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PMC:7161517 / 4247-5889 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T9 475-487 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T10 524-532 Body_part denotes bronchus http://purl.org/sig/ont/fma/fma7409
T11 534-549 Body_part denotes lung parenchyma http://purl.org/sig/ont/fma/fma27360
T12 551-556 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T13 558-569 Body_part denotes endothelium http://purl.org/sig/ont/fma/fma63916
T14 571-578 Body_part denotes kidneys http://purl.org/sig/ont/fma/fma7203
T15 580-588 Body_part denotes duodenum http://purl.org/sig/ont/fma/fma7206
T16 594-609 Body_part denotes small intestine http://purl.org/sig/ont/fma/fma7200
T17 978-991 Body_part denotes phenylalanine http://purl.org/sig/ont/fma/fma82754
T18 1213-1220 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T19 1241-1251 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T20 1274-1283 Body_part denotes intestine http://purl.org/sig/ont/fma/fma7199
T21 1292-1298 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T22 1559-1569 Body_part denotes calmodulin http://purl.org/sig/ont/fma/fma62343
T23 1584-1595 Body_part denotes cytoplasmic http://purl.org/sig/ont/fma/fma66835

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T14 49-52 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T15 435-438 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T16 524-532 Body_part denotes bronchus http://purl.obolibrary.org/obo/UBERON_0002185
T17 534-549 Body_part denotes lung parenchyma http://purl.obolibrary.org/obo/UBERON_0008946
T18 534-538 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T19 539-549 Body_part denotes parenchyma http://purl.obolibrary.org/obo/UBERON_0000353
T20 551-569 Body_part denotes heart, endothelium http://purl.obolibrary.org/obo/UBERON_0008307
T21 551-556 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T22 558-569 Body_part denotes endothelium http://purl.obolibrary.org/obo/UBERON_0001986
T23 580-588 Body_part denotes duodenum http://purl.obolibrary.org/obo/UBERON_0002114
T24 594-609 Body_part denotes small intestine http://purl.obolibrary.org/obo/UBERON_0002108
T25 600-609 Body_part denotes intestine http://purl.obolibrary.org/obo/UBERON_0000160
T26 1274-1283 Body_part denotes intestine http://purl.obolibrary.org/obo/UBERON_0000160
T27 1292-1298 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T28 1596-1600 Body_part denotes tail http://purl.obolibrary.org/obo/UBERON_0002415

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T39 289-292 Disease denotes AT1 http://purl.obolibrary.org/obo/MONDO_0008840
T40 1390-1395 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T30 341-350 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T31 448-449 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T32 466-474 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T33 524-532 http://purl.obolibrary.org/obo/UBERON_0002185 denotes bronchus
T34 534-538 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T35 534-538 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T36 551-556 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T37 551-556 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T38 551-556 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T39 551-556 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T40 558-569 http://purl.obolibrary.org/obo/UBERON_0001986 denotes endothelium
T41 571-578 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidneys
T42 571-578 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidneys
T43 571-578 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidneys
T44 594-609 http://purl.obolibrary.org/obo/UBERON_0002108 denotes small intestine
T45 624-625 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T46 682-683 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T47 769-775 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T48 800-803 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T49 804-805 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T50 1170-1171 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T51 1172-1174 http://purl.obolibrary.org/obo/CLO_0001382 denotes 48
T52 1211-1212 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T53 1274-1283 http://purl.obolibrary.org/obo/UBERON_0000160 denotes intestine
T54 1274-1283 http://www.ebi.ac.uk/efo/EFO_0000834 denotes intestine
T55 1292-1298 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T56 1292-1298 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidney
T57 1292-1298 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidney
T58 1327-1328 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T59 1520-1521 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T60 1557-1558 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T61 1596-1600 http://purl.obolibrary.org/obo/UBERON_0002415 denotes tail

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T43 0-11 Chemical denotes Angiotensin http://purl.obolibrary.org/obo/CHEBI_2719
T44 49-52 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T45 110-121 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T46 161-163 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T47 172-181 Chemical denotes dipeptide http://purl.obolibrary.org/obo/CHEBI_46761
T48 240-242 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T49 278-280 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T50 435-438 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T51 475-487 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T52 724-738 Chemical denotes ACE inhibitors http://purl.obolibrary.org/obo/CHEBI_35457
T53 728-738 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T54 902-904 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T55 947-958 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T56 976-991 Chemical denotes L-phenylalanine http://purl.obolibrary.org/obo/CHEBI_17295|http://purl.obolibrary.org/obo/CHEBI_29997|http://purl.obolibrary.org/obo/CHEBI_58095
T59 978-991 Chemical denotes phenylalanine http://purl.obolibrary.org/obo/CHEBI_28044
T60 1213-1220 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T61 1241-1251 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T62 1241-1246 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T63 1247-1251 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T12 341-358 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathway
T13 341-350 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T14 1396-1404 http://purl.obolibrary.org/obo/GO_0070265 denotes necrosis
T15 1396-1404 http://purl.obolibrary.org/obo/GO_0019835 denotes necrosis
T16 1396-1404 http://purl.obolibrary.org/obo/GO_0008219 denotes necrosis
T17 1396-1404 http://purl.obolibrary.org/obo/GO_0001906 denotes necrosis
T18 1507-1516 http://purl.obolibrary.org/obo/GO_0009058 denotes formation

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T29 0-31 Sentence denotes Angiotensin-Converting Enzyme 2
T30 32-132 Sentence denotes Classically, the RAS involves the conversion of angiotensinogen by renin into angiotensin I (Ang I).
T31 133-203 Sentence denotes Ang I is metabolized to Ang II via the dipeptide carboxypeptidase ACE.
T32 204-304 Sentence denotes The pro-inflammatory effects of Ang II (7, 8, 9) are mediated through Ang II type I (AT1) receptors.
T33 305-439 Sentence denotes Recently, the ACE2 receptor and its signaling pathway were identified as an important counter regulatory mechanism to the classic RAS.
T34 440-615 Sentence denotes ACE2 is a type I integral membrane glycoprotein (15) expressed predominantly in the bronchus, lung parenchyma, heart, endothelium, kidneys, duodenum, and small intestine (16).
T35 616-744 Sentence denotes ACE2 is a monocarboxypeptidase, unlike its homolog, ACE, which is a dipeptidase; ACE2 is not antagonized by ACE inhibitors (17).
T36 745-866 Sentence denotes Although ACE contains 2 active catalytic domains, ACE2 has a single catalytic domain with 42% identical residues (18,19).
T37 867-997 Sentence denotes The major substrate of ACE2 is Ang II, which upon C-terminus cleavage, produces angiotensin 1-7 (Ang1-7) and L-phenylalanine (20).
T38 998-1118 Sentence denotes Other substrates for ACE2 include Ang I, apelin-13, and dynorphin-13, which are catalyzed at much lower affinities (21).
T39 1119-1307 Sentence denotes The non-catalytic C-terminal domain of ACE2 shares a 48% sequence homology with collectrin, a protein involved in neutral amino acid reabsorption from the intestine and the kidney (22,23).
T40 1308-1537 Sentence denotes In the presence of a disintegrin and metalloproteinase 17 (ADAM17), also known as tumor necrosis factor (TNF)-α−converting enzyme (TACE), ACE2 exhibits ectodomain shedding (24), which results in the formation of a soluble enzyme.
T41 1538-1642 Sentence denotes ACE2 also contains a calmodulin domain on its cytoplasmic tail that influences ectodomain shedding (25).

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T7 1390-1395 Phenotype denotes tumor http://purl.obolibrary.org/obo/HP_0002664

LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T117 0-22 PG_10 denotes Angiotensin-Converting
T118 23-31 PG_10;PR:000003622 denotes Enzyme 2
T119 99-104 PR:000013883 denotes renin
T120 110-123 PR:000036008 denotes angiotensin I
T121 125-130 PR:000036008 denotes Ang I
T122 133-136 CHEBI:37886;CHEBI:37886;PR:000036008 denotes Ang
T123 137-138 PR:000036008;CHEBI:16382;CHEBI:16382 denotes I
T124 142-153 GO:0008152 denotes metabolized
T125 157-160 CHEBI:37886;CHEBI:37886 denotes Ang
T126 236-242 PR:000036009 denotes Ang II
T127 274-280 PR:000036009 denotes Ang II
T128 319-323 G_3;PG_10;PR:000003622 denotes ACE2
T129 440-444 G_3;PG_10;PR:000003622 denotes ACE2
T130 466-474 GO:0016020 denotes membrane
T131 475-487 CHEBI:17089;BV_11;CHEBI:17089 denotes glycoprotein
T132 493-502 GO:0010467 denotes expressed
T133 524-532 UBERON:0002185 denotes bronchus
T134 534-549 UBERON:0008946 denotes lung parenchyma
T135 551-556 UBERON:0008307 denotes heart
T136 558-569 UBERON:0008307 denotes endothelium
T137 571-578 UBERON:0002113 denotes kidneys
T138 580-588 UBERON:0002114 denotes duodenum
T139 600-609 UBERON:0002108 denotes intestine
T140 616-620 G_3;PG_10;PR:000003622 denotes ACE2
T141 659-666 SO:0000853 denotes homolog
T142 697-701 G_3;PG_10;PR:000003622 denotes ACE2
T143 728-738 CHEBI:35222;CHEBI:35222 denotes inhibitors
T144 786-793 SO:0000417 denotes domains
T145 795-799 G_3;PG_10;PR:000003622 denotes ACE2
T146 823-829 SO:0000417 denotes domain
T147 890-894 G_3;PG_10;PR:000003622 denotes ACE2
T148 898-904 PR:000036009 denotes Ang II
T149 928-936 MOP:0000780 denotes cleavage
T150 947-960 PR:000036013 denotes angiotensin 1
T151 964-969 PR:000036013 denotes Ang1-
T152 1019-1023 G_3;PG_10;PR:000003622 denotes ACE2
T153 1032-1037 PR:000036008 denotes Ang I
T154 1039-1045 PR:000004135 denotes apelin
T155 1148-1154 SO:0000417 denotes domain
T156 1158-1162 G_3;PG_10;PR:000003622 denotes ACE2
T157 1185-1193 SO:0000853 denotes homology
T158 1199-1209 PR:000016422 denotes collectrin
T159 1274-1283 UBERON:0000160 denotes intestine
T160 1292-1298 UBERON:0002113 denotes kidney
T161 1367-1373 PR:000001279 denotes ADAM17
T162 1413-1416 PR:000000134 denotes TNF
T163 1446-1450 PR:000003622;G_3;PG_10 denotes ACE2
T164 1538-1542 G_3;PG_10;PR:000003622 denotes ACE2
T165 1559-1569 PR:000004978 denotes calmodulin
T166 1570-1576 SO:0000417 denotes domain
T167 1584-1595 GO:0005737 denotes cytoplasmic
T45363 403-407 G_3;PG_10;PR:000003622 denotes lato
T60689 417-421 NCBITaxon:10088 denotes sm t
T27389 427-433 PR:000036009 denotes classi
T28823 459-463 G_3;PG_10;PR:000003622 denotes tegr
T40619 484-488 PR:000000104 denotes ein
T48796 492-496 PR:000009197 denotes exp
T17022 497-502 PR:000002089 denotes essed
T32537 508-511 PR:000045382;GO:0000187 denotes min
T9224 512-521 GO:0000165 denotes ntly in t
T33582 590-596 PR:000036009 denotes and sm
T84252 605-615 UBERON:0002349 denotes tine (16).
T53574 730-734 G_3;PG_10;PR:000003622 denotes hibi
T46680 735-739 PR:000036013 denotes ors
T39192 753-763 GO:0065007 denotes ACE conta
T26804 768-778 GO:0010467 denotes active ca
T20064 818-823 PR:000000134 denotes ytic
T15398 846-850 PR:000001393 denotes al r
T8292 852-860 CL:0000576;PR:000002122 denotes idues (1
T65564 861-886 PR:000002122 denotes ,19). The major substrate
T59008 892-920 PR:000000046 denotes E2 is Ang II, which upon C-t
T45631 924-932 UBERON:0000948 denotes nus clea
T9280 940-944 UBERON:0002048 denotes oduc
T93124 955-964 UBERON:0002048 denotes sin 1-7 (
T11843 1056-1062 G_3;PG_10;PR:000003622 denotes norphi
T96445 1063-1067 PR:000036013 denotes -13,
T35230 1070-1073 PR:000001563 denotes ich
T22891 1078-1104 GO:0065007 denotes catalyzed at much lower af
T24013 1121-1134 PR:000036008 denotes e non-catalyt
T33081 1136-1141 PR:000036008 denotes C-te
T91867 1147-1152 PR:000013883 denotes doma
T97324 1154-1159 PR:000036008 denotes of A
T69975 1176-1182 PR:000036009 denotes sequen
T54028 1235-1245 MOP:0000619 denotes utral amin
T57012 1246-1256 CHEBI:3165;CHEBI:3165 denotes acid reab
T52135 1275-1284 CHEBI:25212;CHEBI:25212 denotes ntestine
T38693 1342-1350 PR:000036009 denotes nd metal
T22665 1367-1373 PR:000036009 denotes ADAM17
T71601 1413-1424 CHEBI:27584;CHEBI:27584 denotes TNF)-α−conv
T2211 1444-1459 UBERON:0001236 denotes , ACE2 exhibits
T65489 1504-1512 UBERON:0002198 denotes he forma
T91280 1514-1525 CHEBI:27584;CHEBI:27584 denotes on of a sol
T15577 1536-1544 GO:0016020 denotes . ACE2 a
T79802 1545-1549 G_3;PG_10;PR:000003622 denotes so c
T96225 1550-1560 GO:0010467 denotes ntains a c
T26369 1562-1572 UBERON:0001986;PR:000006897 denotes modulin do
T89251 1572-1574 PR:000006897 denotes ma
T83262 1584-1597 PR:000036013 denotes cytoplasmic t
T85112 1601-1605 PR:000036013 denotes that
T54914 1613-1626 GO:0005576 denotes ces ectodomai

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
151 0-29 Gene denotes Angiotensin-Converting Enzyme Gene:1636
161 99-104 Gene denotes renin Gene:5972
162 110-123 Gene denotes angiotensin I Gene:183
163 125-130 Gene denotes Ang I Gene:183
164 236-242 Gene denotes Ang II Gene:183
165 319-323 Gene denotes ACE2 Gene:59272
166 133-138 Gene denotes Ang I Gene:183
167 80-95 Gene denotes angiotensinogen Gene:183
168 199-202 Gene denotes ACE Gene:1636
169 157-160 Gene denotes Ang Gene:283
191 440-444 Gene denotes ACE2 Gene:59272
192 616-620 Gene denotes ACE2 Gene:59272
193 668-671 Gene denotes ACE Gene:1636
194 697-701 Gene denotes ACE2 Gene:59272
195 724-727 Gene denotes ACE Gene:1636
196 795-799 Gene denotes ACE2 Gene:59272
197 890-894 Gene denotes ACE2 Gene:59272
198 898-904 Gene denotes Ang II Gene:183
199 964-970 Gene denotes Ang1-7 Gene:284
200 1019-1023 Gene denotes ACE2 Gene:59272
201 1032-1037 Gene denotes Ang I Gene:183
202 1158-1162 Gene denotes ACE2 Gene:59272
203 1199-1209 Gene denotes collectrin Gene:57393
204 1367-1373 Gene denotes ADAM17 Gene:6868
205 1390-1437 Gene denotes tumor necrosis factor (TNF)-α−converting enzyme Gene:6868
206 1439-1443 Gene denotes TACE Gene:6868
207 1446-1450 Gene denotes ACE2 Gene:59272
208 1538-1542 Gene denotes ACE2 Gene:59272
209 754-757 Gene denotes ACE Gene:1636
210 1559-1569 Gene denotes calmodulin Gene:801
211 976-991 Chemical denotes L-phenylalanine MESH:D010649

2_test

Id Subject Object Predicate Lexical cue
32305401-29217510-55252919 244-245 29217510 denotes 7
32305401-10773230-55252920 247-248 10773230 denotes 8
32305401-8307637-55252921 250-251 8307637 denotes 9
32305401-24309898-55252922 611-613 24309898 denotes 16
32305401-15283675-55252923 740-742 15283675 denotes 17
32305401-1649623-55252924 859-861 1649623 denotes 18
32305401-2849100-55252925 862-864 2849100 denotes 19
32305401-11931993-55252926 993-995 11931993 denotes 20
32305401-11815627-55252927 1114-1116 11815627 denotes 21
32305401-18424768-55252928 1303-1305 18424768 denotes 23
32305401-15983030-55252929 1481-1483 15983030 denotes 24
32305401-18070603-55252930 1638-1640 18070603 denotes 25