PMC:7156291 / 13761-17982
Annnotations
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
266 | 28-36 | Species | denotes | patients | Tax:9606 |
267 | 42-50 | Disease | denotes | COVID-19 | MESH:C000657245 |
272 | 89-97 | Species | denotes | patients | Tax:9606 |
273 | 131-139 | Species | denotes | patients | Tax:9606 |
274 | 268-275 | Species | denotes | patient | Tax:9606 |
275 | 327-335 | Species | denotes | patients | Tax:9606 |
278 | 2012-2028 | Disease | denotes | Pleural effusion | MESH:D010996 |
279 | 2065-2080 | Disease | denotes | Lymphadenopathy | MESH:D008206 |
282 | 1147-1155 | Species | denotes | patients | Tax:9606 |
283 | 1161-1169 | Disease | denotes | COVID-19 | MESH:C000657245 |
285 | 2389-2397 | Species | denotes | patients | Tax:9606 |
290 | 470-478 | Species | denotes | patients | Tax:9606 |
291 | 646-654 | Species | denotes | patients | Tax:9606 |
292 | 800-807 | Species | denotes | patient | Tax:9606 |
293 | 1018-1026 | Species | denotes | patients | Tax:9606 |
299 | 2438-2446 | Species | denotes | patients | Tax:9606 |
300 | 2543-2551 | Species | denotes | patients | Tax:9606 |
301 | 2648-2656 | Species | denotes | patients | Tax:9606 |
302 | 2451-2468 | Disease | denotes | pleural effusions | MESH:D010996 |
303 | 2486-2501 | Disease | denotes | lymphadenopathy | MESH:D008206 |
310 | 2827-2832 | Species | denotes | woman | Tax:9606 |
311 | 2867-2874 | Species | denotes | patient | Tax:9606 |
312 | 2852-2866 | Disease | denotes | COVID-infected | MESH:C000657245 |
313 | 2890-2895 | Disease | denotes | fever | MESH:D005334 |
314 | 2897-2902 | Disease | denotes | cough | MESH:D003371 |
315 | 2908-2921 | Disease | denotes | low back pain | MESH:D017116 |
320 | 3533-3540 | Species | denotes | patient | Tax:9606 |
321 | 3518-3532 | Disease | denotes | COVID-infected | MESH:C000657245 |
322 | 3556-3561 | Disease | denotes | fever | MESH:D005334 |
323 | 3566-3571 | Disease | denotes | cough | MESH:D003371 |
326 | 2772-2780 | Species | denotes | patients | Tax:9606 |
327 | 2786-2804 | Disease | denotes | COVID-19 pneumonia | MESH:C000657245 |
LitCovid-PD-FMA-UBERON
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T36 | 1059-1063 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
T37 | 1123-1127 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
T38 | 2183-2187 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
T39 | 2912-2916 | Body_part | denotes | back | http://purl.org/sig/ont/fma/fma25056 |
T40 | 2972-2987 | Body_part | denotes | left lower lobe | http://purl.org/sig/ont/fma/fma7371 |
T41 | 3093-3098 | Body_part | denotes | lungs | http://purl.org/sig/ont/fma/fma68877 |
T42 | 3126-3141 | Body_part | denotes | left lower lobe | http://purl.org/sig/ont/fma/fma7371 |
T43 | 3271-3286 | Body_part | denotes | left lower lobe | http://purl.org/sig/ont/fma/fma7371 |
T44 | 3421-3436 | Body_part | denotes | left lower lobe | http://purl.org/sig/ont/fma/fma7371 |
T45 | 3658-3673 | Body_part | denotes | left lower lobe | http://purl.org/sig/ont/fma/fma7371 |
T46 | 3776-3792 | Body_part | denotes | left lower lobes | http://purl.org/sig/ont/fma/fma7371 |
LitCovid-PD-UBERON
Id | Subject | Object | Predicate | Lexical cue | uberon_id |
---|---|---|---|---|---|
T23 | 1059-1063 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
T24 | 1123-1127 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
T25 | 2012-2028 | Body_part | denotes | Pleural effusion | http://purl.obolibrary.org/obo/UBERON_0000175 |
T26 | 2183-2187 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
T27 | 2451-2468 | Body_part | denotes | pleural effusions | http://purl.obolibrary.org/obo/UBERON_0000175 |
T28 | 2983-2987 | Body_part | denotes | lobe | http://purl.obolibrary.org/obo/UBERON_3010752 |
T29 | 3137-3141 | Body_part | denotes | lobe | http://purl.obolibrary.org/obo/UBERON_3010752 |
T30 | 3282-3286 | Body_part | denotes | lobe | http://purl.obolibrary.org/obo/UBERON_3010752 |
T31 | 3432-3436 | Body_part | denotes | lobe | http://purl.obolibrary.org/obo/UBERON_3010752 |
T32 | 3669-3673 | Body_part | denotes | lobe | http://purl.obolibrary.org/obo/UBERON_3010752 |
T33 | 4145-4149 | Body_part | denotes | lobe | http://purl.obolibrary.org/obo/UBERON_3010752 |
LitCovid-PD-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T40 | 42-50 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T41 | 1161-1169 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T42 | 2065-2080 | Disease | denotes | Lymphadenopathy | http://purl.obolibrary.org/obo/MONDO_0005833 |
T43 | 2486-2501 | Disease | denotes | lymphadenopathy | http://purl.obolibrary.org/obo/MONDO_0005833 |
T44 | 2786-2794 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T45 | 2795-2804 | Disease | denotes | pneumonia | http://purl.obolibrary.org/obo/MONDO_0005249 |
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T76 | 630-631 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
T77 | 692-693 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T78 | 784-785 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T79 | 1059-1063 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
T80 | 1059-1063 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
T81 | 1123-1127 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
T82 | 1123-1127 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
T83 | 1316-1318 | http://purl.obolibrary.org/obo/CLO_0053733 | denotes | 11 |
T84 | 2012-2028 | http://purl.obolibrary.org/obo/UBERON_0000175 | denotes | Pleural effusion |
T85 | 2183-2187 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
T86 | 2183-2187 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
T87 | 2312-2314 | http://purl.obolibrary.org/obo/CLO_0053733 | denotes | 11 |
T88 | 2330-2332 | http://purl.obolibrary.org/obo/CLO_0053733 | denotes | 11 |
T89 | 2451-2468 | http://purl.obolibrary.org/obo/UBERON_0000175 | denotes | pleural effusions |
T90 | 2813-2817 | http://purl.obolibrary.org/obo/CLO_0001599 | denotes | A 54 |
T91 | 2850-2851 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T92 | 2959-2960 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T93 | 3033-3036 | http://purl.obolibrary.org/obo/CLO_0002755 | denotes | d–f |
T94 | 3055-3056 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T95 | 3093-3098 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lungs |
T96 | 3338-3340 | http://purl.obolibrary.org/obo/CLO_0053733 | denotes | 11 |
T97 | 3481-3485 | http://purl.obolibrary.org/obo/CLO_0001568 | denotes | A 24 |
T98 | 3516-3517 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T99 | 3618-3621 | http://purl.obolibrary.org/obo/CLO_0051456 | denotes | a–e |
T100 | 3964-3966 | http://purl.obolibrary.org/obo/CLO_0053733 | denotes | 11 |
LitCovid-PD-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T29 | 2212-2214 | Chemical | denotes | SD | http://purl.obolibrary.org/obo/CHEBI_74807 |
LitCovid-PD-HP
Id | Subject | Object | Predicate | Lexical cue | hp_id |
---|---|---|---|---|---|
T35 | 1351-1370 | Phenotype | denotes | Pulmonary opacities | http://purl.obolibrary.org/obo/HP_0031457 |
T36 | 2012-2028 | Phenotype | denotes | Pleural effusion | http://purl.obolibrary.org/obo/HP_0002202 |
T37 | 2065-2080 | Phenotype | denotes | Lymphadenopathy | http://purl.obolibrary.org/obo/HP_0002716 |
T38 | 2451-2468 | Phenotype | denotes | pleural effusions | http://purl.obolibrary.org/obo/HP_0002202 |
T39 | 2486-2501 | Phenotype | denotes | lymphadenopathy | http://purl.obolibrary.org/obo/HP_0002716 |
T40 | 2795-2804 | Phenotype | denotes | pneumonia | http://purl.obolibrary.org/obo/HP_0002090 |
T41 | 2890-2895 | Phenotype | denotes | fever | http://purl.obolibrary.org/obo/HP_0001945 |
T42 | 2897-2902 | Phenotype | denotes | cough | http://purl.obolibrary.org/obo/HP_0012735 |
T43 | 2908-2921 | Phenotype | denotes | low back pain | http://purl.obolibrary.org/obo/HP_0003419 |
T44 | 3556-3561 | Phenotype | denotes | fever | http://purl.obolibrary.org/obo/HP_0001945 |
T45 | 3566-3571 | Phenotype | denotes | cough | http://purl.obolibrary.org/obo/HP_0012735 |
T46 | 4158-4168 | Phenotype | denotes | atoll sign | http://purl.obolibrary.org/obo/HP_0032983 |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T140 | 0-50 | Sentence | denotes | Evolution of CT findings in patients with COVID-19 |
T141 | 51-112 | Sentence | denotes | The initial CTs of 4 out of 88 (4.5%) patients were negative. |
T142 | 113-236 | Sentence | denotes | Two of these four patients had their baseline CT during days 1–3, one during days 4–7, and one during days 8–10 of disease. |
T143 | 237-363 | Sentence | denotes | Subsequently, CT images of one patient remained negative even during days 8–10, and other patients developed CT abnormalities. |
T144 | 364-629 | Sentence | denotes | There were significant differences between the time interval groups after disease onset in proportions of patients with both GGO and consolidation (χ2 = 22.2, p < 0.01) and the combination of GGO, consolidation, and linear opacities (χ2 = 21.5, p < 0.01) (Table 2). |
T145 | 630-959 | Sentence | denotes | A proportion of patients with GGO and consolidation presented a decreasing trend during the 21 days after disease onset (y = 0.48–0.09x, p < 0.01), while a proportion of patient with all three findings including ground glass opacities, consolidation, and linear opacities presented an increasing trend (y = 0.12–0.11x, p < 0.01). |
T146 | 960-1079 | Sentence | denotes | No significant difference was found in the proportions of patients with other CT findings or total lung severity score. |
T147 | 1080-1204 | Sentence | denotes | Table 2 Evolution of CT findings and total lung severity scores of patients with COVID-19 within 21 days after disease onset |
T148 | 1205-1255 | Sentence | denotes | Characteristic Time after disease onset χ2 p value |
T149 | 1256-1350 | Sentence | denotes | Days 0–3 (n = 37) Days 4–7 (n = 69) Days 8–10 (n = 53) Days 11–14 (n = 49) Days 15–21 (n = 25) |
T150 | 1351-1370 | Sentence | denotes | Pulmonary opacities |
T151 | 1371-1434 | Sentence | denotes | GGO only 8 (21.6) 13 (18.8) 7 (13.2) 4 (8.2) 1 (4.0) 6.6 0.16 |
T152 | 1435-1516 | Sentence | denotes | GGO and consolidation 12 (32.4) 26 (37.7) 8 (15.1) 5 (10.1) 1 (4.0) 22.2 < 0.01 |
T153 | 1517-1593 | Sentence | denotes | GGO and linear opacities 2 (5.4) 2 (2.9) 4 (7.5) 2 (4.1) 2 (8.0) 1.87 0.76 |
T154 | 1594-1664 | Sentence | denotes | Consolidation only 1 (2.8) 6 (8.7) 3 (5.7) 4 (8.2) 1 (4.0) 1.98 0.74 |
T155 | 1665-1749 | Sentence | denotes | Consolidation and linear opacities 0 (0) 2 (2.9) 4 (7.5) 4 (8.2) 3 (12.0) 6.0 0.19 |
T156 | 1750-1854 | Sentence | denotes | GGO, consolidation, and linear opacities 12 (32.4) 19 (27.5) 25 (47.2) 30 (61.2) 17 (68.0) 21.5 < 0.01 |
T157 | 1855-1917 | Sentence | denotes | Negative CT 2 (5.4) 1 (1.5) 2 (3.8) 0 (0.0) 0 (0.0) 4.3 0.36 |
T158 | 1918-1932 | Sentence | denotes | Other findings |
T159 | 1933-2009 | Sentence | denotes | Discrete pulmonary nodules 4 (10.8) 4 (5.8) 3 (5.7) 1 (2.0) 0 (0) 4.8 0.36 |
T160 | 2010-2062 | Sentence | denotes | Pleural effusion 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) – – |
T161 | 2063-2114 | Sentence | denotes | Lymphadenopathy 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) – – |
T162 | 2115-2176 | Sentence | denotes | Cavitation 3 (8.1) 3 (4.3) 1 (1.9) 2 (4.1) 1 (4.0) 2.1 0.72 |
T163 | 2177-2202 | Sentence | denotes | Total lung severity score |
T164 | 2203-2271 | Sentence | denotes | Mean ± SD 3.9 ± 2.7 4.8 ± 2.9 4.9 ± 2.8 5.3 ± 3.3 5.2 ± 2.8 – 0.29 |
T165 | 2272-2337 | Sentence | denotes | Median (range) 4 (0–10) 5 (0–12) 5 (0–11) 5 (1–13) 5 (1–11) – – |
T166 | 2338-2376 | Sentence | denotes | Numbers in parentheses are percentages |
T167 | 2377-2425 | Sentence | denotes | n number of patients, GGO ground glass opacities |
T168 | 2426-2530 | Sentence | denotes | None of the patients had pleural effusions or intrathoracic lymphadenopathy during the follow-up period. |
T169 | 2531-2714 | Sentence | denotes | Some of the patients had cavitation on CT, but these are thought to represent pre-existing conditions as none of the patients in the study cohort developed cavitation on follow-up CT. |
T170 | 2715-2805 | Sentence | denotes | Figures 3 and 4 show the evolution of CT findings of two patients with COVID-19 pneumonia. |
T171 | 2806-3001 | Sentence | denotes | Fig. 3 A 54-year-old woman with exposure to a COVID-infected patient presented with fever, cough, and low back pain for 2 days and remains hospitalized. a–c CT shows left lower lobe GGO on day 2. |
T172 | 3002-3099 | Sentence | denotes | The total severity score is 1. d–f CT on day 7 shows a significant increase in GGO in both lungs. |
T173 | 3100-3147 | Sentence | denotes | The severity score of the left lower lobe is 2. |
T174 | 3148-3244 | Sentence | denotes | The total severity score is 5. g–i CT on day 9 shows bilateral GGO and subpleural consolidation. |
T175 | 3245-3292 | Sentence | denotes | The severity score of the left lower lobe is 3. |
T176 | 3293-3394 | Sentence | denotes | The total severity score is 9. j–l CT on day 11 shows diffuse GGO and linear opacities (thick arrow). |
T177 | 3395-3442 | Sentence | denotes | The severity score of the left lower lobe is 4. |
T178 | 3443-3473 | Sentence | denotes | The total severity score is 12 |
T179 | 3474-3697 | Sentence | denotes | Fig. 4 A 24-year-old man with exposure to a COVID-infected patient presented with fever and cough for 1 day and remains hospitalized currently. a–e CT scan shows GGO in the subpleural left lower lobe on day 1 (thick arrow). |
T180 | 3698-3807 | Sentence | denotes | The overall total severity score is 1. f–j CT on day 4 shows enlarging GGO in left lower lobes (thick arrow). |
T181 | 3808-3908 | Sentence | denotes | The overall total severity score is 3. k–o CT on day 8 shows increased GGO in bilateral lower lobes. |
T182 | 3909-4041 | Sentence | denotes | The total severity score was 5. p–t CT obtained on day 11 shows bilateral ground glass opacities and linear opacities (thick arrow). |
T183 | 4042-4183 | Sentence | denotes | The overall total severity score was 7. u–y CT obtained on day 15 shows improvement of bilateral lower lobe GGO and atoll sign (thick arrow). |
T184 | 4184-4221 | Sentence | denotes | The overall total severity score is 5 |