PMC:7161517 / 13808-14761
Annnotations
LitCovid-PD-FMA-UBERON
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T78 | 199-203 | Body_part | denotes | mRNA | http://purl.org/sig/ont/fma/fma67122 |
T79 | 234-249 | Body_part | denotes | thoracic aortas | http://purl.org/sig/ont/fma/fma3786 |
T80 | 442-456 | Body_part | denotes | thoracic aorta | http://purl.org/sig/ont/fma/fma3786 |
T81 | 662-678 | Body_part | denotes | carotid arteries | http://purl.org/sig/ont/fma/fma3939 |
T82 | 670-678 | Body_part | denotes | arteries | http://purl.org/sig/ont/fma/fma63812 |
T83 | 767-771 | Body_part | denotes | gene | http://purl.org/sig/ont/fma/fma74402 |
T84 | 776-783 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T85 | 822-836 | Body_part | denotes | arterial blood | http://purl.org/sig/ont/fma/fma83066 |
LitCovid-PD-UBERON
Id | Subject | Object | Predicate | Lexical cue | uberon_id |
---|---|---|---|---|---|
T41 | 234-249 | Body_part | denotes | thoracic aortas | http://purl.obolibrary.org/obo/UBERON_0001515 |
T42 | 372-378 | Body_part | denotes | vessel | http://purl.obolibrary.org/obo/UBERON_0000055 |
T43 | 442-456 | Body_part | denotes | thoracic aorta | http://purl.obolibrary.org/obo/UBERON_0001515 |
T44 | 451-456 | Body_part | denotes | aorta | http://purl.obolibrary.org/obo/UBERON_0000947 |
T45 | 822-836 | Body_part | denotes | arterial blood | http://purl.obolibrary.org/obo/UBERON_0013755 |
T46 | 831-836 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
LitCovid-PD-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T61 | 79-82 | Disease | denotes | ARB | http://purl.obolibrary.org/obo/MONDO_0012733 |
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T131 | 53-60 | http://purl.obolibrary.org/obo/CLO_0009985 | denotes | focused |
T132 | 163-164 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T133 | 234-249 | http://purl.obolibrary.org/obo/UBERON_0001515 | denotes | thoracic aortas |
T134 | 234-249 | http://www.ebi.ac.uk/efo/EFO_0002525 | denotes | thoracic aortas |
T135 | 372-378 | http://purl.obolibrary.org/obo/UBERON_0000055 | denotes | vessel |
T136 | 442-456 | http://purl.obolibrary.org/obo/UBERON_0001515 | denotes | thoracic aorta |
T137 | 442-456 | http://www.ebi.ac.uk/efo/EFO_0002525 | denotes | thoracic aorta |
T138 | 646-654 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
T139 | 662-678 | http://www.ebi.ac.uk/efo/EFO_0000818 | denotes | carotid arteries |
T140 | 694-701 | http://purl.obolibrary.org/obo/NCBITaxon_33208 | denotes | animals |
T141 | 767-771 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | gene |
T142 | 822-830 | http://purl.obolibrary.org/obo/UBERON_0001637 | denotes | arterial |
T143 | 822-830 | http://www.ebi.ac.uk/efo/EFO_0000814 | denotes | arterial |
T144 | 831-836 | http://purl.obolibrary.org/obo/UBERON_0000178 | denotes | blood |
T145 | 831-836 | http://www.ebi.ac.uk/efo/EFO_0000296 | denotes | blood |
LitCovid-PD-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T187 | 139-149 | Chemical | denotes | olmesartan | http://purl.obolibrary.org/obo/CHEBI_48416 |
T188 | 278-286 | Chemical | denotes | atenolol | http://purl.obolibrary.org/obo/CHEBI_2904|http://purl.obolibrary.org/obo/CHEBI_55352 |
T190 | 291-302 | Chemical | denotes | hydralazine | http://purl.obolibrary.org/obo/CHEBI_5775 |
T191 | 407-417 | Chemical | denotes | olmesartan | http://purl.obolibrary.org/obo/CHEBI_48416 |
T192 | 563-571 | Chemical | denotes | atenolol | http://purl.obolibrary.org/obo/CHEBI_2904|http://purl.obolibrary.org/obo/CHEBI_55352 |
T194 | 575-586 | Chemical | denotes | hydralazine | http://purl.obolibrary.org/obo/CHEBI_5775 |
T195 | 739-749 | Chemical | denotes | olmesartan | http://purl.obolibrary.org/obo/CHEBI_48416 |
T196 | 776-783 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T197 | 924-932 | Chemical | denotes | atenolol | http://purl.obolibrary.org/obo/CHEBI_2904|http://purl.obolibrary.org/obo/CHEBI_55352 |
T199 | 936-947 | Chemical | denotes | hydralazine | http://purl.obolibrary.org/obo/CHEBI_5775 |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T93 | 0-93 | Sentence | denotes | Similar upregulation of ACE2 was observed in studies focused on the effects of ARB treatment. |
T94 | 94-357 | Sentence | denotes | Spontaneously hypertensive rats treated with olmesartan demonstrated a 5-fold greater expression of ACE2 mRNA and increased Ang1-7 in their thoracic aortas, whereas those treated with atenolol and hydralazine exhibited no change in ACE2 expression or Ang1-7 (44). |
T95 | 358-592 | Sentence | denotes | Comparison of vessel wall dimensions showed that olmesartan selectively reduced the thoracic aorta media-to-lumen ratio, whereas vascular hypertrophy was unchanged in spontaneously hypertensive rats given atenolol or hydralazine (44). |
T96 | 593-702 | Sentence | denotes | There was no change in ACE2/Ang1-7 expression and/or activity in the carotid arteries of the treated animals. |
T97 | 703-953 | Sentence | denotes | The possibility that the effects of olmesartan on vascular ACE2 gene and protein expression were the result of reduced arterial blood pressure was ruled out because of the comparative effect observed in mice treated with atenolol or hydralazine (44). |
LitCovid-PMC-OGER-BB
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T525 | 24-28 | G_3;PG_10;PR:000003622 | denotes | ACE2 |
T526 | 121-125 | NCBITaxon:10114 | denotes | rats |
T527 | 139-149 | CHEBI:48416;CHEBI:48416 | denotes | olmesartan |
T528 | 180-190 | GO:0010467 | denotes | expression |
T529 | 194-198 | G_3;PG_10;PR:000003622 | denotes | ACE2 |
T530 | 218-222 | PR:000036013 | denotes | Ang1 |
T531 | 234-249 | UBERON:0001515 | denotes | thoracic aortas |
T532 | 278-286 | CHEBI:2904;CHEBI:2904 | denotes | atenolol |
T533 | 291-302 | CHEBI:5775;CHEBI:5775 | denotes | hydralazine |
T534 | 326-330 | G_3;PG_10;PR:000003622 | denotes | ACE2 |
T535 | 331-341 | GO:0010467 | denotes | expression |
T536 | 345-349 | PR:000036013 | denotes | Ang1 |
T537 | 372-378 | UBERON:0000055 | denotes | vessel |
T538 | 379-383 | UBERON:0000060 | denotes | wall |
T539 | 442-456 | UBERON:0001515 | denotes | thoracic aorta |
T540 | 457-462 | UBERON:0004363 | denotes | media |
T541 | 552-556 | NCBITaxon:10114 | denotes | rats |
T542 | 563-571 | CHEBI:2904;CHEBI:2904 | denotes | atenolol |
T543 | 575-586 | CHEBI:5775;CHEBI:5775 | denotes | hydralazine |
T544 | 616-620 | G_3;PG_10;PR:000003622 | denotes | ACE2 |
T545 | 621-625 | PR:000036013 | denotes | Ang1 |
T546 | 628-638 | GO:0010467 | denotes | expression |
T547 | 662-678 | UBERON:0005396 | denotes | carotid arteries |
T548 | 694-701 | NCBITaxon:33208 | denotes | animals |
T549 | 762-766 | G_3;PG_10;PR:000003622 | denotes | ACE2 |
T550 | 767-771 | SO:0000704;GO:0010467 | denotes | gene |
T551 | 776-783 | BV_20 | denotes | protein |
T552 | 784-794 | BV_20;GO:0010467 | denotes | expression |
T553 | 822-836 | UBERON:0013755 | denotes | arterial blood |
T554 | 906-910 | NCBITaxon:10088 | denotes | mice |
T555 | 924-932 | CHEBI:2904;CHEBI:2904 | denotes | atenolol |
T556 | 936-947 | CHEBI:5775;CHEBI:5775 | denotes | hydralazine |
T23650 | 64-68 | G_3;PG_10;PR:000003622 | denotes | the |
T20063 | 69-73 | SO:0000704;GO:0010467 | denotes | ffec |
T90002 | 78-85 | BV_20 | denotes | ARB tr |
T2173 | 86-96 | BV_20;GO:0010467 | denotes | atment. Sp |
T84173 | 124-138 | UBERON:0013755 | denotes | s treated with |
T25744 | 208-212 | NCBITaxon:10088 | denotes | incr |
T59010 | 226-234 | CHEBI:2904;CHEBI:2904 | denotes | n their |
T47013 | 238-249 | CHEBI:5775;CHEBI:5775 | denotes | acic aortas |
T34872 | 271-275 | NCBITaxon:10114 | denotes | d wi |
T53714 | 308-311 | CHEBI:37886;CHEBI:37886;PR:000036009 | denotes | ite |
T14892 | 312-314 | PR:000036009 | denotes | n |
T88568 | 331-334 | CHEBI:37886;CHEBI:37886;PR:000036009 | denotes | exp |
T25496 | 335-337 | PR:000036009 | denotes | es |
T6560 | 350-353 | PR:000001251 | denotes | 7 ( |
T62928 | 378-381 | PR:000001191 | denotes | wa |
T35232 | 392-396 | PR:000003622;G_3;PG_10 | denotes | ns s |
T26354 | 407-418 | UBERON:0001986 | denotes | olmesartan |
T89670 | 419-430 | CHEBI:16480;CHEBI:16480 | denotes | electively |
T84189 | 440-450 | GO:0010467 | denotes | e thoracic |
T10845 | 473-477 | PR:000001307 | denotes | atio |
T1909 | 478-488 | GO:0010467 | denotes | whereas v |
T89580 | 522-526 | NCBITaxon:10114 | denotes | in s |
T30307 | 540-551 | CHEBI:9434;CHEBI:9434 | denotes | ypertensive |
T38415 | 586-590 | G_3;PG_10;PR:000003622 | denotes | (44 |
T98868 | 604-615 | UBERON:0001986 | denotes | o change in |
T64155 | 616-627 | CHEBI:16480;CHEBI:16480 | denotes | ACE2/Ang1-7 |
T75423 | 637-647 | GO:0010467 | denotes | n and/or a |
T30401 | 651-663 | UBERON:0000948 | denotes | ity in the c |
T13751 | 664-671 | UBERON:0000055 | denotes | rotid a |
T36514 | 676-691 | UBERON:0002349 | denotes | es of the treat |
T22953 | 724-734 | GO:0010467 | denotes | the effect |
T33050 | 742-745 | PR:000001251 | denotes | esa |
T74336 | 771-782 | CHEBI:9434;CHEBI:9434 | denotes | and protei |
T29878 | 798-806 | GO:0016020 | denotes | e the re |
T86770 | 807-811 | PR:000001307 | denotes | ult |
T46947 | 812-822 | GO:0010467 | denotes | f reduced |
T78149 | 835-863 | PR:000000046 | denotes | d pressure was ruled out bec |
T7543 | 873-883 | GO:0010467 | denotes | e comparat |
T19226 | 914-918 | NCBITaxon:10114 | denotes | ated |
T6758 | 929-944 | UBERON:0001621 | denotes | lol or hydralaz |
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
613 | 24-28 | Gene | denotes | ACE2 | Gene:59272 |
614 | 194-198 | Gene | denotes | ACE2 | Gene:302668 |
615 | 218-224 | Gene | denotes | Ang1-7 | Gene:305843 |
616 | 326-330 | Gene | denotes | ACE2 | Gene:302668 |
617 | 345-351 | Gene | denotes | Ang1-7 | Gene:305843 |
618 | 616-620 | Gene | denotes | ACE2 | Gene:302668 |
619 | 621-627 | Gene | denotes | Ang1-7 | Gene:305843 |
620 | 762-766 | Gene | denotes | ACE2 | Gene:70008 |
621 | 121-125 | Species | denotes | rats | Tax:10116 |
622 | 552-556 | Species | denotes | rats | Tax:10116 |
623 | 906-910 | Species | denotes | mice | Tax:10090 |
624 | 139-149 | Chemical | denotes | olmesartan | MESH:C437965 |
625 | 278-286 | Chemical | denotes | atenolol | MESH:D001262 |
626 | 291-302 | Chemical | denotes | hydralazine | MESH:D006830 |
627 | 407-417 | Chemical | denotes | olmesartan | MESH:C437965 |
628 | 563-571 | Chemical | denotes | atenolol | MESH:D001262 |
629 | 575-586 | Chemical | denotes | hydralazine | MESH:D006830 |
630 | 739-749 | Chemical | denotes | olmesartan | MESH:C437965 |
631 | 924-932 | Chemical | denotes | atenolol | MESH:D001262 |
632 | 936-947 | Chemical | denotes | hydralazine | MESH:D006830 |
633 | 108-120 | Disease | denotes | hypertensive | MESH:D006973 |
634 | 487-507 | Disease | denotes | vascular hypertrophy | MESH:D006984 |
635 | 539-551 | Disease | denotes | hypertensive | MESH:D006973 |
2_test
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
32305401-15833808-55252952 | 353-355 | 15833808 | denotes | 44 |
32305401-15833808-55252953 | 588-590 | 15833808 | denotes | 44 |
32305401-15833808-55252954 | 949-951 | 15833808 | denotes | 44 |