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PMC:7128678 / 506-2161 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
48 512-517 Gene denotes ACE-2 Gene:59272
49 1131-1136 Gene denotes ACE-2 Gene:59272
50 384-389 Gene denotes spike Gene:43740568
51 1266-1267 Gene denotes S Gene:43740568
52 939-940 Gene denotes S Gene:43740568
53 45-63 Species denotes SARS-coronavirus 2 Tax:2697049
54 65-75 Species denotes SARS-CoV-2 Tax:2697049
55 244-252 Species denotes patients Tax:9606
56 766-776 Species denotes SARS-CoV-2 Tax:2697049
57 928-938 Species denotes SARS-CoV-2 Tax:2697049
58 1438-1446 Species denotes patients Tax:9606
59 1461-1471 Species denotes SARS-CoV-2 Tax:2697049
60 478-490 Chemical denotes angiotension
61 548-560 Chemical denotes sialic acids MESH:D012794
62 589-601 Chemical denotes gangliosides MESH:D005732
63 696-707 Chemical denotes chloroquine MESH:D002738
64 794-806 Chemical denotes sialic acids MESH:D012794
65 811-823 Chemical denotes gangliosides MESH:D005732
66 858-869 Chemical denotes ganglioside MESH:D005732
67 1087-1092 Chemical denotes lipid MESH:D008055
68 1226-1244 Chemical denotes hydroxychloroquine MESH:D006886
69 1246-1252 Chemical denotes CLQ-OH
70 1302-1314 Chemical denotes gangliosides MESH:D005732
71 1378-1384 Chemical denotes CLQ-OH
72 235-243 Disease denotes infected MESH:D007239
73 1447-1455 Disease denotes infected MESH:D007239

LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T20 45-49 SP_10 denotes SARS
T21 50-61 NCBITaxon:11118 denotes coronavirus
T22 65-75 SP_7 denotes SARS-CoV-2
T23 153-157 CHEBI:23888;CHEBI:23888 denotes drug
T24 290-295 NCBITaxon:10239;GO:0006260 denotes viral
T25 296-307 GO:0006260 denotes replication
T26 338-348 GO:0009986 denotes surface of
T27 349-360 GO:0045333;CL:0000082 denotes respiratory
T28 361-366 CL:0000082 denotes cells
T29 394-399 NCBITaxon:10239 denotes viral
T30 459-468 PG_1 denotes S protein
T31 512-517 G_3;PG_10;PR:000003622 denotes ACE-2
T32 548-554 CHEBI:30563;CHEBI:30563 denotes sialic
T33 555-560 CHEBI:41865;CHEBI:41865 denotes acids
T34 571-588 GO:0044228 denotes host cell surface
T35 589-601 CHEBI:28892;CHEBI:28892 denotes gangliosides
T36 696-707 CHEBI:3638;DG_10;CHEBI:3638 denotes chloroquine
T37 726-731 CHEBI:23888;CHEBI:23888 denotes drugs
T38 766-776 SP_7 denotes SARS-CoV-2
T39 794-806 CHEBI:26667;CHEBI:26667 denotes sialic acids
T40 811-823 CHEBI:5386;CHEBI:5386 denotes gangliosides
T41 858-869 CHEBI:28892;CHEBI:28892 denotes ganglioside
T42 878-884 SO:0000417 denotes domain
T43 914-920 SO:0000417 denotes domain
T44 928-938 SP_7 denotes SARS-CoV-2
T45 939-948 PG_1 denotes S protein
T46 970-976 SO:0000417 denotes domain
T47 1078-1083 NCBITaxon:10239 denotes virus
T48 1087-1092 CHEBI:18059;CHEBI:18059;GO:0045121 denotes lipid
T49 1093-1098 GO:0045121 denotes rafts
T50 1131-1136 G_3;PG_10;PR:000003622 denotes ACE-2
T51 1226-1244 CHEBI:5801;DG_20;CHEBI:5801 denotes hydroxychloroquine
T52 1260-1265 NCBITaxon:10239 denotes viral
T53 1266-1275 PG_1 denotes S protein
T54 1302-1314 CHEBI:28892;CHEBI:28892 denotes gangliosides
T55 1424-1429 CHEBI:23888;CHEBI:23888 denotes drugs
T56 1461-1471 SP_7 denotes SARS-CoV-2
T57 1612-1616 CHEBI:23888;CHEBI:23888 denotes drug

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T1 361-366 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T2 400-407 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T3 461-468 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T4 576-588 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T5 576-580 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T6 589-601 Body_part denotes gangliosides http://purl.org/sig/ont/fma/fma82816
T7 811-823 Body_part denotes gangliosides http://purl.org/sig/ont/fma/fma82816
T8 858-869 Body_part denotes ganglioside http://purl.org/sig/ont/fma/fma82816
T9 941-948 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T10 1087-1092 Body_part denotes lipid http://purl.org/sig/ont/fma/fma67264
T11 1268-1275 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T12 1302-1314 Body_part denotes gangliosides http://purl.org/sig/ont/fma/fma82816

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 892-895 Body_part denotes tip http://purl.obolibrary.org/obo/UBERON_2001840

LitCovid_AGAC

Id Subject Object Predicate Lexical cue
p88091s19 1060-1070 MPA denotes attachment
p88091s24 1087-1098 MPA denotes lipid rafts

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T6 45-61 Disease denotes SARS-coronavirus http://purl.obolibrary.org/obo/MONDO_0005091
T7 65-73 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T8 766-774 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T9 928-936 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T10 1461-1469 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T3 96-97 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T4 361-366 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T5 576-580 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T6 609-610 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T7 844-845 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T8 1078-1083 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T9 1207-1213 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T10 1564-1565 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T8 153-157 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T9 400-407 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T10 461-468 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T11 548-560 Chemical denotes sialic acids http://purl.obolibrary.org/obo/CHEBI_26667
T12 555-560 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527
T13 589-601 Chemical denotes gangliosides http://purl.obolibrary.org/obo/CHEBI_28892
T14 696-707 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T15 726-731 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T16 794-806 Chemical denotes sialic acids http://purl.obolibrary.org/obo/CHEBI_26667
T17 801-806 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527
T18 811-823 Chemical denotes gangliosides http://purl.obolibrary.org/obo/CHEBI_28892
T19 858-869 Chemical denotes ganglioside http://purl.obolibrary.org/obo/CHEBI_28892
T20 941-948 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T21 1087-1092 Chemical denotes lipid http://purl.obolibrary.org/obo/CHEBI_18059
T22 1226-1244 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T23 1268-1275 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T24 1302-1314 Chemical denotes gangliosides http://purl.obolibrary.org/obo/CHEBI_28892
T25 1424-1429 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T26 1612-1616 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T1 290-307 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T2 290-307 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T9 0-117 Sentence denotes The recent emergence of the novel pathogenic SARS-coronavirus 2 (SARS-CoV-2) is responsible for a worldwide pandemic.
T10 118-267 Sentence denotes Given the global health emergency, drug repositioning is the most reliable option to design an efficient therapy for infected patients without delay.
T11 268-454 Sentence denotes The first step of the viral replication cycle [i.e. attachment to the surface of respiratory cells, mediated by the spike (S) viral protein] offers several potential therapeutic targets.
T12 455-602 Sentence denotes The S protein uses the angiotension-converting enzyme-2 (ACE-2) receptor for entry, but also sialic acids linked to host cell surface gangliosides.
T13 603-843 Sentence denotes Using a combination of structural and molecular modelling approaches, this study showed that chloroquine (CLQ), one of the drugs currently under investigation for SARS-CoV-2 treatment, binds sialic acids and gangliosides with high affinity.
T14 844-964 Sentence denotes A new type of ganglioside-binding domain at the tip of the N-terminal domain of the SARS-CoV-2 S protein was identified.
T15 965-1146 Sentence denotes This domain (111–158), which is fully conserved among clinical isolates worldwide, may improve attachment of the virus to lipid rafts and facilitate contact with the ACE-2 receptor.
T16 1147-1315 Sentence denotes This study showed that, in the presence of CLQ [or its more active derivative, hydroxychloroquine (CLQ-OH)], the viral S protein is no longer able to bind gangliosides.
T17 1316-1472 Sentence denotes The identification of this new mechanism of action of CLQ and CLQ-OH supports the use of these repositioned drugs to cure patients infected with SARS-CoV-2.
T18 1473-1655 Sentence denotes The in-silico approaches used in this study might also be used to assess the efficiency of a broad range of repositioned and/or innovative drug candidates before clinical evaluation.