PMC:7128678 / 29988-30679 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"938","span":{"begin":116,"end":117},"obj":"Gene"},{"id":"939","span":{"begin":105,"end":115},"obj":"Species"},{"id":"940","span":{"begin":408,"end":418},"obj":"Species"},{"id":"941","span":{"begin":60,"end":71},"obj":"Chemical"},{"id":"942","span":{"begin":132,"end":143},"obj":"Chemical"},{"id":"943","span":{"begin":219,"end":235},"obj":"Chemical"},{"id":"944","span":{"begin":335,"end":346},"obj":"Chemical"},{"id":"945","span":{"begin":626,"end":638},"obj":"Chemical"}],"attributes":[{"id":"A938","pred":"tao:has_database_id","subj":"938","obj":"Gene:43740568"},{"id":"A939","pred":"tao:has_database_id","subj":"939","obj":"Tax:2697049"},{"id":"A940","pred":"tao:has_database_id","subj":"940","obj":"Tax:2697049"},{"id":"A941","pred":"tao:has_database_id","subj":"941","obj":"MESH:D005732"},{"id":"A942","pred":"tao:has_database_id","subj":"942","obj":"MESH:D005732"},{"id":"A943","pred":"tao:has_database_id","subj":"943","obj":"MESH:D024361"},{"id":"A944","pred":"tao:has_database_id","subj":"944","obj":"MESH:D005732"},{"id":"A945","pred":"tao:has_database_id","subj":"945","obj":"MESH:D005732"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"This molecular modelling study has identified a new type of ganglioside-binding domain in the NTD of the SARS-CoV-2 S protein. This ganglioside-binding domain consists of a large flat interface enriched in aromatic and basic amino acid residues. It covers a stretch of 52 amino acid residues (111–162), which is longer than all linear ganglioside-binding domains characterized to date [29]. However, the new SARS-CoV-2 motif is organized into three distinct regions, including a central aromatic domain and two terminal basic domains (Fig. 10). Thus, this motif displays the typical features that determine optimal binding to gangliosides (i.e. CH-π stacking and electrostatic interactions)."}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T670","span":{"begin":60,"end":71},"obj":"CHEBI:5386;CHEBI:5386"},{"id":"T671","span":{"begin":80,"end":86},"obj":"SO:0000417"},{"id":"T672","span":{"begin":105,"end":115},"obj":"SP_7"},{"id":"T673","span":{"begin":116,"end":125},"obj":"PG_1"},{"id":"T674","span":{"begin":132,"end":143},"obj":"CHEBI:28892;CHEBI:28892"},{"id":"T675","span":{"begin":152,"end":158},"obj":"SO:0000417"},{"id":"T676","span":{"begin":335,"end":346},"obj":"CHEBI:28892;CHEBI:28892"},{"id":"T677","span":{"begin":355,"end":362},"obj":"SO:0000417"},{"id":"T678","span":{"begin":408,"end":418},"obj":"SP_7"},{"id":"T679","span":{"begin":496,"end":502},"obj":"SO:0000417"},{"id":"T680","span":{"begin":526,"end":533},"obj":"SO:0000417"},{"id":"T681","span":{"begin":626,"end":638},"obj":"CHEBI:5386;CHEBI:5386"}],"text":"This molecular modelling study has identified a new type of ganglioside-binding domain in the NTD of the SARS-CoV-2 S protein. This ganglioside-binding domain consists of a large flat interface enriched in aromatic and basic amino acid residues. It covers a stretch of 52 amino acid residues (111–162), which is longer than all linear ganglioside-binding domains characterized to date [29]. However, the new SARS-CoV-2 motif is organized into three distinct regions, including a central aromatic domain and two terminal basic domains (Fig. 10). Thus, this motif displays the typical features that determine optimal binding to gangliosides (i.e. CH-π stacking and electrostatic interactions)."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T210","span":{"begin":60,"end":71},"obj":"Body_part"},{"id":"T211","span":{"begin":118,"end":125},"obj":"Body_part"},{"id":"T212","span":{"begin":132,"end":143},"obj":"Body_part"},{"id":"T213","span":{"begin":225,"end":235},"obj":"Body_part"},{"id":"T214","span":{"begin":272,"end":282},"obj":"Body_part"},{"id":"T215","span":{"begin":335,"end":346},"obj":"Body_part"},{"id":"T216","span":{"begin":626,"end":638},"obj":"Body_part"}],"attributes":[{"id":"A210","pred":"fma_id","subj":"T210","obj":"http://purl.org/sig/ont/fma/fma82816"},{"id":"A211","pred":"fma_id","subj":"T211","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A212","pred":"fma_id","subj":"T212","obj":"http://purl.org/sig/ont/fma/fma82816"},{"id":"A213","pred":"fma_id","subj":"T213","obj":"http://purl.org/sig/ont/fma/fma82739"},{"id":"A214","pred":"fma_id","subj":"T214","obj":"http://purl.org/sig/ont/fma/fma82739"},{"id":"A215","pred":"fma_id","subj":"T215","obj":"http://purl.org/sig/ont/fma/fma82816"},{"id":"A216","pred":"fma_id","subj":"T216","obj":"http://purl.org/sig/ont/fma/fma82816"}],"text":"This molecular modelling study has identified a new type of ganglioside-binding domain in the NTD of the SARS-CoV-2 S protein. This ganglioside-binding domain consists of a large flat interface enriched in aromatic and basic amino acid residues. It covers a stretch of 52 amino acid residues (111–162), which is longer than all linear ganglioside-binding domains characterized to date [29]. However, the new SARS-CoV-2 motif is organized into three distinct regions, including a central aromatic domain and two terminal basic domains (Fig. 10). Thus, this motif displays the typical features that determine optimal binding to gangliosides (i.e. CH-π stacking and electrostatic interactions)."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T145","span":{"begin":94,"end":97},"obj":"Disease"},{"id":"T147","span":{"begin":105,"end":113},"obj":"Disease"},{"id":"T148","span":{"begin":408,"end":416},"obj":"Disease"}],"attributes":[{"id":"A145","pred":"mondo_id","subj":"T145","obj":"http://purl.obolibrary.org/obo/MONDO_0008449"},{"id":"A146","pred":"mondo_id","subj":"T145","obj":"http://purl.obolibrary.org/obo/MONDO_0018075"},{"id":"A147","pred":"mondo_id","subj":"T147","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A148","pred":"mondo_id","subj":"T148","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"This molecular modelling study has identified a new type of ganglioside-binding domain in the NTD of the SARS-CoV-2 S protein. This ganglioside-binding domain consists of a large flat interface enriched in aromatic and basic amino acid residues. It covers a stretch of 52 amino acid residues (111–162), which is longer than all linear ganglioside-binding domains characterized to date [29]. However, the new SARS-CoV-2 motif is organized into three distinct regions, including a central aromatic domain and two terminal basic domains (Fig. 10). Thus, this motif displays the typical features that determine optimal binding to gangliosides (i.e. CH-π stacking and electrostatic interactions)."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T245","span":{"begin":31,"end":34},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T246","span":{"begin":46,"end":47},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T247","span":{"begin":171,"end":172},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T248","span":{"begin":225,"end":244},"obj":"http://purl.obolibrary.org/obo/CHEBI_33708"},{"id":"T249","span":{"begin":225,"end":244},"obj":"http://purl.obolibrary.org/obo/PR_000036907"},{"id":"T250","span":{"begin":256,"end":257},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T251","span":{"begin":269,"end":271},"obj":"http://purl.obolibrary.org/obo/CLO_0001407"},{"id":"T252","span":{"begin":272,"end":291},"obj":"http://purl.obolibrary.org/obo/CHEBI_33708"},{"id":"T253","span":{"begin":272,"end":291},"obj":"http://purl.obolibrary.org/obo/PR_000036907"},{"id":"T254","span":{"begin":297,"end":300},"obj":"http://purl.obolibrary.org/obo/CLO_0001002"},{"id":"T255","span":{"begin":428,"end":437},"obj":"http://purl.obolibrary.org/obo/OBI_0000245"},{"id":"T256","span":{"begin":477,"end":478},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"This molecular modelling study has identified a new type of ganglioside-binding domain in the NTD of the SARS-CoV-2 S protein. This ganglioside-binding domain consists of a large flat interface enriched in aromatic and basic amino acid residues. It covers a stretch of 52 amino acid residues (111–162), which is longer than all linear ganglioside-binding domains characterized to date [29]. However, the new SARS-CoV-2 motif is organized into three distinct regions, including a central aromatic domain and two terminal basic domains (Fig. 10). Thus, this motif displays the typical features that determine optimal binding to gangliosides (i.e. CH-π stacking and electrostatic interactions)."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T698","span":{"begin":60,"end":71},"obj":"Chemical"},{"id":"T699","span":{"begin":118,"end":125},"obj":"Chemical"},{"id":"T700","span":{"begin":132,"end":143},"obj":"Chemical"},{"id":"T701","span":{"begin":225,"end":235},"obj":"Chemical"},{"id":"T702","span":{"begin":225,"end":230},"obj":"Chemical"},{"id":"T703","span":{"begin":231,"end":235},"obj":"Chemical"},{"id":"T704","span":{"begin":272,"end":282},"obj":"Chemical"},{"id":"T705","span":{"begin":272,"end":277},"obj":"Chemical"},{"id":"T706","span":{"begin":278,"end":282},"obj":"Chemical"},{"id":"T707","span":{"begin":335,"end":346},"obj":"Chemical"},{"id":"T708","span":{"begin":626,"end":638},"obj":"Chemical"}],"attributes":[{"id":"A698","pred":"chebi_id","subj":"T698","obj":"http://purl.obolibrary.org/obo/CHEBI_28892"},{"id":"A699","pred":"chebi_id","subj":"T699","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A700","pred":"chebi_id","subj":"T700","obj":"http://purl.obolibrary.org/obo/CHEBI_28892"},{"id":"A701","pred":"chebi_id","subj":"T701","obj":"http://purl.obolibrary.org/obo/CHEBI_33709"},{"id":"A702","pred":"chebi_id","subj":"T702","obj":"http://purl.obolibrary.org/obo/CHEBI_46882"},{"id":"A703","pred":"chebi_id","subj":"T703","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A704","pred":"chebi_id","subj":"T704","obj":"http://purl.obolibrary.org/obo/CHEBI_33709"},{"id":"A705","pred":"chebi_id","subj":"T705","obj":"http://purl.obolibrary.org/obo/CHEBI_46882"},{"id":"A706","pred":"chebi_id","subj":"T706","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A707","pred":"chebi_id","subj":"T707","obj":"http://purl.obolibrary.org/obo/CHEBI_28892"},{"id":"A708","pred":"chebi_id","subj":"T708","obj":"http://purl.obolibrary.org/obo/CHEBI_28892"}],"text":"This molecular modelling study has identified a new type of ganglioside-binding domain in the NTD of the SARS-CoV-2 S protein. This ganglioside-binding domain consists of a large flat interface enriched in aromatic and basic amino acid residues. It covers a stretch of 52 amino acid residues (111–162), which is longer than all linear ganglioside-binding domains characterized to date [29]. However, the new SARS-CoV-2 motif is organized into three distinct regions, including a central aromatic domain and two terminal basic domains (Fig. 10). Thus, this motif displays the typical features that determine optimal binding to gangliosides (i.e. CH-π stacking and electrostatic interactions)."}

{"project":"LitCovid-sentences","denotations":[{"id":"T234","span":{"begin":0,"end":126},"obj":"Sentence"},{"id":"T235","span":{"begin":127,"end":245},"obj":"Sentence"},{"id":"T236","span":{"begin":246,"end":390},"obj":"Sentence"},{"id":"T237","span":{"begin":391,"end":544},"obj":"Sentence"},{"id":"T238","span":{"begin":545,"end":691},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"This molecular modelling study has identified a new type of ganglioside-binding domain in the NTD of the SARS-CoV-2 S protein. This ganglioside-binding domain consists of a large flat interface enriched in aromatic and basic amino acid residues. It covers a stretch of 52 amino acid residues (111–162), which is longer than all linear ganglioside-binding domains characterized to date [29]. However, the new SARS-CoV-2 motif is organized into three distinct regions, including a central aromatic domain and two terminal basic domains (Fig. 10). Thus, this motif displays the typical features that determine optimal binding to gangliosides (i.e. CH-π stacking and electrostatic interactions)."}