PMC:7161517 / 26727-27422 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T149","span":{"begin":159,"end":166},"obj":"Body_part"},{"id":"T150","span":{"begin":195,"end":202},"obj":"Body_part"},{"id":"T151","span":{"begin":210,"end":217},"obj":"Body_part"},{"id":"T152","span":{"begin":327,"end":333},"obj":"Body_part"},{"id":"T153","span":{"begin":552,"end":562},"obj":"Body_part"}],"attributes":[{"id":"A149","pred":"fma_id","subj":"T149","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A150","pred":"fma_id","subj":"T150","obj":"http://purl.org/sig/ont/fma/fma66836"},{"id":"A151","pred":"fma_id","subj":"T151","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A152","pred":"fma_id","subj":"T152","obj":"http://purl.org/sig/ont/fma/fma82764"},{"id":"A153","pred":"fma_id","subj":"T153","obj":"http://purl.org/sig/ont/fma/fma62343"}],"text":"Proposed Mechanism of Entry for SARS-CoV-2 Via ACE2\nSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds to the catalytic site of ACE2 via its S protein. To gain access to the host cytosol, the S protein undergoes acid dependent proteolytic cleavage by ACE2, tumor necrosis factor (TNF)-α, transmembrane protease serine 2 (TMPRRS2), which results in the formation of an S1 and S2 subunit. S2 fusion peptide inserts into the membrane, which allows for clatherin-dependent endocytosis of ACE2-SARS-CoV-2. Viral binding stimulates TNF-α and calmodulin inhibitors to promote ectodomain cleavage of ACE2. ADAM 17 = disintegrin and metalloprotease 17; other abbreviations as in Figure 1."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T136","span":{"begin":32,"end":40},"obj":"Disease"},{"id":"T137","span":{"begin":52,"end":99},"obj":"Disease"},{"id":"T138","span":{"begin":101,"end":109},"obj":"Disease"},{"id":"T139","span":{"begin":273,"end":278},"obj":"Disease"},{"id":"T140","span":{"begin":505,"end":513},"obj":"Disease"}],"attributes":[{"id":"A136","pred":"mondo_id","subj":"T136","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A137","pred":"mondo_id","subj":"T137","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A138","pred":"mondo_id","subj":"T138","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A139","pred":"mondo_id","subj":"T139","obj":"http://purl.obolibrary.org/obo/MONDO_0005070"},{"id":"A140","pred":"mondo_id","subj":"T140","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"Proposed Mechanism of Entry for SARS-CoV-2 Via ACE2\nSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds to the catalytic site of ACE2 via its S protein. To gain access to the host cytosol, the S protein undergoes acid dependent proteolytic cleavage by ACE2, tumor necrosis factor (TNF)-α, transmembrane protease serine 2 (TMPRRS2), which results in the formation of an S1 and S2 subunit. S2 fusion peptide inserts into the membrane, which allows for clatherin-dependent endocytosis of ACE2-SARS-CoV-2. Viral binding stimulates TNF-α and calmodulin inhibitors to promote ectodomain cleavage of ACE2. ADAM 17 = disintegrin and metalloprotease 17; other abbreviations as in Figure 1."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T240","span":{"begin":384,"end":386},"obj":"http://purl.obolibrary.org/obo/CLO_0050050"},{"id":"T241","span":{"begin":391,"end":393},"obj":"http://purl.obolibrary.org/obo/CLO_0008922"},{"id":"T242","span":{"begin":391,"end":393},"obj":"http://purl.obolibrary.org/obo/CLO_0050052"},{"id":"T243","span":{"begin":403,"end":405},"obj":"http://purl.obolibrary.org/obo/CLO_0008922"},{"id":"T244","span":{"begin":403,"end":405},"obj":"http://purl.obolibrary.org/obo/CLO_0050052"},{"id":"T245","span":{"begin":413,"end":420},"obj":"http://purl.obolibrary.org/obo/PR_000018263"},{"id":"T246","span":{"begin":438,"end":446},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"}],"text":"Proposed Mechanism of Entry for SARS-CoV-2 Via ACE2\nSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds to the catalytic site of ACE2 via its S protein. To gain access to the host cytosol, the S protein undergoes acid dependent proteolytic cleavage by ACE2, tumor necrosis factor (TNF)-α, transmembrane protease serine 2 (TMPRRS2), which results in the formation of an S1 and S2 subunit. S2 fusion peptide inserts into the membrane, which allows for clatherin-dependent endocytosis of ACE2-SARS-CoV-2. Viral binding stimulates TNF-α and calmodulin inhibitors to promote ectodomain cleavage of ACE2. ADAM 17 = disintegrin and metalloprotease 17; other abbreviations as in Figure 1."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T295","span":{"begin":159,"end":166},"obj":"Chemical"},{"id":"T296","span":{"begin":210,"end":217},"obj":"Chemical"},{"id":"T297","span":{"begin":228,"end":232},"obj":"Chemical"},{"id":"T298","span":{"begin":327,"end":333},"obj":"Chemical"},{"id":"T299","span":{"begin":391,"end":393},"obj":"Chemical"},{"id":"T300","span":{"begin":403,"end":405},"obj":"Chemical"},{"id":"T301","span":{"begin":413,"end":420},"obj":"Chemical"},{"id":"T302","span":{"begin":563,"end":573},"obj":"Chemical"}],"attributes":[{"id":"A295","pred":"chebi_id","subj":"T295","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A296","pred":"chebi_id","subj":"T296","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A297","pred":"chebi_id","subj":"T297","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A298","pred":"chebi_id","subj":"T298","obj":"http://purl.obolibrary.org/obo/CHEBI_17822"},{"id":"A299","pred":"chebi_id","subj":"T299","obj":"http://purl.obolibrary.org/obo/CHEBI_29387"},{"id":"A300","pred":"chebi_id","subj":"T300","obj":"http://purl.obolibrary.org/obo/CHEBI_29387"},{"id":"A301","pred":"chebi_id","subj":"T301","obj":"http://purl.obolibrary.org/obo/CHEBI_16670"},{"id":"A302","pred":"chebi_id","subj":"T302","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"}],"text":"Proposed Mechanism of Entry for SARS-CoV-2 Via ACE2\nSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds to the catalytic site of ACE2 via its S protein. To gain access to the host cytosol, the S protein undergoes acid dependent proteolytic cleavage by ACE2, tumor necrosis factor (TNF)-α, transmembrane protease serine 2 (TMPRRS2), which results in the formation of an S1 and S2 subunit. S2 fusion peptide inserts into the membrane, which allows for clatherin-dependent endocytosis of ACE2-SARS-CoV-2. Viral binding stimulates TNF-α and calmodulin inhibitors to promote ectodomain cleavage of ACE2. ADAM 17 = disintegrin and metalloprotease 17; other abbreviations as in Figure 1."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T67","span":{"begin":279,"end":287},"obj":"http://purl.obolibrary.org/obo/GO_0070265"},{"id":"T68","span":{"begin":279,"end":287},"obj":"http://purl.obolibrary.org/obo/GO_0019835"},{"id":"T69","span":{"begin":279,"end":287},"obj":"http://purl.obolibrary.org/obo/GO_0008219"},{"id":"T70","span":{"begin":279,"end":287},"obj":"http://purl.obolibrary.org/obo/GO_0001906"},{"id":"T71","span":{"begin":368,"end":377},"obj":"http://purl.obolibrary.org/obo/GO_0009058"},{"id":"T72","span":{"begin":485,"end":496},"obj":"http://purl.obolibrary.org/obo/GO_0006897"},{"id":"T73","span":{"begin":585,"end":604},"obj":"http://purl.obolibrary.org/obo/GO_0006509"}],"text":"Proposed Mechanism of Entry for SARS-CoV-2 Via ACE2\nSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds to the catalytic site of ACE2 via its S protein. To gain access to the host cytosol, the S protein undergoes acid dependent proteolytic cleavage by ACE2, tumor necrosis factor (TNF)-α, transmembrane protease serine 2 (TMPRRS2), which results in the formation of an S1 and S2 subunit. S2 fusion peptide inserts into the membrane, which allows for clatherin-dependent endocytosis of ACE2-SARS-CoV-2. Viral binding stimulates TNF-α and calmodulin inhibitors to promote ectodomain cleavage of ACE2. ADAM 17 = disintegrin and metalloprotease 17; other abbreviations as in Figure 1."}

{"project":"LitCovid-sentences","denotations":[{"id":"T165","span":{"begin":52,"end":167},"obj":"Sentence"},{"id":"T166","span":{"begin":168,"end":402},"obj":"Sentence"},{"id":"T167","span":{"begin":403,"end":516},"obj":"Sentence"},{"id":"T168","span":{"begin":517,"end":613},"obj":"Sentence"},{"id":"T169","span":{"begin":614,"end":695},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Proposed Mechanism of Entry for SARS-CoV-2 Via ACE2\nSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds to the catalytic site of ACE2 via its S protein. To gain access to the host cytosol, the S protein undergoes acid dependent proteolytic cleavage by ACE2, tumor necrosis factor (TNF)-α, transmembrane protease serine 2 (TMPRRS2), which results in the formation of an S1 and S2 subunit. S2 fusion peptide inserts into the membrane, which allows for clatherin-dependent endocytosis of ACE2-SARS-CoV-2. Viral binding stimulates TNF-α and calmodulin inhibitors to promote ectodomain cleavage of ACE2. ADAM 17 = disintegrin and metalloprotease 17; other abbreviations as in Figure 1."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T41","span":{"begin":273,"end":278},"obj":"Phenotype"}],"attributes":[{"id":"A41","pred":"hp_id","subj":"T41","obj":"http://purl.obolibrary.org/obo/HP_0002664"}],"text":"Proposed Mechanism of Entry for SARS-CoV-2 Via ACE2\nSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds to the catalytic site of ACE2 via its S protein. To gain access to the host cytosol, the S protein undergoes acid dependent proteolytic cleavage by ACE2, tumor necrosis factor (TNF)-α, transmembrane protease serine 2 (TMPRRS2), which results in the formation of an S1 and S2 subunit. S2 fusion peptide inserts into the membrane, which allows for clatherin-dependent endocytosis of ACE2-SARS-CoV-2. Viral binding stimulates TNF-α and calmodulin inhibitors to promote ectodomain cleavage of ACE2. ADAM 17 = disintegrin and metalloprotease 17; other abbreviations as in Figure 1."}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T854","span":{"begin":32,"end":42},"obj":"SP_7"},{"id":"T855","span":{"begin":47,"end":58},"obj":"G_3;PG_10;SP_7"},{"id":"T856","span":{"begin":59,"end":64},"obj":"SP_7"},{"id":"T857","span":{"begin":65,"end":76},"obj":"SP_7;GO:0045333;UBERON:0001004"},{"id":"T858","span":{"begin":77,"end":99},"obj":"SP_7"},{"id":"T859","span":{"begin":101,"end":111},"obj":"SP_7"},{"id":"T860","span":{"begin":144,"end":148},"obj":"G_3;PG_10;PR:000003622"},{"id":"T861","span":{"begin":157,"end":166},"obj":"PG_1"},{"id":"T862","span":{"begin":190,"end":202},"obj":"GO:0044164"},{"id":"T863","span":{"begin":208,"end":217},"obj":"PG_1"},{"id":"T864","span":{"begin":228,"end":232},"obj":"CHEBI:37527;CHEBI:37527"},{"id":"T865","span":{"begin":233,"end":242},"obj":"GO:0010498"},{"id":"T866","span":{"begin":243,"end":254},"obj":"GO:0006508"},{"id":"T867","span":{"begin":255,"end":263},"obj":"MOP:0000780"},{"id":"T868","span":{"begin":267,"end":271},"obj":"G_3;PG_10;PR:000003622"},{"id":"T869","span":{"begin":296,"end":299},"obj":"PR:000000134"},{"id":"T870","span":{"begin":304,"end":317},"obj":"GO:0016020;PG_8"},{"id":"T871","span":{"begin":318,"end":335},"obj":"PG_8"},{"id":"T872","span":{"begin":421,"end":428},"obj":"SO:0000667"},{"id":"T873","span":{"begin":438,"end":446},"obj":"GO:0016020"},{"id":"T874","span":{"begin":465,"end":484},"obj":"GO:0017156"},{"id":"T875","span":{"begin":485,"end":496},"obj":"GO:0006897"},{"id":"T876","span":{"begin":500,"end":504},"obj":"G_3;PG_10;PR:000003622"},{"id":"T877","span":{"begin":505,"end":515},"obj":"SP_7"},{"id":"T878","span":{"begin":542,"end":547},"obj":"PR:000000134"},{"id":"T879","span":{"begin":552,"end":562},"obj":"PR:000004978"},{"id":"T880","span":{"begin":563,"end":573},"obj":"CHEBI:35222;CHEBI:35222"},{"id":"T881","span":{"begin":596,"end":604},"obj":"MOP:0000780"},{"id":"T882","span":{"begin":608,"end":612},"obj":"PR:000003622;G_3;PG_10"},{"id":"T883","span":{"begin":614,"end":621},"obj":"PR:000001279"},{"id":"T886","span":{"begin":52,"end":64},"obj":"SP_7"},{"id":"T884","span":{"begin":32,"end":42},"obj":"SP_7"},{"id":"T885","span":{"begin":47,"end":51},"obj":"G_3;PG_10;PR:000003622"},{"id":"T887","span":{"begin":65,"end":76},"obj":"SP_7;UBERON:0001004;GO:0045333"},{"id":"T888","span":{"begin":77,"end":99},"obj":"SP_7"},{"id":"T889","span":{"begin":101,"end":111},"obj":"SP_7"},{"id":"T890","span":{"begin":144,"end":148},"obj":"G_3;PG_10;PR:000003622"},{"id":"T891","span":{"begin":157,"end":166},"obj":"PG_1"},{"id":"T892","span":{"begin":190,"end":202},"obj":"GO:0044164"},{"id":"T893","span":{"begin":208,"end":217},"obj":"PG_1"},{"id":"T894","span":{"begin":228,"end":232},"obj":"CHEBI:37527;CHEBI:37527"},{"id":"T895","span":{"begin":233,"end":242},"obj":"GO:0010498"},{"id":"T896","span":{"begin":243,"end":254},"obj":"GO:0006508"},{"id":"T897","span":{"begin":255,"end":263},"obj":"MOP:0000780"},{"id":"T898","span":{"begin":267,"end":271},"obj":"G_3;PG_10;PR:000003622"},{"id":"T899","span":{"begin":296,"end":299},"obj":"PR:000000134"},{"id":"T900","span":{"begin":304,"end":317},"obj":"GO:0016020;PG_8"},{"id":"T901","span":{"begin":318,"end":335},"obj":"PG_8"},{"id":"T902","span":{"begin":421,"end":428},"obj":"SO:0000667"},{"id":"T903","span":{"begin":438,"end":446},"obj":"GO:0016020"},{"id":"T904","span":{"begin":465,"end":484},"obj":"GO:0017156"},{"id":"T905","span":{"begin":485,"end":496},"obj":"GO:0006897"},{"id":"T906","span":{"begin":500,"end":504},"obj":"G_3;PG_10;PR:000003622"},{"id":"T907","span":{"begin":505,"end":515},"obj":"SP_7"},{"id":"T908","span":{"begin":542,"end":547},"obj":"PR:000000134"},{"id":"T909","span":{"begin":552,"end":562},"obj":"PR:000004978"},{"id":"T910","span":{"begin":563,"end":573},"obj":"CHEBI:35222;CHEBI:35222"},{"id":"T911","span":{"begin":596,"end":604},"obj":"MOP:0000780"},{"id":"T912","span":{"begin":608,"end":612},"obj":"PR:000003622;G_3;PG_10"},{"id":"T913","span":{"begin":614,"end":621},"obj":"PR:000001279"}],"text":"Proposed Mechanism of Entry for SARS-CoV-2 Via ACE2\nSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds to the catalytic site of ACE2 via its S protein. To gain access to the host cytosol, the S protein undergoes acid dependent proteolytic cleavage by ACE2, tumor necrosis factor (TNF)-α, transmembrane protease serine 2 (TMPRRS2), which results in the formation of an S1 and S2 subunit. S2 fusion peptide inserts into the membrane, which allows for clatherin-dependent endocytosis of ACE2-SARS-CoV-2. Viral binding stimulates TNF-α and calmodulin inhibitors to promote ectodomain cleavage of ACE2. ADAM 17 = disintegrin and metalloprotease 17; other abbreviations as in Figure 1."}

{"project":"LitCovid-PubTator","denotations":[{"id":"1125","span":{"begin":32,"end":42},"obj":"Species"},{"id":"1141","span":{"begin":144,"end":148},"obj":"Gene"},{"id":"1142","span":{"begin":267,"end":271},"obj":"Gene"},{"id":"1143","span":{"begin":273,"end":302},"obj":"Gene"},{"id":"1144","span":{"begin":304,"end":335},"obj":"Gene"},{"id":"1145","span":{"begin":500,"end":504},"obj":"Gene"},{"id":"1146","span":{"begin":542,"end":547},"obj":"Gene"},{"id":"1147","span":{"begin":552,"end":562},"obj":"Gene"},{"id":"1148","span":{"begin":608,"end":612},"obj":"Gene"},{"id":"1149","span":{"begin":614,"end":621},"obj":"Gene"},{"id":"1150","span":{"begin":208,"end":209},"obj":"Gene"},{"id":"1151","span":{"begin":157,"end":158},"obj":"Gene"},{"id":"1152","span":{"begin":52,"end":99},"obj":"Species"},{"id":"1153","span":{"begin":101,"end":111},"obj":"Species"},{"id":"1154","span":{"begin":505,"end":515},"obj":"Species"},{"id":"1155","span":{"begin":465,"end":474},"obj":"Chemical"}],"attributes":[{"id":"A1125","pred":"tao:has_database_id","subj":"1125","obj":"Tax:2697049"},{"id":"A1141","pred":"tao:has_database_id","subj":"1141","obj":"Gene:59272"},{"id":"A1142","pred":"tao:has_database_id","subj":"1142","obj":"Gene:59272"},{"id":"A1143","pred":"tao:has_database_id","subj":"1143","obj":"Gene:7124"},{"id":"A1144","pred":"tao:has_database_id","subj":"1144","obj":"Gene:7113"},{"id":"A1145","pred":"tao:has_database_id","subj":"1145","obj":"Gene:59272"},{"id":"A1146","pred":"tao:has_database_id","subj":"1146","obj":"Gene:7124"},{"id":"A1147","pred":"tao:has_database_id","subj":"1147","obj":"Gene:801"},{"id":"A1148","pred":"tao:has_database_id","subj":"1148","obj":"Gene:59272"},{"id":"A1149","pred":"tao:has_database_id","subj":"1149","obj":"Gene:6868"},{"id":"A1150","pred":"tao:has_database_id","subj":"1150","obj":"Gene:43740568"},{"id":"A1151","pred":"tao:has_database_id","subj":"1151","obj":"Gene:43740568"},{"id":"A1152","pred":"tao:has_database_id","subj":"1152","obj":"Tax:2697049"},{"id":"A1153","pred":"tao:has_database_id","subj":"1153","obj":"Tax:2697049"},{"id":"A1154","pred":"tao:has_database_id","subj":"1154","obj":"Tax:2697049"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Proposed Mechanism of Entry for SARS-CoV-2 Via ACE2\nSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds to the catalytic site of ACE2 via its S protein. To gain access to the host cytosol, the S protein undergoes acid dependent proteolytic cleavage by ACE2, tumor necrosis factor (TNF)-α, transmembrane protease serine 2 (TMPRRS2), which results in the formation of an S1 and S2 subunit. S2 fusion peptide inserts into the membrane, which allows for clatherin-dependent endocytosis of ACE2-SARS-CoV-2. Viral binding stimulates TNF-α and calmodulin inhibitors to promote ectodomain cleavage of ACE2. ADAM 17 = disintegrin and metalloprotease 17; other abbreviations as in Figure 1."}