PMC:7152911 / 127114-131265
Annnotations
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
1964 | 1092-1098 | Chemical | denotes | carbon | MESH:D002244 |
1965 | 1149-1157 | Chemical | denotes | graphene | MESH:D006108 |
1972 | 277-283 | Chemical | denotes | Carbon | MESH:D002244 |
1973 | 308-316 | Chemical | denotes | graphite | MESH:D006108 |
1974 | 318-326 | Chemical | denotes | graphene | MESH:D006108 |
1975 | 539-545 | Chemical | denotes | carbon | MESH:D002244 |
1976 | 659-666 | Chemical | denotes | polymer | MESH:D011108 |
1977 | 736-741 | Chemical | denotes | metal | MESH:D008670 |
1982 | 2999-3007 | Species | denotes | patients | Tax:9606 |
1983 | 3672-3679 | Chemical | denotes | lactate | MESH:D019344 |
1984 | 3681-3688 | Chemical | denotes | glucose | MESH:D005947 |
1985 | 3836-3851 | Disease | denotes | skin irritation | MESH:D012871 |
LitCovid-PD-FMA-UBERON
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T38 | 1337-1342 | Body_part | denotes | tooth | http://purl.org/sig/ont/fma/fma12516 |
T39 | 1343-1349 | Body_part | denotes | enamel | http://purl.org/sig/ont/fma/fma55629 |
T40 | 2227-2232 | Body_part | denotes | organ | http://purl.org/sig/ont/fma/fma67498 |
T41 | 2589-2593 | Body_part | denotes | skin | http://purl.org/sig/ont/fma/fma7163 |
T42 | 2952-2963 | Body_part | denotes | body fluids | http://purl.org/sig/ont/fma/fma280556 |
T43 | 2952-2956 | Body_part | denotes | body | http://purl.org/sig/ont/fma/fma256135 |
T44 | 2973-2978 | Body_part | denotes | blood | http://purl.org/sig/ont/fma/fma9670 |
T45 | 2983-2988 | Body_part | denotes | sweat | http://purl.org/sig/ont/fma/fma12275 |
T46 | 3681-3688 | Body_part | denotes | glucose | http://purl.org/sig/ont/fma/fma82743 |
T47 | 3836-3840 | Body_part | denotes | skin | http://purl.org/sig/ont/fma/fma7163 |
T48 | 3894-3900 | Body_part | denotes | tissue | http://purl.org/sig/ont/fma/fma9637 |
T49 | 3972-3982 | Body_part | denotes | body fluid | http://purl.org/sig/ont/fma/fma280556 |
LitCovid-PD-UBERON
Id | Subject | Object | Predicate | Lexical cue | uberon_id |
---|---|---|---|---|---|
T32 | 1343-1349 | Body_part | denotes | enamel | http://purl.obolibrary.org/obo/UBERON_0001752 |
T33 | 2227-2232 | Body_part | denotes | organ | http://purl.obolibrary.org/obo/UBERON_0000062 |
T34 | 2589-2593 | Body_part | denotes | skin | http://purl.obolibrary.org/obo/UBERON_0000014 |
T35 | 2973-2978 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
T36 | 2983-2988 | Body_part | denotes | sweat | http://purl.obolibrary.org/obo/UBERON_0001089 |
T37 | 3836-3840 | Body_part | denotes | skin | http://purl.obolibrary.org/obo/UBERON_0000014 |
T38 | 3894-3900 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T156 | 151-152 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T157 | 182-187 | http://purl.obolibrary.org/obo/UBERON_0007688 | denotes | field |
T158 | 269-275 | http://purl.obolibrary.org/obo/OBI_0000968 | denotes | device |
T159 | 365-366 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T160 | 816-817 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T161 | 847-848 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T162 | 1043-1044 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T163 | 1132-1133 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | b |
T164 | 1395-1401 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signal |
T165 | 1417-1422 | http://purl.obolibrary.org/obo/UBERON_0007688 | denotes | field |
T166 | 1521-1527 | http://purl.obolibrary.org/obo/OBI_0000968 | denotes | device |
T167 | 1778-1781 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
T168 | 1932-1938 | http://purl.obolibrary.org/obo/OBI_0000968 | denotes | device |
T169 | 1977-1980 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
T170 | 1992-1993 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T171 | 2122-2125 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
T172 | 2227-2232 | http://purl.obolibrary.org/obo/UBERON_0003103 | denotes | organ |
T173 | 2337-2341 | http://purl.obolibrary.org/obo/CLO_0001185 | denotes | 2018 |
T174 | 2574-2581 | http://purl.obolibrary.org/obo/BFO_0000030 | denotes | objects |
T175 | 2589-2593 | http://purl.obolibrary.org/obo/UBERON_0000014 | denotes | skin |
T176 | 2589-2593 | http://purl.obolibrary.org/obo/UBERON_0001003 | denotes | skin |
T177 | 2589-2593 | http://purl.obolibrary.org/obo/UBERON_0002097 | denotes | skin |
T178 | 2589-2593 | http://purl.obolibrary.org/obo/UBERON_0002199 | denotes | skin |
T179 | 2589-2593 | http://www.ebi.ac.uk/efo/EFO_0000962 | denotes | skin |
T180 | 2632-2633 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T181 | 2670-2675 | http://purl.obolibrary.org/obo/UBERON_0007688 | denotes | field |
T182 | 2697-2704 | http://purl.obolibrary.org/obo/OBI_0000968 | denotes | devices |
T183 | 2836-2843 | http://purl.obolibrary.org/obo/OBI_0000968 | denotes | devices |
T184 | 2907-2914 | http://purl.obolibrary.org/obo/OBI_0000968 | denotes | devices |
T185 | 2952-2963 | http://purl.obolibrary.org/obo/UBERON_0006314 | denotes | body fluids |
T186 | 2973-2978 | http://purl.obolibrary.org/obo/UBERON_0000178 | denotes | blood |
T187 | 2973-2978 | http://www.ebi.ac.uk/efo/EFO_0000296 | denotes | blood |
T188 | 3157-3158 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T189 | 3179-3186 | http://purl.obolibrary.org/obo/OBI_0000968 | denotes | devices |
T190 | 3289-3290 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T191 | 3418-3421 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
T192 | 3528-3531 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
T193 | 3836-3840 | http://purl.obolibrary.org/obo/UBERON_0000014 | denotes | skin |
T194 | 3836-3840 | http://purl.obolibrary.org/obo/UBERON_0001003 | denotes | skin |
T195 | 3836-3840 | http://purl.obolibrary.org/obo/UBERON_0002097 | denotes | skin |
T196 | 3836-3840 | http://purl.obolibrary.org/obo/UBERON_0002199 | denotes | skin |
T197 | 3836-3840 | http://www.ebi.ac.uk/efo/EFO_0000962 | denotes | skin |
T198 | 3854-3860 | http://purl.obolibrary.org/obo/OBI_0000968 | denotes | device |
T199 | 3972-3982 | http://purl.obolibrary.org/obo/UBERON_0006314 | denotes | body fluid |
LitCovid-PD-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T14051 | 277-283 | Chemical | denotes | Carbon | http://purl.obolibrary.org/obo/CHEBI_27594 |
T27933 | 308-316 | Chemical | denotes | graphite | http://purl.obolibrary.org/obo/CHEBI_33418|http://purl.obolibrary.org/obo/CHEBI_36977 |
T17305 | 318-326 | Chemical | denotes | graphene | http://purl.obolibrary.org/obo/CHEBI_36973 |
T32717 | 539-545 | Chemical | denotes | carbon | http://purl.obolibrary.org/obo/CHEBI_27594|http://purl.obolibrary.org/obo/CHEBI_33415 |
T41390 | 659-666 | Chemical | denotes | polymer | http://purl.obolibrary.org/obo/CHEBI_33839|http://purl.obolibrary.org/obo/CHEBI_60027 |
T52285 | 918-924 | Chemical | denotes | carbon | http://purl.obolibrary.org/obo/CHEBI_27594|http://purl.obolibrary.org/obo/CHEBI_33415 |
T92009 | 1092-1098 | Chemical | denotes | carbon | http://purl.obolibrary.org/obo/CHEBI_27594|http://purl.obolibrary.org/obo/CHEBI_33415 |
T88468 | 1149-1157 | Chemical | denotes | graphene | http://purl.obolibrary.org/obo/CHEBI_36973 |
T7407 | 2800-2811 | Chemical | denotes | application | http://purl.obolibrary.org/obo/CHEBI_33232 |
T69404 | 3653-3662 | Chemical | denotes | molecules | http://purl.obolibrary.org/obo/CHEBI_25367 |
T128 | 3672-3679 | Chemical | denotes | lactate | http://purl.obolibrary.org/obo/CHEBI_24996 |
T15076 | 3681-3688 | Chemical | denotes | glucose | http://purl.obolibrary.org/obo/CHEBI_17234|http://purl.obolibrary.org/obo/CHEBI_4167 |
T5183 | 3745-3756 | Chemical | denotes | application | http://purl.obolibrary.org/obo/CHEBI_33232 |
LitCovid-PD-GO-BP
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T8 | 1395-1412 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signal processing |
T9 | 3972-3993 | http://purl.obolibrary.org/obo/GO_0007589 | denotes | body fluid secretions |
T10 | 4010-4019 | http://purl.obolibrary.org/obo/GO_0006810 | denotes | transport |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1020 | 0-74 | Sentence | denotes | 5.1 Emerging electrode materials, fabrication processes, and form factors |
T1021 | 75-188 | Sentence | denotes | The ability to create robust, low-cost biosensors for pathogen detection is a significant challenge in the field. |
T1022 | 189-276 | Sentence | denotes | One of the primary methods of reducing cost is decreasing the material cost per device. |
T1023 | 277-381 | Sentence | denotes | Carbon-based electrodes (e.g., graphite, graphene, CNTs), such as those shown in Fig. 7 a (Afonso et al. |
T1024 | 382-407 | Sentence | denotes | 2016) and 7b (Wang et al. |
T1025 | 408-524 | Sentence | denotes | 2013), are now being examined as potential alternatives to relatively more expensive metallic or ceramic electrodes. |
T1026 | 525-647 | Sentence | denotes | Many of these carbon-based materials are also nanoscale in structure, and thus offer advantages regarding nanostructuring. |
T1027 | 648-783 | Sentence | denotes | Similarly, polymer-based electrodes have also been examined as low-cost alternatives to metal electrodes as described in Section 2.1.3. |
T1028 | 784-953 | Sentence | denotes | For example, Afonso et al. used a home craft cutter printer as a highly accessible means of fabricating high quantities of disposable carbon-based sensors (Afonso et al. |
T1029 | 954-960 | Sentence | denotes | 2016). |
T1030 | 961-1124 | Sentence | denotes | Fig. 7 State-of-the-art developments in electrochemical biosensors for pathogens. a) Low-cost, flexible, disposable screen-printed carbon electrodes (Afonso et al. |
T1031 | 1125-1181 | Sentence | denotes | 2016). b) Free-standing graphene electrodes (Wang et al. |
T1032 | 1182-1284 | Sentence | denotes | 2013). c) Paper-based substrates for pathogen detection using electrochemical methods (Bhardwaj et al. |
T1033 | 1285-1365 | Sentence | denotes | 2017). d) Wearable wireless bacterial biosensor for tooth enamel (Mannoor et al. |
T1034 | 1366-1467 | Sentence | denotes | 2012). e) Smartphone-enabled signal processing for field-based environmental monitoring (Jiang et al. |
T1035 | 1468-1474 | Sentence | denotes | 2014). |
T1036 | 1475-1608 | Sentence | denotes | In addition to reducing the material cost per device, efforts to reduce the manufacturing cost of biosensors have also been examined. |
T1037 | 1609-1689 | Sentence | denotes | 3D printing processes have emerged as popular methods for biosensor fabrication. |
T1038 | 1690-1765 | Sentence | denotes | For example, 3D printing is compatible with flexible and curved substrates. |
T1039 | 1766-1949 | Sentence | denotes | 3D printing has also been used for the fabrication of various components of electrochemical biosensors, such as electrodes, substrates, fluid handling components, or device packaging. |
T1040 | 1950-2080 | Sentence | denotes | In particular, 3D printing has emerged as a useful fabrication platform for microfluidic-based analytical platforms (Waheed et al. |
T1041 | 2081-2087 | Sentence | denotes | 2016). |
T1042 | 2088-2201 | Sentence | denotes | For example, to date, 3D printing has enabled the fabrication of electrode-integrated microfluidics (Erkal et al. |
T1043 | 2202-2271 | Sentence | denotes | 2014), 3D microfluidics, organ-conforming microfluidics (Singh et al. |
T1044 | 2272-2336 | Sentence | denotes | 2017a), and transducer-integrated microfluidics (Cesewski et al. |
T1045 | 2337-2343 | Sentence | denotes | 2018). |
T1046 | 2344-2507 | Sentence | denotes | Thus, 3D printing may serve as an important fabrication platform for the creation of wearable microfluidic-based electrochemical biosensors for pathogen detection. |
T1047 | 2508-2676 | Sentence | denotes | The ability to quantify the level of pathogens on the surfaces of objects (e.g., skin, food, and medical equipment) remains a present challenge in the biosensing field. |
T1048 | 2677-2795 | Sentence | denotes | Wearable biomedical devices have emerged as promising tools for point-of-care (POC) diagnostics and health monitoring. |
T1049 | 2796-2897 | Sentence | denotes | The application constraints of wearable devices require them to be lightweight and simple to operate. |
T1050 | 2898-3108 | Sentence | denotes | Wearable devices can provide continuous monitoring of body fluids, such as blood and sweat, allowing patients to obtain real-time bioanalytical information without the inconvenience of facility-based screening. |
T1051 | 3109-3280 | Sentence | denotes | To date, biosensors have been incorporated into a variety of wearable devices, including contact lenses, clothing, bandages, rings, and tattoos (Bandodkar and Wang, 2014). |
T1052 | 3281-3384 | Sentence | denotes | This is a rapidly emerging area linked to smartphone technology for biosensor actuation and monitoring. |
T1053 | 3385-3570 | Sentence | denotes | The rise of flexible electronics has also contributed to the success of incorporating electrochemical biosensors into flexible textiles, which has enhanced their wearability (Rim et al. |
T1054 | 3571-3577 | Sentence | denotes | 2016). |
T1055 | 3578-3779 | Sentence | denotes | Although most wearable electrochemical biosensors are used to detect small molecules, such as lactate, glucose, or electrolytes, there is increasing interest in their application to pathogen detection. |
T1056 | 3780-3935 | Sentence | denotes | Challenges include biocompatibility (e.g., reduction of skin irritation), device power consumption, and biosensor-tissue mechanical and geometric matching. |
T1057 | 3936-4143 | Sentence | denotes | Because of the small sample size of body fluid secretions and the need to transport the sample to the electrode surface, microfluidic formats are now emerging for wearable bioanalytical systems (Singh et al. |
T1058 | 4144-4151 | Sentence | denotes | 2017a). |
2_test
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
32364936-26695279-7713178 | 382-386 | 26695279 | denotes | 2016 |
32364936-23811484-7713179 | 408-412 | 23811484 | denotes | 2013 |
32364936-26695279-7713180 | 954-958 | 26695279 | denotes | 2016 |
32364936-26695279-7713181 | 1125-1129 | 26695279 | denotes | 2016 |
32364936-23811484-7713182 | 1182-1186 | 23811484 | denotes | 2013 |
32364936-22453836-7713183 | 1366-1370 | 22453836 | denotes | 2012 |
32364936-27146365-7713184 | 2081-2085 | 27146365 | denotes | 2016 |
32364936-24763966-7713185 | 2202-2206 | 24763966 | denotes | 2014 |
32364936-29897358-7713187 | 2337-2341 | 29897358 | denotes | 2018 |
32364936-24853270-7713188 | 3274-3278 | 24853270 | denotes | 2014 |
32364936-26898945-7713189 | 3571-3575 | 26898945 | denotes | 2016 |