PMC:7151644 / 2736-4059 JSONTXT

{"project":"2_test","denotations":[{"id":"32296543-25811683-144433879","span":{"begin":273,"end":277},"obj":"25811683"},{"id":"32296543-26111586-144433880","span":{"begin":292,"end":296},"obj":"26111586"},{"id":"32296543-16839713-144433881","span":{"begin":593,"end":597},"obj":"16839713"},{"id":"32296543-17126573-144433882","span":{"begin":623,"end":627},"obj":"17126573"},{"id":"32296543-26050577-144433883","span":{"begin":648,"end":652},"obj":"26050577"},{"id":"32296543-19046011-144433884","span":{"begin":757,"end":761},"obj":"19046011"},{"id":"32296543-22855479-144433885","span":{"begin":1000,"end":1004},"obj":"22855479"},{"id":"32296543-25316698-144433886","span":{"begin":1019,"end":1023},"obj":"25316698"},{"id":"32296543-28786787-144433887","span":{"begin":1038,"end":1042},"obj":"28786787"},{"id":"32296543-31526243-144433888","span":{"begin":1054,"end":1058},"obj":"31526243"}],"text":"Pestiviruses (family: Flaviviridae) are enveloped RNA viruses with highly variable single-stranded positive-sense RNA genomes of ∼12.3 kb that comprises a single large open reading frame (ORF) encoding a polyprotein of about 3,900 amino acids (aa) in length (Postel et al. 2015; Tautz et al. 2015). Some pestiviruses (e.g. bovine viral diarrhea virus, border disease virus, classical swine fever virus) are well-known animal pathogens that cause severe disease including contagious hemorrhagic disease in pigs and respiratory and reproductive disease in cattle and sheep (Vilcek and Nettleton 2006; Valdazo-Gonzalez et al. 2007; Moennig and Becher 2015). Wildlife disease (e.g. wild boar and deer) due to pestiviruses has also been reported (Ridpath et al. 2008; Blome et al. 2017). Following the application of molecular and genomics methods of virus discovery, a number of novel pestiviruses have been identified in recent years, including those from bats, rodents, and harbor porpoises (Wu et al. 2012; Firth et al. 2014; Smith et al. 2017; Jo et al. 2019). Finally, pestivirus-like viruses have also identified in arthropods (Shi et al. 2016a) and arthropods collected from mammals (Harvey et al. 2018). Together, these data highlight the circulation of a diverse range of pestiviruses in a broad range of animal hosts."}