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PMC:7161517 / 118-1130 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T1 66-70 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T2 264-268 Body_part denotes axis http://purl.org/sig/ont/fma/fma12520
T3 738-742 Body_part denotes axis http://purl.org/sig/ont/fma/fma12520
T4 783-787 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T2 783-787 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T3 894-918 Body_part denotes renin-angiotensin system http://purl.obolibrary.org/obo/UBERON_0018229

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T2 0-47 Disease denotes Severe acute respiratory-syndrome coronavirus-2 http://purl.obolibrary.org/obo/MONDO_0100096
T3 49-57 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T4 71-80 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T5 182-190 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T6 559-572 Disease denotes viral disease http://purl.obolibrary.org/obo/MONDO_0005108
T7 631-653 Disease denotes cardiovascular disease http://purl.obolibrary.org/obo/MONDO_0004995
T8 812-820 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T9 821-831 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T10 933-941 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1 66-70 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T2 300-308 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T3 489-492 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T4 783-787 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T5 783-787 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T6 836-839 http://purl.obolibrary.org/obo/CLO_0051582 denotes has

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T2 107-118 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T3 235-246 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T4 358-372 Chemical denotes angiotensin II http://purl.obolibrary.org/obo/CHEBI_2719|http://purl.obolibrary.org/obo/CHEBI_48432|http://purl.obolibrary.org/obo/CHEBI_58506
T7 358-369 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T8 370-372 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T9 392-406 Chemical denotes ACE inhibitors http://purl.obolibrary.org/obo/CHEBI_35457
T10 396-406 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T11 412-429 Chemical denotes mineralocorticoid http://purl.obolibrary.org/obo/CHEBI_25354
T12 439-450 Chemical denotes antagonists http://purl.obolibrary.org/obo/CHEBI_48706
T13 900-911 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T14 919-929 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T4 0-146 Sentence denotes Severe acute respiratory-syndrome coronavirus-2 (SARS-CoV-2) host cell infection is mediated by binding to angiotensin-converting enzyme 2 (ACE2).
T5 147-349 Sentence denotes Systemic dysregulation observed in SARS-CoV was previously postulated to be due to ACE2/angiotensin 1-7 (Ang1-7)/Mas axis downregulation; increased ACE2 activity was shown to mediate disease protection.
T6 350-654 Sentence denotes Because angiotensin II receptor blockers, ACE inhibitors, and mineralocorticoid receptor antagonists increase ACE2 receptor expression, it has been tacitly believed that the use of these agents may facilitate viral disease; thus, they should not be used in high-risk patients with cardiovascular disease.
T7 655-1012 Sentence denotes Based on the anti-inflammatory benefits of the upregulation of the ACE2/Ang1-7/Mas axis and previously demonstrated benefits of lung function improvement in SARS-CoV infections, it has been hypothesized that the benefits of treatment with renin-angiotensin system inhibitors in SARS-CoV-2 may outweigh the risks and at the very least should not be withheld.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T1 631-653 Phenotype denotes cardiovascular disease http://purl.obolibrary.org/obo/HP_0001626

LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T3 0-12 SP_7 denotes Severe acute
T4 13-24 SP_7;UBERON:0001004 denotes respiratory
T5 24-47 SP_7 denotes -syndrome coronavirus-2
T6 49-59 SP_7 denotes SARS-CoV-2
T7 107-138 PG_10;PR:000003622 denotes angiotensin-converting enzyme 2
T8 140-144 G_3;PG_10;PR:000003622 denotes ACE2
T9 156-169 GO:0065007 denotes dysregulation
T10 182-190 SP_10 denotes SARS-CoV
T11 230-234 G_3;PG_10;PR:000003622 denotes ACE2
T12 235-248 PR:000036013 denotes angiotensin 1
T13 252-256 PR:000036013 denotes Ang1
T14 295-299 G_3;PG_10;PR:000003622 denotes ACE2
T15 358-372 DG_37;PR:000001118 denotes angiotensin II
T16 373-381 PR:000001118 denotes receptor
T17 396-406 CHEBI:35222;CHEBI:35222 denotes inhibitors
T18 412-429 CHEBI:25354;CHEBI:25354 denotes mineralocorticoid
T19 430-450 CHEBI:48561;CHEBI:48561 denotes receptor antagonists
T20 460-464 PR:000003622;G_3;PG_10 denotes ACE2
T21 474-484 GO:0010467 denotes expression
T22 537-543 CHEBI:48561;CHEBI:48561 denotes agents
T23 559-564 NCBITaxon:10239 denotes viral
T24 631-645 UBERON:0004535 denotes cardiovascular
T25 722-726 G_3;PG_10;PR:000003622 denotes ACE2
T26 727-731 PR:000036013 denotes Ang1
T27 783-787 UBERON:0002048 denotes lung
T28 812-820 SP_10 denotes SARS-CoV
T29 894-899 PR:000013883 denotes renin
T30 919-929 CHEBI:35222;CHEBI:35222 denotes inhibitors
T31 933-943 SP_7 denotes SARS-CoV-2
T60295 0-12 SP_7 denotes Severe acute
T90939 13-24 SP_7;UBERON:0001004 denotes respiratory
T19070 24-47 SP_7 denotes -syndrome coronavirus-2
T26357 49-59 SP_7 denotes SARS-CoV-2
T3432 107-138 PG_10;PR:000003622 denotes angiotensin-converting enzyme 2
T99057 140-144 G_3;PG_10;PR:000003622 denotes ACE2
T53282 156-169 GO:0065007 denotes dysregulation
T31949 182-190 SP_10 denotes SARS-CoV
T17436 230-234 G_3;PG_10;PR:000003622 denotes ACE2
T37458 235-248 PR:000036013 denotes angiotensin 1
T46294 252-256 PR:000036013 denotes Ang1
T60166 295-299 G_3;PG_10;PR:000003622 denotes ACE2
T39187 358-372 DG_37;PR:000001118 denotes angiotensin II
T33501 373-381 PR:000001118 denotes receptor
T28542 396-406 CHEBI:35222;CHEBI:35222 denotes inhibitors
T14634 412-429 CHEBI:25354;CHEBI:25354 denotes mineralocorticoid
T38268 430-450 CHEBI:48561;CHEBI:48561 denotes receptor antagonists
T7996 460-464 PR:000003622;G_3;PG_10 denotes ACE2
T85494 474-484 GO:0010467 denotes expression
T23807 537-543 CHEBI:48561;CHEBI:48561 denotes agents
T85043 559-564 NCBITaxon:10239 denotes viral
T68089 631-645 UBERON:0004535 denotes cardiovascular
T69502 722-726 G_3;PG_10;PR:000003622 denotes ACE2
T7389 727-731 PR:000036013 denotes Ang1
T3955 783-787 UBERON:0002048 denotes lung
T22854 812-820 SP_10 denotes SARS-CoV
T79821 894-899 PR:000013883 denotes renin
T54661 919-929 CHEBI:35222;CHEBI:35222 denotes inhibitors
T15931 933-943 SP_7 denotes SARS-CoV-2

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
21 107-138 Gene denotes angiotensin-converting enzyme 2 Gene:59272
22 140-144 Gene denotes ACE2 Gene:59272
23 230-250 Gene denotes ACE2/angiotensin 1-7 Gene:59272
24 252-258 Gene denotes Ang1-7 Gene:284
25 295-299 Gene denotes ACE2 Gene:59272
26 392-395 Gene denotes ACE Gene:1636
27 412-438 Gene denotes mineralocorticoid receptor Gene:4306
28 460-464 Gene denotes ACE2 Gene:59272
29 722-726 Gene denotes ACE2 Gene:59272
30 727-733 Gene denotes Ang1-7 Gene:284
31 0-47 Species denotes Severe acute respiratory-syndrome coronavirus-2 Tax:2697049
32 49-59 Species denotes SARS-CoV-2 Tax:2697049
33 182-190 Species denotes SARS-CoV Tax:694009
34 617-625 Species denotes patients Tax:9606
35 933-943 Species denotes SARS-CoV-2 Tax:2697049
36 71-80 Disease denotes infection MESH:D007239
37 559-572 Disease denotes viral disease MESH:D001102
38 631-653 Disease denotes cardiovascular disease MESH:D002318
39 812-831 Disease denotes SARS-CoV infections MESH:C000657245