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PMC:7143804 / 16726-18841 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue
107 393-396 Chemical denotes COC
108 397-400 Chemical denotes H2O
109 401-404 Chemical denotes COC
110 1335-1338 Chemical denotes COC
111 1343-1346 Chemical denotes H2O
112 1700-1703 Chemical denotes COC
113 1711-1714 Chemical denotes H2O

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T43 281-284 Body_part denotes DNA http://purl.org/sig/ont/fma/fma74412
T44 1033-1041 Body_part denotes Appendix http://purl.org/sig/ont/fma/fma14542

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T110 149-151 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T111 279-280 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T112 391-392 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T113 424-430 http://purl.obolibrary.org/obo/OBI_0000968 denotes device
T114 883-886 http://purl.obolibrary.org/obo/CLO_0007052 denotes K−1
T115 967-969 http://purl.obolibrary.org/obo/CLO_0001022 denotes li
T116 967-969 http://purl.obolibrary.org/obo/CLO_0007314 denotes li
T117 1042-1043 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T118 1080-1081 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T119 1119-1121 http://purl.obolibrary.org/obo/CLO_0001022 denotes li
T120 1119-1121 http://purl.obolibrary.org/obo/CLO_0007314 denotes li
T121 1289-1290 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T122 1545-1546 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T123 1672-1673 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T124 1844-1845 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T125 1853-1854 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T126 1896-1899 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T127 1900-1901 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T91 0-3 Chemical denotes MDA http://purl.obolibrary.org/obo/CHEBI_566274
T92 116-119 Chemical denotes HDA http://purl.obolibrary.org/obo/CHEBI_17314
T93 281-284 Chemical denotes DNA http://purl.obolibrary.org/obo/CHEBI_16991
T94 393-396 Chemical denotes COC http://purl.obolibrary.org/obo/CHEBI_53310
T95 397-400 Chemical denotes H2O http://purl.obolibrary.org/obo/CHEBI_15377
T96 401-404 Chemical denotes COC http://purl.obolibrary.org/obo/CHEBI_53310
T97 1335-1338 Chemical denotes COC http://purl.obolibrary.org/obo/CHEBI_53310
T98 1343-1346 Chemical denotes H2O http://purl.obolibrary.org/obo/CHEBI_15377
T99 1700-1703 Chemical denotes COC http://purl.obolibrary.org/obo/CHEBI_53310
T100 1711-1714 Chemical denotes H2O http://purl.obolibrary.org/obo/CHEBI_15377
T101 1722-1725 Chemical denotes COC http://purl.obolibrary.org/obo/CHEBI_53310
T102 1846-1849 Chemical denotes COC http://purl.obolibrary.org/obo/CHEBI_53310
T103 1902-1904 Chemical denotes Tg http://purl.obolibrary.org/obo/CHEBI_9516

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T139 0-234 Sentence denotes MDA is being done at temperatures of around 30 °C [50], which is lower than, for example, temperatures required for HDA (64 °C) [9] or LAMP (65 °C) [11] and the required PCR temperatures of Chung et al. (95 °C, 54 °C, and 72 °C) [28].
T140 235-312 Sentence denotes However, most amplification methods require a DNA denaturation step at 95 °C.
T141 313-1002 Sentence denotes Equation (2) is used to make an estimation of the required heating powers for a COC–H2O–COC stack (in the real device, the upper plate is an adhesive PCR foil, but the thermal properties of this foil are unknown). (2) P=ΔTRth=ΔT∗Aheated∗κCOClCOC,1+κH2OlH2O+κCOClCOC,2+h Here, Rth is defined as the sum of all thermal resistances in series: (3) Rth=1h×Aheated+∑isubstancesliκi×Aheated Here, P is the required power, ΔT is the temperature difference, Rth is the thermal resistance, Aheated is the heated area, h is the convective heat transfer coefficient (being 10 W m−2 K−1 for convection to air [56]), κi is the thermal conductivity of substance i, and li is the thickness of substance i.
T142 1003-1044 Sentence denotes Values for κi can be found in Appendix B.
T143 1045-1125 Sentence denotes From Equation (3), the product Rth×A can be defined as the sum of 1/h and li/κi.
T144 1126-1348 Sentence denotes Based on this summation, one can conclude that the convective heat transfer to the air is the most present heat transfer mechanism within the system (begin almost a factor 100 higher than the heat lost in the COC and H2O).
T145 1349-1541 Sentence denotes This is also evident from solving Equation (2) for every individual temperature differences within the system and also including convective heat transfer directly from the heater into the air.
T146 1542-1802 Sentence denotes If a heated area of 7.7 mm by 10.1 mm is assumed, which covers both the reaction chamber and the temperature monitor chamber, and a system consisting of 1 mm COC–0.5 mm H2O–0.1 mm COC is assumed, than the heater temperatures and powers in Table 1 are required.
T147 1803-1916 Sentence denotes These are all in the workable range when a COC of a proper grade is chosen (e.g., TOPAS 6017 has a Tg of 170 °C).
T148 1917-2037 Sentence denotes The only side note here is that at higher temperatures, the temperature gradient through the system also becomes larger.
T149 2038-2115 Sentence denotes This can be eliminated by using double-sided heating, like Chung et al. [28].

2_test

Id Subject Object Predicate Lexical cue
32106462-16786504-69893315 51-53 16786504 denotes 50
32106462-15247927-69893316 129-130 15247927 denotes 9
32106462-21157218-69893317 149-151 21157218 denotes 11