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PMC:7128678 / 3604-4624 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
117 477-482 Gene denotes spike Gene:43740568
118 484-485 Gene denotes S Gene:43740568
119 581-582 Gene denotes S Gene:43740568
120 32-37 Species denotes human Tax:9606
121 38-51 Species denotes coronaviruses Tax:11118
122 503-513 Species denotes SARS-CoV-2 Tax:2697049
123 850-860 Species denotes SARS-CoV-2 Tax:2697049
124 954-959 Species denotes human Tax:9606
125 960-973 Species denotes coronaviruses Tax:11118
126 1004-1014 Species denotes SARS-CoV-2 Tax:2697049
127 123-134 Chemical denotes sialic-acid MESH:D019158
128 164-176 Chemical denotes gangliosides MESH:D005732
129 398-410 Chemical denotes sialic acids MESH:D012794
130 414-425 Chemical denotes ganglioside MESH:D005732
131 814-832 Chemical denotes hydroxychloroquine MESH:D006886
132 834-840 Chemical denotes CLQ-OH
133 915-921 Chemical denotes CLQ-OH

LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T83 32-37 SP_6;NCBITaxon:9606 denotes human
T84 38-51 NCBITaxon:11118 denotes coronaviruses
T85 82-90 GO:0016020 denotes membrane
T86 123-134 CHEBI:26667;CHEBI:26667 denotes sialic-acid
T87 146-159 CHEBI:17089;CHEBI:17089;BV_11 denotes glycoproteins
T88 164-176 CHEBI:5386;CHEBI:5386 denotes gangliosides
T89 226-243 UBERON:0000065 denotes respiratory tract
T90 398-404 CHEBI:30563;CHEBI:30563 denotes sialic
T91 405-410 CHEBI:41865;CHEBI:41865 denotes acids
T92 414-425 CHEBI:28892;CHEBI:28892 denotes ganglioside
T93 426-438 SO:0000409 denotes binding site
T94 457-463 SO:0000417 denotes domain
T95 487-499 CHEBI:17089;CHEBI:17089;BV_11 denotes glycoprotein
T96 503-513 SP_7 denotes SARS-CoV-2
T97 583-594 CHEBI:28892;CHEBI:28892 denotes ganglioside
T98 645-650 NCBITaxon:10239;GO:0006260 denotes viral
T99 651-662 GO:0006260 denotes replication
T100 693-703 GO:0009986 denotes surface of
T101 704-715 GO:0045333;CL:0000100 denotes respiratory
T102 716-721 CL:0000100 denotes cells
T103 739-748 PG_1 denotes S protein
T104 814-832 CHEBI:5801;DG_20;CHEBI:5801 denotes hydroxychloroquine
T105 850-860 SP_7 denotes SARS-CoV-2
T106 954-959 SP_6;NCBITaxon:9606 denotes human
T107 960-973 NCBITaxon:11118 denotes coronaviruses
T108 1004-1014 SP_7 denotes SARS-CoV-2

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T18 74-81 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T19 82-99 Body_part denotes membrane receptor http://purl.org/sig/ont/fma/fma0326969
T20 146-159 Body_part denotes glycoproteins http://purl.org/sig/ont/fma/fma62925
T21 164-176 Body_part denotes gangliosides http://purl.org/sig/ont/fma/fma82816
T22 226-243 Body_part denotes respiratory tract http://purl.org/sig/ont/fma/fma265130
T23 414-425 Body_part denotes ganglioside http://purl.org/sig/ont/fma/fma82816
T24 487-499 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T25 583-594 Body_part denotes ganglioside http://purl.org/sig/ont/fma/fma82816
T26 716-721 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T27 741-748 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T2 226-243 Body_part denotes respiratory tract http://purl.obolibrary.org/obo/UBERON_0000065

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T18 465-468 Disease denotes NTD http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075
T20 503-511 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T21 850-858 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T22 1004-1012 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T23 32-37 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T24 82-90 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T25 273-274 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T26 337-339 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T27 412-413 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T28 554-555 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T29 716-721 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T30 954-959 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T31 975-981 http://purl.obolibrary.org/obo/CLO_0001302 denotes 3], [4

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T39 74-81 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T40 130-134 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T41 146-159 Chemical denotes glycoproteins http://purl.obolibrary.org/obo/CHEBI_17089
T42 164-176 Chemical denotes gangliosides http://purl.obolibrary.org/obo/CHEBI_28892
T43 398-410 Chemical denotes sialic acids http://purl.obolibrary.org/obo/CHEBI_26667
T44 405-410 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527
T45 414-425 Chemical denotes ganglioside http://purl.obolibrary.org/obo/CHEBI_28892
T46 487-499 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T47 583-594 Chemical denotes ganglioside http://purl.obolibrary.org/obo/CHEBI_28892
T48 741-748 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T49 768-777 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T50 814-832 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T5 645-662 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T6 645-662 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T28 0-249 Sentence denotes One important characteristic of human coronaviruses is that besides their protein membrane receptor, they also depend upon sialic-acid-containing glycoproteins and gangliosides that act as primary attachment factors along the respiratory tract [10].
T29 250-411 Sentence denotes The present study used a combination of structural and molecular modelling approaches [11] to investigate the potential interaction between CLQ and sialic acids.
T30 412-750 Sentence denotes A ganglioside-binding site in the N-terminal domain (NTD) of the spike (S) glycoprotein of SARS-CoV-2 was identified, and CLQ was shown to be a potential blocker of the S–ganglioside interaction which occurs in the first step of the viral replication cycle (i.e. attachment to the surface of respiratory cells, mediated by the S protein).
T31 751-875 Sentence denotes In addition, the antiviral potential of CLQ and its derivative hydroxychloroquine (CLQ-OH) against SARS-CoV-2 were compared.
T32 876-1020 Sentence denotes Overall, this study found that CLQ and CLQ-OH may be used to fight pathogenic human coronaviruses [3], [4], [5], [6], including SARS-CoV-2 [12].

2_test

Id Subject Object Predicate Lexical cue
32251731-23873408-48149940 245-247 23873408 denotes 10
32251731-28205163-48149941 337-339 28205163 denotes 11
32251731-16439323-48149942 985-986 16439323 denotes 5
32251731-29940786-48149943 990-991 29940786 denotes 6
T35411 245-247 23873408 denotes 10
T47978 337-339 28205163 denotes 11
T17061 985-986 16439323 denotes 5
T81743 990-991 29940786 denotes 6