PMC:7164862 / 63-842 JSONTXT

{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/7164862","sourcedb":"PMC","sourceid":"7164862","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7164862","text":"In-vitro studies have shown that chloroquine is effective against several viruses, including severe acute respiratory syndrome coronavirus (SARS-CoV).1 Multiple mechanisms of action have been identified for chloroquine that disrupt the early stage of coronavirus replication. Moreover, chloroquine affects immune system activity by mediating an anti-inflammatory response, which might reduce damage due to the exaggerated inflammatory response.1 At the time of the SARS epidemic, chloroquine was suggested as a drug that could be used to treat this infection.2 However, randomised, double-blind, controlled studies in humans to evaluate its efficacy for this use were not done, and the true clinical efficacy of chloroquine in treating coronavirus infections was not established.","tracks":[{"project":"LitCovid-PubTator","denotations":[{"id":"17","span":{"begin":93,"end":138},"obj":"Species"},{"id":"18","span":{"begin":140,"end":148},"obj":"Species"},{"id":"19","span":{"begin":251,"end":262},"obj":"Species"},{"id":"20","span":{"begin":618,"end":624},"obj":"Species"},{"id":"21","span":{"begin":33,"end":44},"obj":"Chemical"},{"id":"22","span":{"begin":207,"end":218},"obj":"Chemical"},{"id":"23","span":{"begin":286,"end":297},"obj":"Chemical"},{"id":"24","span":{"begin":480,"end":491},"obj":"Chemical"},{"id":"25","span":{"begin":712,"end":723},"obj":"Chemical"},{"id":"26","span":{"begin":549,"end":558},"obj":"Disease"},{"id":"27","span":{"begin":736,"end":758},"obj":"Disease"}],"attributes":[{"id":"A17","pred":"tao:has_database_id","subj":"17","obj":"Tax:694009"},{"id":"A18","pred":"tao:has_database_id","subj":"18","obj":"Tax:694009"},{"id":"A19","pred":"tao:has_database_id","subj":"19","obj":"Tax:11118"},{"id":"A20","pred":"tao:has_database_id","subj":"20","obj":"Tax:9606"},{"id":"A21","pred":"tao:has_database_id","subj":"21","obj":"MESH:D002738"},{"id":"A22","pred":"tao:has_database_id","subj":"22","obj":"MESH:D002738"},{"id":"A23","pred":"tao:has_database_id","subj":"23","obj":"MESH:D002738"},{"id":"A24","pred":"tao:has_database_id","subj":"24","obj":"MESH:D002738"},{"id":"A25","pred":"tao:has_database_id","subj":"25","obj":"MESH:D002738"},{"id":"A26","pred":"tao:has_database_id","subj":"26","obj":"MESH:D007239"},{"id":"A27","pred":"tao:has_database_id","subj":"27","obj":"MESH:D018352"},{"subj":"17","pred":"source","obj":"LitCovid-PubTator"},{"subj":"18","pred":"source","obj":"LitCovid-PubTator"},{"subj":"19","pred":"source","obj":"LitCovid-PubTator"},{"subj":"20","pred":"source","obj":"LitCovid-PubTator"},{"subj":"21","pred":"source","obj":"LitCovid-PubTator"},{"subj":"22","pred":"source","obj":"LitCovid-PubTator"},{"subj":"23","pred":"source","obj":"LitCovid-PubTator"},{"subj":"24","pred":"source","obj":"LitCovid-PubTator"},{"subj":"25","pred":"source","obj":"LitCovid-PubTator"},{"subj":"26","pred":"source","obj":"LitCovid-PubTator"},{"subj":"27","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T1","span":{"begin":306,"end":319},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"fma_id","subj":"T1","obj":"http://purl.org/sig/ont/fma/fma9825"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T1","span":{"begin":306,"end":319},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/UBERON_0002405"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T2","span":{"begin":93,"end":126},"obj":"Disease"},{"id":"T3","span":{"begin":140,"end":148},"obj":"Disease"},{"id":"T4","span":{"begin":465,"end":469},"obj":"Disease"},{"id":"T5","span":{"begin":549,"end":558},"obj":"Disease"},{"id":"T6","span":{"begin":748,"end":758},"obj":"Disease"}],"attributes":[{"id":"A2","pred":"mondo_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A3","pred":"mondo_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A4","pred":"mondo_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A5","pred":"mondo_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A6","pred":"mondo_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T1","span":{"begin":74,"end":81},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T2","span":{"begin":306,"end":319},"obj":"http://purl.obolibrary.org/obo/UBERON_0002405"},{"id":"T3","span":{"begin":320,"end":328},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T4","span":{"begin":444,"end":448},"obj":"http://purl.obolibrary.org/obo/CLO_0001757"},{"id":"T5","span":{"begin":509,"end":510},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T6","span":{"begin":618,"end":624},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T3","span":{"begin":33,"end":44},"obj":"Chemical"},{"id":"T4","span":{"begin":207,"end":218},"obj":"Chemical"},{"id":"T5","span":{"begin":286,"end":297},"obj":"Chemical"},{"id":"T6","span":{"begin":480,"end":491},"obj":"Chemical"},{"id":"T7","span":{"begin":511,"end":515},"obj":"Chemical"},{"id":"T8","span":{"begin":712,"end":723},"obj":"Chemical"}],"attributes":[{"id":"A3","pred":"chebi_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A4","pred":"chebi_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A5","pred":"chebi_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A6","pred":"chebi_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A7","pred":"chebi_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A8","pred":"chebi_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T7","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T8","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T1","span":{"begin":345,"end":371},"obj":"http://purl.obolibrary.org/obo/GO_0050728"},{"id":"T2","span":{"begin":350,"end":371},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T3","span":{"begin":422,"end":443},"obj":"http://purl.obolibrary.org/obo/GO_0006954"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T2","span":{"begin":0,"end":275},"obj":"Sentence"},{"id":"T3","span":{"begin":276,"end":779},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T2","pred":"source","obj":"LitCovid-sentences"},{"subj":"T3","pred":"source","obj":"LitCovid-sentences"}]},{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T4","span":{"begin":33,"end":44},"obj":"CHEBI:3638;DG_10;CHEBI:3638"},{"id":"T5","span":{"begin":74,"end":81},"obj":"NCBITaxon:10239"},{"id":"T6","span":{"begin":93,"end":105},"obj":"SP_10"},{"id":"T7","span":{"begin":106,"end":117},"obj":"SP_10;UBERON:0001004"},{"id":"T8","span":{"begin":118,"end":138},"obj":"SP_10"},{"id":"T9","span":{"begin":140,"end":148},"obj":"SP_10"},{"id":"T10","span":{"begin":207,"end":218},"obj":"CHEBI:3638;DG_10;CHEBI:3638"},{"id":"T11","span":{"begin":251,"end":262},"obj":"NCBITaxon:11118"},{"id":"T12","span":{"begin":263,"end":274},"obj":"GO:0006260"},{"id":"T13","span":{"begin":286,"end":297},"obj":"CHEBI:3638;DG_10;CHEBI:3638"},{"id":"T14","span":{"begin":306,"end":319},"obj":"UBERON:0002405"},{"id":"T15","span":{"begin":465,"end":469},"obj":"SP_10"},{"id":"T16","span":{"begin":480,"end":491},"obj":"CHEBI:3638;DG_10;CHEBI:3638"},{"id":"T17","span":{"begin":511,"end":515},"obj":"CHEBI:23888;CHEBI:23888"},{"id":"T18","span":{"begin":618,"end":624},"obj":"NCBITaxon:9606"},{"id":"T19","span":{"begin":712,"end":723},"obj":"CHEBI:3638;DG_10;CHEBI:3638"},{"id":"T20","span":{"begin":736,"end":747},"obj":"NCBITaxon:11118"},{"id":"T98454","span":{"begin":33,"end":44},"obj":"CHEBI:3638;DG_10;CHEBI:3638"},{"id":"T25476","span":{"begin":74,"end":81},"obj":"NCBITaxon:10239"},{"id":"T35585","span":{"begin":93,"end":105},"obj":"SP_10"},{"id":"T99185","span":{"begin":106,"end":117},"obj":"SP_10;UBERON:0001004"},{"id":"T79442","span":{"begin":118,"end":138},"obj":"SP_10"},{"id":"T65667","span":{"begin":140,"end":148},"obj":"SP_10"},{"id":"T1801","span":{"begin":207,"end":218},"obj":"CHEBI:3638;DG_10;CHEBI:3638"},{"id":"T88121","span":{"begin":251,"end":262},"obj":"NCBITaxon:11118"},{"id":"T96813","span":{"begin":263,"end":274},"obj":"GO:0006260"},{"id":"T9936","span":{"begin":286,"end":297},"obj":"CHEBI:3638;DG_10;CHEBI:3638"},{"id":"T13615","span":{"begin":306,"end":319},"obj":"UBERON:0002405"},{"id":"T96197","span":{"begin":465,"end":469},"obj":"SP_10"},{"id":"T17697","span":{"begin":480,"end":491},"obj":"CHEBI:3638;DG_10;CHEBI:3638"},{"id":"T13009","span":{"begin":511,"end":515},"obj":"CHEBI:23888;CHEBI:23888"},{"id":"T56976","span":{"begin":618,"end":624},"obj":"NCBITaxon:9606"},{"id":"T51915","span":{"begin":712,"end":723},"obj":"CHEBI:3638;DG_10;CHEBI:3638"},{"id":"T97546","span":{"begin":736,"end":747},"obj":"NCBITaxon:11118"}],"attributes":[{"subj":"T4","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T5","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T6","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T7","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T8","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T9","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T10","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T11","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T12","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T13","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T14","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T15","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T16","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T17","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T18","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T19","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T20","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T98454","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T25476","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T35585","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T99185","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T79442","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T65667","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T1801","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T88121","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T96813","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T9936","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T13615","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T96197","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T17697","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T13009","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T56976","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T51915","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T97546","pred":"source","obj":"LitCovid-PMC-OGER-BB"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PubTator","color":"#93eca3","default":true},{"id":"LitCovid-PD-FMA-UBERON","color":"#ec939c"},{"id":"LitCovid-PD-UBERON","color":"#93b6ec"},{"id":"LitCovid-PD-MONDO","color":"#d0ec93"},{"id":"LitCovid-PD-CLO","color":"#ec93ea"},{"id":"LitCovid-PD-CHEBI","color":"#93ecd4"},{"id":"LitCovid-PD-GO-BP","color":"#ecb993"},{"id":"LitCovid-sentences","color":"#9f93ec"},{"id":"LitCovid-PMC-OGER-BB","color":"#a0ec93"}]}]}}