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PMC:7128678 / 27400-28795 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
870 545-550 Gene denotes ACE-2 Gene:59272
871 746-751 Gene denotes ACE-2 Gene:59272
872 1087-1100 Gene denotes neuraminidase Gene:4758
873 409-414 Gene denotes spike Gene:43740568
874 179-184 Species denotes human Tax:9606
875 255-268 Species denotes coronaviruses Tax:11118
876 431-444 Species denotes coronaviruses Tax:11118
877 503-511 Species denotes SARS-CoV Tax:694009
878 516-526 Species denotes SARS-CoV-2 Tax:2697049
879 700-710 Species denotes SARS-CoV-2 Tax:2697049
880 725-733 Species denotes SARS-CoV Tax:694009
881 861-871 Species denotes SARS-CoV-2 Tax:2697049
882 1121-1129 Species denotes MERS-CoV Tax:1335626
883 1139-1144 Species denotes human Tax:9606
884 1248-1265 Species denotes human coronavirus Tax:694448
885 1338-1348 Species denotes SARS-CoV-2 Tax:2697049
886 236-245 Species denotes influenza Tax:11320
887 0-12 Chemical denotes Sialic acids MESH:D012794
888 41-53 Chemical denotes gangliosides MESH:D005732
889 296-307 Chemical denotes sialic-acid MESH:D019158
890 938-949 Chemical denotes sialic-acid MESH:D019158
891 979-991 Chemical denotes gangliosides MESH:D005732
892 1071-1083 Chemical denotes sialic acids MESH:D012794
893 1211-1223 Chemical denotes sialic acids MESH:D012794
894 795-804 Disease denotes infection MESH:D007239
895 1377-1385 Disease denotes COVID-19 MESH:C000657245

LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T611 0-6 CHEBI:30563;CHEBI:30563 denotes Sialic
T612 23-36 CHEBI:17089;CHEBI:17089;BV_11 denotes glycoproteins
T613 41-53 CHEBI:30563;CHEBI:30563 denotes gangliosides
T614 83-90 NCBITaxon:10239 denotes viruses
T615 134-144 GO:0035376 denotes cell entry
T616 157-164 NCBITaxon:10239 denotes viruses
T617 179-184 SP_6;NCBITaxon:9606 denotes human
T618 209-226 UBERON:0000065 denotes respiratory tract
T619 236-245 NCBITaxon:7719 denotes influenza
T620 255-268 NCBITaxon:11118 denotes coronaviruses
T621 296-307 CHEBI:26667;CHEBI:26667 denotes sialic-acid
T622 319-331 GO:0009986 denotes cell surface
T623 403-408 NCBITaxon:10239 denotes viral
T624 431-444 NCBITaxon:11118 denotes coronaviruses
T625 480-481 PG_18 denotes S
T626 482-494 PG_18;CHEBI:17089;BV_11;CHEBI:17089 denotes glycoprotein
T627 503-511 SP_10 denotes SARS-CoV
T628 516-526 SP_7 denotes SARS-CoV-2
T629 545-550 G_3;PG_10;PR:000003622 denotes ACE-2
T630 632-639 NCBITaxon:10239 denotes viruses
T631 700-710 SP_7 denotes SARS-CoV-2
T632 725-733 SP_10 denotes SARS-CoV
T633 746-751 G_3;PG_10;PR:000003622 denotes ACE-2
T634 812-835 UBERON:0001557 denotes upper respiratory tract
T635 861-871 SP_7 denotes SARS-CoV-2
T636 897-909 GO:0009986 denotes cell surface
T637 938-949 CHEBI:26667;CHEBI:26667 denotes sialic-acid
T638 961-974 CHEBI:17089;CHEBI:17089;BV_11 denotes glycoproteins
T639 979-991 CHEBI:28892;CHEBI:28892 denotes gangliosides
T640 1058-1070 GO:0009986 denotes cell surface
T641 1071-1083 CHEBI:26667;CHEBI:26667 denotes sialic acids
T642 1121-1129 SP_9 denotes MERS-CoV
T643 1130-1138 GO:0035376 denotes entry of
T644 1139-1144 SP_6;NCBITaxon:9606 denotes human
T645 1145-1151 UBERON:0001005 denotes airway
T646 1248-1253 SP_6;NCBITaxon:9606 denotes human
T647 1254-1265 NCBITaxon:11118 denotes coronavirus
T648 1323-1334 GO:0006260 denotes replication
T649 1338-1348 SP_7 denotes SARS-CoV-2
T650 1377-1385 SP_7 denotes COVID-19
T12 1377-1385 SP_7 denotes COVID-19

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T183 23-36 Body_part denotes glycoproteins http://purl.org/sig/ont/fma/fma62925
T184 41-53 Body_part denotes gangliosides http://purl.org/sig/ont/fma/fma82816
T185 134-138 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T186 209-226 Body_part denotes respiratory tract http://purl.org/sig/ont/fma/fma265130
T187 319-331 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T188 319-323 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T189 375-383 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T190 482-494 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T191 551-558 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T192 812-835 Body_part denotes upper respiratory tract http://purl.org/sig/ont/fma/fma45661
T193 897-909 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T194 897-901 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T195 961-974 Body_part denotes glycoproteins http://purl.org/sig/ont/fma/fma62925
T196 979-991 Body_part denotes gangliosides http://purl.org/sig/ont/fma/fma82816
T197 1058-1070 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T198 1058-1062 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T199 1152-1157 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T17 209-226 Body_part denotes respiratory tract http://purl.obolibrary.org/obo/UBERON_0000065
T18 324-342 Body_part denotes surface structures http://purl.obolibrary.org/obo/UBERON_0003102
T19 812-835 Body_part denotes upper respiratory tract http://purl.obolibrary.org/obo/UBERON_0001557
T20 818-835 Body_part denotes respiratory tract http://purl.obolibrary.org/obo/UBERON_0000065

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T131 236-245 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T132 503-511 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T133 516-524 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T134 700-708 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T135 725-733 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T136 795-835 Disease denotes infection of the upper respiratory tract http://purl.obolibrary.org/obo/MONDO_0024355
T137 795-804 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T138 861-869 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T139 1338-1346 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T140 1377-1385 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T222 66-67 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T223 83-90 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T224 134-138 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T225 157-164 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T226 179-184 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T227 319-323 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T228 566-569 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T229 589-590 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T230 632-639 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T231 897-901 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T232 1025-1028 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T233 1058-1062 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T234 1139-1144 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T235 1145-1151 http://purl.obolibrary.org/obo/UBERON_0001005 denotes airway
T236 1152-1157 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T237 1229-1230 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T238 1248-1253 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T664 7-12 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527
T665 23-36 Chemical denotes glycoproteins http://purl.obolibrary.org/obo/CHEBI_17089
T666 41-53 Chemical denotes gangliosides http://purl.obolibrary.org/obo/CHEBI_28892
T667 303-307 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T668 375-383 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T669 482-494 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T670 551-558 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T671 945-949 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T672 961-974 Chemical denotes glycoproteins http://purl.obolibrary.org/obo/CHEBI_17089
T673 979-991 Chemical denotes gangliosides http://purl.obolibrary.org/obo/CHEBI_28892
T674 1071-1083 Chemical denotes sialic acids http://purl.obolibrary.org/obo/CHEBI_26667
T675 1078-1083 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527
T676 1211-1223 Chemical denotes sialic acids http://purl.obolibrary.org/obo/CHEBI_26667
T677 1218-1223 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T216 0-150 Sentence denotes Sialic acids linked to glycoproteins and gangliosides are used by a broad range of viruses as receptors and/or attachment factors for cell entry [10].
T217 151-277 Sentence denotes These viruses include major human pathogens affecting the respiratory tract, such as influenza [21] and coronaviruses [22,23].
T218 278-415 Sentence denotes The attachment to sialic-acid-containing cell surface structures is mediated by receptor-binding proteins that belong to the viral spike.
T219 416-502 Sentence denotes In the case of coronaviruses, this function is fulfilled by the S glycoprotein [9,24].
T220 503-644 Sentence denotes SARS-CoV and SARS-CoV-2 interact with the ACE-2 protein, which has been identified as a key determinant of the contagiousness of viruses [8].
T221 645-836 Sentence denotes However, considering the increased transmissibility of SARS-CoV-2 compared with SARS-CoV, binding to ACE-2 alone might not be enough to ensure robust infection of the upper respiratory tract.
T222 837-992 Sentence denotes Thus, it is likely that SARS-CoV-2 might also bind to other cell surface attachment factors, such as sialic-acid-containing glycoproteins and gangliosides.
T223 993-1163 Sentence denotes Consistent with this notion, it has been shown that depletion of cell surface sialic acids by neuraminidase treatment inhibited MERS-CoV entry of human airway cells [25].
T224 1164-1395 Sentence denotes These data, which provide direct evidence that sialic acids play a critical role in human coronavirus attachment, broaden the therapeutic options to block the replication of SARS-CoV-2 that is responsible for the COVID-19 pandemic.

2_test

Id Subject Object Predicate Lexical cue
32251731-23873408-48149954 146-148 23873408 denotes 10
32251731-18279660-48149955 270-272 18279660 denotes 22
32251731-31160783-48149956 273-275 31160783 denotes 23
32251731-14647384-48149957 641-642 14647384 denotes 8
32251731-28923942-48149958 1159-1161 28923942 denotes 25
T91694 146-148 23873408 denotes 10
T27796 270-272 18279660 denotes 22
T7913 273-275 31160783 denotes 23
T30832 641-642 14647384 denotes 8
T17881 1159-1161 28923942 denotes 25