PMC:7152911 / 65837-66899 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7152911","sourcedb":"PMC","sourceid":"7152911","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7152911","text":"2.2.2 Carbohydrate-binding proteins\nCarbohydrate-binding proteins, such as lectins, also provide selective biorecognition elements for pathogen detection based on their ability to selectively bind ligands on target species. Peptide-based biorecognition elements are relatively low-cost, can be produced with high yield automated synthesis processes, and are modifiable (Pavan and Berti, 2012). For example, lectins have been investigated as biorecognition elements for pathogen detection through their ability to selectively bind glycosylated proteins on the surfaces of viruses and cells (Reina et al. 2008). Concanavalin A (ConA) lectin has been extensively investigated for E. coli detection (see Table 1) (Jantra et al. 2011; Saucedo et al. 2019; Xi et al. 2011; Yang et al. 2016b). While not yet widely investigated for pathogen detection using electrochemical biosensors, Etayash et al. recently showed that oligopeptides also provide attractive biorecognition elements for real-time biosensor-based detection of breast cancer cells (Etayash et al. 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