PMC:7161517 / 5891-9732
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T24 | 16-20 | Body_part | denotes | Axis | http://purl.org/sig/ont/fma/fma12520 |
| T25 | 353-362 | Body_part | denotes | G protein | http://purl.org/sig/ont/fma/fma61788 |
| T26 | 778-794 | Body_part | denotes | cardiac myocytes | http://purl.org/sig/ont/fma/fma14067 |
| T27 | 807-818 | Body_part | denotes | fibroblasts | http://purl.org/sig/ont/fma/fma63877 |
| T28 | 917-921 | Body_part | denotes | mRNA | http://purl.org/sig/ont/fma/fma67122 |
| T29 | 925-941 | Body_part | denotes | cardiac myocytes | http://purl.org/sig/ont/fma/fma14067 |
| T30 | 976-987 | Body_part | denotes | fibroblasts | http://purl.org/sig/ont/fma/fma63877 |
| T31 | 997-1005 | Body_part | denotes | myocytes | http://purl.org/sig/ont/fma/fma67328 |
| T32 | 1059-1063 | Body_part | denotes | mRNA | http://purl.org/sig/ont/fma/fma67122 |
| T33 | 1104-1108 | Body_part | denotes | mRNA | http://purl.org/sig/ont/fma/fma67122 |
| T34 | 1174-1181 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T35 | 1399-1412 | Body_part | denotes | cardiomyocyte | http://purl.org/sig/ont/fma/fma14067 |
| T36 | 1537-1548 | Body_part | denotes | fibroblasts | http://purl.org/sig/ont/fma/fma63877 |
| T37 | 1562-1579 | Body_part | denotes | endothelial cells | http://purl.org/sig/ont/fma/fma66772 |
| T38 | 1574-1579 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T39 | 1658-1662 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T40 | 2038-2044 | Body_part | denotes | tissue | http://purl.org/sig/ont/fma/fma9637 |
| T41 | 2049-2055 | Body_part | denotes | plasma | http://purl.org/sig/ont/fma/fma62970 |
| T42 | 2573-2577 | Body_part | denotes | axis | http://purl.org/sig/ont/fma/fma12520 |
| T43 | 2627-2636 | Body_part | denotes | cytokines | http://purl.org/sig/ont/fma/fma84050 |
| T44 | 2653-2664 | Body_part | denotes | interleukin | http://purl.org/sig/ont/fma/fma86578 |
| T45 | 2665-2671 | Body_part | denotes | (IL)-1 | http://purl.org/sig/ont/fma/fma86583 |
| T46 | 2666-2668 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
| T47 | 2674-2676 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
| T48 | 2680-2688 | Body_part | denotes | monocyte | http://purl.org/sig/ont/fma/fma62864 |
| T49 | 2705-2712 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T50 | 2767-2771 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
| T51 | 2901-2905 | Body_part | denotes | Axis | http://purl.org/sig/ont/fma/fma12520 |
| T52 | 3273-3288 | Body_part | denotes | adrenal medulla | http://purl.org/sig/ont/fma/fma15633 |
| T53 | 3293-3313 | Body_part | denotes | antidiuretic hormone | http://purl.org/sig/ont/fma/fma74646 |
| T54 | 3323-3342 | Body_part | denotes | posterior pituitary | http://purl.org/sig/ont/fma/fma74636 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T29 | 2038-2044 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
| T30 | 2767-2771 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
| T31 | 2877-2880 | Body_part | denotes | RAS | http://purl.obolibrary.org/obo/UBERON_0018229 |
| T32 | 3273-3288 | Body_part | denotes | adrenal medulla | http://purl.obolibrary.org/obo/UBERON_0001236 |
| T33 | 3810-3813 | Body_part | denotes | RAS | http://purl.obolibrary.org/obo/UBERON_0018229 |
| T34 | 3816-3840 | Body_part | denotes | renin-angiotensin system | http://purl.obolibrary.org/obo/UBERON_0018229 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T41 | 1019-1021 | Disease | denotes | ET | http://purl.obolibrary.org/obo/MONDO_0005029 |
| T42 | 1122-1124 | Disease | denotes | ET | http://purl.obolibrary.org/obo/MONDO_0005029 |
| T43 | 1232-1234 | Disease | denotes | ET | http://purl.obolibrary.org/obo/MONDO_0005029 |
| T44 | 1501-1504 | Disease | denotes | AT1 | http://purl.obolibrary.org/obo/MONDO_0008840 |
| T45 | 2782-2804 | Disease | denotes | pulmonary hypertension | http://purl.obolibrary.org/obo/MONDO_0005149 |
| T46 | 2792-2804 | Disease | denotes | hypertension | http://purl.obolibrary.org/obo/MONDO_0005044 |
| T47 | 3126-3138 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
| T48 | 3219-3222 | Disease | denotes | AT1 | http://purl.obolibrary.org/obo/MONDO_0008840 |
| T49 | 3333-3342 | Disease | denotes | pituitary | http://purl.obolibrary.org/obo/MONDO_0021156 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T62 | 41-42 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T63 | 243-246 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T64 | 247-248 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T65 | 353-379 | http://purl.obolibrary.org/obo/PR_000030035 | denotes | G protein coupled receptor |
| T66 | 381-385 | http://purl.obolibrary.org/obo/PR_000030035 | denotes | GPCR |
| T67 | 498-499 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T68 | 522-532 | http://purl.obolibrary.org/obo/PR_000001898 | denotes | neprilysin |
| T69 | 588-589 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T70 | 741-748 | http://purl.obolibrary.org/obo/CLO_0009985 | denotes | focused |
| T71 | 778-794 | http://purl.obolibrary.org/obo/CL_0000746 | denotes | cardiac myocytes |
| T72 | 807-818 | http://purl.obolibrary.org/obo/CL_0000057 | denotes | fibroblasts |
| T73 | 885-893 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T74 | 925-941 | http://purl.obolibrary.org/obo/CL_0000746 | denotes | cardiac myocytes |
| T75 | 964-972 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T76 | 976-987 | http://purl.obolibrary.org/obo/CL_0000057 | denotes | fibroblasts |
| T77 | 997-1005 | http://purl.obolibrary.org/obo/CL_0000187 | denotes | myocytes |
| T78 | 1164-1173 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activated |
| T79 | 1237-1245 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activate |
| T80 | 1260-1266 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signal |
| T81 | 1384-1392 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
| T82 | 1399-1412 | http://purl.obolibrary.org/obo/CL_0000746 | denotes | cardiomyocyte |
| T83 | 1466-1474 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T84 | 1537-1548 | http://purl.obolibrary.org/obo/CL_0000057 | denotes | fibroblasts |
| T85 | 1562-1579 | http://purl.obolibrary.org/obo/CL_0000115 | denotes | endothelial cells |
| T86 | 1658-1668 | http://purl.obolibrary.org/obo/CL_0000000 | denotes | cell types |
| T87 | 1693-1702 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activates |
| T88 | 1717-1726 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signaling |
| T89 | 1768-1777 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signaling |
| T90 | 1995-1997 | http://purl.obolibrary.org/obo/CLO_0001302 | denotes | 34 |
| T91 | 2011-2016 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T92 | 2049-2055 | http://purl.obolibrary.org/obo/UBERON_0001969 | denotes | plasma |
| T93 | 2070-2073 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T94 | 2074-2075 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T95 | 2208-2210 | http://purl.obolibrary.org/obo/CLO_0001000 | denotes | 35 |
| T96 | 2339-2348 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signaling |
| T97 | 2680-2688 | http://purl.obolibrary.org/obo/CL_0000576 | denotes | monocyte |
| T98 | 2767-2771 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T99 | 2767-2771 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
| T100 | 2831-2833 | http://purl.obolibrary.org/obo/CLO_0001313 | denotes | 36 |
| T101 | 2851-2853 | http://purl.obolibrary.org/obo/CLO_0053794 | denotes | 41 |
| T102 | 3323-3332 | http://purl.obolibrary.org/obo/UBERON_0001353 | denotes | posterior |
| T103 | 3366-3374 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
| T104 | 3457-3463 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signal |
| T105 | 3771-3781 | http://purl.obolibrary.org/obo/PR_000001898 | denotes | neprilysin |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T64 | 98-100 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
| T65 | 190-192 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
| T66 | 277-288 | Chemical | denotes | antioxidant | http://purl.obolibrary.org/obo/CHEBI_22586 |
| T67 | 355-362 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T68 | 500-504 | Chemical | denotes | zinc | http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185 |
| T70 | 855-857 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
| T71 | 1019-1021 | Chemical | denotes | ET | http://purl.obolibrary.org/obo/CHEBI_73510 |
| T72 | 1116-1118 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
| T73 | 1122-1124 | Chemical | denotes | ET | http://purl.obolibrary.org/obo/CHEBI_73510 |
| T74 | 1142-1152 | Chemical | denotes | inhibitors | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T75 | 1156-1163 | Chemical | denotes | mitogen | http://purl.obolibrary.org/obo/CHEBI_52290 |
| T76 | 1174-1181 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T77 | 1225-1227 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
| T78 | 1232-1234 | Chemical | denotes | ET | http://purl.obolibrary.org/obo/CHEBI_73510 |
| T79 | 1364-1366 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
| T80 | 1690-1692 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
| T81 | 1974-1984 | Chemical | denotes | bradykinin | http://purl.obolibrary.org/obo/CHEBI_3165 |
| T82 | 2258-2260 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
| T83 | 2421-2423 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
| T84 | 2666-2668 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T86 | 2674-2676 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T88 | 2705-2712 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T89 | 2877-2880 | Chemical | denotes | RAS | http://purl.obolibrary.org/obo/CHEBI_63620 |
| T90 | 2917-2932 | Chemical | denotes | Angiotensinogen | http://purl.obolibrary.org/obo/CHEBI_2720 |
| T91 | 2949-2960 | Chemical | denotes | angiotensin | http://purl.obolibrary.org/obo/CHEBI_48433 |
| T92 | 3008-3010 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
| T93 | 3015-3026 | Chemical | denotes | angiotensin | http://purl.obolibrary.org/obo/CHEBI_48433 |
| T94 | 3074-3084 | Chemical | denotes | bradykinin | http://purl.obolibrary.org/obo/CHEBI_3165 |
| T95 | 3103-3114 | Chemical | denotes | metabolites | http://purl.obolibrary.org/obo/CHEBI_25212 |
| T96 | 3176-3178 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
| T97 | 3199-3201 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
| T98 | 3242-3253 | Chemical | denotes | aldosterone | http://purl.obolibrary.org/obo/CHEBI_27584|http://purl.obolibrary.org/obo/CHEBI_30834 |
| T100 | 3306-3313 | Chemical | denotes | hormone | http://purl.obolibrary.org/obo/CHEBI_24621 |
| T101 | 3344-3355 | Chemical | denotes | Aldosterone | http://purl.obolibrary.org/obo/CHEBI_27584 |
| T102 | 3392-3404 | Chemical | denotes | Endothelin-1 | http://purl.obolibrary.org/obo/CHEBI_80240 |
| T103 | 3414-3425 | Chemical | denotes | angiotensin | http://purl.obolibrary.org/obo/CHEBI_48433 |
| T104 | 3507-3509 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
| T105 | 3749-3753 | Chemical | denotes | zinc | http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185 |
| T107 | 3782-3788 | Chemical | denotes | prolyl | http://purl.obolibrary.org/obo/CHEBI_26274|http://purl.obolibrary.org/obo/CHEBI_32874 |
| T109 | 3804-3807 | Chemical | denotes | PEP | http://purl.obolibrary.org/obo/CHEBI_18021|http://purl.obolibrary.org/obo/CHEBI_44897 |
| T111 | 3810-3813 | Chemical | denotes | RAS | http://purl.obolibrary.org/obo/CHEBI_63620 |
| T112 | 3822-3833 | Chemical | denotes | angiotensin | http://purl.obolibrary.org/obo/CHEBI_48433 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T19 | 21-31 | http://purl.obolibrary.org/obo/GO_0065007 | denotes | Regulation |
| T20 | 756-766 | http://purl.obolibrary.org/obo/GO_0065007 | denotes | regulation |
| T21 | 1284-1290 | http://purl.obolibrary.org/obo/GO_0004707 | denotes | (ERK)1 |
| T22 | 1291-1295 | http://purl.obolibrary.org/obo/GO_0004707 | denotes | ERK2 |
| T23 | 1717-1735 | http://purl.obolibrary.org/obo/GO_0007165 | denotes | signaling cascades |
| T24 | 1717-1726 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
| T25 | 1768-1786 | http://purl.obolibrary.org/obo/GO_0007165 | denotes | signaling pathways |
| T26 | 1768-1777 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
| T27 | 2311-2315 | http://purl.obolibrary.org/obo/GO_0004707 | denotes | ERK1 |
| T28 | 2339-2348 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
| T29 | 2733-2739 | http://purl.obolibrary.org/obo/GO_0040007 | denotes | growth |
| T30 | 2906-2916 | http://purl.obolibrary.org/obo/GO_0065007 | denotes | Regulation |
| T31 | 3126-3138 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
| T32 | 3242-3263 | http://purl.obolibrary.org/obo/GO_0035932 | denotes | aldosterone secretion |
| T33 | 3254-3263 | http://purl.obolibrary.org/obo/GO_0046903 | denotes | secretion |
| T34 | 3481-3487 | http://purl.obolibrary.org/obo/GO_0004707 | denotes | (ERK)1 |
| T35 | 3488-3492 | http://purl.obolibrary.org/obo/GO_0004707 | denotes | ERK2 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T42 | 0-31 | Sentence | denotes | ACE2/Ang1-7/Mas Axis Regulation |
| T43 | 32-108 | Sentence | denotes | Ang I is a decapeptide that is converted into the octapeptide Ang II by ACE. |
| T44 | 109-235 | Sentence | denotes | Unlike ACE, Ang I can be converted to Ang1-9 by ACE2, and, more importantly, Ang II is converted to Ang 1-7 through ACE2 (17). |
| T45 | 236-411 | Sentence | denotes | Ang1-7 has a range of anti-inflammatory, antioxidant, vasodilatory, and natriuretic effects that are mediated by the G protein coupled receptor (GPCR) Mas receptor (11,26,27). |
| T46 | 412-626 | Sentence | denotes | Ang1-7 may be produced directly from Ang I through the alternative pathways involving a zinc metallopeptidase neprilysin or conversion of Ang1-9 to Ang1-7 via ACE, although at a significantly lower efficiency (17). |
| T47 | 627-732 | Sentence | denotes | Genetic deletion studies have established ACE2 as an essential regulator of cardiovascular function (28). |
| T48 | 733-993 | Sentence | denotes | Studies focused on the regulation of ACE2 in cardiac myocytes and cardiac fibroblasts have demonstrated that although Ang II significantly reduced ACE2 activity and downregulated ACE2 mRNA in cardiac myocytes, it only reduced ACE2 activity in fibroblasts (29). |
| T49 | 994-1080 | Sentence | denotes | In myocytes, endothelin (ET)-1 also significantly decreased ACE2 mRNA production (29). |
| T50 | 1081-1316 | Sentence | denotes | This reduction in ACE2 mRNA by Ang II or ET-1 was blocked by inhibitors of mitogen-activated protein kinase 1 (MAPK1), which suggested that Ang II and ET-1 activate extracellular signal-regulated kinase (ERK)1/ERK2 to reduce ACE2 (29). |
| T51 | 1317-1528 | Sentence | denotes | Furthermore, in vivo murine studies showed Ang II−mediated loss of membrane-bound cardiomyocyte ACE2 correlated with the upregulation of TACE/ADAM17 activity, which was prevented with AT1 receptor blockade (30). |
| T52 | 1529-1685 | Sentence | denotes | Cardiac fibroblasts and coronary endothelial cells also express ACE2 and TACE, and this reciprocal relationship extends to these cell types as well (31,32). |
| T53 | 1686-1856 | Sentence | denotes | Ang II activates several other signaling cascades, such as the PKC and JAK2-STAT3 signaling pathways, which results in myocardial hypertrophy and increased fibrosis (33). |
| T54 | 1857-1999 | Sentence | denotes | The binding of Ang1-7 to the C-terminal domain also inhibits the proteolytic function of the ACE enzyme and promotes bradykinin function (34). |
| T55 | 2000-2212 | Sentence | denotes | Studies in human vascular and cardiac tissue and plasma showed Ang1-7 has a higher affinity to ACE than Ang I, which suggests the inhibitory effects of Ang1-7 on ACE may contribute to its protective effects (35). |
| T56 | 2213-2514 | Sentence | denotes | The treatment of ACE2 knockout mice with Ang II infusion and recombinant ACE2 (rhACE2) eliminated ERK1/2, JAK2-STAT3, and PKC signaling by rhACE2 and was at least partially responsible for attenuation of Ang II−induced myocardial hypertrophy and fibrosis and improvement in diastolic dysfunction (33). |
| T57 | 2515-2867 | Sentence | denotes | Other studies highlighted the role of the ACE2/Ang1-7/Mas axis in modulating the expression of pro-inflammatory cytokines, such as TNF-α, interleukin (IL)-1β, IL-6, monocyte chemoattractant protein-1, and transforming growth factor-β in cardiac and/or lung fibrosis, pulmonary hypertension, and vascular remodeling (36, 37, 38, 39, 40, 41) (Figure 1 ). |
| T58 | 2868-2916 | Sentence | denotes | Figure 1 RAS and ACE2/Ang1-7/Mas Axis Regulation |
| T59 | 2917-2981 | Sentence | denotes | Angiotensinogen is converted to angiotensin I (Ang I) via renin. |
| T60 | 2982-3139 | Sentence | denotes | Ang I is converted to Ang II via angiotensin-converting enzyme (ACE), which also hydrolyzes bradykinin into its inactive metabolites, promoting inflammation. |
| T61 | 3140-3343 | Sentence | denotes | The pro-inflammatory effects of Ang II are mediated by Ang II type I receptor (AT1), which stimulates aldosterone secretion from the adrenal medulla and antidiuretic hormone from the posterior pituitary. |
| T62 | 3344-3391 | Sentence | denotes | Aldosterone decreases membrane ACE2 expression. |
| T63 | 3392-3502 | Sentence | denotes | Endothelin-1 inhibits angiotensin 1-7 (Ang1-7) via extracellular signal-regulated kinase (ERK)1/ERK2 pathways. |
| T64 | 3503-3656 | Sentence | denotes | Ang II, under favorable conditions (dashed line), can be converted to Ang1-7 via ACE2, whose counter regulatory effects are mediated by the Mas receptor. |
| T65 | 3657-3809 | Sentence | denotes | Ang1-7 can also be formed via conversion of Ang I to an intermediate Ang1-9 or directly via zinc metallopeptidase neprilysin/prolyl endopeptidase (PEP). |
| T66 | 3810-3841 | Sentence | denotes | RAS = renin-angiotensin system. |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T8 | 2792-2804 | Phenotype | denotes | hypertension | http://purl.obolibrary.org/obo/HP_0000822 |
LitCovid-PMC-OGER-BB
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T168 | 0-4 | G_3;PG_10;PR:000003622 | denotes | ACE2 |
| T169 | 5-9 | PR:000036013 | denotes | Ang1 |
| T170 | 21-31 | GO:0065007 | denotes | Regulation |
| T171 | 32-37 | PR:000036008 | denotes | Ang I |
| T172 | 94-100 | PR:000036009 | denotes | Ang II |
| T173 | 121-126 | PR:000036008 | denotes | Ang I |
| T174 | 147-151 | PR:000036012 | denotes | Ang1 |
| T175 | 157-161 | PR:000003622;G_3;PG_10 | denotes | ACE2 |
| T176 | 186-192 | PR:000036009 | denotes | Ang II |
| T177 | 209-214 | PR:000036013 | denotes | Ang 1 |
| T178 | 225-229 | PR:000003622;G_3;PG_10 | denotes | ACE2 |
| T179 | 236-241 | PR:000036013 | denotes | Ang1- |
| T180 | 258-275 | CHEBI:67079;CHEBI:67079 | denotes | anti-inflammatory |
| T181 | 387-390 | PR:000001563 | denotes | Mas |
| T182 | 412-418 | PR:000036013 | denotes | Ang1-7 |
| T183 | 449-454 | PR:000036008 | denotes | Ang I |
| T184 | 522-532 | PR:000001898 | denotes | neprilysin |
| T185 | 550-556 | PR:000036012 | denotes | Ang1-9 |
| T186 | 560-566 | PR:000036013 | denotes | Ang1-7 |
| T187 | 627-634 | SO:0000704 | denotes | Genetic |
| T188 | 669-673 | G_3;PG_10;PR:000003622 | denotes | ACE2 |
| T189 | 703-717 | UBERON:0004535 | denotes | cardiovascular |
| T190 | 756-766 | GO:0065007 | denotes | regulation |
| T191 | 770-774 | G_3;PG_10;PR:000003622 | denotes | ACE2 |
| T192 | 778-785 | UBERON:0000948;CL:0000746 | denotes | cardiac |
| T193 | 786-794 | CL:0000746 | denotes | myocytes |
| T194 | 799-806 | UBERON:0000948;CL:0002548 | denotes | cardiac |
| T195 | 807-818 | CL:0002548 | denotes | fibroblasts |
| T196 | 851-857 | PR:000036009 | denotes | Ang II |
| T197 | 880-884 | G_3;PG_10;PR:000003622 | denotes | ACE2 |
| T198 | 912-916 | G_3;PG_10;PR:000003622 | denotes | ACE2 |
| T199 | 925-932 | UBERON:0000948;CL:0000746 | denotes | cardiac |
| T200 | 933-941 | CL:0000746 | denotes | myocytes |
| T201 | 959-963 | G_3;PG_10;PR:000003622 | denotes | ACE2 |
| T202 | 976-987 | CL:0000057 | denotes | fibroblasts |
| T203 | 997-1005 | CL:0000187 | denotes | myocytes |
| T204 | 1007-1017 | UBERON:0001986 | denotes | endothelin |
| T205 | 1054-1058 | G_3;PG_10;PR:000003622 | denotes | ACE2 |
| T206 | 1099-1103 | G_3;PG_10;PR:000003622 | denotes | ACE2 |
| T207 | 1112-1118 | PR:000036009 | denotes | Ang II |
| T208 | 1122-1126 | PR:000006897 | denotes | ET-1 |
| T209 | 1142-1152 | CHEBI:35222;CHEBI:35222 | denotes | inhibitors |
| T210 | 1156-1163 | CHEBI:52290;CHEBI:52290;PR:000000103 | denotes | mitogen |
| T211 | 1163-1190 | PR:000000103 | denotes | -activated protein kinase 1 |
| T212 | 1192-1197 | PR:000000103 | denotes | MAPK1 |
| T213 | 1221-1227 | PR:000036009 | denotes | Ang II |
| T214 | 1232-1236 | PR:000006897 | denotes | ET-1 |
| T215 | 1246-1259 | GO:0005576 | denotes | extracellular |
| T216 | 1267-1276 | GO:0065007 | denotes | regulated |
| T217 | 1285-1288 | PR:000007130 | denotes | ERK |
| T218 | 1291-1295 | PR:000000103 | denotes | ERK2 |
| T219 | 1306-1310 | G_3;PG_10;PR:000003622 | denotes | ACE2 |
| T220 | 1338-1344 | NCBITaxon:39107 | denotes | murine |
| T221 | 1360-1366 | PR:000036009 | denotes | Ang II |
| T222 | 1384-1392 | GO:0016020 | denotes | membrane |
| T223 | 1399-1412 | CL:0000746 | denotes | cardiomyocyte |
| T224 | 1413-1417 | PR:000003622;G_3;PG_10 | denotes | ACE2 |
| T225 | 1459-1465 | PR:000001279 | denotes | ADAM17 |
| T226 | 1501-1504 | PR:000001251 | denotes | AT1 |
| T227 | 1529-1536 | UBERON:0000948;CL:0002548 | denotes | Cardiac |
| T228 | 1537-1548 | CL:0002548 | denotes | fibroblasts |
| T229 | 1553-1561 | UBERON:0005985;CL:0002364 | denotes | coronary |
| T230 | 1562-1573 | UBERON:0001986;CL:0000115 | denotes | endothelial |
| T231 | 1574-1579 | CL:0000115 | denotes | cells |
| T232 | 1585-1592 | GO:0010467 | denotes | express |
| T233 | 1593-1597 | G_3;PG_10;PR:000003622 | denotes | ACE2 |
| T234 | 1602-1606 | PR:000001279 | denotes | TACE |
| T235 | 1686-1692 | PR:000036009 | denotes | Ang II |
| T236 | 1749-1752 | PR:000045382 | denotes | PKC |
| T237 | 1757-1761 | PR:000009197 | denotes | JAK2 |
| T238 | 1762-1767 | PR:000002089 | denotes | STAT3 |
| T239 | 1805-1815 | UBERON:0002349 | denotes | myocardial |
| T240 | 1872-1876 | PR:000036013 | denotes | Ang1 |
| T241 | 1897-1903 | SO:0000417 | denotes | domain |
| T242 | 1922-1933 | GO:0006508 | denotes | proteolytic |
| T243 | 2011-2016 | SP_6;NCBITaxon:9606 | denotes | human |
| T244 | 2030-2037 | UBERON:0000948 | denotes | cardiac |
| T245 | 2038-2044 | UBERON:0000479 | denotes | tissue |
| T246 | 2049-2055 | UBERON:0001969 | denotes | plasma |
| T247 | 2063-2067 | PR:000036013 | denotes | Ang1 |
| T248 | 2104-2109 | PR:000036008 | denotes | Ang I |
| T249 | 2152-2156 | PR:000036013 | denotes | Ang1 |
| T250 | 2230-2234 | G_3;PG_10;PR:000003622 | denotes | ACE2 |
| T251 | 2244-2248 | NCBITaxon:10088 | denotes | mice |
| T252 | 2254-2260 | PR:000036009 | denotes | Ang II |
| T253 | 2286-2290 | G_3;PG_10;PR:000003622 | denotes | ACE2 |
| T254 | 2311-2315 | PR:000000104 | denotes | ERK1 |
| T255 | 2319-2323 | PR:000009197 | denotes | JAK2 |
| T256 | 2324-2329 | PR:000002089 | denotes | STAT3 |
| T257 | 2335-2338 | PR:000045382;GO:0000187 | denotes | PKC |
| T258 | 2339-2348 | GO:0000165 | denotes | signaling |
| T259 | 2417-2423 | PR:000036009 | denotes | Ang II |
| T260 | 2432-2442 | UBERON:0002349 | denotes | myocardial |
| T261 | 2557-2561 | G_3;PG_10;PR:000003622 | denotes | ACE2 |
| T262 | 2562-2566 | PR:000036013 | denotes | Ang1 |
| T263 | 2581-2591 | GO:0065007 | denotes | modulating |
| T264 | 2596-2606 | GO:0010467 | denotes | expression |
| T265 | 2646-2651 | PR:000000134 | denotes | TNF-α |
| T266 | 2674-2678 | PR:000001393 | denotes | IL-6 |
| T267 | 2680-2688 | CL:0000576;PR:000002122 | denotes | monocyte |
| T268 | 2689-2714 | PR:000002122 | denotes | chemoattractant protein-1 |
| T269 | 2720-2748 | PR:000000046 | denotes | transforming growth factor-β |
| T270 | 2752-2759 | UBERON:0000948 | denotes | cardiac |
| T271 | 2767-2771 | UBERON:0002048 | denotes | lung |
| T272 | 2782-2791 | UBERON:0002048 | denotes | pulmonary |
| T273 | 2885-2889 | G_3;PG_10;PR:000003622 | denotes | ACE2 |
| T274 | 2890-2894 | PR:000036013 | denotes | Ang1 |
| T275 | 2897-2900 | PR:000001563 | denotes | Mas |
| T276 | 2906-2932 | GO:0065007 | denotes | Regulation Angiotensinogen |
| T277 | 2949-2962 | PR:000036008 | denotes | angiotensin I |
| T278 | 2964-2969 | PR:000036008 | denotes | Ang I |
| T279 | 2975-2980 | PR:000013883 | denotes | renin |
| T280 | 2982-2987 | PR:000036008 | denotes | Ang I |
| T281 | 3004-3010 | PR:000036009 | denotes | Ang II |
| T282 | 3063-3073 | MOP:0000619 | denotes | hydrolyzes |
| T283 | 3074-3084 | CHEBI:3165;CHEBI:3165 | denotes | bradykinin |
| T284 | 3103-3114 | CHEBI:25212;CHEBI:25212 | denotes | metabolites |
| T285 | 3172-3178 | PR:000036009 | denotes | Ang II |
| T286 | 3195-3201 | PR:000036009 | denotes | Ang II |
| T287 | 3242-3253 | CHEBI:27584;CHEBI:27584 | denotes | aldosterone |
| T288 | 3273-3288 | UBERON:0001236 | denotes | adrenal medulla |
| T289 | 3333-3342 | UBERON:0002198 | denotes | pituitary |
| T290 | 3344-3355 | CHEBI:27584;CHEBI:27584 | denotes | Aldosterone |
| T291 | 3366-3374 | GO:0016020 | denotes | membrane |
| T292 | 3375-3379 | G_3;PG_10;PR:000003622 | denotes | ACE2 |
| T293 | 3380-3390 | GO:0010467 | denotes | expression |
| T294 | 3392-3402 | UBERON:0001986;PR:000006897 | denotes | Endothelin |
| T295 | 3402-3404 | PR:000006897 | denotes | -1 |
| T296 | 3414-3427 | PR:000036013 | denotes | angiotensin 1 |
| T297 | 3431-3435 | PR:000036013 | denotes | Ang1 |
| T298 | 3443-3456 | GO:0005576 | denotes | extracellular |
| T299 | 3464-3473 | GO:0065007 | denotes | regulated |
| T300 | 3488-3492 | PR:000000103 | denotes | ERK2 |
| T301 | 3503-3509 | PR:000036009 | denotes | Ang II |
| T302 | 3573-3577 | PR:000036013 | denotes | Ang1 |
| T303 | 3584-3588 | PR:000003622;G_3;PG_10 | denotes | ACE2 |
| T304 | 3657-3662 | PR:000036013 | denotes | Ang1- |
| T305 | 3701-3706 | PR:000036008 | denotes | Ang I |
| T306 | 3726-3732 | PR:000036012 | denotes | Ang1-9 |
| T307 | 3771-3781 | PR:000001898 | denotes | neprilysin |
| T308 | 3816-3821 | PR:000013883 | denotes | renin |
| T315 | 475-480 | PR:000013883 | denotes | ive p |
| T316 | 482-487 | PR:000036008 | denotes | hways |
| T317 | 504-512 | PR:000036009 | denotes | metallo |
| T318 | 565-575 | MOP:0000619 | denotes | 7 via ACE, |
| T90424 | 15-20 | PR:000000103 | denotes | Axis |
| T29796 | 31-37 | PR:000036009 | denotes | Ang I |
| T98730 | 101-105 | PR:000036013 | denotes | by A |
| T86736 | 112-116 | PR:000003622;G_3;PG_10 | denotes | ike |
| T89530 | 185-190 | PR:000036013 | denotes | Ang |
| T48188 | 229-234 | PR:000036008 | denotes | (17) |
| T41061 | 254-260 | PR:000036012 | denotes | of an |
| T94791 | 298-308 | PR:000001898 | denotes | tory, and |
| T37488 | 343-348 | PR:000013883 | denotes | ed by |
| T309 | 386-390 | G_3;PG_10;PR:000003622 | denotes | Mas |
| T310 | 391-395 | PR:000036013 | denotes | rece |
| T311 | 406-416 | GO:0065007 | denotes | ,27). Ang1 |
| T312 | 417-432 | CHEBI:2720;CHEBI:2720 | denotes | 7 may be produc |
| T313 | 449-462 | PR:000036008 | denotes | Ang I through |
| T314 | 464-469 | PR:000036008 | denotes | he al |
| T319 | 576-586 | CHEBI:3165;CHEBI:3165 | denotes | although a |
| T320 | 605-614 | CHEBI:25212;CHEBI:25212 | denotes | ower effi |
| T321 | 672-678 | PR:000036009 | denotes | 2 as a |
| T322 | 695-701 | PR:000036009 | denotes | ator o |
| T323 | 741-752 | CHEBI:27584;CHEBI:27584 | denotes | focused on |
| T324 | 772-787 | UBERON:0001236 | denotes | E2 in cardiac m |
| T325 | 832-840 | UBERON:0002198 | denotes | ated tha |
| T326 | 842-853 | CHEBI:27584;CHEBI:27584 | denotes | although An |
| T327 | 864-872 | GO:0016020 | denotes | icantly |
| T328 | 873-877 | G_3;PG_10;PR:000003622 | denotes | educ |
| T329 | 878-888 | GO:0010467 | denotes | d ACE2 act |
| T330 | 890-900 | UBERON:0001986;PR:000006897 | denotes | ity and do |
| T331 | 900-902 | PR:000006897 | denotes | wn |
| T332 | 912-925 | PR:000036013 | denotes | ACE2 mRNA in |
| T333 | 929-933 | PR:000036013 | denotes | iac |
| T334 | 941-954 | GO:0005576 | denotes | , it only red |
| T335 | 962-971 | GO:0065007 | denotes | 2 activit |
| T336 | 986-990 | PR:000000103 | denotes | s (2 |
| T337 | 1001-1007 | PR:000036009 | denotes | ytes, |
| T338 | 1071-1075 | PR:000036013 | denotes | ion |
| T339 | 1082-1086 | PR:000003622;G_3;PG_10 | denotes | his |
| T340 | 1155-1160 | PR:000036013 | denotes | mito |
| T341 | 1199-1204 | PR:000036008 | denotes | whic |
| T342 | 1224-1230 | PR:000036012 | denotes | II an |
| T343 | 1267-1277 | PR:000001898 | denotes | regulated |
| T344 | 1312-1317 | PR:000013883 | denotes | 29). |
| T9018 | 1338-1343 | G_3;PG_10;PR:000003622 | denotes | murin |
| T63740 | 1344-1354 | GO:0065007 | denotes | studies s |
| T78761 | 1359-1373 | UBERON:0004535 | denotes | Ang II−mediat |
| T29306 | 1422-1436 | UBERON:0004535 | denotes | elated with th |
| T37860 | 1450-1460 | GO:0065007 | denotes | of TACE/A |
| T4521 | 1469-1479 | CHEBI:35222;CHEBI:35222 | denotes | ivity, whi |
| T92757 | 1546-1560 | UBERON:0004535 | denotes | ts and coronar |
| T57057 | 1618-1623 | PR:000013883 | denotes | ecipr |
| T50692 | 1660-1676 | SP_7 | denotes | ll types as well |
| T26520 | 1678-1691 | PR:000036008 | denotes | 31,32). Ang I |
| T11517 | 1693-1698 | PR:000036008 | denotes | activ |
| T49885 | 1716-1722 | PR:000036009 | denotes | signa |
| T78357 | 1796-1806 | CHEBI:35222;CHEBI:35222 | denotes | sults in m |
| T32486 | 1840-1846 | PR:000036009 | denotes | d fibr |
| T30438 | 1868-1872 | PR:000001251 | denotes | of |
| T84915 | 1900-1916 | UBERON:0002053 | denotes | ain also inhibit |
| T14662 | 1924-1939 | UBERON:0001236 | denotes | oteolytic funct |
| T3622 | 1954-1965 | CHEBI:27584;CHEBI:27584 | denotes | enzyme and |
| T2367 | 1991-2008 | CHEBI:25354;CHEBI:25354 | denotes | on (34). Studies |
| T70131 | 2030-2035 | CHEBI:15377;CHEBI:15377 | denotes | cardi |
| T22478 | 2065-2069 | CHEBI:24866;CHEBI:24866 | denotes | g1-7 |
| T53819 | 2100-2117 | CHEBI:25354;CHEBI:25354 | denotes | han Ang I, which |
| T50077 | 2118-2138 | CHEBI:48561;CHEBI:48561 | denotes | uggests the inhibito |
| T85097 | 2167-2175 | UBERON:0002198 | denotes | ay contr |
| T97767 | 2177-2183 | PR:000036009 | denotes | ute to |
| T62349 | 2236-2241 | CHEBI:15377;CHEBI:15377 | denotes | nocko |
| T2176 | 2269-2276 | UBERON:0000479 | denotes | and re |
| T70273 | 2339-2347 | MOP:0000568 | denotes | signalin |
| T88849 | 2360-2369 | GO:0006915 | denotes | nd was at |
| T55720 | 2453-2456 | CHEBI:37886;CHEBI:37886;PR:000036009 | denotes | y a |
| T28600 | 2457-2459 | PR:000036009 | denotes | d |
| T83802 | 2471-2475 | PR:000001251 | denotes | imp |
| T53803 | 2477-2483 | PR:000036009 | denotes | vement |
| T72294 | 2509-2522 | PR:000036013 | denotes | (33). Other s |
| T20825 | 2526-2531 | PR:000036013 | denotes | es hi |
| T14954 | 2539-2543 | PR:000003622;G_3;PG_10 | denotes | d th |
| T39929 | 2565-2568 | PR:000001563 | denotes | 1-7 |
| T49406 | 2621-2625 | G_3;PG_10;PR:000003622 | denotes | ator |
| T29031 | 2626-2630 | PR:000036013 | denotes | cyt |
| T97645 | 2697-2702 | PR:000013883 | denotes | racta |
| T54224 | 2729-2733 | PR:000001251 | denotes | ing |
| T94906 | 2738-2742 | PR:000003622;G_3;PG_10 | denotes | h fa |
| T80849 | 2756-2762 | PR:000036009 | denotes | iac an |
| T57333 | 2774-2778 | PR:000001251 | denotes | bros |
| T66538 | 2802-2806 | PR:000003622;G_3;PG_10 | denotes | on, |
| T53794 | 2864-2868 | G_3;PG_10;PR:000003622 | denotes | ). |
| T49835 | 2908-2914 | PR:000036009 | denotes | gulati |
| T23691 | 2929-2934 | PR:000036013 | denotes | gen i |
| T96566 | 2938-2942 | G_3;PG_10;PR:000003622 | denotes | nver |
| T43762 | 3001-3013 | SP_10 | denotes | to Ang II vi |
| T84544 | 3014-3024 | SP_10;UBERON:0001004 | denotes | angiotens |
| T62103 | 3025-3045 | SP_10 | denotes | n-converting enzyme |
| T45099 | 3047-3055 | SP_10 | denotes | CE), whi |
| T96697 | 3063-3071 | SP_10 | denotes | hydrolyz |
| T67126 | 3073-3077 | G_3;PG_10;PR:000003622 | denotes | bra |
| T70630 | 3087-3096 | PG_1 | denotes | to its in |
| T4074 | 3122-3127 | NCBITaxon:10239;GO:0035376 | denotes | ing i |
| T7619 | 3128-3133 | GO:0035376 | denotes | flamm |
| T1702 | 3143-3155 | GO:0044164 | denotes | pro-inflamm |
| T51851 | 3186-3191 | NCBITaxon:10239;GO:0006260 | denotes | iated |
| T38954 | 3192-3203 | GO:0006260 | denotes | by Ang II t |
| T34720 | 3218-3224 | PR:000036009 | denotes | (AT1), |
| T28581 | 3233-3238 | PR:000003622;G_3;PG_10 | denotes | imula |
| T52593 | 3267-3272 | NCBITaxon:10239 | denotes | m the |
| T53738 | 3338-3342 | PR:000001251 | denotes | tary |
| T14088 | 3367-3372 | PR:000001607 | denotes | embra |
| T411 | 3423-3428 | PR:000013883 | denotes | in 1- |
| T412 | 3465-3473 | SP_7 | denotes | egulated |
| T413 | 3484-3497 | PR:000036008 | denotes | K)1/ERK2 path |
| T414 | 3499-3504 | PR:000036008 | denotes | ys. A |
| T415 | 3646-3652 | PR:000036009 | denotes | recep |
| T416 | 3674-3678 | PR:000001251 | denotes | e fo |
| T417 | 3706-3722 | UBERON:0002053 | denotes | to an intermedi |
| T418 | 3730-3745 | UBERON:0001236 | denotes | -9 or directly |
| T419 | 3762-3773 | CHEBI:27584;CHEBI:27584 | denotes | eptidase ne |
| T420 | 3799-3816 | CHEBI:25354;CHEBI:25354 | denotes | ase (PEP). RAS = |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 214 | 0-4 | Gene | denotes | ACE2 | Gene:59272 |
| 215 | 5-11 | Gene | denotes | Ang1-7 | Gene:284 |
| 218 | 2885-2889 | Gene | denotes | ACE2 | Gene:59272 |
| 219 | 2890-2896 | Gene | denotes | Ang1-7 | Gene:284 |
| 247 | 2917-2932 | Gene | denotes | Angiotensinogen | Gene:183 |
| 248 | 2949-2962 | Gene | denotes | angiotensin I | Gene:183 |
| 249 | 2964-2969 | Gene | denotes | Ang I | Gene:183 |
| 250 | 2982-2987 | Gene | denotes | Ang I | Gene:183 |
| 251 | 3004-3010 | Gene | denotes | Ang II | Gene:183 |
| 252 | 3015-3044 | Gene | denotes | angiotensin-converting enzyme | Gene:1636 |
| 253 | 3046-3049 | Gene | denotes | ACE | Gene:1636 |
| 254 | 3074-3084 | Gene | denotes | bradykinin | Gene:3827 |
| 255 | 3172-3178 | Gene | denotes | Ang II | Gene:183 |
| 256 | 3375-3379 | Gene | denotes | ACE2 | Gene:59272 |
| 257 | 3392-3404 | Gene | denotes | Endothelin-1 | Gene:1906 |
| 258 | 3431-3437 | Gene | denotes | Ang1-7 | Gene:284 |
| 259 | 3443-3487 | Gene | denotes | extracellular signal-regulated kinase (ERK)1 | Gene:5594 |
| 260 | 3488-3492 | Gene | denotes | ERK2 | Gene:5594 |
| 261 | 3503-3509 | Gene | denotes | Ang II | Gene:183 |
| 262 | 3573-3579 | Gene | denotes | Ang1-7 | Gene:284 |
| 263 | 3584-3588 | Gene | denotes | ACE2 | Gene:59272 |
| 264 | 3657-3663 | Gene | denotes | Ang1-7 | Gene:284 |
| 265 | 3726-3732 | Gene | denotes | Ang1-9 | Gene:284 |
| 266 | 3771-3781 | Gene | denotes | neprilysin | Gene:4311 |
| 267 | 3782-3802 | Gene | denotes | prolyl endopeptidase | Gene:5550 |
| 268 | 3804-3807 | Gene | denotes | PEP | Gene:5550 |
| 269 | 3701-3706 | Gene | denotes | Ang I | Gene:183 |
| 270 | 2975-2980 | Gene | denotes | renin | Gene:5972 |
| 271 | 3242-3253 | Chemical | denotes | aldosterone | MESH:D000450 |
| 272 | 3344-3355 | Chemical | denotes | Aldosterone | MESH:D000450 |
| 273 | 3126-3138 | Disease | denotes | inflammation | MESH:D007249 |
| 350 | 32-37 | Gene | denotes | Ang I | Gene:183 |
| 351 | 94-100 | Gene | denotes | Ang II | Gene:183 |
| 352 | 104-107 | Gene | denotes | ACE | Gene:1636 |
| 353 | 116-119 | Gene | denotes | ACE | Gene:1636 |
| 354 | 121-126 | Gene | denotes | Ang I | Gene:183 |
| 355 | 147-153 | Gene | denotes | Ang1-9 | Gene:284 |
| 356 | 157-161 | Gene | denotes | ACE2 | Gene:59272 |
| 357 | 186-192 | Gene | denotes | Ang II | Gene:183 |
| 358 | 209-216 | Gene | denotes | Ang 1-7 | Gene:284 |
| 359 | 225-229 | Gene | denotes | ACE2 | Gene:59272 |
| 360 | 236-242 | Gene | denotes | Ang1-7 | Gene:284 |
| 361 | 353-379 | Gene | denotes | G protein coupled receptor | Gene:1909 |
| 362 | 381-385 | Gene | denotes | GPCR | Gene:1909 |
| 363 | 412-418 | Gene | denotes | Ang1-7 | Gene:284 |
| 364 | 522-532 | Gene | denotes | neprilysin | Gene:4311 |
| 365 | 550-556 | Gene | denotes | Ang1-9 | Gene:284 |
| 366 | 560-566 | Gene | denotes | Ang1-7 | Gene:284 |
| 367 | 571-574 | Gene | denotes | ACE | Gene:1636 |
| 368 | 669-673 | Gene | denotes | ACE2 | Gene:59272 |
| 369 | 770-774 | Gene | denotes | ACE2 | Gene:59272 |
| 370 | 851-857 | Gene | denotes | Ang II | Gene:183 |
| 371 | 880-884 | Gene | denotes | ACE2 | Gene:59272 |
| 372 | 912-916 | Gene | denotes | ACE2 | Gene:59272 |
| 373 | 959-963 | Gene | denotes | ACE2 | Gene:59272 |
| 374 | 1054-1058 | Gene | denotes | ACE2 | Gene:59272 |
| 375 | 1099-1103 | Gene | denotes | ACE2 | Gene:59272 |
| 376 | 1112-1118 | Gene | denotes | Ang II | Gene:183 |
| 377 | 1156-1190 | Gene | denotes | mitogen-activated protein kinase 1 | Gene:5594 |
| 378 | 1192-1197 | Gene | denotes | MAPK1 | Gene:5594 |
| 379 | 1221-1227 | Gene | denotes | Ang II | Gene:183 |
| 380 | 1246-1290 | Gene | denotes | extracellular signal-regulated kinase (ERK)1 | Gene:5594 |
| 381 | 1291-1295 | Gene | denotes | ERK2 | Gene:5594 |
| 382 | 1306-1310 | Gene | denotes | ACE2 | Gene:59272 |
| 383 | 1413-1417 | Gene | denotes | ACE2 | Gene:70008 |
| 384 | 1454-1458 | Gene | denotes | TACE | Gene:11491 |
| 385 | 1459-1465 | Gene | denotes | ADAM17 | Gene:11491 |
| 386 | 1593-1597 | Gene | denotes | ACE2 | Gene:70008 |
| 387 | 1602-1606 | Gene | denotes | TACE | Gene:11491 |
| 388 | 1686-1692 | Gene | denotes | Ang II | Gene:11606 |
| 389 | 1757-1761 | Gene | denotes | JAK2 | Gene:16452 |
| 390 | 1762-1767 | Gene | denotes | STAT3 | Gene:20848 |
| 391 | 1872-1878 | Gene | denotes | Ang1-7 | Gene:11727 |
| 392 | 1950-1953 | Gene | denotes | ACE | Gene:11421 |
| 393 | 1974-1984 | Gene | denotes | bradykinin | Gene:3827 |
| 394 | 2063-2069 | Gene | denotes | Ang1-7 | Gene:284 |
| 395 | 2095-2098 | Gene | denotes | ACE | Gene:1636 |
| 396 | 2104-2109 | Gene | denotes | Ang I | Gene:183 |
| 397 | 2152-2158 | Gene | denotes | Ang1-7 | Gene:284 |
| 398 | 2162-2165 | Gene | denotes | ACE | Gene:1636 |
| 399 | 2230-2234 | Gene | denotes | ACE2 | Gene:70008 |
| 400 | 2254-2260 | Gene | denotes | Ang II | Gene:11606 |
| 401 | 2286-2290 | Gene | denotes | ACE2 | Gene:70008 |
| 402 | 2311-2317 | Gene | denotes | ERK1/2 | Gene:26417 |
| 403 | 2319-2323 | Gene | denotes | JAK2 | Gene:16452 |
| 404 | 2324-2329 | Gene | denotes | STAT3 | Gene:20848 |
| 405 | 2417-2423 | Gene | denotes | Ang II | Gene:11606 |
| 406 | 2557-2561 | Gene | denotes | ACE2 | Gene:70008 |
| 407 | 2562-2568 | Gene | denotes | Ang1-7 | Gene:11727 |
| 408 | 2646-2651 | Gene | denotes | TNF-α | Gene:7124 |
| 409 | 2653-2672 | Gene | denotes | interleukin (IL)-1β | Gene:3552 |
| 410 | 2674-2678 | Gene | denotes | IL-6 | Gene:3569 |
| 411 | 2680-2714 | Gene | denotes | monocyte chemoattractant protein-1 | Gene:6347 |
| 412 | 2720-2748 | Gene | denotes | transforming growth factor-β | Gene:7124 |
| 413 | 449-454 | Gene | denotes | Ang I | Gene:183 |
| 414 | 1360-1363 | Gene | denotes | Ang | Gene:11727 |
| 415 | 1338-1344 | Species | denotes | murine | Tax:10090 |
| 416 | 2011-2016 | Species | denotes | human | Tax:9606 |
| 417 | 2244-2248 | Species | denotes | mice | Tax:10090 |
| 418 | 2352-2358 | Chemical | denotes | rhACE2 | |
| 419 | 1805-1827 | Disease | denotes | myocardial hypertrophy | MESH:D006332 |
| 420 | 1842-1850 | Disease | denotes | fibrosis | MESH:D005355 |
| 421 | 2432-2454 | Disease | denotes | myocardial hypertrophy | MESH:D006332 |
| 422 | 2459-2467 | Disease | denotes | fibrosis | MESH:D005355 |
| 423 | 2487-2508 | Disease | denotes | diastolic dysfunction | MESH:D007022 |
| 424 | 2772-2780 | Disease | denotes | fibrosis | MESH:D005355 |
| 425 | 2782-2804 | Disease | denotes | pulmonary hypertension | MESH:D006976 |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32305401-15283675-55252931 | 231-233 | 15283675 | denotes | 17 |
| 32305401-20102883-55252932 | 404-406 | 20102883 | denotes | 26 |
| 32305401-15283675-55252933 | 622-624 | 15283675 | denotes | 17 |
| 32305401-12075344-55252934 | 728-730 | 12075344 | denotes | 28 |
| 32305401-24332999-55252935 | 1524-1526 | 24332999 | denotes | 30 |
| 32305401-1828192-55252936 | 1678-1680 | 1828192 | denotes | 31 |
| 32305401-20679547-55252937 | 1852-1854 | 20679547 | denotes | 33 |
| 32305401-18417117-55252938 | 2208-2210 | 18417117 | denotes | 35 |
| 32305401-20679547-55252939 | 2510-2512 | 20679547 | denotes | 33 |
| 32305401-16024575-55252940 | 2831-2833 | 16024575 | denotes | 36 |
| 32305401-19715669-55252941 | 2835-2837 | 19715669 | denotes | 37 |
| 32305401-17098828-55252942 | 2839-2841 | 17098828 | denotes | 38 |
| 32305401-21952934-55252943 | 2843-2845 | 21952934 | denotes | 39 |
| 32305401-19246717-55252944 | 2847-2849 | 19246717 | denotes | 40 |
| 32305401-19564552-55252945 | 2851-2853 | 19564552 | denotes | 41 |