PMC:7161517 / 1154-1612 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue	uberon_id
T4	112-115	Body_part	denotes	RAS	http://purl.obolibrary.org/obo/UBERON_0018229
T5	168-171	Body_part	denotes	RAS	http://purl.obolibrary.org/obo/UBERON_0018229

Id	Subject	Object	Predicate	Lexical cue	mondo_id
T11	14-22	Disease	denotes	COVID-19	http://purl.obolibrary.org/obo/MONDO_0100096
T12	69-77	Disease	denotes	SARS-CoV	http://purl.obolibrary.org/obo/MONDO_0005091
T13	385-407	Disease	denotes	cardiovascular disease	http://purl.obolibrary.org/obo/MONDO_0004995
T14	412-420	Disease	denotes	COVID-19	http://purl.obolibrary.org/obo/MONDO_0100096

Id	Subject	Object	Predicate	Lexical cue
T7	23-26	http://purl.obolibrary.org/obo/CLO_0051582	denotes	has
T8	190-200	http://purl.obolibrary.org/obo/CLO_0001658	denotes	activation
T9	282-290	http://purl.obolibrary.org/obo/CLO_0001658	denotes	activity

Id	Subject	Object	Predicate	Lexical cue	chebi_id
T15	112-115	Chemical	denotes	RAS	http://purl.obolibrary.org/obo/CHEBI_63620
T16	168-171	Chemical	denotes	RAS	http://purl.obolibrary.org/obo/CHEBI_63620
T17	235-249	Chemical	denotes	ACE inhibitors	http://purl.obolibrary.org/obo/CHEBI_35457
T18	239-249	Chemical	denotes	inhibitors	http://purl.obolibrary.org/obo/CHEBI_35222

Id	Subject	Object	Predicate	Lexical cue
T1	349-359	http://purl.obolibrary.org/obo/GO_0065007	denotes	regulation

Id	Subject	Object	Predicate	Lexical cue
T9	0-10	Sentence	denotes	Highlights
T10	11-68	Sentence	denotes	• COVID-19 has been associated with cardiac involvement.
T11	69-116	Sentence	denotes	SARS-CoV-2 requires binding to ACE2 in the RAS.
T12	117-231	Sentence	denotes	• The ACE2/Ang1-7/Mas pathway counterbalances the RAS, which results in activation of anti-inflammatory pathways.
T13	232-306	Sentence	denotes	• ACE inhibitors, ARBs, and MRAs upregulate ACE2 activity and expression.
T14	307-458	Sentence	denotes	• More data are required to determine if regulation of ACE2 in patients with cardiovascular disease and COVID-19 would help improve clinical outcomes.

Id	Subject	Object	Predicate	Lexical cue	hp_id
T2	385-407	Phenotype	denotes	cardiovascular disease	http://purl.obolibrary.org/obo/HP_0001626

Id	Subject	Object	Predicate	Lexical cue
T32	14-22	SP_7	denotes	COVID-19
T33	48-55	UBERON:0000948	denotes	cardiac
T34	69-79	SP_7	denotes	SARS-CoV-2
T35	100-104	G_3;PG_10;PR:000003622	denotes	ACE2
T36	124-128	G_3;PG_10;PR:000003622	denotes	ACE2
T37	129-133	PR:000036013	denotes	Ang1
T38	239-249	CHEBI:35222;CHEBI:35222	denotes	inhibitors
T39	277-281	G_3;PG_10;PR:000003622	denotes	ACE2
T40	295-305	GO:0010467	denotes	expression
T41	349-359	GO:0065007	denotes	regulation
T42	363-367	G_3;PG_10;PR:000003622	denotes	ACE2
T43	385-399	UBERON:0004535	denotes	cardiovascular
T44	412-420	SP_7	denotes	COVID-19
T15393	14-22	SP_7	denotes	COVID-19
T97887	48-55	UBERON:0000948	denotes	cardiac
T56833	69-79	SP_7	denotes	SARS-CoV-2
T99319	100-104	G_3;PG_10;PR:000003622	denotes	ACE2
T59141	124-128	G_3;PG_10;PR:000003622	denotes	ACE2
T38767	129-133	PR:000036013	denotes	Ang1
T18838	239-249	CHEBI:35222;CHEBI:35222	denotes	inhibitors
T45066	277-281	G_3;PG_10;PR:000003622	denotes	ACE2
T55988	295-305	GO:0010467	denotes	expression
T19730	349-359	GO:0065007	denotes	regulation
T92247	363-367	G_3;PG_10;PR:000003622	denotes	ACE2
T73655	385-399	UBERON:0004535	denotes	cardiovascular
T52119	412-420	SP_7	denotes	COVID-19

Id	Subject	Object	Predicate	Lexical cue	tao:has_database_id
44	100-104	Gene	denotes	ACE2	Gene:59272
45	69-79	Species	denotes	SARS-CoV-2	Tax:2697049
46	14-22	Disease	denotes	COVID-19	MESH:C000657245
47	48-67	Disease	denotes	cardiac involvement	MESH:D006331
50	124-128	Gene	denotes	ACE2	Gene:59272
51	129-135	Gene	denotes	Ang1-7	Gene:284
54	235-238	Gene	denotes	ACE	Gene:1636
55	277-281	Gene	denotes	ACE2	Gene:59272
60	363-367	Gene	denotes	ACE2	Gene:59272
61	371-379	Species	denotes	patients	Tax:9606
62	385-407	Disease	denotes	cardiovascular disease	MESH:D002318
63	412-420	Disease	denotes	COVID-19	MESH:C000657245