PMC:7161517 / 277-762 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T2","span":{"begin":105,"end":109},"obj":"Body_part"}],"attributes":[{"id":"A2","pred":"fma_id","subj":"T2","obj":"http://purl.org/sig/ont/fma/fma12520"}],"text":"regulation observed in SARS-CoV was previously postulated to be due to ACE2/angiotensin 1-7 (Ang1-7)/Mas axis downregulation; increased ACE2 activity was shown to mediate disease protection. Because angiotensin II receptor blockers, ACE inhibitors, and mineralocorticoid receptor antagonists increase ACE2 receptor expression, it has been tacitly believed that the use of these agents may facilitate viral disease; thus, they should not be used in high-risk patients with cardiovascula"}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T5","span":{"begin":23,"end":31},"obj":"Disease"},{"id":"T6","span":{"begin":400,"end":413},"obj":"Disease"}],"attributes":[{"id":"A5","pred":"mondo_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A6","pred":"mondo_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/MONDO_0005108"}],"text":"regulation observed in SARS-CoV was previously postulated to be due to ACE2/angiotensin 1-7 (Ang1-7)/Mas axis downregulation; increased ACE2 activity was shown to mediate disease protection. Because angiotensin II receptor blockers, ACE inhibitors, and mineralocorticoid receptor antagonists increase ACE2 receptor expression, it has been tacitly believed that the use of these agents may facilitate viral disease; thus, they should not be used in high-risk patients with cardiovascula"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T2","span":{"begin":141,"end":149},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T3","span":{"begin":330,"end":333},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"}],"text":"regulation observed in SARS-CoV was previously postulated to be due to ACE2/angiotensin 1-7 (Ang1-7)/Mas axis downregulation; increased ACE2 activity was shown to mediate disease protection. Because angiotensin II receptor blockers, ACE inhibitors, and mineralocorticoid receptor antagonists increase ACE2 receptor expression, it has been tacitly believed that the use of these agents may facilitate viral disease; thus, they should not be used in high-risk patients with cardiovascula"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T3","span":{"begin":76,"end":87},"obj":"Chemical"},{"id":"T4","span":{"begin":199,"end":213},"obj":"Chemical"},{"id":"T7","span":{"begin":199,"end":210},"obj":"Chemical"},{"id":"T8","span":{"begin":211,"end":213},"obj":"Chemical"},{"id":"T9","span":{"begin":233,"end":247},"obj":"Chemical"},{"id":"T10","span":{"begin":237,"end":247},"obj":"Chemical"},{"id":"T11","span":{"begin":253,"end":270},"obj":"Chemical"},{"id":"T12","span":{"begin":280,"end":291},"obj":"Chemical"}],"attributes":[{"id":"A3","pred":"chebi_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CHEBI_48433"},{"id":"A4","pred":"chebi_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/CHEBI_2719"},{"id":"A5","pred":"chebi_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/CHEBI_48432"},{"id":"A6","pred":"chebi_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/CHEBI_58506"},{"id":"A7","pred":"chebi_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/CHEBI_48433"},{"id":"A8","pred":"chebi_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/CHEBI_74067"},{"id":"A9","pred":"chebi_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/CHEBI_35457"},{"id":"A10","pred":"chebi_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A11","pred":"chebi_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/CHEBI_25354"},{"id":"A12","pred":"chebi_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/CHEBI_48706"}],"text":"regulation observed in SARS-CoV was previously postulated to be due to ACE2/angiotensin 1-7 (Ang1-7)/Mas axis downregulation; increased ACE2 activity was shown to mediate disease protection. Because angiotensin II receptor blockers, ACE inhibitors, and mineralocorticoid receptor antagonists increase ACE2 receptor expression, it has been tacitly believed that the use of these agents may facilitate viral disease; thus, they should not be used in high-risk patients with cardiovascula"}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T10","span":{"begin":23,"end":31},"obj":"SP_10"},{"id":"T11","span":{"begin":71,"end":75},"obj":"G_3;PG_10;PR:000003622"},{"id":"T12","span":{"begin":76,"end":89},"obj":"PR:000036013"},{"id":"T13","span":{"begin":93,"end":97},"obj":"PR:000036013"},{"id":"T14","span":{"begin":136,"end":140},"obj":"G_3;PG_10;PR:000003622"},{"id":"T15","span":{"begin":199,"end":213},"obj":"DG_37;PR:000001118"},{"id":"T16","span":{"begin":214,"end":222},"obj":"PR:000001118"},{"id":"T17","span":{"begin":237,"end":247},"obj":"CHEBI:35222;CHEBI:35222"},{"id":"T18","span":{"begin":253,"end":270},"obj":"CHEBI:25354;CHEBI:25354"},{"id":"T19","span":{"begin":271,"end":291},"obj":"CHEBI:48561;CHEBI:48561"},{"id":"T20","span":{"begin":301,"end":305},"obj":"PR:000003622;G_3;PG_10"},{"id":"T21","span":{"begin":315,"end":325},"obj":"GO:0010467"},{"id":"T22","span":{"begin":378,"end":384},"obj":"CHEBI:48561;CHEBI:48561"},{"id":"T23","span":{"begin":400,"end":405},"obj":"NCBITaxon:10239"},{"id":"T31949","span":{"begin":23,"end":31},"obj":"SP_10"},{"id":"T17436","span":{"begin":71,"end":75},"obj":"G_3;PG_10;PR:000003622"},{"id":"T37458","span":{"begin":76,"end":89},"obj":"PR:000036013"},{"id":"T46294","span":{"begin":93,"end":97},"obj":"PR:000036013"},{"id":"T60166","span":{"begin":136,"end":140},"obj":"G_3;PG_10;PR:000003622"},{"id":"T39187","span":{"begin":199,"end":213},"obj":"DG_37;PR:000001118"},{"id":"T33501","span":{"begin":214,"end":222},"obj":"PR:000001118"},{"id":"T28542","span":{"begin":237,"end":247},"obj":"CHEBI:35222;CHEBI:35222"},{"id":"T14634","span":{"begin":253,"end":270},"obj":"CHEBI:25354;CHEBI:25354"},{"id":"T38268","span":{"begin":271,"end":291},"obj":"CHEBI:48561;CHEBI:48561"},{"id":"T7996","span":{"begin":301,"end":305},"obj":"PR:000003622;G_3;PG_10"},{"id":"T85494","span":{"begin":315,"end":325},"obj":"GO:0010467"},{"id":"T23807","span":{"begin":378,"end":384},"obj":"CHEBI:48561;CHEBI:48561"},{"id":"T85043","span":{"begin":400,"end":405},"obj":"NCBITaxon:10239"}],"text":"regulation observed in SARS-CoV was previously postulated to be due to ACE2/angiotensin 1-7 (Ang1-7)/Mas axis downregulation; increased ACE2 activity was shown to mediate disease protection. Because angiotensin II receptor blockers, ACE inhibitors, and mineralocorticoid receptor antagonists increase ACE2 receptor expression, it has been tacitly believed that the use of these agents may facilitate viral disease; thus, they should not be used in high-risk patients with cardiovascula"}

{"project":"LitCovid-PubTator","denotations":[{"id":"23","span":{"begin":71,"end":91},"obj":"Gene"},{"id":"24","span":{"begin":93,"end":99},"obj":"Gene"},{"id":"25","span":{"begin":136,"end":140},"obj":"Gene"},{"id":"26","span":{"begin":233,"end":236},"obj":"Gene"},{"id":"27","span":{"begin":253,"end":279},"obj":"Gene"},{"id":"28","span":{"begin":301,"end":305},"obj":"Gene"},{"id":"33","span":{"begin":23,"end":31},"obj":"Species"},{"id":"34","span":{"begin":458,"end":466},"obj":"Species"},{"id":"37","span":{"begin":400,"end":413},"obj":"Disease"}],"attributes":[{"id":"A23","pred":"tao:has_database_id","subj":"23","obj":"Gene:59272"},{"id":"A24","pred":"tao:has_database_id","subj":"24","obj":"Gene:284"},{"id":"A25","pred":"tao:has_database_id","subj":"25","obj":"Gene:59272"},{"id":"A26","pred":"tao:has_database_id","subj":"26","obj":"Gene:1636"},{"id":"A27","pred":"tao:has_database_id","subj":"27","obj":"Gene:4306"},{"id":"A28","pred":"tao:has_database_id","subj":"28","obj":"Gene:59272"},{"id":"A33","pred":"tao:has_database_id","subj":"33","obj":"Tax:694009"},{"id":"A34","pred":"tao:has_database_id","subj":"34","obj":"Tax:9606"},{"id":"A37","pred":"tao:has_database_id","subj":"37","obj":"MESH:D001102"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"regulation observed in SARS-CoV was previously postulated to be due to ACE2/angiotensin 1-7 (Ang1-7)/Mas axis downregulation; increased ACE2 activity was shown to mediate disease protection. Because angiotensin II receptor blockers, ACE inhibitors, and mineralocorticoid receptor antagonists increase ACE2 receptor expression, it has been tacitly believed that the use of these agents may facilitate viral disease; thus, they should not be used in high-risk patients with cardiovascula"}