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PMC:7128678 / 21027-22204 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
618 347-378 Gene denotes angiotensin-converting enzyme-2 Gene:59272
619 380-385 Gene denotes ACE-2 Gene:59272
620 867-868 Gene denotes S Gene:43740568
621 390-400 Species denotes SARS-CoV-2 Tax:2697049
622 330-342 Chemical denotes gangliosides MESH:D005732
623 639-650 Chemical denotes ganglioside MESH:D005732
624 687-692 Chemical denotes Lipid MESH:D008055
625 739-751 Chemical denotes gangliosides MESH:D005732
626 768-779 Chemical denotes cholesterol MESH:D002784
627 1040-1051 Chemical denotes ganglioside MESH:D005732
628 1098-1103 Chemical denotes lipid MESH:D008055
629 1142-1153 Chemical denotes chloroquine MESH:D002738
630 1158-1176 Chemical denotes hydroxychloroquine MESH:D006886
631 902-911 Disease denotes infection MESH:D007239
637 75-76 Gene denotes S Gene:43740568
638 64-74 Species denotes SARS-CoV-2 Tax:2697049
639 168-174 Chemical denotes CLQ-OH
640 272-284 Chemical denotes sialic acids MESH:D012794
641 289-301 Chemical denotes gangliosides MESH:D005732

LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T449 64-74 SP_7 denotes SARS-CoV-2
T450 75-84 PG_1 denotes S protein
T451 272-284 CHEBI:26667;CHEBI:26667 denotes sialic acids
T452 289-301 CHEBI:30563;CHEBI:30563 denotes gangliosides
T453 330-342 CHEBI:5386;CHEBI:5386 denotes gangliosides
T454 347-378 PG_10;PR:000003622 denotes angiotensin-converting enzyme-2
T455 380-385 G_3;PG_10;PR:000003622 denotes ACE-2
T456 390-394 PR:000014459;SP_7 denotes SARS
T457 394-400 SP_7 denotes -CoV-2
T458 424-429 NCBITaxon:10239 denotes viral
T459 460-467 SO:0000417 denotes domains
T460 558-564 SO:0000417 denotes domain
T461 578-583 G_3;PG_10;PR:000003622 denotes ACE-2
T462 613-619 SO:0000417 denotes domain
T463 639-650 CHEBI:16856;CHEBI:16856 denotes ganglioside
T464 656-662 SO:0000417 denotes domain
T465 670-685 GO:0005886 denotes plasma membrane
T466 687-692 CHEBI:18059;CHEBI:18059;GO:0045121 denotes Lipid
T467 693-698 GO:0045121 denotes rafts
T468 710-718 GO:0016020 denotes membrane
T469 719-726 GO:0044425 denotes domains
T470 739-751 CHEBI:5386;CHEBI:5386 denotes gangliosides
T471 768-779 CHEBI:16113;CHEBI:16113 denotes cholesterol
T472 861-866 NCBITaxon:10239 denotes viral
T473 867-876 PG_1 denotes S protein
T474 1040-1051 CHEBI:5386;CHEBI:5386 denotes ganglioside
T475 1060-1066 SO:0000417 denotes domain
T476 1098-1103 CHEBI:18059;CHEBI:18059;GO:0045121 denotes lipid
T477 1104-1109 GO:0045121 denotes rafts
T478 1142-1153 CHEBI:3638;CHEBI:3638;DG_10 denotes chloroquine
T479 1158-1176 CHEBI:5801;CHEBI:5801;DG_20 denotes hydroxychloroquine

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T129 77-84 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T130 289-301 Body_part denotes gangliosides http://purl.org/sig/ont/fma/fma82816
T131 330-342 Body_part denotes gangliosides http://purl.org/sig/ont/fma/fma82816
T132 411-418 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T133 430-437 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T134 639-650 Body_part denotes ganglioside http://purl.org/sig/ont/fma/fma82816
T135 670-685 Body_part denotes plasma membrane http://purl.org/sig/ont/fma/fma63841
T136 687-692 Body_part denotes Lipid http://purl.org/sig/ont/fma/fma67264
T137 739-751 Body_part denotes gangliosides http://purl.org/sig/ont/fma/fma82816
T138 869-876 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T139 983-993 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T140 1040-1051 Body_part denotes ganglioside http://purl.org/sig/ont/fma/fma82816
T141 1098-1103 Body_part denotes lipid http://purl.org/sig/ont/fma/fma67264

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T91 64-72 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T92 390-398 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T93 621-624 Disease denotes NTD http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075
T95 902-911 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T96 1018-1021 Disease denotes NTD http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T165 5-6 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T166 252-253 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T167 670-676 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T168 677-685 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T169 710-718 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T170 799-800 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T171 983-1002 http://purl.obolibrary.org/obo/CHEBI_33708 denotes amino acid residues
T172 983-1002 http://purl.obolibrary.org/obo/PR_000036907 denotes amino acid residues
T173 1007-1010 http://purl.obolibrary.org/obo/CLO_0001002 denotes 162
T174 1027-1028 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T494 77-84 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T495 272-284 Chemical denotes sialic acids http://purl.obolibrary.org/obo/CHEBI_26667
T496 279-284 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527
T497 289-301 Chemical denotes gangliosides http://purl.obolibrary.org/obo/CHEBI_28892
T498 330-342 Chemical denotes gangliosides http://purl.obolibrary.org/obo/CHEBI_28892
T499 347-358 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T500 411-418 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T501 430-437 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T502 639-650 Chemical denotes ganglioside http://purl.obolibrary.org/obo/CHEBI_28892
T503 687-692 Chemical denotes Lipid http://purl.obolibrary.org/obo/CHEBI_18059
T504 739-751 Chemical denotes gangliosides http://purl.obolibrary.org/obo/CHEBI_28892
T505 768-779 Chemical denotes cholesterol http://purl.obolibrary.org/obo/CHEBI_16113
T506 869-876 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T507 983-993 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T508 983-988 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T509 989-993 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T510 1040-1051 Chemical denotes ganglioside http://purl.obolibrary.org/obo/CHEBI_28892
T511 1098-1103 Chemical denotes lipid http://purl.obolibrary.org/obo/CHEBI_18059
T512 1142-1153 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T513 1158-1176 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T177 0-109 Sentence denotes Such a dual receptor model, consistent with the topology of the SARS-CoV-2 S protein, is proposed in Fig. 8 .
T178 110-302 Sentence denotes With this model in mind, the potential effects of CLQ and CLQ-OH were studied, both of which, according to the molecular modelling data, have a high affinity for sialic acids and gangliosides.
T179 303-419 Sentence denotes Fig. 8 Dual recognition of gangliosides and angiotensin-converting enzyme-2 (ACE-2) by SARS-CoV-2 spike (S) protein.
T180 420-536 Sentence denotes The viral protein displays two distinct domains, the tips of which are available for distinct types of interactions.
T181 537-686 Sentence denotes The receptor-binding domain binds to the ACE-2 receptor, and the N-terminal domain (NTD) binds to the ganglioside-rich domain of the plasma membrane.
T182 687-920 Sentence denotes Lipid rafts, which are membrane domains enriched in gangliosides (in yellow) and cholesterol (in blue), provide a perfect attractive interface for adequately positioning the viral S protein at the first step of the infection process.
T183 921-1177 Sentence denotes These structural and molecular modelling studies suggest that amino acid residues 111–162 of the NTD form a functional ganglioside-binding domain, the interaction of which with lipid rafts can be efficiently prevented by chloroquine and hydroxychloroquine.