PMC:7161517 / 118-1130
Annnotations
LitCovid-PD-FMA-UBERON
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T1 | 66-70 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T2 | 264-268 | Body_part | denotes | axis | http://purl.org/sig/ont/fma/fma12520 |
T3 | 738-742 | Body_part | denotes | axis | http://purl.org/sig/ont/fma/fma12520 |
T4 | 783-787 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
LitCovid-PD-UBERON
Id | Subject | Object | Predicate | Lexical cue | uberon_id |
---|---|---|---|---|---|
T2 | 783-787 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
T3 | 894-918 | Body_part | denotes | renin-angiotensin system | http://purl.obolibrary.org/obo/UBERON_0018229 |
LitCovid-PD-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T2 | 0-47 | Disease | denotes | Severe acute respiratory-syndrome coronavirus-2 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T3 | 49-57 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T4 | 71-80 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
T5 | 182-190 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T6 | 559-572 | Disease | denotes | viral disease | http://purl.obolibrary.org/obo/MONDO_0005108 |
T7 | 631-653 | Disease | denotes | cardiovascular disease | http://purl.obolibrary.org/obo/MONDO_0004995 |
T8 | 812-820 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T9 | 821-831 | Disease | denotes | infections | http://purl.obolibrary.org/obo/MONDO_0005550 |
T10 | 933-941 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 66-70 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T2 | 300-308 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
T3 | 489-492 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
T4 | 783-787 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
T5 | 783-787 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
T6 | 836-839 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
LitCovid-PD-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T2 | 107-118 | Chemical | denotes | angiotensin | http://purl.obolibrary.org/obo/CHEBI_48433 |
T3 | 235-246 | Chemical | denotes | angiotensin | http://purl.obolibrary.org/obo/CHEBI_48433 |
T4 | 358-372 | Chemical | denotes | angiotensin II | http://purl.obolibrary.org/obo/CHEBI_2719|http://purl.obolibrary.org/obo/CHEBI_48432|http://purl.obolibrary.org/obo/CHEBI_58506 |
T7 | 358-369 | Chemical | denotes | angiotensin | http://purl.obolibrary.org/obo/CHEBI_48433 |
T8 | 370-372 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
T9 | 392-406 | Chemical | denotes | ACE inhibitors | http://purl.obolibrary.org/obo/CHEBI_35457 |
T10 | 396-406 | Chemical | denotes | inhibitors | http://purl.obolibrary.org/obo/CHEBI_35222 |
T11 | 412-429 | Chemical | denotes | mineralocorticoid | http://purl.obolibrary.org/obo/CHEBI_25354 |
T12 | 439-450 | Chemical | denotes | antagonists | http://purl.obolibrary.org/obo/CHEBI_48706 |
T13 | 900-911 | Chemical | denotes | angiotensin | http://purl.obolibrary.org/obo/CHEBI_48433 |
T14 | 919-929 | Chemical | denotes | inhibitors | http://purl.obolibrary.org/obo/CHEBI_35222 |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T4 | 0-146 | Sentence | denotes | Severe acute respiratory-syndrome coronavirus-2 (SARS-CoV-2) host cell infection is mediated by binding to angiotensin-converting enzyme 2 (ACE2). |
T5 | 147-349 | Sentence | denotes | Systemic dysregulation observed in SARS-CoV was previously postulated to be due to ACE2/angiotensin 1-7 (Ang1-7)/Mas axis downregulation; increased ACE2 activity was shown to mediate disease protection. |
T6 | 350-654 | Sentence | denotes | Because angiotensin II receptor blockers, ACE inhibitors, and mineralocorticoid receptor antagonists increase ACE2 receptor expression, it has been tacitly believed that the use of these agents may facilitate viral disease; thus, they should not be used in high-risk patients with cardiovascular disease. |
T7 | 655-1012 | Sentence | denotes | Based on the anti-inflammatory benefits of the upregulation of the ACE2/Ang1-7/Mas axis and previously demonstrated benefits of lung function improvement in SARS-CoV infections, it has been hypothesized that the benefits of treatment with renin-angiotensin system inhibitors in SARS-CoV-2 may outweigh the risks and at the very least should not be withheld. |
LitCovid-PD-HP
Id | Subject | Object | Predicate | Lexical cue | hp_id |
---|---|---|---|---|---|
T1 | 631-653 | Phenotype | denotes | cardiovascular disease | http://purl.obolibrary.org/obo/HP_0001626 |
LitCovid-PMC-OGER-BB
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T3 | 0-12 | SP_7 | denotes | Severe acute |
T4 | 13-24 | SP_7;UBERON:0001004 | denotes | respiratory |
T5 | 24-47 | SP_7 | denotes | -syndrome coronavirus-2 |
T6 | 49-59 | SP_7 | denotes | SARS-CoV-2 |
T7 | 107-138 | PG_10;PR:000003622 | denotes | angiotensin-converting enzyme 2 |
T8 | 140-144 | G_3;PG_10;PR:000003622 | denotes | ACE2 |
T9 | 156-169 | GO:0065007 | denotes | dysregulation |
T10 | 182-190 | SP_10 | denotes | SARS-CoV |
T11 | 230-234 | G_3;PG_10;PR:000003622 | denotes | ACE2 |
T12 | 235-248 | PR:000036013 | denotes | angiotensin 1 |
T13 | 252-256 | PR:000036013 | denotes | Ang1 |
T14 | 295-299 | G_3;PG_10;PR:000003622 | denotes | ACE2 |
T15 | 358-372 | DG_37;PR:000001118 | denotes | angiotensin II |
T16 | 373-381 | PR:000001118 | denotes | receptor |
T17 | 396-406 | CHEBI:35222;CHEBI:35222 | denotes | inhibitors |
T18 | 412-429 | CHEBI:25354;CHEBI:25354 | denotes | mineralocorticoid |
T19 | 430-450 | CHEBI:48561;CHEBI:48561 | denotes | receptor antagonists |
T20 | 460-464 | PR:000003622;G_3;PG_10 | denotes | ACE2 |
T21 | 474-484 | GO:0010467 | denotes | expression |
T22 | 537-543 | CHEBI:48561;CHEBI:48561 | denotes | agents |
T23 | 559-564 | NCBITaxon:10239 | denotes | viral |
T24 | 631-645 | UBERON:0004535 | denotes | cardiovascular |
T25 | 722-726 | G_3;PG_10;PR:000003622 | denotes | ACE2 |
T26 | 727-731 | PR:000036013 | denotes | Ang1 |
T27 | 783-787 | UBERON:0002048 | denotes | lung |
T28 | 812-820 | SP_10 | denotes | SARS-CoV |
T29 | 894-899 | PR:000013883 | denotes | renin |
T30 | 919-929 | CHEBI:35222;CHEBI:35222 | denotes | inhibitors |
T31 | 933-943 | SP_7 | denotes | SARS-CoV-2 |
T60295 | 0-12 | SP_7 | denotes | Severe acute |
T90939 | 13-24 | SP_7;UBERON:0001004 | denotes | respiratory |
T19070 | 24-47 | SP_7 | denotes | -syndrome coronavirus-2 |
T26357 | 49-59 | SP_7 | denotes | SARS-CoV-2 |
T3432 | 107-138 | PG_10;PR:000003622 | denotes | angiotensin-converting enzyme 2 |
T99057 | 140-144 | G_3;PG_10;PR:000003622 | denotes | ACE2 |
T53282 | 156-169 | GO:0065007 | denotes | dysregulation |
T31949 | 182-190 | SP_10 | denotes | SARS-CoV |
T17436 | 230-234 | G_3;PG_10;PR:000003622 | denotes | ACE2 |
T37458 | 235-248 | PR:000036013 | denotes | angiotensin 1 |
T46294 | 252-256 | PR:000036013 | denotes | Ang1 |
T60166 | 295-299 | G_3;PG_10;PR:000003622 | denotes | ACE2 |
T39187 | 358-372 | DG_37;PR:000001118 | denotes | angiotensin II |
T33501 | 373-381 | PR:000001118 | denotes | receptor |
T28542 | 396-406 | CHEBI:35222;CHEBI:35222 | denotes | inhibitors |
T14634 | 412-429 | CHEBI:25354;CHEBI:25354 | denotes | mineralocorticoid |
T38268 | 430-450 | CHEBI:48561;CHEBI:48561 | denotes | receptor antagonists |
T7996 | 460-464 | PR:000003622;G_3;PG_10 | denotes | ACE2 |
T85494 | 474-484 | GO:0010467 | denotes | expression |
T23807 | 537-543 | CHEBI:48561;CHEBI:48561 | denotes | agents |
T85043 | 559-564 | NCBITaxon:10239 | denotes | viral |
T68089 | 631-645 | UBERON:0004535 | denotes | cardiovascular |
T69502 | 722-726 | G_3;PG_10;PR:000003622 | denotes | ACE2 |
T7389 | 727-731 | PR:000036013 | denotes | Ang1 |
T3955 | 783-787 | UBERON:0002048 | denotes | lung |
T22854 | 812-820 | SP_10 | denotes | SARS-CoV |
T79821 | 894-899 | PR:000013883 | denotes | renin |
T54661 | 919-929 | CHEBI:35222;CHEBI:35222 | denotes | inhibitors |
T15931 | 933-943 | SP_7 | denotes | SARS-CoV-2 |
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
21 | 107-138 | Gene | denotes | angiotensin-converting enzyme 2 | Gene:59272 |
22 | 140-144 | Gene | denotes | ACE2 | Gene:59272 |
23 | 230-250 | Gene | denotes | ACE2/angiotensin 1-7 | Gene:59272 |
24 | 252-258 | Gene | denotes | Ang1-7 | Gene:284 |
25 | 295-299 | Gene | denotes | ACE2 | Gene:59272 |
26 | 392-395 | Gene | denotes | ACE | Gene:1636 |
27 | 412-438 | Gene | denotes | mineralocorticoid receptor | Gene:4306 |
28 | 460-464 | Gene | denotes | ACE2 | Gene:59272 |
29 | 722-726 | Gene | denotes | ACE2 | Gene:59272 |
30 | 727-733 | Gene | denotes | Ang1-7 | Gene:284 |
31 | 0-47 | Species | denotes | Severe acute respiratory-syndrome coronavirus-2 | Tax:2697049 |
32 | 49-59 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
33 | 182-190 | Species | denotes | SARS-CoV | Tax:694009 |
34 | 617-625 | Species | denotes | patients | Tax:9606 |
35 | 933-943 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
36 | 71-80 | Disease | denotes | infection | MESH:D007239 |
37 | 559-572 | Disease | denotes | viral disease | MESH:D001102 |
38 | 631-653 | Disease | denotes | cardiovascular disease | MESH:D002318 |
39 | 812-831 | Disease | denotes | SARS-CoV infections | MESH:C000657245 |