PMC:7128678 / 506-2161 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7128678","sourcedb":"PMC","sourceid":"7128678","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7128678","text":"The recent emergence of the novel pathogenic SARS-coronavirus 2 (SARS-CoV-2) is responsible for a worldwide pandemic. Given the global health emergency, drug repositioning is the most reliable option to design an efficient therapy for infected patients without delay. The first step of the viral replication cycle [i.e. attachment to the surface of respiratory cells, mediated by the spike (S) viral protein] offers several potential therapeutic targets. The S protein uses the angiotension-converting enzyme-2 (ACE-2) receptor for entry, but also sialic acids linked to host cell surface gangliosides. Using a combination of structural and molecular modelling approaches, this study showed that chloroquine (CLQ), one of the drugs currently under investigation for SARS-CoV-2 treatment, binds sialic acids and gangliosides with high affinity. A new type of ganglioside-binding domain at the tip of the N-terminal domain of the SARS-CoV-2 S protein was identified. This domain (111–158), which is fully conserved among clinical isolates worldwide, may improve attachment of the virus to lipid rafts and facilitate contact with the ACE-2 receptor. This study showed that, in the presence of CLQ [or its more active derivative, hydroxychloroquine (CLQ-OH)], the viral S protein is no longer able to bind gangliosides. The identification of this new mechanism of action of CLQ and CLQ-OH supports the use of these repositioned drugs to cure patients infected with SARS-CoV-2. The in-silico approaches used in this study might also be used to assess the efficiency of a broad range of repositioned and/or innovative drug candidates before clinical evaluation.","tracks":[{"project":"LitCovid-PubTator","denotations":[{"id":"48","span":{"begin":512,"end":517},"obj":"Gene"},{"id":"49","span":{"begin":1131,"end":1136},"obj":"Gene"},{"id":"50","span":{"begin":384,"end":389},"obj":"Gene"},{"id":"51","span":{"begin":1266,"end":1267},"obj":"Gene"},{"id":"52","span":{"begin":939,"end":940},"obj":"Gene"},{"id":"53","span":{"begin":45,"end":63},"obj":"Species"},{"id":"54","span":{"begin":65,"end":75},"obj":"Species"},{"id":"55","span":{"begin":244,"end":252},"obj":"Species"},{"id":"56","span":{"begin":766,"end":776},"obj":"Species"},{"id":"57","span":{"begin":928,"end":938},"obj":"Species"},{"id":"58","span":{"begin":1438,"end":1446},"obj":"Species"},{"id":"59","span":{"begin":1461,"end":1471},"obj":"Species"},{"id":"60","span":{"begin":478,"end":490},"obj":"Chemical"},{"id":"61","span":{"begin":548,"end":560},"obj":"Chemical"},{"id":"62","span":{"begin":589,"end":601},"obj":"Chemical"},{"id":"63","span":{"begin":696,"end":707},"obj":"Chemical"},{"id":"64","span":{"begin":794,"end":806},"obj":"Chemical"},{"id":"65","span":{"begin":811,"end":823},"obj":"Chemical"},{"id":"66","span":{"begin":858,"end":869},"obj":"Chemical"},{"id":"67","span":{"begin":1087,"end":1092},"obj":"Chemical"},{"id":"68","span":{"begin":1226,"end":1244},"obj":"Chemical"},{"id":"69","span":{"begin":1246,"end":1252},"obj":"Chemical"},{"id":"70","span":{"begin":1302,"end":1314},"obj":"Chemical"},{"id":"71","span":{"begin":1378,"end":1384},"obj":"Chemical"},{"id":"72","span":{"begin":235,"end":243},"obj":"Disease"},{"id":"73","span":{"begin":1447,"end":1455},"obj":"Disease"}],"attributes":[{"id":"A48","pred":"tao:has_database_id","subj":"48","obj":"Gene:59272"},{"id":"A49","pred":"tao:has_database_id","subj":"49","obj":"Gene:59272"},{"id":"A50","pred":"tao:has_database_id","subj":"50","obj":"Gene:43740568"},{"id":"A51","pred":"tao:has_database_id","subj":"51","obj":"Gene:43740568"},{"id":"A52","pred":"tao:has_database_id","subj":"52","obj":"Gene:43740568"},{"id":"A53","pred":"tao:has_database_id","subj":"53","obj":"Tax:2697049"},{"id":"A54","pred":"tao:has_database_id","subj":"54","obj":"Tax:2697049"},{"id":"A55","pred":"tao:has_database_id","subj":"55","obj":"Tax:9606"},{"id":"A56","pred":"tao:has_database_id","subj":"56","obj":"Tax:2697049"},{"id":"A57","pred":"tao:has_database_id","subj":"57","obj":"Tax:2697049"},{"id":"A58","pred":"tao:has_database_id","subj":"58","obj":"Tax:9606"},{"id":"A59","pred":"tao:has_database_id","subj":"59","obj":"Tax:2697049"},{"id":"A61","pred":"tao:has_database_id","subj":"61","obj":"MESH:D012794"},{"id":"A62","pred":"tao:has_database_id","subj":"62","obj":"MESH:D005732"},{"id":"A63","pred":"tao:has_database_id","subj":"63","obj":"MESH:D002738"},{"id":"A64","pred":"tao:has_database_id","subj":"64","obj":"MESH:D012794"},{"id":"A65","pred":"tao:has_database_id","subj":"65","obj":"MESH:D005732"},{"id":"A66","pred":"tao:has_database_id","subj":"66","obj":"MESH:D005732"},{"id":"A67","pred":"tao:has_database_id","subj":"67","obj":"MESH:D008055"},{"id":"A68","pred":"tao:has_database_id","subj":"68","obj":"MESH:D006886"},{"id":"A70","pred":"tao:has_database_id","subj":"70","obj":"MESH:D005732"},{"id":"A72","pred":"tao:has_database_id","subj":"72","obj":"MESH:D007239"},{"id":"A73","pred":"tao:has_database_id","subj":"73","obj":"MESH:D007239"},{"subj":"48","pred":"source","obj":"LitCovid-PubTator"},{"subj":"49","pred":"source","obj":"LitCovid-PubTator"},{"subj":"50","pred":"source","obj":"LitCovid-PubTator"},{"subj":"51","pred":"source","obj":"LitCovid-PubTator"},{"subj":"52","pred":"source","obj":"LitCovid-PubTator"},{"subj":"53","pred":"source","obj":"LitCovid-PubTator"},{"subj":"54","pred":"source","obj":"LitCovid-PubTator"},{"subj":"55","pred":"source","obj":"LitCovid-PubTator"},{"subj":"56","pred":"source","obj":"LitCovid-PubTator"},{"subj":"57","pred":"source","obj":"LitCovid-PubTator"},{"subj":"58","pred":"source","obj":"LitCovid-PubTator"},{"subj":"59","pred":"source","obj":"LitCovid-PubTator"},{"subj":"60","pred":"source","obj":"LitCovid-PubTator"},{"subj":"61","pred":"source","obj":"LitCovid-PubTator"},{"subj":"62","pred":"source","obj":"LitCovid-PubTator"},{"subj":"63","pred":"source","obj":"LitCovid-PubTator"},{"subj":"64","pred":"source","obj":"LitCovid-PubTator"},{"subj":"65","pred":"source","obj":"LitCovid-PubTator"},{"subj":"66","pred":"source","obj":"LitCovid-PubTator"},{"subj":"67","pred":"source","obj":"LitCovid-PubTator"},{"subj":"68","pred":"source","obj":"LitCovid-PubTator"},{"subj":"69","pred":"source","obj":"LitCovid-PubTator"},{"subj":"70","pred":"source","obj":"LitCovid-PubTator"},{"subj":"71","pred":"source","obj":"LitCovid-PubTator"},{"subj":"72","pred":"source","obj":"LitCovid-PubTator"},{"subj":"73","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T20","span":{"begin":45,"end":49},"obj":"SP_10"},{"id":"T21","span":{"begin":50,"end":61},"obj":"NCBITaxon:11118"},{"id":"T22","span":{"begin":65,"end":75},"obj":"SP_7"},{"id":"T23","span":{"begin":153,"end":157},"obj":"CHEBI:23888;CHEBI:23888"},{"id":"T24","span":{"begin":290,"end":295},"obj":"NCBITaxon:10239;GO:0006260"},{"id":"T25","span":{"begin":296,"end":307},"obj":"GO:0006260"},{"id":"T26","span":{"begin":338,"end":348},"obj":"GO:0009986"},{"id":"T27","span":{"begin":349,"end":360},"obj":"GO:0045333;CL:0000082"},{"id":"T28","span":{"begin":361,"end":366},"obj":"CL:0000082"},{"id":"T29","span":{"begin":394,"end":399},"obj":"NCBITaxon:10239"},{"id":"T30","span":{"begin":459,"end":468},"obj":"PG_1"},{"id":"T31","span":{"begin":512,"end":517},"obj":"G_3;PG_10;PR:000003622"},{"id":"T32","span":{"begin":548,"end":554},"obj":"CHEBI:30563;CHEBI:30563"},{"id":"T33","span":{"begin":555,"end":560},"obj":"CHEBI:41865;CHEBI:41865"},{"id":"T34","span":{"begin":571,"end":588},"obj":"GO:0044228"},{"id":"T35","span":{"begin":589,"end":601},"obj":"CHEBI:28892;CHEBI:28892"},{"id":"T36","span":{"begin":696,"end":707},"obj":"CHEBI:3638;DG_10;CHEBI:3638"},{"id":"T37","span":{"begin":726,"end":731},"obj":"CHEBI:23888;CHEBI:23888"},{"id":"T38","span":{"begin":766,"end":776},"obj":"SP_7"},{"id":"T39","span":{"begin":794,"end":806},"obj":"CHEBI:26667;CHEBI:26667"},{"id":"T40","span":{"begin":811,"end":823},"obj":"CHEBI:5386;CHEBI:5386"},{"id":"T41","span":{"begin":858,"end":869},"obj":"CHEBI:28892;CHEBI:28892"},{"id":"T42","span":{"begin":878,"end":884},"obj":"SO:0000417"},{"id":"T43","span":{"begin":914,"end":920},"obj":"SO:0000417"},{"id":"T44","span":{"begin":928,"end":938},"obj":"SP_7"},{"id":"T45","span":{"begin":939,"end":948},"obj":"PG_1"},{"id":"T46","span":{"begin":970,"end":976},"obj":"SO:0000417"},{"id":"T47","span":{"begin":1078,"end":1083},"obj":"NCBITaxon:10239"},{"id":"T48","span":{"begin":1087,"end":1092},"obj":"CHEBI:18059;CHEBI:18059;GO:0045121"},{"id":"T49","span":{"begin":1093,"end":1098},"obj":"GO:0045121"},{"id":"T50","span":{"begin":1131,"end":1136},"obj":"G_3;PG_10;PR:000003622"},{"id":"T51","span":{"begin":1226,"end":1244},"obj":"CHEBI:5801;DG_20;CHEBI:5801"},{"id":"T52","span":{"begin":1260,"end":1265},"obj":"NCBITaxon:10239"},{"id":"T53","span":{"begin":1266,"end":1275},"obj":"PG_1"},{"id":"T54","span":{"begin":1302,"end":1314},"obj":"CHEBI:28892;CHEBI:28892"},{"id":"T55","span":{"begin":1424,"end":1429},"obj":"CHEBI:23888;CHEBI:23888"},{"id":"T56","span":{"begin":1461,"end":1471},"obj":"SP_7"},{"id":"T57","span":{"begin":1612,"end":1616},"obj":"CHEBI:23888;CHEBI:23888"}],"attributes":[{"subj":"T20","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T21","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T22","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T23","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T24","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T25","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T26","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T27","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T28","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T29","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T30","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T31","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T32","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T33","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T34","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T35","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T36","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T37","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T38","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T39","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T40","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T41","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T42","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T43","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T44","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T45","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T46","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T47","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T48","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T49","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T50","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T51","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T52","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T53","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T54","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T55","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T56","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T57","pred":"source","obj":"LitCovid-PMC-OGER-BB"}]},{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T1","span":{"begin":361,"end":366},"obj":"Body_part"},{"id":"T2","span":{"begin":400,"end":407},"obj":"Body_part"},{"id":"T3","span":{"begin":461,"end":468},"obj":"Body_part"},{"id":"T4","span":{"begin":576,"end":588},"obj":"Body_part"},{"id":"T5","span":{"begin":576,"end":580},"obj":"Body_part"},{"id":"T6","span":{"begin":589,"end":601},"obj":"Body_part"},{"id":"T7","span":{"begin":811,"end":823},"obj":"Body_part"},{"id":"T8","span":{"begin":858,"end":869},"obj":"Body_part"},{"id":"T9","span":{"begin":941,"end":948},"obj":"Body_part"},{"id":"T10","span":{"begin":1087,"end":1092},"obj":"Body_part"},{"id":"T11","span":{"begin":1268,"end":1275},"obj":"Body_part"},{"id":"T12","span":{"begin":1302,"end":1314},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"fma_id","subj":"T1","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A2","pred":"fma_id","subj":"T2","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A3","pred":"fma_id","subj":"T3","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A4","pred":"fma_id","subj":"T4","obj":"http://purl.org/sig/ont/fma/fma67653"},{"id":"A5","pred":"fma_id","subj":"T5","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A6","pred":"fma_id","subj":"T6","obj":"http://purl.org/sig/ont/fma/fma82816"},{"id":"A7","pred":"fma_id","subj":"T7","obj":"http://purl.org/sig/ont/fma/fma82816"},{"id":"A8","pred":"fma_id","subj":"T8","obj":"http://purl.org/sig/ont/fma/fma82816"},{"id":"A9","pred":"fma_id","subj":"T9","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A10","pred":"fma_id","subj":"T10","obj":"http://purl.org/sig/ont/fma/fma67264"},{"id":"A11","pred":"fma_id","subj":"T11","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A12","pred":"fma_id","subj":"T12","obj":"http://purl.org/sig/ont/fma/fma82816"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T7","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T8","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T9","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T10","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T11","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T12","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T1","span":{"begin":892,"end":895},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/UBERON_2001840"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid_AGAC","denotations":[{"id":"p88091s19","span":{"begin":1060,"end":1070},"obj":"MPA"},{"id":"p88091s24","span":{"begin":1087,"end":1098},"obj":"MPA"}],"attributes":[{"subj":"p88091s19","pred":"source","obj":"LitCovid_AGAC"},{"subj":"p88091s24","pred":"source","obj":"LitCovid_AGAC"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T6","span":{"begin":45,"end":61},"obj":"Disease"},{"id":"T7","span":{"begin":65,"end":73},"obj":"Disease"},{"id":"T8","span":{"begin":766,"end":774},"obj":"Disease"},{"id":"T9","span":{"begin":928,"end":936},"obj":"Disease"},{"id":"T10","span":{"begin":1461,"end":1469},"obj":"Disease"}],"attributes":[{"id":"A6","pred":"mondo_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A7","pred":"mondo_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A8","pred":"mondo_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A9","pred":"mondo_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A10","pred":"mondo_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T7","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T8","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T9","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T10","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T3","span":{"begin":96,"end":97},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T4","span":{"begin":361,"end":366},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T5","span":{"begin":576,"end":580},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T6","span":{"begin":609,"end":610},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T7","span":{"begin":844,"end":845},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T8","span":{"begin":1078,"end":1083},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T9","span":{"begin":1207,"end":1213},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T10","span":{"begin":1564,"end":1565},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"attributes":[{"subj":"T3","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T7","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T8","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T9","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T10","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T8","span":{"begin":153,"end":157},"obj":"Chemical"},{"id":"T9","span":{"begin":400,"end":407},"obj":"Chemical"},{"id":"T10","span":{"begin":461,"end":468},"obj":"Chemical"},{"id":"T11","span":{"begin":548,"end":560},"obj":"Chemical"},{"id":"T12","span":{"begin":555,"end":560},"obj":"Chemical"},{"id":"T13","span":{"begin":589,"end":601},"obj":"Chemical"},{"id":"T14","span":{"begin":696,"end":707},"obj":"Chemical"},{"id":"T15","span":{"begin":726,"end":731},"obj":"Chemical"},{"id":"T16","span":{"begin":794,"end":806},"obj":"Chemical"},{"id":"T17","span":{"begin":801,"end":806},"obj":"Chemical"},{"id":"T18","span":{"begin":811,"end":823},"obj":"Chemical"},{"id":"T19","span":{"begin":858,"end":869},"obj":"Chemical"},{"id":"T20","span":{"begin":941,"end":948},"obj":"Chemical"},{"id":"T21","span":{"begin":1087,"end":1092},"obj":"Chemical"},{"id":"T22","span":{"begin":1226,"end":1244},"obj":"Chemical"},{"id":"T23","span":{"begin":1268,"end":1275},"obj":"Chemical"},{"id":"T24","span":{"begin":1302,"end":1314},"obj":"Chemical"},{"id":"T25","span":{"begin":1424,"end":1429},"obj":"Chemical"},{"id":"T26","span":{"begin":1612,"end":1616},"obj":"Chemical"}],"attributes":[{"id":"A8","pred":"chebi_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A9","pred":"chebi_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A10","pred":"chebi_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A11","pred":"chebi_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/CHEBI_26667"},{"id":"A12","pred":"chebi_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A13","pred":"chebi_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/CHEBI_28892"},{"id":"A14","pred":"chebi_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A15","pred":"chebi_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A16","pred":"chebi_id","subj":"T16","obj":"http://purl.obolibrary.org/obo/CHEBI_26667"},{"id":"A17","pred":"chebi_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A18","pred":"chebi_id","subj":"T18","obj":"http://purl.obolibrary.org/obo/CHEBI_28892"},{"id":"A19","pred":"chebi_id","subj":"T19","obj":"http://purl.obolibrary.org/obo/CHEBI_28892"},{"id":"A20","pred":"chebi_id","subj":"T20","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A21","pred":"chebi_id","subj":"T21","obj":"http://purl.obolibrary.org/obo/CHEBI_18059"},{"id":"A22","pred":"chebi_id","subj":"T22","obj":"http://purl.obolibrary.org/obo/CHEBI_5801"},{"id":"A23","pred":"chebi_id","subj":"T23","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A24","pred":"chebi_id","subj":"T24","obj":"http://purl.obolibrary.org/obo/CHEBI_28892"},{"id":"A25","pred":"chebi_id","subj":"T25","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A26","pred":"chebi_id","subj":"T26","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"subj":"T8","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T9","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T10","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T11","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T12","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T13","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T14","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T15","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T16","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T17","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T18","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T19","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T20","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T21","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T22","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T23","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T24","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T25","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T26","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T1","span":{"begin":290,"end":307},"obj":"http://purl.obolibrary.org/obo/GO_0019079"},{"id":"T2","span":{"begin":290,"end":307},"obj":"http://purl.obolibrary.org/obo/GO_0019058"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T9","span":{"begin":0,"end":117},"obj":"Sentence"},{"id":"T10","span":{"begin":118,"end":267},"obj":"Sentence"},{"id":"T11","span":{"begin":268,"end":454},"obj":"Sentence"},{"id":"T12","span":{"begin":455,"end":602},"obj":"Sentence"},{"id":"T13","span":{"begin":603,"end":843},"obj":"Sentence"},{"id":"T14","span":{"begin":844,"end":964},"obj":"Sentence"},{"id":"T15","span":{"begin":965,"end":1146},"obj":"Sentence"},{"id":"T16","span":{"begin":1147,"end":1315},"obj":"Sentence"},{"id":"T17","span":{"begin":1316,"end":1472},"obj":"Sentence"},{"id":"T18","span":{"begin":1473,"end":1655},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T9","pred":"source","obj":"LitCovid-sentences"},{"subj":"T10","pred":"source","obj":"LitCovid-sentences"},{"subj":"T11","pred":"source","obj":"LitCovid-sentences"},{"subj":"T12","pred":"source","obj":"LitCovid-sentences"},{"subj":"T13","pred":"source","obj":"LitCovid-sentences"},{"subj":"T14","pred":"source","obj":"LitCovid-sentences"},{"subj":"T15","pred":"source","obj":"LitCovid-sentences"},{"subj":"T16","pred":"source","obj":"LitCovid-sentences"},{"subj":"T17","pred":"source","obj":"LitCovid-sentences"},{"subj":"T18","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PubTator","color":"#93ecd6","default":true},{"id":"LitCovid-PMC-OGER-BB","color":"#ecbc93"},{"id":"LitCovid-PD-FMA-UBERON","color":"#a293ec"},{"id":"LitCovid-PD-UBERON","color":"#9eec93"},{"id":"LitCovid_AGAC","color":"#ec93b8"},{"id":"LitCovid-PD-MONDO","color":"#93d2ec"},{"id":"LitCovid-PD-CLO","color":"#ecec93"},{"id":"LitCovid-PD-CHEBI","color":"#d293ec"},{"id":"LitCovid-PD-GO-BP","color":"#93ecb8"},{"id":"LitCovid-sentences","color":"#ec9e93"}]}]}}