PMC:7152911 / 133733-135331 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"2015","span":{"begin":1012,"end":1019},"obj":"Species"},{"id":"2016","span":{"begin":651,"end":658},"obj":"Chemical"},{"id":"2017","span":{"begin":664,"end":668},"obj":"Chemical"},{"id":"2018","span":{"begin":898,"end":905},"obj":"Chemical"},{"id":"2019","span":{"begin":954,"end":956},"obj":"Chemical"},{"id":"2020","span":{"begin":1115,"end":1132},"obj":"Chemical"},{"id":"2021","span":{"begin":1072,"end":1079},"obj":"Disease"}],"attributes":[{"id":"A2015","pred":"tao:has_database_id","subj":"2015","obj":"Tax:562"},{"id":"A2016","pred":"tao:has_database_id","subj":"2016","obj":"MESH:D005998"},{"id":"A2017","pred":"tao:has_database_id","subj":"2017","obj":"MESH:D014508"},{"id":"A2018","pred":"tao:has_database_id","subj":"2018","obj":"MESH:D000096"},{"id":"A2019","pred":"tao:has_database_id","subj":"2019","obj":"MESH:D006046"},{"id":"A2020","pred":"tao:has_database_id","subj":"2020","obj":"MESH:D006861"},{"id":"A2021","pred":"tao:has_database_id","subj":"2021","obj":"MESH:C535882"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"5.5 Saturation-free continuous monitoring formats\nThe inability to regenerate biosensors is a major hindrance to biosensor-based process monitoring and control applications. While various biosensors must be disposed of after a single use, the regeneration of biosensor surfaces using chemical approaches has been leveraged as an approach for creating multiple-use biosensors. Biosensor regeneration approaches typically involve chemically-mediated dissociation of the target from the immobilized biorecognition element or removal of the biorecognition element altogether. This can be accomplished through acid-base mediated regeneration, detergents, glycine, and urea as well as achieved by thermal regeneration, plasma cleaning, or even direct electrochemical desorption (Goode et al. 2015; Huang et al. 2010; Zelada-Guillen et al. 2010). For example, Dweik et al. used a combination of organic (acetone) and plasma cleaning protocols to regenerate an Au interdigitated microelectrode array after detection of E. coli to use devices five times each (Dweik et al. 2012). Johnson and Mutharasan used a liquid-phase hydrogen peroxide-mediated UV-photooxidation process for regeneration of biosensor surfaces as an alternative to aggressive chemical treatments, such as those based on the use of high- or low-pH solutions (Johnson and Mutharasan, 2013b). We note that an ideal biosensor regeneration (i.e., cleaning) approach for process monitoring applications would remove the captured target in situ using a chemical-free approach and preserve the biorecognition layer for subsequent measurements."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T50","span":{"begin":651,"end":658},"obj":"Body_part"},{"id":"T51","span":{"begin":714,"end":720},"obj":"Body_part"},{"id":"T52","span":{"begin":911,"end":917},"obj":"Body_part"}],"attributes":[{"id":"A50","pred":"fma_id","subj":"T50","obj":"http://purl.org/sig/ont/fma/fma82753"},{"id":"A51","pred":"fma_id","subj":"T51","obj":"http://purl.org/sig/ont/fma/fma62970"},{"id":"A52","pred":"fma_id","subj":"T52","obj":"http://purl.org/sig/ont/fma/fma62970"}],"text":"5.5 Saturation-free continuous monitoring formats\nThe inability to regenerate biosensors is a major hindrance to biosensor-based process monitoring and control applications. While various biosensors must be disposed of after a single use, the regeneration of biosensor surfaces using chemical approaches has been leveraged as an approach for creating multiple-use biosensors. Biosensor regeneration approaches typically involve chemically-mediated dissociation of the target from the immobilized biorecognition element or removal of the biorecognition element altogether. This can be accomplished through acid-base mediated regeneration, detergents, glycine, and urea as well as achieved by thermal regeneration, plasma cleaning, or even direct electrochemical desorption (Goode et al. 2015; Huang et al. 2010; Zelada-Guillen et al. 2010). For example, Dweik et al. used a combination of organic (acetone) and plasma cleaning protocols to regenerate an Au interdigitated microelectrode array after detection of E. coli to use devices five times each (Dweik et al. 2012). Johnson and Mutharasan used a liquid-phase hydrogen peroxide-mediated UV-photooxidation process for regeneration of biosensor surfaces as an alternative to aggressive chemical treatments, such as those based on the use of high- or low-pH solutions (Johnson and Mutharasan, 2013b). We note that an ideal biosensor regeneration (i.e., cleaning) approach for process monitoring applications would remove the captured target in situ using a chemical-free approach and preserve the biorecognition layer for subsequent measurements."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T219","span":{"begin":93,"end":94},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T220","span":{"begin":226,"end":227},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T221","span":{"begin":305,"end":308},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T222","span":{"begin":714,"end":720},"obj":"http://purl.obolibrary.org/obo/UBERON_0001969"},{"id":"T223","span":{"begin":872,"end":873},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T224","span":{"begin":889,"end":896},"obj":"http://purl.obolibrary.org/obo/OBI_0100026"},{"id":"T225","span":{"begin":889,"end":896},"obj":"http://purl.obolibrary.org/obo/UBERON_0000468"},{"id":"T226","span":{"begin":911,"end":917},"obj":"http://purl.obolibrary.org/obo/UBERON_0001969"},{"id":"T227","span":{"begin":1027,"end":1034},"obj":"http://purl.obolibrary.org/obo/OBI_0000968"},{"id":"T228","span":{"begin":1100,"end":1101},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T229","span":{"begin":1507,"end":1508},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"5.5 Saturation-free continuous monitoring formats\nThe inability to regenerate biosensors is a major hindrance to biosensor-based process monitoring and control applications. While various biosensors must be disposed of after a single use, the regeneration of biosensor surfaces using chemical approaches has been leveraged as an approach for creating multiple-use biosensors. Biosensor regeneration approaches typically involve chemically-mediated dissociation of the target from the immobilized biorecognition element or removal of the biorecognition element altogether. This can be accomplished through acid-base mediated regeneration, detergents, glycine, and urea as well as achieved by thermal regeneration, plasma cleaning, or even direct electrochemical desorption (Goode et al. 2015; Huang et al. 2010; Zelada-Guillen et al. 2010). For example, Dweik et al. used a combination of organic (acetone) and plasma cleaning protocols to regenerate an Au interdigitated microelectrode array after detection of E. coli to use devices five times each (Dweik et al. 2012). Johnson and Mutharasan used a liquid-phase hydrogen peroxide-mediated UV-photooxidation process for regeneration of biosensor surfaces as an alternative to aggressive chemical treatments, such as those based on the use of high- or low-pH solutions (Johnson and Mutharasan, 2013b). We note that an ideal biosensor regeneration (i.e., cleaning) approach for process monitoring applications would remove the captured target in situ using a chemical-free approach and preserve the biorecognition layer for subsequent measurements."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T97738","span":{"begin":606,"end":610},"obj":"Chemical"},{"id":"T30089","span":{"begin":611,"end":615},"obj":"Chemical"},{"id":"T2572","span":{"begin":651,"end":658},"obj":"Chemical"},{"id":"T93186","span":{"begin":664,"end":668},"obj":"Chemical"},{"id":"T90680","span":{"begin":898,"end":905},"obj":"Chemical"},{"id":"T48726","span":{"begin":954,"end":956},"obj":"Chemical"},{"id":"T27352","span":{"begin":1115,"end":1132},"obj":"Chemical"},{"id":"T67965","span":{"begin":1115,"end":1123},"obj":"Chemical"},{"id":"T44570","span":{"begin":1124,"end":1132},"obj":"Chemical"}],"attributes":[{"id":"A91580","pred":"chebi_id","subj":"T97738","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A54352","pred":"chebi_id","subj":"T30089","obj":"http://purl.obolibrary.org/obo/CHEBI_22695"},{"id":"A79125","pred":"chebi_id","subj":"T2572","obj":"http://purl.obolibrary.org/obo/CHEBI_15428"},{"id":"A16724","pred":"chebi_id","subj":"T2572","obj":"http://purl.obolibrary.org/obo/CHEBI_29947"},{"id":"A27978","pred":"chebi_id","subj":"T2572","obj":"http://purl.obolibrary.org/obo/CHEBI_57305"},{"id":"A67752","pred":"chebi_id","subj":"T93186","obj":"http://purl.obolibrary.org/obo/CHEBI_16199"},{"id":"A7753","pred":"chebi_id","subj":"T90680","obj":"http://purl.obolibrary.org/obo/CHEBI_15347"},{"id":"A78006","pred":"chebi_id","subj":"T48726","obj":"http://purl.obolibrary.org/obo/CHEBI_29287"},{"id":"A47126","pred":"chebi_id","subj":"T27352","obj":"http://purl.obolibrary.org/obo/CHEBI_16240"},{"id":"A32661","pred":"chebi_id","subj":"T67965","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A31225","pred":"chebi_id","subj":"T44570","obj":"http://purl.obolibrary.org/obo/CHEBI_44785"}],"text":"5.5 Saturation-free continuous monitoring formats\nThe inability to regenerate biosensors is a major hindrance to biosensor-based process monitoring and control applications. While various biosensors must be disposed of after a single use, the regeneration of biosensor surfaces using chemical approaches has been leveraged as an approach for creating multiple-use biosensors. Biosensor regeneration approaches typically involve chemically-mediated dissociation of the target from the immobilized biorecognition element or removal of the biorecognition element altogether. This can be accomplished through acid-base mediated regeneration, detergents, glycine, and urea as well as achieved by thermal regeneration, plasma cleaning, or even direct electrochemical desorption (Goode et al. 2015; Huang et al. 2010; Zelada-Guillen et al. 2010). For example, Dweik et al. used a combination of organic (acetone) and plasma cleaning protocols to regenerate an Au interdigitated microelectrode array after detection of E. coli to use devices five times each (Dweik et al. 2012). Johnson and Mutharasan used a liquid-phase hydrogen peroxide-mediated UV-photooxidation process for regeneration of biosensor surfaces as an alternative to aggressive chemical treatments, such as those based on the use of high- or low-pH solutions (Johnson and Mutharasan, 2013b). We note that an ideal biosensor regeneration (i.e., cleaning) approach for process monitoring applications would remove the captured target in situ using a chemical-free approach and preserve the biorecognition layer for subsequent measurements."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T14","span":{"begin":244,"end":256},"obj":"http://purl.obolibrary.org/obo/GO_0031099"},{"id":"T15","span":{"begin":387,"end":399},"obj":"http://purl.obolibrary.org/obo/GO_0031099"},{"id":"T16","span":{"begin":625,"end":637},"obj":"http://purl.obolibrary.org/obo/GO_0031099"},{"id":"T17","span":{"begin":700,"end":712},"obj":"http://purl.obolibrary.org/obo/GO_0031099"},{"id":"T18","span":{"begin":1172,"end":1184},"obj":"http://purl.obolibrary.org/obo/GO_0031099"},{"id":"T19","span":{"begin":1385,"end":1397},"obj":"http://purl.obolibrary.org/obo/GO_0031099"}],"text":"5.5 Saturation-free continuous monitoring formats\nThe inability to regenerate biosensors is a major hindrance to biosensor-based process monitoring and control applications. While various biosensors must be disposed of after a single use, the regeneration of biosensor surfaces using chemical approaches has been leveraged as an approach for creating multiple-use biosensors. Biosensor regeneration approaches typically involve chemically-mediated dissociation of the target from the immobilized biorecognition element or removal of the biorecognition element altogether. This can be accomplished through acid-base mediated regeneration, detergents, glycine, and urea as well as achieved by thermal regeneration, plasma cleaning, or even direct electrochemical desorption (Goode et al. 2015; Huang et al. 2010; Zelada-Guillen et al. 2010). For example, Dweik et al. used a combination of organic (acetone) and plasma cleaning protocols to regenerate an Au interdigitated microelectrode array after detection of E. coli to use devices five times each (Dweik et al. 2012). Johnson and Mutharasan used a liquid-phase hydrogen peroxide-mediated UV-photooxidation process for regeneration of biosensor surfaces as an alternative to aggressive chemical treatments, such as those based on the use of high- or low-pH solutions (Johnson and Mutharasan, 2013b). We note that an ideal biosensor regeneration (i.e., cleaning) approach for process monitoring applications would remove the captured target in situ using a chemical-free approach and preserve the biorecognition layer for subsequent measurements."}

{"project":"LitCovid-sentences","denotations":[{"id":"T1082","span":{"begin":0,"end":50},"obj":"Sentence"},{"id":"T1083","span":{"begin":51,"end":174},"obj":"Sentence"},{"id":"T1084","span":{"begin":175,"end":376},"obj":"Sentence"},{"id":"T1085","span":{"begin":377,"end":572},"obj":"Sentence"},{"id":"T1086","span":{"begin":573,"end":786},"obj":"Sentence"},{"id":"T1087","span":{"begin":787,"end":805},"obj":"Sentence"},{"id":"T1088","span":{"begin":806,"end":833},"obj":"Sentence"},{"id":"T1089","span":{"begin":834,"end":840},"obj":"Sentence"},{"id":"T1090","span":{"begin":841,"end":1064},"obj":"Sentence"},{"id":"T1091","span":{"begin":1065,"end":1071},"obj":"Sentence"},{"id":"T1092","span":{"begin":1072,"end":1352},"obj":"Sentence"},{"id":"T1093","span":{"begin":1353,"end":1598},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"5.5 Saturation-free continuous monitoring formats\nThe inability to regenerate biosensors is a major hindrance to biosensor-based process monitoring and control applications. While various biosensors must be disposed of after a single use, the regeneration of biosensor surfaces using chemical approaches has been leveraged as an approach for creating multiple-use biosensors. Biosensor regeneration approaches typically involve chemically-mediated dissociation of the target from the immobilized biorecognition element or removal of the biorecognition element altogether. This can be accomplished through acid-base mediated regeneration, detergents, glycine, and urea as well as achieved by thermal regeneration, plasma cleaning, or even direct electrochemical desorption (Goode et al. 2015; Huang et al. 2010; Zelada-Guillen et al. 2010). For example, Dweik et al. used a combination of organic (acetone) and plasma cleaning protocols to regenerate an Au interdigitated microelectrode array after detection of E. coli to use devices five times each (Dweik et al. 2012). Johnson and Mutharasan used a liquid-phase hydrogen peroxide-mediated UV-photooxidation process for regeneration of biosensor surfaces as an alternative to aggressive chemical treatments, such as those based on the use of high- or low-pH solutions (Johnson and Mutharasan, 2013b). We note that an ideal biosensor regeneration (i.e., cleaning) approach for process monitoring applications would remove the captured target in situ using a chemical-free approach and preserve the biorecognition layer for subsequent measurements."}

{"project":"2_test","denotations":[{"id":"32364936-25402969-7713196","span":{"begin":787,"end":791},"obj":"25402969"},{"id":"32364936-19932018-7713197","span":{"begin":806,"end":810},"obj":"19932018"},{"id":"32364936-20961052-7713198","span":{"begin":834,"end":838},"obj":"20961052"},{"id":"32364936-22608418-7713199","span":{"begin":1065,"end":1069},"obj":"22608418"}],"text":"5.5 Saturation-free continuous monitoring formats\nThe inability to regenerate biosensors is a major hindrance to biosensor-based process monitoring and control applications. While various biosensors must be disposed of after a single use, the regeneration of biosensor surfaces using chemical approaches has been leveraged as an approach for creating multiple-use biosensors. Biosensor regeneration approaches typically involve chemically-mediated dissociation of the target from the immobilized biorecognition element or removal of the biorecognition element altogether. This can be accomplished through acid-base mediated regeneration, detergents, glycine, and urea as well as achieved by thermal regeneration, plasma cleaning, or even direct electrochemical desorption (Goode et al. 2015; Huang et al. 2010; Zelada-Guillen et al. 2010). For example, Dweik et al. used a combination of organic (acetone) and plasma cleaning protocols to regenerate an Au interdigitated microelectrode array after detection of E. coli to use devices five times each (Dweik et al. 2012). Johnson and Mutharasan used a liquid-phase hydrogen peroxide-mediated UV-photooxidation process for regeneration of biosensor surfaces as an alternative to aggressive chemical treatments, such as those based on the use of high- or low-pH solutions (Johnson and Mutharasan, 2013b). We note that an ideal biosensor regeneration (i.e., cleaning) approach for process monitoring applications would remove the captured target in situ using a chemical-free approach and preserve the biorecognition layer for subsequent measurements."}