PMC:7152911 / 108682-111303 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1731 2594-2601 Species denotes E. coli Tax:562
1732 2410-2417 Chemical denotes glucose MESH:D005947
1733 2436-2453 Chemical denotes hydrogen peroxide MESH:D006861
1744 1901-1903 Gene denotes mL Gene:21832
1745 1576-1578 Gene denotes mL Gene:21832
1746 1553-1560 Species denotes E. coli Tax:562
1747 1769-1783 Species denotes S. typhimurium Tax:90371
1748 1684-1698 Species denotes S. typhimurium Tax:90371
1749 1323-1325 Chemical denotes Au MESH:D006046
1750 1491-1499 Chemical denotes thionine MESH:C009469
1751 1524-1528 Chemical denotes H2O2 MESH:D006861
1752 1648-1655 Chemical denotes glucose MESH:D005947
1753 1812-1819 Chemical denotes glucose MESH:D005947

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T5 1122-1130 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T6 1404-1412 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T7 1500-1508 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T8 1648-1655 Body_part denotes glucose http://purl.org/sig/ont/fma/fma82743
T9 1812-1819 Body_part denotes glucose http://purl.org/sig/ont/fma/fma82743
T10 2410-2417 Body_part denotes glucose http://purl.org/sig/ont/fma/fma82743

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T55 61-68 http://purl.obolibrary.org/obo/CLO_0007225 denotes labeled
T56 151-152 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T57 182-183 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T58 320-326 http://purl.obolibrary.org/obo/CLO_0007225 denotes Labels
T59 341-342 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T60 450-456 http://purl.obolibrary.org/obo/CLO_0007225 denotes labels
T61 598-599 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T62 651-657 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T63 853-858 http://purl.obolibrary.org/obo/CLO_0007225 denotes label
T64 1002-1003 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T65 1027-1028 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T66 1161-1162 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T67 1208-1215 http://purl.obolibrary.org/obo/CLO_0007225 denotes labeled
T68 1276-1277 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T69 1291-1292 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T70 1585-1586 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T71 1730-1736 http://purl.obolibrary.org/obo/CLO_0007225 denotes labels
T72 1860-1861 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T73 1886-1889 http://purl.obolibrary.org/obo/CLO_0054060 denotes 102
T74 1965-1971 http://purl.obolibrary.org/obo/SO_0000418 denotes signal
T75 2061-2062 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T76 2142-2149 http://purl.obolibrary.org/obo/CLO_0007225 denotes labeled
T77 2173-2174 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T78 2206-2207 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T79 2344-2345 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T80 2508-2509 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T81 2511-2517 http://purl.obolibrary.org/obo/SO_0000418 denotes Signal

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T85992 377-389 Chemical denotes nanoparticle http://purl.obolibrary.org/obo/CHEBI_50803
T79871 853-858 Chemical denotes label http://purl.obolibrary.org/obo/CHEBI_35209
T38535 1259-1262 Chemical denotes EIS http://purl.obolibrary.org/obo/CHEBI_73498
T3489 1323-1325 Chemical denotes Au http://purl.obolibrary.org/obo/CHEBI_29287
T53259 1491-1499 Chemical denotes thionine http://purl.obolibrary.org/obo/CHEBI_52295
T27782 1524-1528 Chemical denotes H2O2 http://purl.obolibrary.org/obo/CHEBI_16240
T3704 1648-1655 Chemical denotes glucose http://purl.obolibrary.org/obo/CHEBI_17234|http://purl.obolibrary.org/obo/CHEBI_4167
T88418 1790-1792 Chemical denotes Au http://purl.obolibrary.org/obo/CHEBI_29287
T37293 1804-1807 Chemical denotes EIS http://purl.obolibrary.org/obo/CHEBI_73498
T37013 1812-1819 Chemical denotes glucose http://purl.obolibrary.org/obo/CHEBI_17234|http://purl.obolibrary.org/obo/CHEBI_4167
T63449 2176-2184 Chemical denotes electron http://purl.obolibrary.org/obo/CHEBI_10545
T53377 2410-2417 Chemical denotes glucose http://purl.obolibrary.org/obo/CHEBI_17234|http://purl.obolibrary.org/obo/CHEBI_4167
T87981 2436-2453 Chemical denotes hydrogen peroxide http://purl.obolibrary.org/obo/CHEBI_16240
T8061 2436-2444 Chemical denotes hydrogen http://purl.obolibrary.org/obo/CHEBI_49637
T99997 2445-2453 Chemical denotes peroxide http://purl.obolibrary.org/obo/CHEBI_44785

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T2 520-529 http://purl.obolibrary.org/obo/GO_0006810 denotes transport
T3 2176-2193 http://purl.obolibrary.org/obo/GO_0022904 denotes electron transfer

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T891 0-162 Sentence denotes Here, we classify assays that use secondary binding steps as labeled approaches in Table 1, Table 2 regardless of if the primary binding step produced a response.
T892 163-319 Sentence denotes There is, however, a more subtle distinction if binding of the secondary species is used for amplification or verification purposes as previously discussed.
T893 320-400 Sentence denotes Labels often include a biorecognition element-enzyme or -nanoparticle conjugate.
T894 401-619 Sentence denotes In electrochemical biosensing applications, such labels often serve the purpose of altering the material properties or transport processes of the electrode-electrolyte interface, often by inducing a secondary reaction.
T895 620-781 Sentence denotes Secondary binding of optically-active nanomaterials to captured targets can also enable the use of optical transducers for simultaneous detection or bioanalysis.
T896 782-884 Sentence denotes Enzymes are among the most commonly used secondary binding species for label-based pathogen detection.
T897 885-1026 Sentence denotes As shown in Table 2, electrochemical biosensors for pathogen detection that employ enzymes are commonly performed as a sandwich assay format.
T898 1027-1179 Sentence denotes A schematic of secondary binding steps for biosensor amplification based on the binding of HRP-antibody conjugates is shown in Fig. 6 a (Kokkinos et al.
T899 1180-1186 Sentence denotes 2016).
T900 1187-1368 Sentence denotes Hong et al. used HRP-labeled secondary antibodies to amplify the CV and EIS responses of a concanavalin A-functionalized nanostructured Au electrode to detect norovirus (Hong et al.
T901 1369-1375 Sentence denotes 2015).
T902 1376-1625 Sentence denotes Gayathri et al. used an HRP-antibody conjugate to induce an enzyme-assisted reduction reaction with an immobilized thionine-antibody receptor in an H2O2 system for detection of E. coli down to 50 CFU/mL using a sandwich assay format (Gayathri et al.
T903 1626-1632 Sentence denotes 2016).
T904 1633-1914 Sentence denotes Xu et al. used glucose oxidase and monoclonal anti-S. typhimurium to functionalize magnetic bead labels for separation and detection of S. typhimurium on an Au IDAM using EIS and glucose to catalyze the reaction that exhibited a linear working range of 102 to 106 CFU/mL (Xu et al.
T905 1915-1922 Sentence denotes 2016b).
T906 1923-2500 Sentence denotes Fig. 6 Highlight of secondary binding and signal amplification approaches utilized in electrochemical biosensor-based pathogen detection. a) Four amplification approaches associated with the secondary binding of enzyme-labeled secondary antibodies: (A) electron transfer mediation; (B) nanostructuring of surface for increased rate of charge transfer kinetics; (C) conversion of electrochemically inactive substrate into a detectable electroactive product; (D) catalysis of oxidation of glucose for production of hydrogen peroxide for electrochemical detection (Kokkinos et al.
T907 2501-2614 Sentence denotes 2016). b) Signal amplification via non-selective binding of AuNPs to bound bacterial target (E. coli) (Wan et al.
T908 2615-2621 Sentence denotes 2016).

2_test

Id Subject Object Predicate Lexical cue
32364936-25254625-7713148 1369-1373 25254625 denotes 2015
32364936-27040944-7713149 1626-1630 27040944 denotes 2016
32364936-26796138-7713151 2615-2619 26796138 denotes 2016