> top > docs > PMC:7148425 > spans > 4902-7058 > annotations

PMC:7148425 / 4902-7058 JSONTXT

Annnotations TAB JSON ListView MergeView

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
71 1511-1517 Species denotes people Tax:9606
72 300-313 Disease denotes lymphopoiesis
73 766-775 Disease denotes infection MESH:D007239
74 1366-1375 Disease denotes infection MESH:D007239
75 1945-1956 Disease denotes detrimental MESH:D008569
76 1972-1992 Disease denotes SARS-CoV-2 infection MESH:C000657245
77 2086-2095 Disease denotes infection MESH:D007239

2_test

Id Subject Object Predicate Lexical cue
32300370-31528180-46535324 122-123 31528180 denotes 6
T20747 122-123 31528180 denotes 6

LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T66 55-61 UBERON:0002405 denotes immune
T67 177-190 UBERON:0002405 denotes immune system
T68 237-243 UBERON:0002405;GO:0006955;CL:0000738 denotes immune
T69 244-248 CL:0000738;GO:0070285 denotes cell
T70 249-259 GO:0016064 denotes production
T71 267-278 UBERON:0002371 denotes bone marrow
T72 300-313 GO:0019835 denotes lymphopoiesis
T73 338-345 CL:0000763 denotes myeloid
T74 401-407 UBERON:0002370 denotes Thymic
T75 461-468 CL:0000084 denotes T cells
T76 530-541 CL:0000080 denotes circulating
T77 548-555 CL:0000236 denotes B cells
T78 584-591 CL:0000084 denotes T cells
T79 673-678 GO:0007568 denotes aging
T80 724-730 UBERON:0002405;CL:0000738 denotes immune
T81 731-736 CL:0000738 denotes cells
T82 742-753 CL:0000775 denotes neutrophils
T83 828-841 UBERON:0002405 denotes immune system
T84 917-925 GO:0002250 denotes adaptive
T85 926-932 GO:0002250;UBERON:0002405 denotes immune
T86 933-942 GO:0002250 denotes responses
T87 976-983 CHEBI:59132;CHEBI:59132 denotes antigen
T88 1031-1041 UBERON:0000029 denotes lymph node
T89 1104-1111 GO:0065007 denotes control
T90 1204-1212 GO:0002250 denotes adaptive
T91 1213-1219 GO:0002250;UBERON:0002405 denotes immune
T92 1220-1228 GO:0002250 denotes response
T93 1289-1297 CHEBI:35224;CHEBI:35224 denotes effector
T94 1298-1305 CL:0000911 denotes T cells
T95 1310-1317 CL:0000236 denotes B cells
T96 1433-1439 UBERON:0007023 denotes adults
T97 1487-1497 NCBITaxon:1 denotes individual
T98 1511-1517 NCBITaxon:9606 denotes people
T99 1696-1702 UBERON:0002405 denotes immune
T100 1734-1744 NCBITaxon:1 denotes individual
T101 1822-1833 GO:0000075 denotes checkpoints
T102 1882-1888 UBERON:0002405 denotes immune
T103 1972-1982 SP_7 denotes SARS-CoV-2
T74120 55-61 UBERON:0002405 denotes immune
T50706 177-190 UBERON:0002405 denotes immune system
T63255 237-243 UBERON:0002405;GO:0006955;CL:0000738 denotes immune
T92543 244-248 CL:0000738;GO:0070285 denotes cell
T80900 249-259 GO:0016064 denotes production
T49243 267-278 UBERON:0002371 denotes bone marrow
T20340 300-313 GO:0019835 denotes lymphopoiesis
T58375 338-345 CL:0000763 denotes myeloid
T52332 401-407 UBERON:0002370 denotes Thymic
T92765 461-468 CL:0000084 denotes T cells
T36406 530-541 CL:0000080 denotes circulating
T46772 548-555 CL:0000236 denotes B cells
T63184 584-591 CL:0000084 denotes T cells
T55334 673-678 GO:0007568 denotes aging
T64610 724-730 UBERON:0002405;CL:0000738 denotes immune
T19866 731-736 CL:0000738 denotes cells
T84536 742-753 CL:0000775 denotes neutrophils
T6164 828-841 UBERON:0002405 denotes immune system
T80860 917-925 GO:0002250 denotes adaptive
T77233 926-932 GO:0002250;UBERON:0002405 denotes immune
T97927 933-942 GO:0002250 denotes responses
T29382 976-983 CHEBI:59132;CHEBI:59132 denotes antigen
T56898 1031-1041 UBERON:0000029 denotes lymph node
T51529 1104-1111 GO:0065007 denotes control
T1622 1204-1212 GO:0002250 denotes adaptive
T73017 1213-1219 GO:0002250;UBERON:0002405 denotes immune
T10815 1220-1228 GO:0002250 denotes response
T75965 1289-1297 CHEBI:35224;CHEBI:35224 denotes effector
T21829 1298-1305 CL:0000911 denotes T cells
T28203 1310-1317 CL:0000236 denotes B cells
T27153 1433-1439 UBERON:0007023 denotes adults
T25164 1487-1497 NCBITaxon:1 denotes individual
T77782 1511-1517 NCBITaxon:9606 denotes people
T97146 1696-1702 UBERON:0002405 denotes immune
T68314 1734-1744 NCBITaxon:1 denotes individual
T95197 1822-1833 GO:0000075 denotes checkpoints
T18482 1882-1888 UBERON:0002405 denotes immune
T9428 1972-1982 SP_7 denotes SARS-CoV-2

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T24 177-190 Body_part denotes immune system http://purl.org/sig/ont/fma/fma9825
T25 244-248 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T26 267-278 Body_part denotes bone marrow http://purl.org/sig/ont/fma/fma9608
T27 354-359 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T28 463-468 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T29 550-555 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T30 586-591 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T31 731-736 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T32 742-753 Body_part denotes neutrophils http://purl.org/sig/ont/fma/fma62860
T33 828-841 Body_part denotes immune system http://purl.org/sig/ont/fma/fma9825
T34 976-1000 Body_part denotes antigen-presenting cells http://purl.org/sig/ont/fma/fma273565
T35 995-1000 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T36 1031-1041 Body_part denotes lymph node http://purl.org/sig/ont/fma/fma5034
T37 1300-1305 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T38 1312-1317 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T9 177-190 Body_part denotes immune system http://purl.obolibrary.org/obo/UBERON_0002405
T10 267-278 Body_part denotes bone marrow http://purl.obolibrary.org/obo/UBERON_0002371
T11 828-841 Body_part denotes immune system http://purl.obolibrary.org/obo/UBERON_0002405
T12 1031-1041 Body_part denotes lymph node http://purl.obolibrary.org/obo/UBERON_0000029
T13 1031-1036 Body_part denotes lymph http://purl.obolibrary.org/obo/UBERON_0002391

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T19 766-775 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T20 1366-1375 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T21 1972-1980 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T22 1983-1992 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T23 2086-2095 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T42 177-190 http://purl.obolibrary.org/obo/UBERON_0002405 denotes immune system
T43 244-248 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T44 267-271 http://purl.obolibrary.org/obo/UBERON_0002481 denotes bone
T45 354-359 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T46 455-468 http://purl.obolibrary.org/obo/CL_0000898 denotes naïve T cells
T47 548-555 http://purl.obolibrary.org/obo/CL_0000236 denotes B cells
T48 578-591 http://purl.obolibrary.org/obo/CL_0000898 denotes naïve T cells
T49 731-736 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T50 828-841 http://purl.obolibrary.org/obo/UBERON_0002405 denotes immune system
T51 995-1000 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T52 1031-1041 http://purl.obolibrary.org/obo/UBERON_0000029 denotes lymph node
T53 1289-1305 http://purl.obolibrary.org/obo/CL_0000911 denotes effector T cells
T54 1310-1317 http://purl.obolibrary.org/obo/CL_0000236 denotes B cells
T55 1748-1749 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T56 1970-1971 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T5 976-983 Chemical denotes antigen http://purl.obolibrary.org/obo/CHEBI_59132
T6 1289-1297 Chemical denotes effector http://purl.obolibrary.org/obo/CHEBI_35224

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T9 673-678 http://purl.obolibrary.org/obo/GO_0007568 denotes aging
T10 717-730 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immune
T11 869-891 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory responses
T12 917-942 http://purl.obolibrary.org/obo/GO_0002250 denotes adaptive immune responses
T13 1127-1148 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory response
T14 1204-1228 http://purl.obolibrary.org/obo/GO_0002250 denotes adaptive immune response
T15 1213-1228 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T28 0-46 Sentence denotes Immunosenescence and its underlying mechanisms
T29 47-201 Sentence denotes Altered immune competence with increasing age, so-called immunosenescence [6], is the result of changes at multiple levels of the immune system over time.
T30 202-400 Sentence denotes It includes the altered balance of immune cell production in the bone marrow resulting in reduced lymphopoiesis and increased output of myeloid lineage cells which are also functionally compromised.
T31 401-512 Sentence denotes Thymic involution substantially reduces the output of naïve T cells and the TCR repertoire contracts over time.
T32 513-659 Sentence denotes Although loss of circulating naïve B cells is less profound than naïve T cells, reduced BCR repertoire diversity with age is also well recognized.
T33 660-892 Sentence denotes Furthermore, aging is associated with the dysfunction of innate immune cells like neutrophils at sites of infection possibly due to the poorer capacity of the adaptive immune system to reign in over-exuberant inflammatory responses.
T34 893-1055 Sentence denotes The ability to generate adaptive immune responses is compromised by dysfunction of antigen-presenting cells and disorganised and fibrotic lymph node architecture.
T35 1056-1318 Sentence denotes Collectively, these changes prevent appropriate control of the initial inflammatory response and decrease the generation of an efficient and robust adaptive immune response which requires the production of large number of functional effector T cells and B cells.
T36 1319-1608 Sentence denotes For all these reasons, protective responses to infection or vaccination tend to be on average lower in many older adults than in the young, but there is enormous inter-individual variation in people owing to the individual variations of genetics and the history of environmental exposures.
T37 1609-1673 Sentence denotes Hence, two crucial questions are raised by these considerations:
T38 1674-1898 Sentence denotes 1) how can we measure immune and physiological status in an individual in a clinically meaningful manner and 2) how can we intervene at the crucial checkpoints thus identified in order to restore appropriate immune function?
T39 1899-2156 Sentence denotes Identification of biomarkers of protective or detrimental responses to a SARS-CoV-2 infection or vaccine and determination of the kinetic pattern of these biomarkers during the course of infection or vaccine response are critical to address these questions.