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PMC:7161517 / 31944-33323 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T195 743-748 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T196 832-837 Body_part denotes Heart http://purl.org/sig/ont/fma/fma7088
T197 851-856 Body_part denotes Heart http://purl.org/sig/ont/fma/fma7088
T198 1059-1065 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T85 743-748 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T86 832-837 Body_part denotes Heart http://purl.obolibrary.org/obo/UBERON_0000948
T87 851-856 Body_part denotes Heart http://purl.obolibrary.org/obo/UBERON_0000948
T88 958-961 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T89 1059-1065 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T90 1248-1251 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T91 1323-1326 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T176 3-11 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T177 335-347 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T178 387-395 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T179 422-444 Disease denotes cardiovascular disease http://purl.obolibrary.org/obo/MONDO_0004995
T180 449-457 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T181 743-756 Disease denotes heart failure http://purl.obolibrary.org/obo/MONDO_0005252
T182 851-864 Disease denotes Heart Failure http://purl.obolibrary.org/obo/MONDO_0005252
T183 1107-1115 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T184 1133-1155 Disease denotes cardiovascular disease http://purl.obolibrary.org/obo/MONDO_0004995
T185 1222-1230 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T186 1370-1378 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T308 29-37 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T309 522-523 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T310 566-567 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T311 743-748 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T312 743-748 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T313 743-748 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T314 743-748 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T315 832-837 http://purl.obolibrary.org/obo/UBERON_0000948 denotes Heart
T316 832-837 http://purl.obolibrary.org/obo/UBERON_0007100 denotes Heart
T317 832-837 http://purl.obolibrary.org/obo/UBERON_0015228 denotes Heart
T318 832-837 http://www.ebi.ac.uk/efo/EFO_0000815 denotes Heart
T319 851-856 http://purl.obolibrary.org/obo/UBERON_0000948 denotes Heart
T320 851-856 http://purl.obolibrary.org/obo/UBERON_0007100 denotes Heart
T321 851-856 http://purl.obolibrary.org/obo/UBERON_0015228 denotes Heart
T322 851-856 http://www.ebi.ac.uk/efo/EFO_0000815 denotes Heart
T323 1016-1017 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T334 472-486 Chemical denotes ACE inhibitors http://purl.obolibrary.org/obo/CHEBI_35457
T335 476-486 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T336 958-961 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T337 962-973 Chemical denotes antagonists http://purl.obolibrary.org/obo/CHEBI_48706
T338 1248-1251 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T339 1252-1262 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T340 1323-1326 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T87 250-260 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T88 335-347 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T194 0-398 Sentence denotes If SARS-CoV-2 down-regulates membrane-bound ACE2 by promoting the ADAM17−mediated ectodomain shedding, resulting in increased concentrations of soluble ACE2 without compromising viral propagation, we hypothesize this would result in the overall down regulation of the ACE2/Ang1-7/Mas pathway, which would contribute to the severity of inflammation and systemic dysregulation observed in SARS-CoV-2.
T195 399-757 Sentence denotes Thus, in patients with cardiovascular disease and SARS-CoV-2, the use of ACE inhibitors, ARBs, or MRAs may be favorable as a method to endogenously upregulate ACE2 as a compensatory mechanism that provides anti-inflammatory, antifibrotic, and antithrombotic support as well as reduction in progression of vascular and/or cardiac remodeling and heart failure.
T196 758-1156 Sentence denotes Several societies, including the American College of Cardiology, American Heart Association, Heart Failure Society of America (68), and European Society of Cardiology (69) have recommended continuing RAS antagonists because of the lack of conclusive data on a link between upregulation of systemic or tissue ACE2 and the increased susceptibility to COVID-19 in patients with cardiovascular disease.
T197 1157-1379 Sentence denotes Based on our review, we hypothesize cardiovascular patients with COVID-19 should remain on RAS inhibitors because of the protective effects of the ACE2 pathway until RAS blockade is proven to increase the risk of COVID-19.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T49 422-444 Phenotype denotes cardiovascular disease http://purl.obolibrary.org/obo/HP_0001626
T50 743-756 Phenotype denotes heart failure http://purl.obolibrary.org/obo/HP_0001635
T51 851-864 Phenotype denotes Heart Failure http://purl.obolibrary.org/obo/HP_0001635
T52 1133-1155 Phenotype denotes cardiovascular disease http://purl.obolibrary.org/obo/HP_0001626

LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T1034 3-13 SP_7 denotes SARS-CoV-2
T1035 29-37 GO:0016020 denotes membrane
T1036 44-48 G_3;PG_10;PR:000003622 denotes ACE2
T1037 66-72 PR:000001279 denotes ADAM17
T1038 152-156 G_3;PG_10;PR:000003622 denotes ACE2
T1039 178-183 NCBITaxon:10239 denotes viral
T1040 268-272 G_3;PG_10;PR:000003622 denotes ACE2
T1041 273-277 PR:000036013 denotes Ang1
T1042 280-283 PR:000001563 denotes Mas
T1043 361-374 GO:0065007 denotes dysregulation
T1044 387-397 SP_7 denotes SARS-CoV-2
T1045 422-436 UBERON:0004535 denotes cardiovascular
T1046 449-459 SP_7 denotes SARS-CoV-2
T1047 476-486 CHEBI:35222;CHEBI:35222 denotes inhibitors
T1048 558-562 G_3;PG_10;PR:000003622 denotes ACE2
T1049 720-727 UBERON:0000948 denotes cardiac
T1050 743-748 UBERON:0000948 denotes heart
T1051 811-821 UBERON:0000948 denotes Cardiology
T1052 832-837 UBERON:0000948 denotes Heart
T1053 851-856 UBERON:0000948 denotes Heart
T1054 914-924 UBERON:0000948 denotes Cardiology
T1055 1059-1065 UBERON:0000479 denotes tissue
T1056 1066-1070 G_3;PG_10;PR:000003622 denotes ACE2
T1057 1107-1115 SP_7 denotes COVID-19
T1058 1133-1147 UBERON:0004535 denotes cardiovascular
T1059 1193-1207 UBERON:0004535 denotes cardiovascular
T1060 1222-1230 SP_7 denotes COVID-19
T1061 1252-1262 CHEBI:35222;CHEBI:35222 denotes inhibitors
T1062 1304-1308 G_3;PG_10;PR:000003622 denotes ACE2
T1063 1370-1378 SP_7 denotes COVID-19
T49 268-272 G_3;PG_10;PR:000003622 denotes ACE2
T50 273-277 PR:000036013 denotes Ang1
T51 476-486 CHEBI:35222;CHEBI:35222 denotes inhibitors
T56 1133-1147 UBERON:0004535 denotes cardiovascular
T42119 1222-1230 SP_7 denotes COVID-19
T90528 3-13 SP_7 denotes SARS-CoV-2
T82967 29-37 GO:0016020 denotes membrane
T4860 44-48 G_3;PG_10;PR:000003622 denotes ACE2
T49764 66-72 PR:000001279 denotes ADAM17
T57158 152-156 G_3;PG_10;PR:000003622 denotes ACE2
T51582 178-183 NCBITaxon:10239 denotes viral
T18657 268-272 G_3;PG_10;PR:000003622 denotes ACE2
T56429 273-277 PR:000036013 denotes Ang1
T24733 280-283 PR:000001563 denotes Mas
T40354 361-374 GO:0065007 denotes dysregulation
T61569 387-397 SP_7 denotes SARS-CoV-2
T7547 422-436 UBERON:0004535 denotes cardiovascular
T55968 449-459 SP_7 denotes SARS-CoV-2
T80913 476-486 CHEBI:35222;CHEBI:35222 denotes inhibitors
T91618 558-562 G_3;PG_10;PR:000003622 denotes ACE2
T66182 720-727 UBERON:0000948 denotes cardiac
T49783 743-748 UBERON:0000948 denotes heart
T17759 811-821 UBERON:0000948 denotes Cardiology
T7351 832-837 UBERON:0000948 denotes Heart
T73963 851-856 UBERON:0000948 denotes Heart
T87034 914-924 UBERON:0000948 denotes Cardiology
T40873 1059-1065 UBERON:0000479 denotes tissue
T70153 1066-1070 G_3;PG_10;PR:000003622 denotes ACE2
T30590 1107-1115 SP_7 denotes COVID-19
T5335 1133-1147 UBERON:0004535 denotes cardiovascular
T24575 1193-1207 UBERON:0004535 denotes cardiovascular
T78530 1222-1230 SP_7 denotes COVID-19
T40154 1252-1262 CHEBI:35222;CHEBI:35222 denotes inhibitors
T60460 1304-1308 G_3;PG_10;PR:000003622 denotes ACE2
T33728 1370-1378 SP_7 denotes COVID-19

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1354 44-48 Gene denotes ACE2 Gene:59272
1355 66-72 Gene denotes ADAM17 Gene:6868
1356 152-156 Gene denotes ACE2 Gene:59272
1357 268-272 Gene denotes ACE2 Gene:59272
1358 273-279 Gene denotes Ang1-7 Gene:284
1359 472-475 Gene denotes ACE Gene:1636
1360 558-562 Gene denotes ACE2 Gene:59272
1361 1066-1070 Gene denotes ACE2 Gene:59272
1362 1304-1308 Gene denotes ACE2 Gene:59272
1363 3-13 Species denotes SARS-CoV-2 Tax:2697049
1364 387-397 Species denotes SARS-CoV-2 Tax:2697049
1365 408-416 Species denotes patients Tax:9606
1366 449-459 Species denotes SARS-CoV-2 Tax:2697049
1367 1119-1127 Species denotes patients Tax:9606
1368 1208-1216 Species denotes patients Tax:9606
1369 335-347 Disease denotes inflammation MESH:D007249
1370 422-444 Disease denotes cardiovascular disease MESH:D002318
1371 743-756 Disease denotes heart failure MESH:D006333
1372 1107-1115 Disease denotes COVID-19 MESH:C000657245
1373 1133-1155 Disease denotes cardiovascular disease MESH:D002318
1374 1222-1230 Disease denotes COVID-19 MESH:C000657245
1375 1370-1378 Disease denotes COVID-19 MESH:C000657245