBI_48432|http://purl.obolibrary.org/obo/CHEBI_58506
T15 385-396 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T16 397-399 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T17 564-567 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T18 568-578 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T19 708-710 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T21 875-897 Chemical denotes antihypertensive drugs http://purl.obolibrary.org/obo/CHEBI_35674
T22 892-897 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T23 943-948 Chemical denotes ACEIs http://purl.obolibrary.org/obo/CHEBI_35457
T24 1752-1755 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T25 1873-1875 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T26 2005-2007 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T27 2347-2349 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T28 2428-2430 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T29 2491-2496 Chemical denotes ACEIs http://purl.obolibrary.org/obo/CHEBI_35457
T30 2535-2537 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T31 2643-2654 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T32 2663-2666 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T33 2752-2755 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T34 2756-2766 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T35 2776-2816 Chemical denotes angiotensin-converting enzyme inhibitors http://purl.obolibrary.org/obo/CHEBI_35457
T36 2776-2787 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T37 2799-2816 Chemical denotes enzyme inhibitors http://purl.obolibrary.org/obo/CHEBI_23924
T38 2806-2816 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T39 2818-2823 Chemical denotes ACEIs http://purl.obolibrary.org/obo/CHEBI_35457
T40 2829-2843 Chemical denotes angiotensin II http://purl.obolibrary.org/obo/CHEBI_2719|http://purl.obolibrary.org/obo/CHEBI_48432|http://purl.obolibrary.org/obo/CHEBI_58506
T43 2829-2840 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T44 2841-2843 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T45 2974-2977 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T46 2978-2988 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T47 3676-3678 Chemical denotes Co http://purl.obolibrary.org/obo/CHEBI_27638
T48 4595-4616 Chemical denotes antihypertensive drug http://purl.obolibrary.org/obo/CHEBI_35674
T49 4612-4616 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T50 5320-5342 Chemical denotes antihypertensive drugs http://purl.obolibrary.org/obo/CHEBI_35674
T51 5337-5342 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T52 5454-5470 Chemical denotes antihypertensive http://purl.obolibrary.org/obo/CHEBI_35674
T53 5576-5592 Chemical denotes antihypertensive http://purl.obolibrary.org/obo/CHEBI_35674
T54 5617-5622 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T55 5680-5685 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T56 5708-5713 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T57 5765-5787 Chemical denotes antihypertensive drugs http://purl.obolibrary.org/obo/CHEBI_35674
T58 5782-5787 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T59 5799-5823 Chemical denotes calcium channel blockers http://purl.obolibrary.org/obo/CHEBI_38215
T60 5799-5806 Chemical denotes calcium http://purl.obolibrary.org/obo/CHEBI_22984|http://purl.obolibrary.org/obo/CHEBI_29320
T62 5847-5856 Chemical denotes diuretics http://purl.obolibrary.org/obo/CHEBI_35498
T63 5899-5904 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T64 5944-5949 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T65 6393-6395 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T66 6591-6596 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T67 6618-6623 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T68 6775-6780 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T69 6805-6810 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T70 6924-6929 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T71 6960-6965 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T72 7032-7037 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T73 7156-7161 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T74 7244-7246 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T75 7360-7365 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T76 7462-7467 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T77 7615-7620 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T78 7662-7667 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T79 7813-7818 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T80 7938-7940 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T82 7980-7985 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T83 8021-8028 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T84 8147-8152 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T85 8208-8213 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T86 8469-8474 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T87 8529-8534 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T88 8650-8657 Chemical denotes lactate http://purl.obolibrary.org/obo/CHEBI_24996
T89 8706-8708 Chemical denotes S3 http://purl.obolibrary.org/obo/CHEBI_29388
T90 8878-8883 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T91 8900-8905 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T92 9005-9007 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T94 9345-9348 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T95 9479-9482 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T96 9581-9584 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T97 9640-9645 Chemical denotes ACEIs http://purl.obolibrary.org/obo/CHEBI_35457
T98 9681-9683 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T99 9715-9720 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T100 9903-9906 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T101 9907-9917 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T102 10019-10033 Chemical denotes Angiotensin II http://purl.obolibrary.org/obo/CHEBI_2719
T103 10031-10033 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T104 10091-10105 Chemical denotes Angiotensin II http://purl.obolibrary.org/obo/CHEBI_2719
T105 10103-10105 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T106 10165-10168 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T107 10169-10179 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T108 10265-10279 Chemical denotes Angiotensin II http://purl.obolibrary.org/obo/CHEBI_2719
T109 10277-10279 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T110 10553-10558 Chemical denotes ACEIs http://purl.obolibrary.org/obo/CHEBI_35457
T111 10579-10582 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T112 10832-10834 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T114 10920-10923 Chemical denotes LPS http://purl.obolibrary.org/obo/CHEBI_16412|http://purl.obolibrary.org/obo/CHEBI_52603|http://purl.obolibrary.org/obo/CHEBI_89981
T117 11450-11453 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T118 11454-11464 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T119 11538-11547 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T120 11784-11787 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T121 11788-11798 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T122 11972-11988 Chemical denotes antihypertensive http://purl.obolibrary.org/obo/CHEBI_35674

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T1 9511-9523 http://purl.obolibrary.org/obo/GO_0009405 denotes pathogenesis
T2 10771-10792 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory response
T3 11104-11123 http://purl.obolibrary.org/obo/GO_0001816 denotes cytokine production
T4 11481-11506 http://purl.obolibrary.org/obo/GO_1903901 denotes inhibit viral replication
T5 11489-11506 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T6 11489-11506 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T7 11587-11629 http://purl.obolibrary.org/obo/GO_0050728 denotes inhibiting inflammatory responses, and the
T8 11598-11620 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory responses

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T1 0-104 Sentence denotes Renin-angiotensin system inhibitors improve the clinical outcomes of COVID-19 patients with hypertension
T2 105-135 Sentence denotes Emerging Microbes & Infections
T3 136-138 Sentence denotes J.
T4 139-150 Sentence denotes Meng et al.
T5 152-160 Sentence denotes Abstract
T6 161-169 Sentence denotes ABSTRACT
T7 170-487 Sentence denotes The dysfunction of the renin-angiotensin system (RAS) has been observed in coronavirus infection disease (COVID-19) patients, but whether RAS inhibitors, such as angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II type 1 receptor blockers (ARBs), are associated with clinical outcomes remains unknown.
T8 488-579 Sentence denotes COVID-19 patients with hypertension were enrolled to evaluate the effect of RAS inhibitors.
T9 580-733 Sentence denotes We observed that patients receiving ACEI or ARB therapy had a lower rate of severe diseases and a trend toward a lower level of IL-6 in peripheral blood.
T10 734-898 Sentence denotes In addition, ACEI or ARB therapy increased CD3 and CD8 T cell counts in peripheral blood and decreased the peak viral load compared to other antihypertensive drugs.
T11 899-1062 Sentence denotes This evidence supports the benefit of using ACEIs or ARBs to potentially contribute to the improvement of clinical outcomes of COVID-19 patients with hypertension.
T12 1064-1076 Sentence denotes Introduction
T13 1077-1238 Sentence denotes The COVID-19 outbreak caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to endanger global health and to hamper the world economy.
T14 1239-1303 Sentence denotes This outbreak started in December 2019 in Wuhan, Hubei Province.
T15 1304-1394 Sentence denotes Unfortunately, currently, there is still no specific and effective treatment for COVID-19.
T16 1395-1553 Sentence denotes Evidence shows that elderly people with SARS-CoV-2 infections and cardiovascular diseases, including hypertension, are at risk of developing severe cases [1].
T17 1554-1751 Sentence denotes A hypertension survey from 2012 to 2015 reported that 23.2% of Chinese people ≥18 years of age had hypertension, whereas the prevalence of hypertension was >55% among citizens ≥65 years of age [2].
T18 1752-1937 Sentence denotes RAS plays an important role in regulating electrolyte balance and blood pressure and comprises two pathways: the ACE/Ang II/AT1R pathway and the ACE2/Ang (1–7)/Mas receptor pathway [3].
T19 1938-2155 Sentence denotes Under normal physiological conditions, the activity of the ACE/Ang II/AT1R axis and the ACE2/Ang (1–7)/Mas receptor axis are in a dynamic equilibrium state, maintaining the normal function of the corresponding system.
T20 2156-2256 Sentence denotes Similar to SARS, SARS-CoV-2 is believed to invade the host through the cell entry receptor ACE2 [4].
T21 2257-2405 Sentence denotes SARS-CoV infections reduce ACE2 expression, resulting in an imbalance between the ACE/Ang II/AT1R axis and the ACE2/Ang (1–7)/Mas receptor axis [5].
T22 2406-2490 Sentence denotes Targeting the ACE/Ang II/AT1R axis is a novel therapeutic strategy for hypertension.
T23 2491-2613 Sentence denotes ACEIs and ARAs not only inhibit the ACE/Ang II/AT1R pathway but also modulate the ACE2/Ang (1–7)/Mas receptor pathway [6].
T24 2614-2931 Sentence denotes The dysfunction of the renin-angiotensin system (RAS) has been observed in coronavirus infection disease (COVID-19) patients, but whether RAS inhibitors, such as angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II type 1 receptor blockers (ARBs), are associated with clinical outcomes remains unknown.
T25 2932-3047 Sentence denotes Here, we aimed to evaluate the ability of RAS inhibitors to protect against COVID-19 in patients with hypertension.
T26 3049-3056 Sentence denotes Methods
T27 3057-3139 Sentence denotes This study was approved by the Shenzhen Third People’s Hospital Ethical Committee.
T28 3140-3223 Sentence denotes Verbal informed consent was obtained from all patients or patients’ family members.
T29 3224-3405 Sentence denotes We performed a retrospective review of medical records from hospitalized patients with COVID-19 admitted to the Shenzhen Third People’s Hospital from 11 January to 23 February 2020.
T30 3406-3502 Sentence denotes The information on patients with hypertension was extracted from all enrolled COVID-19 patients.
T31 3503-3635 Sentence denotes We reviewed the clinical data extracted from electronic medical records, including clinical symptoms, signs and laboratory findings.
T32 3636-3734 Sentence denotes A commercial real-time PCR kit (GeneoDX Co., Ltd., Shanghai, China) was used to detect SARS-CoV-2.
T33 3735-3859 Sentence denotes Samples were considered positive if the cycle threshold value (Ct-value) less than 37 and negative if Ct-value more than 40.
T34 3860-3936 Sentence denotes Samples with a Ct-value between 37 and 40 require confirmation by retesting.
T35 3937-4057 Sentence denotes Samples identified as positive by the local laboratory were further validated by the key laboratory of the Shenzhen CDC.
T36 4058-4232 Sentence denotes The severity of COVID-19 wasidentified during the hospitalization according to the guidelines established by the National Health Commission of the People’s Republic of China.
T37 4233-4381 Sentence denotes Therapeutic regimens for COVID-19 patients complied with guidelines established by the National Health Commission of the People’s Republic of China.
T38 4382-4517 Sentence denotes Hypertension was classified as Grade 1, Grade 2 and Grade 3 according to 2018 guidelines of the European Society of Hypertension (ESH).
T39 4518-4628 Sentence denotes Hypertensive patients with COVID-19 were divided into two subgroups based on antihypertensive drug treatments.
T40 4629-4710 Sentence denotes Detailed information on the enrolled patients is shown in supplementary Table S1.
T41 4711-4776 Sentence denotes The SPSS 18.0 software package was used for statistical analysis.
T42 4777-4922 Sentence denotes Measurement data are expressed as the median and interquartile range (IQR), and the difference between groups was compared by an unpaired t test.
T43 4923-5032 Sentence denotes Count data are expressed as percentages, and the difference between groups was tested by the Chi-square test.
T44 5033-5083 Sentence denotes P < 0.05 was considered statistically significant.
T45 5085-5092 Sentence denotes Results
T46 5093-5203 Sentence denotes A total of 417 COVID-19 patients were admitted to the Shenzhen Third People’s Hospital as of 23 February 2020.
T47 5204-5255 Sentence denotes Among these patients, 51 (12.23%) had hypertension.
T48 5256-5413 Sentence denotes Nine patients (17.6%) with Grade 1hypertension did not take any antihypertensive drugs during hospitalization and were excluded from the subsequent analysis.
T49 5414-5512 Sentence denotes The other 42 patients (82.4%) receiving antihypertensive therapy were included in further studies.
T50 5513-5857 Sentence denotes The 42 analyzed patients were divided into two groups based on antihypertensive therapies: the ACEI/ARB group (17 patients) included patients treated with ACEI or ARB drugs, and the non-ACEI/ARB group (25 patients) included patients treated with other antihypertensive drugs, including calcium channel blockers (CCBs), β-blockers and diuretics.
T51 5858-6038 Sentence denotes Eight patients (32%) in the non-ACEI/ARB group and 5 patients (29.41%)in the ACEI/ARB group had other comorbidities, such as type 2 diabetes (T2D) and coronary heart disease (CHD).
T52 6039-6178 Sentence denotes The vast majority of hypertensive patients had received the current therapeutic regimens shown in supplementary Table S1 for over one year.
T53 6179-6289 Sentence denotes The blood pressure of patients was well-controlled with the above therapeutic regimens during hospitalization.
T54 6290-6396 Sentence denotes The comparison of baseline characteristics between the two groups is summarized in supplementary Table S2.
T55 6397-6505 Sentence denotes The median age of the analyzed subjects was 64.5 years (IQR, 55.8–69.0 years), and 57.1% of them were males.
T56 6506-6624 Sentence denotes No significant differences in hypertension grades were observed between the ACEI/ARB group and the non-ACEI/ARB group.
T57 6625-6671 Sentence denotes Both groups showed similar signs and symptoms.
T58 6672-6811 Sentence denotes The median number of days from the onset of symptoms to hospital admission was 2.0 in the non-ACEI/ARB group and 3.0 in the ACEI/ARB group.
T59 6812-6966 Sentence denotes Meanwhile, the median number of days from symptom onset to hospital discharge was 16.5 days in the non-ACEI/ARB group and 20.0 days in the ACEI/ARB group.
T60 6967-7075 Sentence denotes The median heart rate and respiratory rate from the non-ACEI/ARB group were 90.5 bpm and 20.0, respectively.
T61 7076-7199 Sentence denotes In comparison, the median heart rate and respiratory rate from the non-ACEI/ARB group were 80.0 bmp and 20.0, respectively.
T62 7200-7303 Sentence denotes All baseline characteristics shown in Table S2 were not significantly different between the two groups.
T63 7304-7432 Sentence denotes During hospitalization, 12 patients in the non-ACEI/ARB group (48%) were categorized into severe subgroups and one patient died.
T64 7433-7567 Sentence denotes In contrast, in the ACEI/ARB group, only 4 patients (23.5%) were categorized into severe subgroups and no patients died (Figure 1(A)).
T65 7568-7761 Sentence denotes The percentage of severe cases in the ACEI/ARB group was higher than that in the non-ACEI/ARB group, but this difference was not significant, possibly due to the small number of clinical cases.
T66 7762-7881 Sentence denotes We next examined the effects of taking ACEI or ARB drugs on laboratory findings of COVID-19 patients with hypertension.
T67 7882-7986 Sentence denotes As shown in Figure 1(B), there was a trend toward lower IL-6 levels in patients from the ACEI/ARB group.
T68 7987-8085 Sentence denotes No marked variation in C-reactive protein (CRP) was observed between the two groups (Figure 1(B)).
T69 8086-8214 Sentence denotes The absolute number of CD3+ and CD8+ T cells in the ACEI/ARB group was significantly higher than that in the non-ACEI/ARB group.
T70 8215-8308 Sentence denotes There were no significant changes in CD4+ T cell counts between the two groups (Figure 1(C)).
T71 8309-8549 Sentence denotes In addition, although the viral load was not different between the two groups at hospital admission, the peak viral load during hospitalization in the ACEI/ARB group was significantly lower than that in the non-ACEI/ARB group (Figure 1(D)).
T72 8550-8778 Sentence denotes Other laboratory findings, such as white blood cell counts, neutrophil counts, platelet counts, and lactate dehydrogenase, are shown in supplementary Table S3, and no significant differences were observed between the two groups.
T73 8779-8788 Sentence denotes Figure 1.
T74 8789-9191 Sentence denotes Summarized clinical, inflammatory, immunological, and viral findings in the non-ACEI/ARB group and the ACE/ARB group. (A) The disease severity distribution of the two groups during hospitalization. (B) The levels of IL-6 and CRP in peripheral blood. (C) Absolute numbers of CD3+, CD4+, and CD8+ T cells in peripheral blood. (D) Viral load on hospital admission and maximum value during hospitalization.
T75 9192-9237 Sentence denotes The data are expressed as the median and IQR.
T76 9238-9307 Sentence denotes An unpaired t test was used, and P < 0.05 was considered significant.
T77 9309-9319 Sentence denotes Discussion
T78 9320-9467 Sentence denotes It was reported that the RAS plays a critical role in regulating hypertension and acute lung injury caused by viruses, such as SARS and H7N9 [5,7].
T79 9468-9570 Sentence denotes Changes in RAS activity are related to the pathogenesis of hypertension and inflammatory lung disease.
T80 9571-9639 Sentence denotes Targeting RAS is an effective antihypertension therapeutic strategy.
T81 9640-9747 Sentence denotes ACEIs and ARB, which inhibit the ACE/Ang II/AT1R system, are commonly used drugs for hypertensive patients.
T82 9748-9853 Sentence denotes Recent evidence suggests that hypertensive COVID-19 patients are predisposed to develop severe cases [1].
T83 9854-9957 Sentence denotes Thus, it is important to determine the effect of RAS inhibitors on COVID-19 patients with hypertension.
T84 9958-10065 Sentence denotes Studies have suggested that COVID-19 patients have increased Angiotensin II compared to healthy people [8].
T85 10066-10151 Sentence denotes The abnormal increase in Angiotensin II was related to hypertension and lung failure.
T86 10152-10264 Sentence denotes In addition, RAS inhibitors have been shown to be associated with reduced mortality in patients with sepsis [9].
T87 10265-10378 Sentence denotes Angiotensin II positively regulates the expression of inflammatory cytokines through the activation of AT1R [10].
T88 10379-10478 Sentence denotes Excessively high levels of inflammatory cytokines are harmful to the outcomes of COVID-19 patients.
T89 10479-10583 Sentence denotes Thus, it was suggested that it is beneficial for COVID-19 patients to use ACEIs/ARBs to inhibit the RAS.
T90 10584-10654 Sentence denotes However, until now, no confirmed clinical evidence has been available.
T91 10655-10954 Sentence denotes In this study, COVID-19 patients with hypertension were enrolled, and we found that ACEI/ARB therapy attenuated the inflammatory response, potentially through the inhibition of IL-6 levels, which is consistent with the findings that ACEI and ARB therapy alleviated LPS-induced pneumonic injury [11].
T92 10955-11129 Sentence denotes For patients with chronic heart failure, it has been proven that ACEI therapy was associated with decreased Th1/Th2 cytokine ratios and inflammatory cytokine production [12].
T93 11130-11262 Sentence denotes This study also suggests that ACEI/ARB therapy had a beneficial effect on the immune system by avoiding peripheral T cell depletion.
T94 11263-11356 Sentence denotes Furthermore, the viral load was reported to be highly correlated with severe lung injury [8].
T95 11357-11712 Sentence denotes It was also observed that ACEI/ARB therapy decreased the viral load, but we hypothesize that RAS inhibitors do not directly inhibit viral replication; rather, they play an indirect antiviral role by regulating immune function and inhibiting inflammatory responses, and the mechanism needs to be clarified through in vitro and in vivostudies in the future.
T96 11713-11999 Sentence denotes Taken together, this is the first clinical evidence demonstrating that RAS inhibitors improve the clinical outcomes of COVID-19 patients with hypertension, suggesting that these patients could benefit from the persistent or preferential usage of ACEI/ARB for antihypertensive treatment.
T97 12001-12023 Sentence denotes Supplementary Material
T98 12024-12045 Sentence denotes Supplemental Material
T99 12047-12067 Sentence denotes Disclosure statement
T100 12068-12132 Sentence denotes No potential conflict of interest was reported by the author(s).
T101 12134-12139 Sentence denotes ORCID
T102 12140-12191 Sentence denotes Guoliang Zhang http://orcid.org/0000-0002-3617-5449

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T1 92-104 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T2 511-523 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T3 1049-1061 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T4 1461-1484 Phenotype denotes cardiovascular diseases http://purl.obolibrary.org/obo/HP_0001626
T5 1496-1508 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T6 1556-1568 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T7 1653-1665 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T8 1693-1705 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T9 2477-2489 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T10 3034-3046 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T11 3439-3451 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T12 4382-4394 Phenotype denotes Hypertension http://purl.obolibrary.org/obo/HP_0000822
T13 4498-4510 Phenotype denotes Hypertension http://purl.obolibrary.org/obo/HP_0000822
T14 4518-4530 Phenotype denotes Hypertensive http://purl.obolibrary.org/obo/HP_0000822
T15 5242-5254 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T16 5983-5998 Phenotype denotes type 2 diabetes http://purl.obolibrary.org/obo/HP_0005978
T17 6536-6548 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T18 7868-7880 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T19 9385-9397 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T20 9402-9419 Phenotype denotes acute lung injury http://www.orpha.net/ORDO/Orphanet_178320
T21 9527-9539 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T22 9557-9569 Phenotype denotes lung disease http://purl.obolibrary.org/obo/HP_0002088
T23 9944-9956 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T24 10121-10133 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T25 10253-10259 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T26 10693-10705 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T27 10973-10994 Phenotype denotes chronic heart failure http://purl.obolibrary.org/obo/HP_0001635
T28 11855-11867 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822

2_test

Id Subject Object Predicate Lexical cue
32228222-25194138-27780682 1934-1935 25194138 denotes 3
32228222-16007097-27780683 2402-2403 16007097 denotes 5
32228222-16007097-27780684 9462-9463 16007097 denotes 5
32228222-31838905-27780685 10261-10262 31838905 denotes 9
32228222-31805278-27780686 10950-10952 31805278 denotes 11
32228222-15067208-27780687 11125-11127 15067208 denotes 12