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PMC:7152911 / 67599-69255 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1425 1290-1299 Species denotes C. parvum Tax:5807
1426 293-309 Chemical denotes oligonucleotides MESH:D009841
1427 695-710 Chemical denotes oligonucleotide MESH:D009841

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T152 16-19 Body_part denotes DNA http://purl.org/sig/ont/fma/fma74412
T153 156-159 Body_part denotes DNA http://purl.org/sig/ont/fma/fma74412
T154 1119-1122 Body_part denotes DNA http://purl.org/sig/ont/fma/fma74412

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T463 31-32 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T464 127-128 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T465 455-456 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T466 492-493 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T467 680-681 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T468 883-884 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T469 1051-1052 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T470 1110-1111 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T471 1145-1146 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T472 1408-1411 http://purl.obolibrary.org/obo/CLO_0051582 denotes has

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T83556 0-19 Chemical denotes Single-stranded DNA http://purl.obolibrary.org/obo/CHEBI_9160
T94086 16-19 Chemical denotes DNA http://purl.obolibrary.org/obo/CHEBI_16991
T14585 21-26 Chemical denotes ssDNA http://purl.obolibrary.org/obo/CHEBI_9160
T20829 101-106 Chemical denotes ssDNA http://purl.obolibrary.org/obo/CHEBI_9160
T89112 156-159 Chemical denotes DNA http://purl.obolibrary.org/obo/CHEBI_16991
T93354 174-179 Chemical denotes ssDNA http://purl.obolibrary.org/obo/CHEBI_9160
T35047 180-188 Chemical denotes aptamers http://purl.obolibrary.org/obo/CHEBI_140488
T63521 293-309 Chemical denotes oligonucleotides http://purl.obolibrary.org/obo/CHEBI_7754
T41981 337-346 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T62122 550-557 Chemical denotes ligands http://purl.obolibrary.org/obo/CHEBI_52214
T9235 695-710 Chemical denotes oligonucleotide http://purl.obolibrary.org/obo/CHEBI_7754
T54261 767-775 Chemical denotes aptamers http://purl.obolibrary.org/obo/CHEBI_140488
T49855 1005-1012 Chemical denotes aptamer http://purl.obolibrary.org/obo/CHEBI_140488
T32746 1119-1122 Chemical denotes DNA http://purl.obolibrary.org/obo/CHEBI_16991
T99337 1250-1257 Chemical denotes aptamer http://purl.obolibrary.org/obo/CHEBI_140488
T97 1372-1380 Chemical denotes aptamers http://purl.obolibrary.org/obo/CHEBI_140488
T86290 1525-1532 Chemical denotes aptamer http://purl.obolibrary.org/obo/CHEBI_140488

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T28 1544-1555 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T546 0-94 Sentence denotes Single-stranded DNA (ssDNA) is a useful biorecognition element for the detection of pathogens.
T547 95-263 Sentence denotes While ssDNA is commonly used as a biorecognition element for DNA-based assays, ssDNA aptamers are commonly used for pathogen detection using electrochemical biosensors.
T548 264-396 Sentence denotes Aptamers are single-stranded oligonucleotides capable of binding various molecules with high affinity and selectivity (Lakhin et al.
T549 397-420 Sentence denotes 2013; Reverdatto et al.
T550 421-427 Sentence denotes 2015).
T551 428-624 Sentence denotes Aptamers are isolated from a large random sequence pool through a selection process that utilizes systematic evolution of ligands by exponential enrichment, also known as SELEX (Stoltenburg et al.
T552 625-631 Sentence denotes 2007).
T553 632-760 Sentence denotes Suitable binding sequences can be isolated from a large random oligonucleotide sequence pool and subsequently amplified for use.
T554 761-842 Sentence denotes Thus, aptamers can exhibit high selectivity to target species (Stoltenburg et al.
T555 843-849 Sentence denotes 2007).
T556 850-957 Sentence denotes Aptamers can also be produced at a lower cost than alternative biorecognition elements, such as antibodies.
T557 958-1185 Sentence denotes Giamberardino et al. used SELEX to discover an aptamer for norovirus detection, which showed a million-fold higher binding affinity for the target than a random DNA strand that served as a negative control (Giamberardino et al.
T558 1186-1192 Sentence denotes 2013).
T559 1193-1344 Sentence denotes Iqbal et al. performed 10 rounds of SELEX to discover 14 aptamer clones with high affinities for C. parvum for detection in fruit samples (Iqbal et al.
T560 1345-1351 Sentence denotes 2015).
T561 1352-1649 Sentence denotes However, the use of aptamers as biorecognition elements has not yet replaced traditional biorecognition elements, such as antibodies, because of several challenges, such as aptamer stability, degradation, cross-reactivity, and reproducibility using alternative processing approaches (Lakhin et al.
T562 1650-1656 Sentence denotes 2013).

2_test

Id Subject Object Predicate Lexical cue
32364936-24455181-7713083 397-401 24455181 denotes 2013
32364936-25866267-7713084 421-425 25866267 denotes 2015
32364936-17627883-7713085 625-629 17627883 denotes 2007
32364936-17627883-7713086 843-847 17627883 denotes 2007
32364936-24455181-7713087 1650-1654 24455181 denotes 2013