PMC:7161517 / 511-996 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T3","span":{"begin":345,"end":349},"obj":"Body_part"},{"id":"T4","span":{"begin":390,"end":394},"obj":"Body_part"}],"attributes":[{"id":"A3","pred":"fma_id","subj":"T3","obj":"http://purl.org/sig/ont/fma/fma12520"},{"id":"A4","pred":"fma_id","subj":"T4","obj":"http://purl.org/sig/ont/fma/fma7195"}],"text":"CE inhibitors, and mineralocorticoid receptor antagonists increase ACE2 receptor expression, it has been tacitly believed that the use of these agents may facilitate viral disease; thus, they should not be used in high-risk patients with cardiovascular disease. Based on the anti-inflammatory benefits of the upregulation of the ACE2/Ang1-7/Mas axis and previously demonstrated benefits of lung function improvement in SARS-CoV infections, it has been hypothesized that the benefits of"}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T2","span":{"begin":390,"end":394},"obj":"Body_part"}],"attributes":[{"id":"A2","pred":"uberon_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"}],"text":"CE inhibitors, and mineralocorticoid receptor antagonists increase ACE2 receptor expression, it has been tacitly believed that the use of these agents may facilitate viral disease; thus, they should not be used in high-risk patients with cardiovascular disease. Based on the anti-inflammatory benefits of the upregulation of the ACE2/Ang1-7/Mas axis and previously demonstrated benefits of lung function improvement in SARS-CoV infections, it has been hypothesized that the benefits of"}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T6","span":{"begin":166,"end":179},"obj":"Disease"},{"id":"T7","span":{"begin":238,"end":260},"obj":"Disease"},{"id":"T8","span":{"begin":419,"end":427},"obj":"Disease"},{"id":"T9","span":{"begin":428,"end":438},"obj":"Disease"}],"attributes":[{"id":"A6","pred":"mondo_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/MONDO_0005108"},{"id":"A7","pred":"mondo_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/MONDO_0004995"},{"id":"A8","pred":"mondo_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A9","pred":"mondo_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"}],"text":"CE inhibitors, and mineralocorticoid receptor antagonists increase ACE2 receptor expression, it has been tacitly believed that the use of these agents may facilitate viral disease; thus, they should not be used in high-risk patients with cardiovascular disease. Based on the anti-inflammatory benefits of the upregulation of the ACE2/Ang1-7/Mas axis and previously demonstrated benefits of lung function improvement in SARS-CoV infections, it has been hypothesized that the benefits of"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T3","span":{"begin":96,"end":99},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T4","span":{"begin":390,"end":394},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T5","span":{"begin":390,"end":394},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T6","span":{"begin":443,"end":446},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"}],"text":"CE inhibitors, and mineralocorticoid receptor antagonists increase ACE2 receptor expression, it has been tacitly believed that the use of these agents may facilitate viral disease; thus, they should not be used in high-risk patients with cardiovascular disease. Based on the anti-inflammatory benefits of the upregulation of the ACE2/Ang1-7/Mas axis and previously demonstrated benefits of lung function improvement in SARS-CoV infections, it has been hypothesized that the benefits of"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T10","span":{"begin":3,"end":13},"obj":"Chemical"},{"id":"T11","span":{"begin":19,"end":36},"obj":"Chemical"},{"id":"T12","span":{"begin":46,"end":57},"obj":"Chemical"}],"attributes":[{"id":"A10","pred":"chebi_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A11","pred":"chebi_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/CHEBI_25354"},{"id":"A12","pred":"chebi_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/CHEBI_48706"}],"text":"CE inhibitors, and mineralocorticoid receptor antagonists increase ACE2 receptor expression, it has been tacitly believed that the use of these agents may facilitate viral disease; thus, they should not be used in high-risk patients with cardiovascular disease. Based on the anti-inflammatory benefits of the upregulation of the ACE2/Ang1-7/Mas axis and previously demonstrated benefits of lung function improvement in SARS-CoV infections, it has been hypothesized that the benefits of"}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T1","span":{"begin":238,"end":260},"obj":"Phenotype"}],"attributes":[{"id":"A1","pred":"hp_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/HP_0001626"}],"text":"CE inhibitors, and mineralocorticoid receptor antagonists increase ACE2 receptor expression, it has been tacitly believed that the use of these agents may facilitate viral disease; thus, they should not be used in high-risk patients with cardiovascular disease. Based on the anti-inflammatory benefits of the upregulation of the ACE2/Ang1-7/Mas axis and previously demonstrated benefits of lung function improvement in SARS-CoV infections, it has been hypothesized that the benefits of"}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T17","span":{"begin":3,"end":13},"obj":"CHEBI:35222;CHEBI:35222"},{"id":"T18","span":{"begin":19,"end":36},"obj":"CHEBI:25354;CHEBI:25354"},{"id":"T19","span":{"begin":37,"end":57},"obj":"CHEBI:48561;CHEBI:48561"},{"id":"T20","span":{"begin":67,"end":71},"obj":"PR:000003622;G_3;PG_10"},{"id":"T21","span":{"begin":81,"end":91},"obj":"GO:0010467"},{"id":"T22","span":{"begin":144,"end":150},"obj":"CHEBI:48561;CHEBI:48561"},{"id":"T23","span":{"begin":166,"end":171},"obj":"NCBITaxon:10239"},{"id":"T24","span":{"begin":238,"end":252},"obj":"UBERON:0004535"},{"id":"T25","span":{"begin":329,"end":333},"obj":"G_3;PG_10;PR:000003622"},{"id":"T26","span":{"begin":334,"end":338},"obj":"PR:000036013"},{"id":"T27","span":{"begin":390,"end":394},"obj":"UBERON:0002048"},{"id":"T28","span":{"begin":419,"end":427},"obj":"SP_10"},{"id":"T28542","span":{"begin":3,"end":13},"obj":"CHEBI:35222;CHEBI:35222"},{"id":"T14634","span":{"begin":19,"end":36},"obj":"CHEBI:25354;CHEBI:25354"},{"id":"T38268","span":{"begin":37,"end":57},"obj":"CHEBI:48561;CHEBI:48561"},{"id":"T7996","span":{"begin":67,"end":71},"obj":"PR:000003622;G_3;PG_10"},{"id":"T85494","span":{"begin":81,"end":91},"obj":"GO:0010467"},{"id":"T23807","span":{"begin":144,"end":150},"obj":"CHEBI:48561;CHEBI:48561"},{"id":"T85043","span":{"begin":166,"end":171},"obj":"NCBITaxon:10239"},{"id":"T68089","span":{"begin":238,"end":252},"obj":"UBERON:0004535"},{"id":"T69502","span":{"begin":329,"end":333},"obj":"G_3;PG_10;PR:000003622"},{"id":"T7389","span":{"begin":334,"end":338},"obj":"PR:000036013"},{"id":"T3955","span":{"begin":390,"end":394},"obj":"UBERON:0002048"},{"id":"T22854","span":{"begin":419,"end":427},"obj":"SP_10"}],"text":"CE inhibitors, and mineralocorticoid receptor antagonists increase ACE2 receptor expression, it has been tacitly believed that the use of these agents may facilitate viral disease; thus, they should not be used in high-risk patients with cardiovascular disease. Based on the anti-inflammatory benefits of the upregulation of the ACE2/Ang1-7/Mas axis and previously demonstrated benefits of lung function improvement in SARS-CoV infections, it has been hypothesized that the benefits of"}

{"project":"LitCovid-PubTator","denotations":[{"id":"27","span":{"begin":19,"end":45},"obj":"Gene"},{"id":"28","span":{"begin":67,"end":71},"obj":"Gene"},{"id":"29","span":{"begin":329,"end":333},"obj":"Gene"},{"id":"30","span":{"begin":334,"end":340},"obj":"Gene"},{"id":"34","span":{"begin":224,"end":232},"obj":"Species"},{"id":"37","span":{"begin":166,"end":179},"obj":"Disease"},{"id":"38","span":{"begin":238,"end":260},"obj":"Disease"},{"id":"39","span":{"begin":419,"end":438},"obj":"Disease"}],"attributes":[{"id":"A27","pred":"tao:has_database_id","subj":"27","obj":"Gene:4306"},{"id":"A28","pred":"tao:has_database_id","subj":"28","obj":"Gene:59272"},{"id":"A29","pred":"tao:has_database_id","subj":"29","obj":"Gene:59272"},{"id":"A30","pred":"tao:has_database_id","subj":"30","obj":"Gene:284"},{"id":"A34","pred":"tao:has_database_id","subj":"34","obj":"Tax:9606"},{"id":"A37","pred":"tao:has_database_id","subj":"37","obj":"MESH:D001102"},{"id":"A38","pred":"tao:has_database_id","subj":"38","obj":"MESH:D002318"},{"id":"A39","pred":"tao:has_database_id","subj":"39","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"CE inhibitors, and mineralocorticoid receptor antagonists increase ACE2 receptor expression, it has been tacitly believed that the use of these agents may facilitate viral disease; thus, they should not be used in high-risk patients with cardiovascular disease. Based on the anti-inflammatory benefits of the upregulation of the ACE2/Ang1-7/Mas axis and previously demonstrated benefits of lung function improvement in SARS-CoV infections, it has been hypothesized that the benefits of"}