PMC:7128678 / 22206-25005
Annnotations
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 646 | 83-84 | Gene | denotes | S | Gene:43740568 |
| 647 | 72-82 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 648 | 36-42 | Chemical | denotes | CLQ-OH | |
| 649 | 116-128 | Chemical | denotes | gangliosides | MESH:D005732 |
| 671 | 1955-1973 | Chemical | denotes | hydroxychloroquine | MESH:D006886 |
| 672 | 1975-1981 | Chemical | denotes | CLQ-OH | |
| 673 | 2021-2024 | Chemical | denotes | GM1 | MESH:D005677 |
| 674 | 2045-2048 | Chemical | denotes | GM1 | MESH:D005677 |
| 675 | 2073-2079 | Chemical | denotes | CLQ-OH | |
| 676 | 2129-2135 | Chemical | denotes | CLQ-OH | |
| 677 | 2151-2154 | Chemical | denotes | GM1 | MESH:D005677 |
| 678 | 2242-2249 | Chemical | denotes | glucose | MESH:D005947 |
| 679 | 2259-2262 | Chemical | denotes | GM1 | MESH:D005677 |
| 680 | 2286-2292 | Chemical | denotes | CLQ-OH | |
| 681 | 2329-2332 | Chemical | denotes | GM1 | MESH:D005677 |
| 682 | 2368-2373 | Chemical | denotes | N-137 | MESH:C022084 |
| 683 | 2412-2433 | Chemical | denotes | N-acetylgalactosamine | MESH:D000116 |
| 684 | 2445-2448 | Chemical | denotes | GM1 | MESH:D005677 |
| 685 | 2503-2509 | Chemical | denotes | CLQ-OH | |
| 686 | 2526-2529 | Chemical | denotes | GM1 | MESH:D005677 |
| 687 | 2625-2631 | Chemical | denotes | CLQ-OH | |
| 688 | 2651-2654 | Chemical | denotes | GM1 | MESH:D005677 |
| 689 | 2723-2726 | Chemical | denotes | GM1 | MESH:D005677 |
| 690 | 2737-2743 | Chemical | denotes | CLQ-OH | |
| 691 | 2787-2798 | Chemical | denotes | ganglioside | MESH:D005732 |
| 730 | 1732-1733 | Gene | denotes | S | Gene:43740568 |
| 731 | 213-223 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 732 | 1721-1731 | Species | denotes | SARS-Cov-2 | Tax:2697049 |
| 733 | 174-180 | Chemical | denotes | CLQ-OH | |
| 734 | 243-255 | Chemical | denotes | gangliosides | MESH:D005732 |
| 735 | 273-276 | Chemical | denotes | GM1 | MESH:D005677 |
| 736 | 312-315 | Chemical | denotes | GM1 | MESH:D005677 |
| 737 | 359-370 | Chemical | denotes | ganglioside | MESH:D005732 |
| 738 | 451-457 | Chemical | denotes | CLQ-OH | |
| 739 | 518-521 | Chemical | denotes | GM1 | MESH:D005677 |
| 740 | 526-529 | Chemical | denotes | GM1 | MESH:D005677 |
| 741 | 649-655 | Chemical | denotes | CLQ-OH | |
| 742 | 665-668 | Chemical | denotes | GM1 | MESH:D005677 |
| 743 | 745-753 | Chemical | denotes | hydrogen | MESH:D006859 |
| 744 | 842-850 | Chemical | denotes | hydrogen | MESH:D006859 |
| 745 | 865-868 | Chemical | denotes | Asn | MESH:D001216 |
| 746 | 932-935 | Chemical | denotes | Phe | MESH:D010649 |
| 747 | 964-967 | Chemical | denotes | Asn | MESH:D001216 |
| 748 | 997-1005 | Chemical | denotes | hydrogen | MESH:D006859 |
| 749 | 1021-1027 | Chemical | denotes | GalNAc | |
| 750 | 1039-1042 | Chemical | denotes | GM1 | MESH:D005677 |
| 751 | 1089-1092 | Chemical | denotes | Phe | MESH:D010649 |
| 752 | 1127-1130 | Chemical | denotes | Glc | MESH:D005947 |
| 753 | 1142-1145 | Chemical | denotes | GM1 | MESH:D005677 |
| 754 | 1170-1176 | Chemical | denotes | CLQ-OH | |
| 755 | 1188-1196 | Chemical | denotes | nitrogen | MESH:D009584 |
| 756 | 1247-1250 | Chemical | denotes | Glc | MESH:D005947 |
| 757 | 1286-1289 | Chemical | denotes | Phe | MESH:D010649 |
| 758 | 1307-1313 | Chemical | denotes | CLQ-OH | |
| 759 | 1384-1390 | Chemical | denotes | CLQ-OH | |
| 760 | 1429-1434 | Chemical | denotes | sugar | MESH:D000073893 |
| 761 | 1447-1458 | Chemical | denotes | ganglioside | MESH:D005732 |
| 762 | 1479-1497 | Chemical | denotes | GalNAc ganglioside | |
| 763 | 1538-1549 | Chemical | denotes | ganglioside | MESH:D005732 |
| 764 | 1569-1576 | Chemical | denotes | Asn-137 | |
| 765 | 1634-1640 | Chemical | denotes | CLQ-OH | |
| 766 | 1679-1690 | Chemical | denotes | ganglioside | MESH:D005732 |
| 767 | 1754-1765 | Chemical | denotes | ganglioside | MESH:D005732 |
LitCovid-PMC-OGER-BB
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T506 | 72-82 | SP_7 | denotes | SARS-CoV-2 |
| T507 | 83-92 | PG_1 | denotes | S protein |
| T508 | 103-115 | GO:0009986 | denotes | cell surface |
| T509 | 116-128 | CHEBI:16856;CHEBI:16856 | denotes | gangliosides |
| T510 | 213-223 | SP_7 | denotes | SARS-CoV-2 |
| T511 | 227-242 | GO:0005886 | denotes | plasma membrane |
| T512 | 243-255 | CHEBI:16856;CHEBI:16856 | denotes | gangliosides |
| T513 | 277-284 | GO:0032991 | denotes | complex |
| T514 | 307-311 | CHEBI:23888;CHEBI:23888 | denotes | drug |
| T515 | 316-323 | GO:0032991 | denotes | complex |
| T516 | 359-370 | CHEBI:5386;CHEBI:5386 | denotes | ganglioside |
| T517 | 445-449 | CHEBI:23888;CHEBI:23888 | denotes | drug |
| T518 | 546-551 | NCBITaxon:10239 | denotes | viral |
| T519 | 568-572 | CHEBI:23888;CHEBI:23888 | denotes | drug |
| T520 | 634-639 | CHEBI:23888;CHEBI:23888 | denotes | drugs |
| T521 | 694-704 | GO:0065007 | denotes | controlled |
| T522 | 915-923 | GO:0045177 | denotes | aromatic |
| T523 | 1127-1130 | PR:000022772 | denotes | Glc |
| T524 | 1220-1224 | CHEBI:23888;CHEBI:23888 | denotes | drug |
| T525 | 1391-1399 | CHEBI:36357;CHEBI:36357 | denotes | molecule |
| T526 | 1447-1458 | CHEBI:5386;CHEBI:5386 | denotes | ganglioside |
| T527 | 1486-1497 | CHEBI:16856;CHEBI:16856 | denotes | ganglioside |
| T528 | 1538-1549 | CHEBI:5386;CHEBI:5386 | denotes | ganglioside |
| T529 | 1555-1565 | CHEBI:50325;CHEBI:50325 | denotes | side chain |
| T530 | 1654-1663 | CHEBI:36357;CHEBI:36357 | denotes | molecules |
| T531 | 1679-1690 | CHEBI:16856;CHEBI:16856 | denotes | ganglioside |
| T532 | 1721-1731 | SP_7 | denotes | SARS-Cov-2 |
| T533 | 1732-1741 | PG_1 | denotes | S protein |
| T534 | 1754-1765 | CHEBI:28892;CHEBI:28892 | denotes | ganglioside |
| T535 | 1955-1973 | CHEBI:5801;DG_20;CHEBI:5801 | denotes | hydroxychloroquine |
| T536 | 1999-2005 | SO:0000417 | denotes | domain |
| T537 | 2080-2089 | CHEBI:36357;CHEBI:36357 | denotes | molecules |
| T538 | 2136-2145 | CHEBI:36357;CHEBI:36357 | denotes | molecules |
| T539 | 2242-2249 | CHEBI:17234;CHEBI:17234 | denotes | glucose |
| T540 | 2412-2433 | CHEBI:28800;CHEBI:28800 | denotes | N-acetylgalactosamine |
| T541 | 2555-2559 | CHEBI:23888;CHEBI:23888 | denotes | drug |
| T542 | 2632-2641 | CHEBI:36357;CHEBI:36357 | denotes | molecules |
| T543 | 2744-2753 | CHEBI:36357;CHEBI:36357 | denotes | molecules |
| T544 | 2787-2798 | CHEBI:5386;CHEBI:5386 | denotes | ganglioside |
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T142 | 85-92 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T143 | 103-115 | Body_part | denotes | cell surface | http://purl.org/sig/ont/fma/fma67653 |
| T144 | 103-107 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T145 | 116-128 | Body_part | denotes | gangliosides | http://purl.org/sig/ont/fma/fma82816 |
| T146 | 227-242 | Body_part | denotes | plasma membrane | http://purl.org/sig/ont/fma/fma63841 |
| T147 | 243-255 | Body_part | denotes | gangliosides | http://purl.org/sig/ont/fma/fma82816 |
| T148 | 359-370 | Body_part | denotes | ganglioside | http://purl.org/sig/ont/fma/fma82816 |
| T149 | 552-559 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T150 | 958-962 | Body_part | denotes | hand | http://purl.org/sig/ont/fma/fma9712 |
| T151 | 1057-1061 | Body_part | denotes | hand | http://purl.org/sig/ont/fma/fma9712 |
| T152 | 1127-1130 | Body_part | denotes | Glc | http://purl.org/sig/ont/fma/fma82743 |
| T153 | 1247-1250 | Body_part | denotes | Glc | http://purl.org/sig/ont/fma/fma82743 |
| T154 | 1429-1434 | Body_part | denotes | sugar | http://purl.org/sig/ont/fma/fma82737 |
| T155 | 1447-1458 | Body_part | denotes | ganglioside | http://purl.org/sig/ont/fma/fma82816 |
| T156 | 1486-1497 | Body_part | denotes | ganglioside | http://purl.org/sig/ont/fma/fma82816 |
| T157 | 1538-1549 | Body_part | denotes | ganglioside | http://purl.org/sig/ont/fma/fma82816 |
| T158 | 1679-1690 | Body_part | denotes | ganglioside | http://purl.org/sig/ont/fma/fma82816 |
| T159 | 1734-1741 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T160 | 1754-1765 | Body_part | denotes | ganglioside | http://purl.org/sig/ont/fma/fma82816 |
| T161 | 2242-2249 | Body_part | denotes | glucose | http://purl.org/sig/ont/fma/fma82743 |
| T162 | 2412-2433 | Body_part | denotes | N-acetylgalactosamine | http://purl.org/sig/ont/fma/fma82786 |
| T163 | 2787-2798 | Body_part | denotes | ganglioside | http://purl.org/sig/ont/fma/fma82816 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T13 | 958-962 | Body_part | denotes | hand | http://purl.obolibrary.org/obo/UBERON_0002398 |
| T14 | 1057-1061 | Body_part | denotes | hand | http://purl.obolibrary.org/obo/UBERON_0002398 |
| T15 | 1418-1421 | Body_part | denotes | tip | http://purl.obolibrary.org/obo/UBERON_2001840 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T98 | 72-80 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T99 | 213-221 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T100 | 269-272 | Disease | denotes | NTD | http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075 |
| T102 | 433-436 | Disease | denotes | NTD | http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075 |
| T104 | 622-625 | Disease | denotes | NTD | http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075 |
| T106 | 833-836 | Disease | denotes | NTD | http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075 |
| T108 | 1518-1521 | Disease | denotes | NTD | http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075 |
| T110 | 1721-1725 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T111 | 2007-2010 | Disease | denotes | NTD | http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075 |
| T113 | 2116-2119 | Disease | denotes | NTD | http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075 |
| T115 | 2389-2392 | Disease | denotes | NTD | http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075 |
| T117 | 2588-2591 | Disease | denotes | NTD | http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075 |
| T119 | 2708-2711 | Disease | denotes | NTD | http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T175 | 103-107 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T176 | 138-141 | http://purl.obolibrary.org/obo/PR_000001343 | denotes | aim |
| T177 | 227-233 | http://purl.obolibrary.org/obo/UBERON_0001969 | denotes | plasma |
| T178 | 234-242 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
| T179 | 305-306 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T180 | 674-675 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T181 | 708-709 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T182 | 743-744 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T183 | 763-764 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T184 | 946-957 | http://purl.obolibrary.org/obo/UBERON_0002481 | denotes | (b). On one |
| T185 | 984-985 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T186 | 1261-1265 | http://purl.obolibrary.org/obo/CLO_0001387 | denotes | 4(c) |
| T187 | 1505-1506 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | b |
| T188 | 1677-1678 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T189 | 1719-1720 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T190 | 2178-2179 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T191 | 2180-2181 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | b |
| T192 | 2337-2338 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T514 | 43-52 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
| T515 | 85-92 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T516 | 116-128 | Chemical | denotes | gangliosides | http://purl.obolibrary.org/obo/CHEBI_28892 |
| T517 | 243-255 | Chemical | denotes | gangliosides | http://purl.obolibrary.org/obo/CHEBI_28892 |
| T518 | 273-276 | Chemical | denotes | GM1 | http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110 |
| T521 | 307-311 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T522 | 312-315 | Chemical | denotes | GM1 | http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110 |
| T525 | 359-370 | Chemical | denotes | ganglioside | http://purl.obolibrary.org/obo/CHEBI_28892 |
| T526 | 445-449 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T527 | 518-521 | Chemical | denotes | GM1 | http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110 |
| T530 | 526-529 | Chemical | denotes | GM1 | http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110 |
| T533 | 552-559 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T534 | 568-572 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T535 | 634-639 | Chemical | denotes | drugs | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T536 | 665-668 | Chemical | denotes | GM1 | http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110 |
| T539 | 745-753 | Chemical | denotes | hydrogen | http://purl.obolibrary.org/obo/CHEBI_49637 |
| T540 | 842-850 | Chemical | denotes | hydrogen | http://purl.obolibrary.org/obo/CHEBI_49637 |
| T541 | 865-868 | Chemical | denotes | Asn | http://purl.obolibrary.org/obo/CHEBI_17196|http://purl.obolibrary.org/obo/CHEBI_22653|http://purl.obolibrary.org/obo/CHEBI_50347 |
| T544 | 932-935 | Chemical | denotes | Phe | http://purl.obolibrary.org/obo/CHEBI_17295|http://purl.obolibrary.org/obo/CHEBI_29997 |
| T546 | 964-967 | Chemical | denotes | Asn | http://purl.obolibrary.org/obo/CHEBI_17196|http://purl.obolibrary.org/obo/CHEBI_22653|http://purl.obolibrary.org/obo/CHEBI_50347 |
| T549 | 997-1005 | Chemical | denotes | hydrogen | http://purl.obolibrary.org/obo/CHEBI_49637 |
| T550 | 1021-1027 | Chemical | denotes | GalNAc | http://purl.obolibrary.org/obo/CHEBI_28037|http://purl.obolibrary.org/obo/CHEBI_28800 |
| T552 | 1039-1042 | Chemical | denotes | GM1 | http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110 |
| T555 | 1089-1092 | Chemical | denotes | Phe | http://purl.obolibrary.org/obo/CHEBI_17295|http://purl.obolibrary.org/obo/CHEBI_29997 |
| T557 | 1127-1130 | Chemical | denotes | Glc | http://purl.obolibrary.org/obo/CHEBI_17234 |
| T558 | 1142-1145 | Chemical | denotes | GM1 | http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110 |
| T561 | 1188-1196 | Chemical | denotes | nitrogen | http://purl.obolibrary.org/obo/CHEBI_25555 |
| T562 | 1220-1224 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T563 | 1247-1250 | Chemical | denotes | Glc | http://purl.obolibrary.org/obo/CHEBI_17234 |
| T564 | 1286-1289 | Chemical | denotes | Phe | http://purl.obolibrary.org/obo/CHEBI_17295|http://purl.obolibrary.org/obo/CHEBI_29997 |
| T566 | 1391-1399 | Chemical | denotes | molecule | http://purl.obolibrary.org/obo/CHEBI_25367 |
| T567 | 1447-1458 | Chemical | denotes | ganglioside | http://purl.obolibrary.org/obo/CHEBI_28892 |
| T568 | 1479-1485 | Chemical | denotes | GalNAc | http://purl.obolibrary.org/obo/CHEBI_28037|http://purl.obolibrary.org/obo/CHEBI_28800 |
| T570 | 1486-1497 | Chemical | denotes | ganglioside | http://purl.obolibrary.org/obo/CHEBI_28892 |
| T571 | 1538-1549 | Chemical | denotes | ganglioside | http://purl.obolibrary.org/obo/CHEBI_28892 |
| T572 | 1569-1572 | Chemical | denotes | Asn | http://purl.obolibrary.org/obo/CHEBI_17196|http://purl.obolibrary.org/obo/CHEBI_22653|http://purl.obolibrary.org/obo/CHEBI_50347 |
| T575 | 1654-1663 | Chemical | denotes | molecules | http://purl.obolibrary.org/obo/CHEBI_25367 |
| T576 | 1679-1690 | Chemical | denotes | ganglioside | http://purl.obolibrary.org/obo/CHEBI_28892 |
| T577 | 1734-1741 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T578 | 1754-1765 | Chemical | denotes | ganglioside | http://purl.obolibrary.org/obo/CHEBI_28892 |
| T579 | 1955-1973 | Chemical | denotes | hydroxychloroquine | http://purl.obolibrary.org/obo/CHEBI_5801 |
| T580 | 2021-2024 | Chemical | denotes | GM1 | http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110 |
| T583 | 2045-2048 | Chemical | denotes | GM1 | http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110 |
| T586 | 2080-2089 | Chemical | denotes | molecules | http://purl.obolibrary.org/obo/CHEBI_25367 |
| T587 | 2136-2145 | Chemical | denotes | molecules | http://purl.obolibrary.org/obo/CHEBI_25367 |
| T588 | 2151-2154 | Chemical | denotes | GM1 | http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110 |
| T591 | 2242-2249 | Chemical | denotes | glucose | http://purl.obolibrary.org/obo/CHEBI_17234|http://purl.obolibrary.org/obo/CHEBI_4167 |
| T593 | 2259-2262 | Chemical | denotes | GM1 | http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110 |
| T596 | 2329-2332 | Chemical | denotes | GM1 | http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110 |
| T599 | 2412-2433 | Chemical | denotes | N-acetylgalactosamine | http://purl.obolibrary.org/obo/CHEBI_28800 |
| T600 | 2445-2448 | Chemical | denotes | GM1 | http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110 |
| T603 | 2526-2529 | Chemical | denotes | GM1 | http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110 |
| T606 | 2555-2559 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T607 | 2632-2641 | Chemical | denotes | molecules | http://purl.obolibrary.org/obo/CHEBI_25367 |
| T608 | 2651-2654 | Chemical | denotes | GM1 | http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110 |
| T611 | 2723-2726 | Chemical | denotes | GM1 | http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110 |
| T614 | 2744-2753 | Chemical | denotes | molecules | http://purl.obolibrary.org/obo/CHEBI_25367 |
| T615 | 2787-2798 | Chemical | denotes | ganglioside | http://purl.obolibrary.org/obo/CHEBI_28892 |
LitCovid-PD-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glyco_epitope_db_id |
|---|---|---|---|---|---|
| T27 | 273-276 | GlycoEpitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T28 | 312-315 | GlycoEpitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T29 | 518-521 | GlycoEpitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T30 | 526-529 | GlycoEpitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T31 | 665-668 | GlycoEpitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T32 | 1039-1042 | GlycoEpitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T33 | 1142-1145 | GlycoEpitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T34 | 2021-2024 | GlycoEpitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T35 | 2045-2048 | GlycoEpitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T36 | 2151-2154 | GlycoEpitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T37 | 2259-2262 | GlycoEpitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T38 | 2329-2332 | GlycoEpitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T39 | 2445-2448 | GlycoEpitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T40 | 2526-2529 | GlycoEpitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T41 | 2651-2654 | GlycoEpitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T42 | 2723-2726 | GlycoEpitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T184 | 0-128 | Sentence | denotes | 3.7 Molecular mechanism of CLQ and CLQ-OH antiviral effect: preventing SARS-CoV-2 S protein access to cell surface gangliosides |
| T185 | 129-334 | Sentence | denotes | With the aim of establishing whether CLQ and CLQ-OH could prevent the attachment of SARS-CoV-2 to plasma membrane gangliosides, the initial NTD–GM1 complex was superposed with a drug–GM1 complex (Fig. 9 ). |
| T186 | 335-398 | Sentence | denotes | To improve clarity, the ganglioside is not presented in Fig. 9. |
| T187 | 399-588 | Sentence | denotes | This superposition shows that the NTD and the drug (CLQ-OH in this case) share the same spatial position when bound to GM1, so GM1 cannot bind the viral protein and the drug simultaneously. |
| T188 | 589-813 | Sentence | denotes | This is due to the fact that the NTD and the drugs (CLQ and CLQ-OH) bind to GM1 with a similar mechanism controlled by a dyad of functional interactions: a hydrogen bond and a geometrically perfect CH-π stacking interaction. |
| T189 | 814-950 | Sentence | denotes | In the case of the NTD, the hydrogen bond involves Asn-167, whereas CH-π stacking is mediated by the aromatic ring of Phe-135 Fig. 6(b). |
| T190 | 951-1043 | Sentence | denotes | On one hand, Asn-167 establishes a network of hydrogen bonds with the GalNAc residue of GM1. |
| T191 | 1044-1146 | Sentence | denotes | On the other hand, the flat aromatic ring of Phe-135 stacks on to the cycle of the Glc residue of GM1. |
| T192 | 1147-1266 | Sentence | denotes | In the case of CLQ and CLQ-OH, it is the nitrogen-containing ring of the drug that stacks on to the Glc ring Fig. 4(c). |
| T193 | 1267-1373 | Sentence | denotes | Note that both the Phe-135 (in red) and CLQ-OH (in green) rings are located in the same position (Fig. 9). |
| T194 | 1374-1508 | Sentence | denotes | The other CLQ-OH molecule, which covers the tip of the sugar part of the ganglioside, interacts with the GalNAc ganglioside Fig. 4(b). |
| T195 | 1509-1618 | Sentence | denotes | When the NTD is bound to the ganglioside, the side chain of Asn-137 is found in this exact position (Fig. 9). |
| T196 | 1619-1787 | Sentence | denotes | Thus, once two CLQ-OH (or two CLQ) molecules are bound to a ganglioside Fig. 4(e,f), any binding of a SARS-Cov-2 S protein to the same ganglioside is totally prevented. |
| T197 | 1788-1924 | Sentence | denotes | The energy required to overcome this steric incompatibility is estimated to be several hundred kJ.mol−1, which is far too high to occur. |
| T198 | 1925-1983 | Sentence | denotes | Fig. 9 Mechanism of action of hydroxychloroquine (CLQ-OH). |
| T199 | 1984-2090 | Sentence | denotes | The N-terminal domain (NTD) bound to GM1 was superposed onto GM1 in interaction with two CLQ-OH molecules. |
| T200 | 2091-2363 | Sentence | denotes | The models only show the NTD and both CLQ-OH molecules (not GM1, to improve clarity). (a,b) The aromatic ring of F-135 (in red), which stacks onto the glucose cycle of GM1, overlaps the aromatic CLQ-OH rings (in green) which also bind to GM1 via a CH-π stacking mechanism. |
| T201 | 2364-2799 | Sentence | denotes | The N-137 residue of the NTD interacts with the N-acetylgalactosamine residue of GM1, but this interaction cannot occur in the presence of CLQ-OH as this part of GM1 is totally masked by the drug. (c,d) Superposition of the NTD surface (in purple) with the two CLQ-OH molecules bound to GM1, illustrating the steric impossibility that prevents NTD binding to GM1 when both CLQ-OH molecules are already interacting with the ganglioside. |