
PMC:7156291 / 8683-11037
Annnotations
LitCovid-PubTator
{"project":"LitCovid-PubTator","denotations":[{"id":"181","span":{"begin":1532,"end":1535},"obj":"Gene"},{"id":"182","span":{"begin":1633,"end":1651},"obj":"Gene"},{"id":"183","span":{"begin":482,"end":489},"obj":"Species"},{"id":"184","span":{"begin":714,"end":721},"obj":"Species"},{"id":"185","span":{"begin":495,"end":498},"obj":"Disease"},{"id":"186","span":{"begin":705,"end":713},"obj":"Disease"},{"id":"187","span":{"begin":769,"end":785},"obj":"Disease"},{"id":"188","span":{"begin":798,"end":803},"obj":"Disease"},{"id":"189","span":{"begin":842,"end":849},"obj":"Disease"},{"id":"190","span":{"begin":884,"end":903},"obj":"Disease"},{"id":"191","span":{"begin":916,"end":928},"obj":"Disease"},{"id":"192","span":{"begin":967,"end":975},"obj":"Disease"},{"id":"193","span":{"begin":986,"end":992},"obj":"Disease"},{"id":"194","span":{"begin":1000,"end":1008},"obj":"Disease"},{"id":"195","span":{"begin":1017,"end":1025},"obj":"Disease"},{"id":"197","span":{"begin":418,"end":425},"obj":"Species"},{"id":"199","span":{"begin":1753,"end":1761},"obj":"Species"},{"id":"201","span":{"begin":1825,"end":1828},"obj":"Gene"},{"id":"203","span":{"begin":1856,"end":1861},"obj":"Chemical"},{"id":"206","span":{"begin":2156,"end":2159},"obj":"Gene"},{"id":"207","span":{"begin":2194,"end":2212},"obj":"Gene"},{"id":"216","span":{"begin":356,"end":374},"obj":"Gene"},{"id":"217","span":{"begin":62,"end":70},"obj":"Species"},{"id":"218","span":{"begin":142,"end":149},"obj":"Species"},{"id":"219","span":{"begin":335,"end":343},"obj":"Species"},{"id":"220","span":{"begin":400,"end":408},"obj":"Species"},{"id":"221","span":{"begin":133,"end":141},"obj":"Disease"},{"id":"222","span":{"begin":188,"end":193},"obj":"Disease"},{"id":"223","span":{"begin":206,"end":211},"obj":"Disease"}],"attributes":[{"id":"A181","pred":"tao:has_database_id","subj":"181","obj":"Gene:26503"},{"id":"A182","pred":"tao:has_database_id","subj":"182","obj":"Gene:1401"},{"id":"A183","pred":"tao:has_database_id","subj":"183","obj":"Tax:9606"},{"id":"A184","pred":"tao:has_database_id","subj":"184","obj":"Tax:9606"},{"id":"A185","pred":"tao:has_database_id","subj":"185","obj":"MESH:C000657245"},{"id":"A186","pred":"tao:has_database_id","subj":"186","obj":"MESH:D007239"},{"id":"A187","pred":"tao:has_database_id","subj":"187","obj":"MESH:D051271"},{"id":"A188","pred":"tao:has_database_id","subj":"188","obj":"MESH:D003371"},{"id":"A189","pred":"tao:has_database_id","subj":"189","obj":"MESH:D005221"},{"id":"A190","pred":"tao:has_database_id","subj":"190","obj":"MESH:D004417"},{"id":"A191","pred":"tao:has_database_id","subj":"191","obj":"MESH:D010608"},{"id":"A192","pred":"tao:has_database_id","subj":"192","obj":"MESH:D006261"},{"id":"A193","pred":"tao:has_database_id","subj":"193","obj":"MESH:D009325"},{"id":"A194","pred":"tao:has_database_id","subj":"194","obj":"MESH:D014839"},{"id":"A195","pred":"tao:has_database_id","subj":"195","obj":"MESH:D003967"},{"id":"A197","pred":"tao:has_database_id","subj":"197","obj":"Tax:9606"},{"id":"A199","pred":"tao:has_database_id","subj":"199","obj":"Tax:9606"},{"id":"A201","pred":"tao:has_database_id","subj":"201","obj":"Gene:26503"},{"id":"A206","pred":"tao:has_database_id","subj":"206","obj":"Gene:26503"},{"id":"A207","pred":"tao:has_database_id","subj":"207","obj":"Gene:1401"},{"id":"A216","pred":"tao:has_database_id","subj":"216","obj":"Gene:1401"},{"id":"A217","pred":"tao:has_database_id","subj":"217","obj":"Tax:9606"},{"id":"A218","pred":"tao:has_database_id","subj":"218","obj":"Tax:9606"},{"id":"A219","pred":"tao:has_database_id","subj":"219","obj":"Tax:9606"},{"id":"A220","pred":"tao:has_database_id","subj":"220","obj":"Tax:9606"},{"id":"A221","pred":"tao:has_database_id","subj":"221","obj":"MESH:D007239"},{"id":"A222","pred":"tao:has_database_id","subj":"222","obj":"MESH:D005334"},{"id":"A223","pred":"tao:has_database_id","subj":"223","obj":"MESH:D003371"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"The demographics of the study cohort are detailed in Table 1. Patients with exposure history (recent travel to Wuhan or contact with infected patient) accounted for 85.2% of study cohort. Fever (84.1%) and cough (56.8%) were the most common presenting symptoms. Low lymphocyte and white cell counts were observed in 26.4% and 25.0% of patients, while high C-reactive protein was observed in 55.0% of patients.\nTable 1 Patient demographics and laboratory test results\nCharacteristic Patient with NCP (n = 88)\nAge (years)a 42.7 ± 14.5\nAge group (years)\n \u003c 15 2 (2.3)\n 15–44 48 (54.5)\n 45–64 28 (31.8)\n ≥ 65 10 (11.4)\nMale sex 51 (58.0)\nExposure history\n Recent travel to Wuhan 45 (51.1)\n Contact with infected patient 30 (34.1)\n Unknown exposure 13 (14.8)\nInitial symptoms\n Fever 74 (84.1)\n Cough 50 (56.8)\n Expectoration 19 (21.6)\n Fatigue 15 (17.0)\n Chest distress and/or shortness of breath 12 (13.6)\n Pharyngalgia 10 (11.4)\n Muscle soreness 7 (8.0)\n Headache 5 (5.7)\n Nausea and/or vomiting 0 (0)\n Diarrhea 0 (0)\n No obvious symptoms 3 (3.4)\nLaboratory testing at initial hospital visitb\n White blood cell count (–, ↑, ↓) 62 (70.5), 4 (4.5), 22 (25.0)\n Lymphocyte count (–, ↑, ↓) 62 (71.3), 2 (2.3), 23 (26.4)\n Percent lymphocytes (–, ↑, ↓) 55 (62.5), 7 (8.0), 26 (29.5)\n Percent neutrophilic granulocyte (–, ↑, ↓) 59 (67.1), 17 (19.3), 12 (13.6)\n Percent monocytes (–, ↑, ↓) 59 (67.1), 26 (29.5), 3 (3.4)\n Hemoglobin (–, ↑, ↓) 68 (77.3), 8 (9.1), 12 (13.6)\n ALT (–, ↑, ↓) 70 (79.5), 16 (18.2), 2 (2.3)\n AST (–, ↑, ↓) 73 (83.0), 15 (17.0), 0 (0)\n Creatine kinase (–, ↑, ↓) 73 (84.9), 4 (4.6), 9 (10.5)\n C-reactive protein (–, ↑, ↓) 36 (45.0), 44 (55.0), 0 (0)\nUnless otherwise indicated, data are reported as the number of patients, with percentages in parentheses\nALT alanine aminotransferase, AST aspartate aminotransferase\naData are reported as the mean ± standard derivation\nbThe signs –, ↑, and ↓ represent within, above, and below normal ranges of laboratory results, respectively. Normal ranges of white blood cell count, lymphocyte count, percent lymphocytes, percent neutrophilic granulocyte, percent monocytes, ALT, AST, creatine kinase, hemoglobin, and C-reactive protein were 3.5–9.5 × 109/L, 1.10–3.20 × 109/L, 20–50%, 3.0–10.0%, 40–75%, 115–150 g/L, 7–40 U/L, 13–35 U/L, 40–200 U/L, and 0–10 mg/L, respectively"}
LitCovid-PD-FMA-UBERON
{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T11","span":{"begin":266,"end":276},"obj":"Body_part"},{"id":"T12","span":{"begin":287,"end":291},"obj":"Body_part"},{"id":"T13","span":{"begin":367,"end":374},"obj":"Body_part"},{"id":"T14","span":{"begin":862,"end":867},"obj":"Body_part"},{"id":"T15","span":{"begin":941,"end":947},"obj":"Body_part"},{"id":"T16","span":{"begin":1110,"end":1126},"obj":"Body_part"},{"id":"T17","span":{"begin":1122,"end":1126},"obj":"Body_part"},{"id":"T18","span":{"begin":1175,"end":1185},"obj":"Body_part"},{"id":"T19","span":{"begin":1242,"end":1253},"obj":"Body_part"},{"id":"T20","span":{"begin":1304,"end":1316},"obj":"Body_part"},{"id":"T21","span":{"begin":1317,"end":1328},"obj":"Body_part"},{"id":"T22","span":{"begin":1381,"end":1390},"obj":"Body_part"},{"id":"T23","span":{"begin":1433,"end":1443},"obj":"Body_part"},{"id":"T24","span":{"begin":1644,"end":1651},"obj":"Body_part"},{"id":"T25","span":{"begin":1799,"end":1806},"obj":"Body_part"},{"id":"T26","span":{"begin":2035,"end":2051},"obj":"Body_part"},{"id":"T27","span":{"begin":2047,"end":2051},"obj":"Body_part"},{"id":"T28","span":{"begin":2059,"end":2069},"obj":"Body_part"},{"id":"T29","span":{"begin":2085,"end":2096},"obj":"Body_part"},{"id":"T30","span":{"begin":2106,"end":2118},"obj":"Body_part"},{"id":"T31","span":{"begin":2119,"end":2130},"obj":"Body_part"},{"id":"T32","span":{"begin":2140,"end":2149},"obj":"Body_part"},{"id":"T33","span":{"begin":2178,"end":2188},"obj":"Body_part"},{"id":"T34","span":{"begin":2205,"end":2212},"obj":"Body_part"}],"attributes":[{"id":"A11","pred":"fma_id","subj":"T11","obj":"http://purl.org/sig/ont/fma/fma62863"},{"id":"A12","pred":"fma_id","subj":"T12","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A13","pred":"fma_id","subj":"T13","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A14","pred":"fma_id","subj":"T14","obj":"http://purl.org/sig/ont/fma/fma9576"},{"id":"A15","pred":"fma_id","subj":"T15","obj":"http://purl.org/sig/ont/fma/fma32558"},{"id":"A16","pred":"fma_id","subj":"T16","obj":"http://purl.org/sig/ont/fma/fma62852"},{"id":"A17","pred":"fma_id","subj":"T17","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A18","pred":"fma_id","subj":"T18","obj":"http://purl.org/sig/ont/fma/fma62863"},{"id":"A19","pred":"fma_id","subj":"T19","obj":"http://purl.org/sig/ont/fma/fma62863"},{"id":"A20","pred":"fma_id","subj":"T20","obj":"http://purl.org/sig/ont/fma/fma62860"},{"id":"A21","pred":"fma_id","subj":"T21","obj":"http://purl.org/sig/ont/fma/fma62854"},{"id":"A22","pred":"fma_id","subj":"T22","obj":"http://purl.org/sig/ont/fma/fma62864"},{"id":"A23","pred":"fma_id","subj":"T23","obj":"http://purl.org/sig/ont/fma/fma62293"},{"id":"A24","pred":"fma_id","subj":"T24","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A25","pred":"fma_id","subj":"T25","obj":"http://purl.org/sig/ont/fma/fma82749"},{"id":"A26","pred":"fma_id","subj":"T26","obj":"http://purl.org/sig/ont/fma/fma62852"},{"id":"A27","pred":"fma_id","subj":"T27","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A28","pred":"fma_id","subj":"T28","obj":"http://purl.org/sig/ont/fma/fma62863"},{"id":"A29","pred":"fma_id","subj":"T29","obj":"http://purl.org/sig/ont/fma/fma62863"},{"id":"A30","pred":"fma_id","subj":"T30","obj":"http://purl.org/sig/ont/fma/fma62860"},{"id":"A31","pred":"fma_id","subj":"T31","obj":"http://purl.org/sig/ont/fma/fma62854"},{"id":"A32","pred":"fma_id","subj":"T32","obj":"http://purl.org/sig/ont/fma/fma62864"},{"id":"A33","pred":"fma_id","subj":"T33","obj":"http://purl.org/sig/ont/fma/fma62293"},{"id":"A34","pred":"fma_id","subj":"T34","obj":"http://purl.org/sig/ont/fma/fma67257"}],"text":"The demographics of the study cohort are detailed in Table 1. Patients with exposure history (recent travel to Wuhan or contact with infected patient) accounted for 85.2% of study cohort. Fever (84.1%) and cough (56.8%) were the most common presenting symptoms. Low lymphocyte and white cell counts were observed in 26.4% and 25.0% of patients, while high C-reactive protein was observed in 55.0% of patients.\nTable 1 Patient demographics and laboratory test results\nCharacteristic Patient with NCP (n = 88)\nAge (years)a 42.7 ± 14.5\nAge group (years)\n \u003c 15 2 (2.3)\n 15–44 48 (54.5)\n 45–64 28 (31.8)\n ≥ 65 10 (11.4)\nMale sex 51 (58.0)\nExposure history\n Recent travel to Wuhan 45 (51.1)\n Contact with infected patient 30 (34.1)\n Unknown exposure 13 (14.8)\nInitial symptoms\n Fever 74 (84.1)\n Cough 50 (56.8)\n Expectoration 19 (21.6)\n Fatigue 15 (17.0)\n Chest distress and/or shortness of breath 12 (13.6)\n Pharyngalgia 10 (11.4)\n Muscle soreness 7 (8.0)\n Headache 5 (5.7)\n Nausea and/or vomiting 0 (0)\n Diarrhea 0 (0)\n No obvious symptoms 3 (3.4)\nLaboratory testing at initial hospital visitb\n White blood cell count (–, ↑, ↓) 62 (70.5), 4 (4.5), 22 (25.0)\n Lymphocyte count (–, ↑, ↓) 62 (71.3), 2 (2.3), 23 (26.4)\n Percent lymphocytes (–, ↑, ↓) 55 (62.5), 7 (8.0), 26 (29.5)\n Percent neutrophilic granulocyte (–, ↑, ↓) 59 (67.1), 17 (19.3), 12 (13.6)\n Percent monocytes (–, ↑, ↓) 59 (67.1), 26 (29.5), 3 (3.4)\n Hemoglobin (–, ↑, ↓) 68 (77.3), 8 (9.1), 12 (13.6)\n ALT (–, ↑, ↓) 70 (79.5), 16 (18.2), 2 (2.3)\n AST (–, ↑, ↓) 73 (83.0), 15 (17.0), 0 (0)\n Creatine kinase (–, ↑, ↓) 73 (84.9), 4 (4.6), 9 (10.5)\n C-reactive protein (–, ↑, ↓) 36 (45.0), 44 (55.0), 0 (0)\nUnless otherwise indicated, data are reported as the number of patients, with percentages in parentheses\nALT alanine aminotransferase, AST aspartate aminotransferase\naData are reported as the mean ± standard derivation\nbThe signs –, ↑, and ↓ represent within, above, and below normal ranges of laboratory results, respectively. Normal ranges of white blood cell count, lymphocyte count, percent lymphocytes, percent neutrophilic granulocyte, percent monocytes, ALT, AST, creatine kinase, hemoglobin, and C-reactive protein were 3.5–9.5 × 109/L, 1.10–3.20 × 109/L, 20–50%, 3.0–10.0%, 40–75%, 115–150 g/L, 7–40 U/L, 13–35 U/L, 40–200 U/L, and 0–10 mg/L, respectively"}
LitCovid-PD-UBERON
{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T17","span":{"begin":862,"end":867},"obj":"Body_part"},{"id":"T18","span":{"begin":1116,"end":1121},"obj":"Body_part"},{"id":"T19","span":{"begin":2041,"end":2046},"obj":"Body_part"}],"attributes":[{"id":"A17","pred":"uberon_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/UBERON_0001443"},{"id":"A18","pred":"uberon_id","subj":"T18","obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"A19","pred":"uberon_id","subj":"T19","obj":"http://purl.obolibrary.org/obo/UBERON_0000178"}],"text":"The demographics of the study cohort are detailed in Table 1. Patients with exposure history (recent travel to Wuhan or contact with infected patient) accounted for 85.2% of study cohort. Fever (84.1%) and cough (56.8%) were the most common presenting symptoms. Low lymphocyte and white cell counts were observed in 26.4% and 25.0% of patients, while high C-reactive protein was observed in 55.0% of patients.\nTable 1 Patient demographics and laboratory test results\nCharacteristic Patient with NCP (n = 88)\nAge (years)a 42.7 ± 14.5\nAge group (years)\n \u003c 15 2 (2.3)\n 15–44 48 (54.5)\n 45–64 28 (31.8)\n ≥ 65 10 (11.4)\nMale sex 51 (58.0)\nExposure history\n Recent travel to Wuhan 45 (51.1)\n Contact with infected patient 30 (34.1)\n Unknown exposure 13 (14.8)\nInitial symptoms\n Fever 74 (84.1)\n Cough 50 (56.8)\n Expectoration 19 (21.6)\n Fatigue 15 (17.0)\n Chest distress and/or shortness of breath 12 (13.6)\n Pharyngalgia 10 (11.4)\n Muscle soreness 7 (8.0)\n Headache 5 (5.7)\n Nausea and/or vomiting 0 (0)\n Diarrhea 0 (0)\n No obvious symptoms 3 (3.4)\nLaboratory testing at initial hospital visitb\n White blood cell count (–, ↑, ↓) 62 (70.5), 4 (4.5), 22 (25.0)\n Lymphocyte count (–, ↑, ↓) 62 (71.3), 2 (2.3), 23 (26.4)\n Percent lymphocytes (–, ↑, ↓) 55 (62.5), 7 (8.0), 26 (29.5)\n Percent neutrophilic granulocyte (–, ↑, ↓) 59 (67.1), 17 (19.3), 12 (13.6)\n Percent monocytes (–, ↑, ↓) 59 (67.1), 26 (29.5), 3 (3.4)\n Hemoglobin (–, ↑, ↓) 68 (77.3), 8 (9.1), 12 (13.6)\n ALT (–, ↑, ↓) 70 (79.5), 16 (18.2), 2 (2.3)\n AST (–, ↑, ↓) 73 (83.0), 15 (17.0), 0 (0)\n Creatine kinase (–, ↑, ↓) 73 (84.9), 4 (4.6), 9 (10.5)\n C-reactive protein (–, ↑, ↓) 36 (45.0), 44 (55.0), 0 (0)\nUnless otherwise indicated, data are reported as the number of patients, with percentages in parentheses\nALT alanine aminotransferase, AST aspartate aminotransferase\naData are reported as the mean ± standard derivation\nbThe signs –, ↑, and ↓ represent within, above, and below normal ranges of laboratory results, respectively. Normal ranges of white blood cell count, lymphocyte count, percent lymphocytes, percent neutrophilic granulocyte, percent monocytes, ALT, AST, creatine kinase, hemoglobin, and C-reactive protein were 3.5–9.5 × 109/L, 1.10–3.20 × 109/L, 20–50%, 3.0–10.0%, 40–75%, 115–150 g/L, 7–40 U/L, 13–35 U/L, 40–200 U/L, and 0–10 mg/L, respectively"}
LitCovid-PD-MONDO
{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T35","span":{"begin":1017,"end":1025},"obj":"Disease"}],"attributes":[{"id":"A35","pred":"mondo_id","subj":"T35","obj":"http://purl.obolibrary.org/obo/MONDO_0001673"}],"text":"The demographics of the study cohort are detailed in Table 1. Patients with exposure history (recent travel to Wuhan or contact with infected patient) accounted for 85.2% of study cohort. Fever (84.1%) and cough (56.8%) were the most common presenting symptoms. Low lymphocyte and white cell counts were observed in 26.4% and 25.0% of patients, while high C-reactive protein was observed in 55.0% of patients.\nTable 1 Patient demographics and laboratory test results\nCharacteristic Patient with NCP (n = 88)\nAge (years)a 42.7 ± 14.5\nAge group (years)\n \u003c 15 2 (2.3)\n 15–44 48 (54.5)\n 45–64 28 (31.8)\n ≥ 65 10 (11.4)\nMale sex 51 (58.0)\nExposure history\n Recent travel to Wuhan 45 (51.1)\n Contact with infected patient 30 (34.1)\n Unknown exposure 13 (14.8)\nInitial symptoms\n Fever 74 (84.1)\n Cough 50 (56.8)\n Expectoration 19 (21.6)\n Fatigue 15 (17.0)\n Chest distress and/or shortness of breath 12 (13.6)\n Pharyngalgia 10 (11.4)\n Muscle soreness 7 (8.0)\n Headache 5 (5.7)\n Nausea and/or vomiting 0 (0)\n Diarrhea 0 (0)\n No obvious symptoms 3 (3.4)\nLaboratory testing at initial hospital visitb\n White blood cell count (–, ↑, ↓) 62 (70.5), 4 (4.5), 22 (25.0)\n Lymphocyte count (–, ↑, ↓) 62 (71.3), 2 (2.3), 23 (26.4)\n Percent lymphocytes (–, ↑, ↓) 55 (62.5), 7 (8.0), 26 (29.5)\n Percent neutrophilic granulocyte (–, ↑, ↓) 59 (67.1), 17 (19.3), 12 (13.6)\n Percent monocytes (–, ↑, ↓) 59 (67.1), 26 (29.5), 3 (3.4)\n Hemoglobin (–, ↑, ↓) 68 (77.3), 8 (9.1), 12 (13.6)\n ALT (–, ↑, ↓) 70 (79.5), 16 (18.2), 2 (2.3)\n AST (–, ↑, ↓) 73 (83.0), 15 (17.0), 0 (0)\n Creatine kinase (–, ↑, ↓) 73 (84.9), 4 (4.6), 9 (10.5)\n C-reactive protein (–, ↑, ↓) 36 (45.0), 44 (55.0), 0 (0)\nUnless otherwise indicated, data are reported as the number of patients, with percentages in parentheses\nALT alanine aminotransferase, AST aspartate aminotransferase\naData are reported as the mean ± standard derivation\nbThe signs –, ↑, and ↓ represent within, above, and below normal ranges of laboratory results, respectively. Normal ranges of white blood cell count, lymphocyte count, percent lymphocytes, percent neutrophilic granulocyte, percent monocytes, ALT, AST, creatine kinase, hemoglobin, and C-reactive protein were 3.5–9.5 × 109/L, 1.10–3.20 × 109/L, 20–50%, 3.0–10.0%, 40–75%, 115–150 g/L, 7–40 U/L, 13–35 U/L, 40–200 U/L, and 0–10 mg/L, respectively"}
LitCovid-PD-CLO
{"project":"LitCovid-PD-CLO","denotations":[{"id":"T42","span":{"begin":287,"end":291},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T43","span":{"begin":454,"end":458},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T44","span":{"begin":519,"end":520},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T45","span":{"begin":574,"end":576},"obj":"http://purl.obolibrary.org/obo/CLO_0001382"},{"id":"T46","span":{"begin":586,"end":588},"obj":"http://purl.obolibrary.org/obo/CLO_0053799"},{"id":"T47","span":{"begin":619,"end":623},"obj":"http://purl.obolibrary.org/obo/UBERON_0003101"},{"id":"T48","span":{"begin":619,"end":623},"obj":"http://www.ebi.ac.uk/efo/EFO_0000970"},{"id":"T49","span":{"begin":680,"end":682},"obj":"http://purl.obolibrary.org/obo/CLO_0053799"},{"id":"T50","span":{"begin":862,"end":867},"obj":"http://www.ebi.ac.uk/efo/EFO_0000965"},{"id":"T51","span":{"begin":941,"end":947},"obj":"http://purl.obolibrary.org/obo/UBERON_0001630"},{"id":"T52","span":{"begin":941,"end":947},"obj":"http://purl.obolibrary.org/obo/UBERON_0005090"},{"id":"T53","span":{"begin":941,"end":947},"obj":"http://www.ebi.ac.uk/efo/EFO_0000801"},{"id":"T54","span":{"begin":941,"end":947},"obj":"http://www.ebi.ac.uk/efo/EFO_0001949"},{"id":"T55","span":{"begin":1073,"end":1080},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T56","span":{"begin":1116,"end":1121},"obj":"http://www.ebi.ac.uk/efo/EFO_0000296"},{"id":"T57","span":{"begin":1122,"end":1126},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T58","span":{"begin":1163,"end":1165},"obj":"http://purl.obolibrary.org/obo/CLO_0050507"},{"id":"T59","span":{"begin":1381,"end":1390},"obj":"http://purl.obolibrary.org/obo/CL_0000576"},{"id":"T60","span":{"begin":1662,"end":1664},"obj":"http://purl.obolibrary.org/obo/CLO_0001313"},{"id":"T61","span":{"begin":2041,"end":2046},"obj":"http://www.ebi.ac.uk/efo/EFO_0000296"},{"id":"T62","span":{"begin":2047,"end":2051},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T63","span":{"begin":2140,"end":2149},"obj":"http://purl.obolibrary.org/obo/CL_0000576"},{"id":"T64","span":{"begin":2307,"end":2309},"obj":"http://purl.obolibrary.org/obo/CLO_0001000"}],"text":"The demographics of the study cohort are detailed in Table 1. Patients with exposure history (recent travel to Wuhan or contact with infected patient) accounted for 85.2% of study cohort. Fever (84.1%) and cough (56.8%) were the most common presenting symptoms. Low lymphocyte and white cell counts were observed in 26.4% and 25.0% of patients, while high C-reactive protein was observed in 55.0% of patients.\nTable 1 Patient demographics and laboratory test results\nCharacteristic Patient with NCP (n = 88)\nAge (years)a 42.7 ± 14.5\nAge group (years)\n \u003c 15 2 (2.3)\n 15–44 48 (54.5)\n 45–64 28 (31.8)\n ≥ 65 10 (11.4)\nMale sex 51 (58.0)\nExposure history\n Recent travel to Wuhan 45 (51.1)\n Contact with infected patient 30 (34.1)\n Unknown exposure 13 (14.8)\nInitial symptoms\n Fever 74 (84.1)\n Cough 50 (56.8)\n Expectoration 19 (21.6)\n Fatigue 15 (17.0)\n Chest distress and/or shortness of breath 12 (13.6)\n Pharyngalgia 10 (11.4)\n Muscle soreness 7 (8.0)\n Headache 5 (5.7)\n Nausea and/or vomiting 0 (0)\n Diarrhea 0 (0)\n No obvious symptoms 3 (3.4)\nLaboratory testing at initial hospital visitb\n White blood cell count (–, ↑, ↓) 62 (70.5), 4 (4.5), 22 (25.0)\n Lymphocyte count (–, ↑, ↓) 62 (71.3), 2 (2.3), 23 (26.4)\n Percent lymphocytes (–, ↑, ↓) 55 (62.5), 7 (8.0), 26 (29.5)\n Percent neutrophilic granulocyte (–, ↑, ↓) 59 (67.1), 17 (19.3), 12 (13.6)\n Percent monocytes (–, ↑, ↓) 59 (67.1), 26 (29.5), 3 (3.4)\n Hemoglobin (–, ↑, ↓) 68 (77.3), 8 (9.1), 12 (13.6)\n ALT (–, ↑, ↓) 70 (79.5), 16 (18.2), 2 (2.3)\n AST (–, ↑, ↓) 73 (83.0), 15 (17.0), 0 (0)\n Creatine kinase (–, ↑, ↓) 73 (84.9), 4 (4.6), 9 (10.5)\n C-reactive protein (–, ↑, ↓) 36 (45.0), 44 (55.0), 0 (0)\nUnless otherwise indicated, data are reported as the number of patients, with percentages in parentheses\nALT alanine aminotransferase, AST aspartate aminotransferase\naData are reported as the mean ± standard derivation\nbThe signs –, ↑, and ↓ represent within, above, and below normal ranges of laboratory results, respectively. Normal ranges of white blood cell count, lymphocyte count, percent lymphocytes, percent neutrophilic granulocyte, percent monocytes, ALT, AST, creatine kinase, hemoglobin, and C-reactive protein were 3.5–9.5 × 109/L, 1.10–3.20 × 109/L, 20–50%, 3.0–10.0%, 40–75%, 115–150 g/L, 7–40 U/L, 13–35 U/L, 40–200 U/L, and 0–10 mg/L, respectively"}
LitCovid-PD-CHEBI
{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T13","span":{"begin":367,"end":374},"obj":"Chemical"},{"id":"T14","span":{"begin":537,"end":542},"obj":"Chemical"},{"id":"T15","span":{"begin":1433,"end":1443},"obj":"Chemical"},{"id":"T16","span":{"begin":1532,"end":1535},"obj":"Chemical"},{"id":"T17","span":{"begin":1576,"end":1584},"obj":"Chemical"},{"id":"T18","span":{"begin":1644,"end":1651},"obj":"Chemical"},{"id":"T19","span":{"begin":1799,"end":1806},"obj":"Chemical"},{"id":"T20","span":{"begin":1825,"end":1828},"obj":"Chemical"},{"id":"T21","span":{"begin":1829,"end":1838},"obj":"Chemical"},{"id":"T24","span":{"begin":2156,"end":2159},"obj":"Chemical"},{"id":"T25","span":{"begin":2161,"end":2169},"obj":"Chemical"},{"id":"T27","span":{"begin":2178,"end":2188},"obj":"Chemical"},{"id":"T28","span":{"begin":2205,"end":2212},"obj":"Chemical"}],"attributes":[{"id":"A13","pred":"chebi_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A14","pred":"chebi_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/CHEBI_24433"},{"id":"A15","pred":"chebi_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/CHEBI_5656"},{"id":"A16","pred":"chebi_id","subj":"T16","obj":"http://purl.obolibrary.org/obo/CHEBI_76649"},{"id":"A17","pred":"chebi_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/CHEBI_16919"},{"id":"A18","pred":"chebi_id","subj":"T18","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A19","pred":"chebi_id","subj":"T19","obj":"http://purl.obolibrary.org/obo/CHEBI_16449"},{"id":"A20","pred":"chebi_id","subj":"T20","obj":"http://purl.obolibrary.org/obo/CHEBI_76649"},{"id":"A21","pred":"chebi_id","subj":"T21","obj":"http://purl.obolibrary.org/obo/CHEBI_132943"},{"id":"A22","pred":"chebi_id","subj":"T21","obj":"http://purl.obolibrary.org/obo/CHEBI_29995"},{"id":"A23","pred":"chebi_id","subj":"T21","obj":"http://purl.obolibrary.org/obo/CHEBI_72314"},{"id":"A24","pred":"chebi_id","subj":"T24","obj":"http://purl.obolibrary.org/obo/CHEBI_76649"},{"id":"A25","pred":"chebi_id","subj":"T25","obj":"http://purl.obolibrary.org/obo/CHEBI_16919"},{"id":"A26","pred":"chebi_id","subj":"T25","obj":"http://purl.obolibrary.org/obo/CHEBI_57947"},{"id":"A27","pred":"chebi_id","subj":"T27","obj":"http://purl.obolibrary.org/obo/CHEBI_35143"},{"id":"A28","pred":"chebi_id","subj":"T28","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"}],"text":"The demographics of the study cohort are detailed in Table 1. Patients with exposure history (recent travel to Wuhan or contact with infected patient) accounted for 85.2% of study cohort. Fever (84.1%) and cough (56.8%) were the most common presenting symptoms. Low lymphocyte and white cell counts were observed in 26.4% and 25.0% of patients, while high C-reactive protein was observed in 55.0% of patients.\nTable 1 Patient demographics and laboratory test results\nCharacteristic Patient with NCP (n = 88)\nAge (years)a 42.7 ± 14.5\nAge group (years)\n \u003c 15 2 (2.3)\n 15–44 48 (54.5)\n 45–64 28 (31.8)\n ≥ 65 10 (11.4)\nMale sex 51 (58.0)\nExposure history\n Recent travel to Wuhan 45 (51.1)\n Contact with infected patient 30 (34.1)\n Unknown exposure 13 (14.8)\nInitial symptoms\n Fever 74 (84.1)\n Cough 50 (56.8)\n Expectoration 19 (21.6)\n Fatigue 15 (17.0)\n Chest distress and/or shortness of breath 12 (13.6)\n Pharyngalgia 10 (11.4)\n Muscle soreness 7 (8.0)\n Headache 5 (5.7)\n Nausea and/or vomiting 0 (0)\n Diarrhea 0 (0)\n No obvious symptoms 3 (3.4)\nLaboratory testing at initial hospital visitb\n White blood cell count (–, ↑, ↓) 62 (70.5), 4 (4.5), 22 (25.0)\n Lymphocyte count (–, ↑, ↓) 62 (71.3), 2 (2.3), 23 (26.4)\n Percent lymphocytes (–, ↑, ↓) 55 (62.5), 7 (8.0), 26 (29.5)\n Percent neutrophilic granulocyte (–, ↑, ↓) 59 (67.1), 17 (19.3), 12 (13.6)\n Percent monocytes (–, ↑, ↓) 59 (67.1), 26 (29.5), 3 (3.4)\n Hemoglobin (–, ↑, ↓) 68 (77.3), 8 (9.1), 12 (13.6)\n ALT (–, ↑, ↓) 70 (79.5), 16 (18.2), 2 (2.3)\n AST (–, ↑, ↓) 73 (83.0), 15 (17.0), 0 (0)\n Creatine kinase (–, ↑, ↓) 73 (84.9), 4 (4.6), 9 (10.5)\n C-reactive protein (–, ↑, ↓) 36 (45.0), 44 (55.0), 0 (0)\nUnless otherwise indicated, data are reported as the number of patients, with percentages in parentheses\nALT alanine aminotransferase, AST aspartate aminotransferase\naData are reported as the mean ± standard derivation\nbThe signs –, ↑, and ↓ represent within, above, and below normal ranges of laboratory results, respectively. Normal ranges of white blood cell count, lymphocyte count, percent lymphocytes, percent neutrophilic granulocyte, percent monocytes, ALT, AST, creatine kinase, hemoglobin, and C-reactive protein were 3.5–9.5 × 109/L, 1.10–3.20 × 109/L, 20–50%, 3.0–10.0%, 40–75%, 115–150 g/L, 7–40 U/L, 13–35 U/L, 40–200 U/L, and 0–10 mg/L, respectively"}
LitCovid-PD-HP
{"project":"LitCovid-PD-HP","denotations":[{"id":"T25","span":{"begin":188,"end":193},"obj":"Phenotype"},{"id":"T26","span":{"begin":206,"end":211},"obj":"Phenotype"},{"id":"T27","span":{"begin":780,"end":785},"obj":"Phenotype"},{"id":"T28","span":{"begin":798,"end":803},"obj":"Phenotype"},{"id":"T29","span":{"begin":842,"end":849},"obj":"Phenotype"},{"id":"T30","span":{"begin":884,"end":903},"obj":"Phenotype"},{"id":"T31","span":{"begin":916,"end":928},"obj":"Phenotype"},{"id":"T32","span":{"begin":967,"end":975},"obj":"Phenotype"},{"id":"T33","span":{"begin":986,"end":1008},"obj":"Phenotype"},{"id":"T34","span":{"begin":1017,"end":1025},"obj":"Phenotype"}],"attributes":[{"id":"A25","pred":"hp_id","subj":"T25","obj":"http://purl.obolibrary.org/obo/HP_0001945"},{"id":"A26","pred":"hp_id","subj":"T26","obj":"http://purl.obolibrary.org/obo/HP_0012735"},{"id":"A27","pred":"hp_id","subj":"T27","obj":"http://purl.obolibrary.org/obo/HP_0001945"},{"id":"A28","pred":"hp_id","subj":"T28","obj":"http://purl.obolibrary.org/obo/HP_0012735"},{"id":"A29","pred":"hp_id","subj":"T29","obj":"http://purl.obolibrary.org/obo/HP_0012378"},{"id":"A30","pred":"hp_id","subj":"T30","obj":"http://purl.obolibrary.org/obo/HP_0002098"},{"id":"A31","pred":"hp_id","subj":"T31","obj":"http://purl.obolibrary.org/obo/HP_0033050"},{"id":"A32","pred":"hp_id","subj":"T32","obj":"http://purl.obolibrary.org/obo/HP_0002315"},{"id":"A33","pred":"hp_id","subj":"T33","obj":"http://purl.obolibrary.org/obo/HP_0002017"},{"id":"A34","pred":"hp_id","subj":"T34","obj":"http://purl.obolibrary.org/obo/HP_0002014"}],"text":"The demographics of the study cohort are detailed in Table 1. Patients with exposure history (recent travel to Wuhan or contact with infected patient) accounted for 85.2% of study cohort. Fever (84.1%) and cough (56.8%) were the most common presenting symptoms. Low lymphocyte and white cell counts were observed in 26.4% and 25.0% of patients, while high C-reactive protein was observed in 55.0% of patients.\nTable 1 Patient demographics and laboratory test results\nCharacteristic Patient with NCP (n = 88)\nAge (years)a 42.7 ± 14.5\nAge group (years)\n \u003c 15 2 (2.3)\n 15–44 48 (54.5)\n 45–64 28 (31.8)\n ≥ 65 10 (11.4)\nMale sex 51 (58.0)\nExposure history\n Recent travel to Wuhan 45 (51.1)\n Contact with infected patient 30 (34.1)\n Unknown exposure 13 (14.8)\nInitial symptoms\n Fever 74 (84.1)\n Cough 50 (56.8)\n Expectoration 19 (21.6)\n Fatigue 15 (17.0)\n Chest distress and/or shortness of breath 12 (13.6)\n Pharyngalgia 10 (11.4)\n Muscle soreness 7 (8.0)\n Headache 5 (5.7)\n Nausea and/or vomiting 0 (0)\n Diarrhea 0 (0)\n No obvious symptoms 3 (3.4)\nLaboratory testing at initial hospital visitb\n White blood cell count (–, ↑, ↓) 62 (70.5), 4 (4.5), 22 (25.0)\n Lymphocyte count (–, ↑, ↓) 62 (71.3), 2 (2.3), 23 (26.4)\n Percent lymphocytes (–, ↑, ↓) 55 (62.5), 7 (8.0), 26 (29.5)\n Percent neutrophilic granulocyte (–, ↑, ↓) 59 (67.1), 17 (19.3), 12 (13.6)\n Percent monocytes (–, ↑, ↓) 59 (67.1), 26 (29.5), 3 (3.4)\n Hemoglobin (–, ↑, ↓) 68 (77.3), 8 (9.1), 12 (13.6)\n ALT (–, ↑, ↓) 70 (79.5), 16 (18.2), 2 (2.3)\n AST (–, ↑, ↓) 73 (83.0), 15 (17.0), 0 (0)\n Creatine kinase (–, ↑, ↓) 73 (84.9), 4 (4.6), 9 (10.5)\n C-reactive protein (–, ↑, ↓) 36 (45.0), 44 (55.0), 0 (0)\nUnless otherwise indicated, data are reported as the number of patients, with percentages in parentheses\nALT alanine aminotransferase, AST aspartate aminotransferase\naData are reported as the mean ± standard derivation\nbThe signs –, ↑, and ↓ represent within, above, and below normal ranges of laboratory results, respectively. Normal ranges of white blood cell count, lymphocyte count, percent lymphocytes, percent neutrophilic granulocyte, percent monocytes, ALT, AST, creatine kinase, hemoglobin, and C-reactive protein were 3.5–9.5 × 109/L, 1.10–3.20 × 109/L, 20–50%, 3.0–10.0%, 40–75%, 115–150 g/L, 7–40 U/L, 13–35 U/L, 40–200 U/L, and 0–10 mg/L, respectively"}
LitCovid-sentences
{"project":"LitCovid-sentences","denotations":[{"id":"T79","span":{"begin":0,"end":61},"obj":"Sentence"},{"id":"T80","span":{"begin":62,"end":187},"obj":"Sentence"},{"id":"T81","span":{"begin":188,"end":261},"obj":"Sentence"},{"id":"T82","span":{"begin":262,"end":409},"obj":"Sentence"},{"id":"T83","span":{"begin":410,"end":466},"obj":"Sentence"},{"id":"T84","span":{"begin":467,"end":507},"obj":"Sentence"},{"id":"T85","span":{"begin":508,"end":532},"obj":"Sentence"},{"id":"T86","span":{"begin":533,"end":550},"obj":"Sentence"},{"id":"T87","span":{"begin":551,"end":565},"obj":"Sentence"},{"id":"T88","span":{"begin":566,"end":583},"obj":"Sentence"},{"id":"T89","span":{"begin":584,"end":601},"obj":"Sentence"},{"id":"T90","span":{"begin":602,"end":618},"obj":"Sentence"},{"id":"T91","span":{"begin":619,"end":637},"obj":"Sentence"},{"id":"T92","span":{"begin":638,"end":654},"obj":"Sentence"},{"id":"T93","span":{"begin":655,"end":689},"obj":"Sentence"},{"id":"T94","span":{"begin":690,"end":731},"obj":"Sentence"},{"id":"T95","span":{"begin":732,"end":760},"obj":"Sentence"},{"id":"T96","span":{"begin":761,"end":777},"obj":"Sentence"},{"id":"T97","span":{"begin":778,"end":795},"obj":"Sentence"},{"id":"T98","span":{"begin":796,"end":813},"obj":"Sentence"},{"id":"T99","span":{"begin":814,"end":839},"obj":"Sentence"},{"id":"T100","span":{"begin":840,"end":859},"obj":"Sentence"},{"id":"T101","span":{"begin":860,"end":913},"obj":"Sentence"},{"id":"T102","span":{"begin":914,"end":938},"obj":"Sentence"},{"id":"T103","span":{"begin":939,"end":964},"obj":"Sentence"},{"id":"T104","span":{"begin":965,"end":983},"obj":"Sentence"},{"id":"T105","span":{"begin":984,"end":1014},"obj":"Sentence"},{"id":"T106","span":{"begin":1015,"end":1031},"obj":"Sentence"},{"id":"T107","span":{"begin":1032,"end":1061},"obj":"Sentence"},{"id":"T108","span":{"begin":1062,"end":1107},"obj":"Sentence"},{"id":"T109","span":{"begin":1108,"end":1172},"obj":"Sentence"},{"id":"T110","span":{"begin":1173,"end":1231},"obj":"Sentence"},{"id":"T111","span":{"begin":1232,"end":1293},"obj":"Sentence"},{"id":"T112","span":{"begin":1294,"end":1370},"obj":"Sentence"},{"id":"T113","span":{"begin":1371,"end":1430},"obj":"Sentence"},{"id":"T114","span":{"begin":1431,"end":1483},"obj":"Sentence"},{"id":"T115","span":{"begin":1484,"end":1529},"obj":"Sentence"},{"id":"T116","span":{"begin":1530,"end":1573},"obj":"Sentence"},{"id":"T117","span":{"begin":1574,"end":1630},"obj":"Sentence"},{"id":"T118","span":{"begin":1631,"end":1689},"obj":"Sentence"},{"id":"T119","span":{"begin":1690,"end":1794},"obj":"Sentence"},{"id":"T120","span":{"begin":1795,"end":1855},"obj":"Sentence"},{"id":"T121","span":{"begin":1856,"end":1908},"obj":"Sentence"},{"id":"T122","span":{"begin":1909,"end":2017},"obj":"Sentence"},{"id":"T123","span":{"begin":2018,"end":2354},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"The demographics of the study cohort are detailed in Table 1. Patients with exposure history (recent travel to Wuhan or contact with infected patient) accounted for 85.2% of study cohort. Fever (84.1%) and cough (56.8%) were the most common presenting symptoms. Low lymphocyte and white cell counts were observed in 26.4% and 25.0% of patients, while high C-reactive protein was observed in 55.0% of patients.\nTable 1 Patient demographics and laboratory test results\nCharacteristic Patient with NCP (n = 88)\nAge (years)a 42.7 ± 14.5\nAge group (years)\n \u003c 15 2 (2.3)\n 15–44 48 (54.5)\n 45–64 28 (31.8)\n ≥ 65 10 (11.4)\nMale sex 51 (58.0)\nExposure history\n Recent travel to Wuhan 45 (51.1)\n Contact with infected patient 30 (34.1)\n Unknown exposure 13 (14.8)\nInitial symptoms\n Fever 74 (84.1)\n Cough 50 (56.8)\n Expectoration 19 (21.6)\n Fatigue 15 (17.0)\n Chest distress and/or shortness of breath 12 (13.6)\n Pharyngalgia 10 (11.4)\n Muscle soreness 7 (8.0)\n Headache 5 (5.7)\n Nausea and/or vomiting 0 (0)\n Diarrhea 0 (0)\n No obvious symptoms 3 (3.4)\nLaboratory testing at initial hospital visitb\n White blood cell count (–, ↑, ↓) 62 (70.5), 4 (4.5), 22 (25.0)\n Lymphocyte count (–, ↑, ↓) 62 (71.3), 2 (2.3), 23 (26.4)\n Percent lymphocytes (–, ↑, ↓) 55 (62.5), 7 (8.0), 26 (29.5)\n Percent neutrophilic granulocyte (–, ↑, ↓) 59 (67.1), 17 (19.3), 12 (13.6)\n Percent monocytes (–, ↑, ↓) 59 (67.1), 26 (29.5), 3 (3.4)\n Hemoglobin (–, ↑, ↓) 68 (77.3), 8 (9.1), 12 (13.6)\n ALT (–, ↑, ↓) 70 (79.5), 16 (18.2), 2 (2.3)\n AST (–, ↑, ↓) 73 (83.0), 15 (17.0), 0 (0)\n Creatine kinase (–, ↑, ↓) 73 (84.9), 4 (4.6), 9 (10.5)\n C-reactive protein (–, ↑, ↓) 36 (45.0), 44 (55.0), 0 (0)\nUnless otherwise indicated, data are reported as the number of patients, with percentages in parentheses\nALT alanine aminotransferase, AST aspartate aminotransferase\naData are reported as the mean ± standard derivation\nbThe signs –, ↑, and ↓ represent within, above, and below normal ranges of laboratory results, respectively. Normal ranges of white blood cell count, lymphocyte count, percent lymphocytes, percent neutrophilic granulocyte, percent monocytes, ALT, AST, creatine kinase, hemoglobin, and C-reactive protein were 3.5–9.5 × 109/L, 1.10–3.20 × 109/L, 20–50%, 3.0–10.0%, 40–75%, 115–150 g/L, 7–40 U/L, 13–35 U/L, 40–200 U/L, and 0–10 mg/L, respectively"}