PMC:7128678 / 16142-17074 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"494","span":{"begin":131,"end":142},"obj":"Chemical"},{"id":"495","span":{"begin":373,"end":376},"obj":"Chemical"},{"id":"496","span":{"begin":378,"end":381},"obj":"Chemical"},{"id":"497","span":{"begin":389,"end":392},"obj":"Chemical"},{"id":"498","span":{"begin":489,"end":500},"obj":"Chemical"},{"id":"499","span":{"begin":732,"end":735},"obj":"Chemical"},{"id":"500","span":{"begin":737,"end":740},"obj":"Chemical"},{"id":"501","span":{"begin":748,"end":751},"obj":"Chemical"},{"id":"502","span":{"begin":785,"end":796},"obj":"Chemical"},{"id":"503","span":{"begin":899,"end":910},"obj":"Chemical"}],"attributes":[{"id":"A494","pred":"tao:has_database_id","subj":"494","obj":"MESH:D005732"},{"id":"A495","pred":"tao:has_database_id","subj":"495","obj":"MESH:D005998"},{"id":"A496","pred":"tao:has_database_id","subj":"496","obj":"MESH:D011392"},{"id":"A497","pred":"tao:has_database_id","subj":"497","obj":"MESH:D012694"},{"id":"A498","pred":"tao:has_database_id","subj":"498","obj":"MESH:D005732"},{"id":"A499","pred":"tao:has_database_id","subj":"499","obj":"MESH:D005998"},{"id":"A500","pred":"tao:has_database_id","subj":"500","obj":"MESH:D011392"},{"id":"A501","pred":"tao:has_database_id","subj":"501","obj":"MESH:D012694"},{"id":"A502","pred":"tao:has_database_id","subj":"502","obj":"MESH:D005732"},{"id":"A503","pred":"tao:has_database_id","subj":"503","obj":"MESH:D005732"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"The amino acid sequence of the planar interfacial surface located at the tip of the NTD was analysed for the presence of consensus ganglioside-binding domains [20]. These motifs are constituted by a triad of mandatory amino acid residues such as (K,R)-Xn-(F,Y,W)-Xn-(K,R). The Xn intercalating segments, usually four to five residues, may contain any amino acid, but often Gly, Pro and/or Ser residues. The strict application of this algorithm did not allow the detection of any potential ganglioside-binding domain in this region of the NTD. However, an intriguing over-representation of aromatic and basic residues was found in the 129–158 segment: 129-KVCEFQFCNDPFLGVYYHKNNKSWMESEFR-158. This 30-amino acid stretch also contains Gly, Pro and/or Ser residues that are often found in ganglioside-binding motifs. These observations supported the notion that the tip of the NTD could display a large ganglioside-attachment interface."}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T362","span":{"begin":121,"end":130},"obj":"SO:0000993"},{"id":"T363","span":{"begin":131,"end":142},"obj":"CHEBI:16856;CHEBI:16856"},{"id":"T364","span":{"begin":151,"end":158},"obj":"SO:0000417"},{"id":"T365","span":{"begin":489,"end":500},"obj":"CHEBI:28892;CHEBI:28892"},{"id":"T366","span":{"begin":509,"end":515},"obj":"SO:0000417"},{"id":"T367","span":{"begin":785,"end":796},"obj":"CHEBI:28892;CHEBI:28892"},{"id":"T368","span":{"begin":899,"end":910},"obj":"CHEBI:28892;CHEBI:28892"}],"text":"The amino acid sequence of the planar interfacial surface located at the tip of the NTD was analysed for the presence of consensus ganglioside-binding domains [20]. These motifs are constituted by a triad of mandatory amino acid residues such as (K,R)-Xn-(F,Y,W)-Xn-(K,R). The Xn intercalating segments, usually four to five residues, may contain any amino acid, but often Gly, Pro and/or Ser residues. The strict application of this algorithm did not allow the detection of any potential ganglioside-binding domain in this region of the NTD. However, an intriguing over-representation of aromatic and basic residues was found in the 129–158 segment: 129-KVCEFQFCNDPFLGVYYHKNNKSWMESEFR-158. This 30-amino acid stretch also contains Gly, Pro and/or Ser residues that are often found in ganglioside-binding motifs. These observations supported the notion that the tip of the NTD could display a large ganglioside-attachment interface."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T86","span":{"begin":4,"end":14},"obj":"Body_part"},{"id":"T87","span":{"begin":131,"end":142},"obj":"Body_part"},{"id":"T88","span":{"begin":218,"end":228},"obj":"Body_part"},{"id":"T89","span":{"begin":351,"end":361},"obj":"Body_part"},{"id":"T90","span":{"begin":489,"end":500},"obj":"Body_part"},{"id":"T91","span":{"begin":699,"end":709},"obj":"Body_part"},{"id":"T92","span":{"begin":785,"end":796},"obj":"Body_part"},{"id":"T93","span":{"begin":899,"end":910},"obj":"Body_part"}],"attributes":[{"id":"A86","pred":"fma_id","subj":"T86","obj":"http://purl.org/sig/ont/fma/fma82739"},{"id":"A87","pred":"fma_id","subj":"T87","obj":"http://purl.org/sig/ont/fma/fma82816"},{"id":"A88","pred":"fma_id","subj":"T88","obj":"http://purl.org/sig/ont/fma/fma82739"},{"id":"A89","pred":"fma_id","subj":"T89","obj":"http://purl.org/sig/ont/fma/fma82739"},{"id":"A90","pred":"fma_id","subj":"T90","obj":"http://purl.org/sig/ont/fma/fma82816"},{"id":"A91","pred":"fma_id","subj":"T91","obj":"http://purl.org/sig/ont/fma/fma82739"},{"id":"A92","pred":"fma_id","subj":"T92","obj":"http://purl.org/sig/ont/fma/fma82816"},{"id":"A93","pred":"fma_id","subj":"T93","obj":"http://purl.org/sig/ont/fma/fma82816"}],"text":"The amino acid sequence of the planar interfacial surface located at the tip of the NTD was analysed for the presence of consensus ganglioside-binding domains [20]. These motifs are constituted by a triad of mandatory amino acid residues such as (K,R)-Xn-(F,Y,W)-Xn-(K,R). The Xn intercalating segments, usually four to five residues, may contain any amino acid, but often Gly, Pro and/or Ser residues. The strict application of this algorithm did not allow the detection of any potential ganglioside-binding domain in this region of the NTD. However, an intriguing over-representation of aromatic and basic residues was found in the 129–158 segment: 129-KVCEFQFCNDPFLGVYYHKNNKSWMESEFR-158. This 30-amino acid stretch also contains Gly, Pro and/or Ser residues that are often found in ganglioside-binding motifs. These observations supported the notion that the tip of the NTD could display a large ganglioside-attachment interface."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T10","span":{"begin":73,"end":76},"obj":"Body_part"},{"id":"T11","span":{"begin":862,"end":865},"obj":"Body_part"}],"attributes":[{"id":"A10","pred":"uberon_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/UBERON_2001840"},{"id":"A11","pred":"uberon_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/UBERON_2001840"}],"text":"The amino acid sequence of the planar interfacial surface located at the tip of the NTD was analysed for the presence of consensus ganglioside-binding domains [20]. These motifs are constituted by a triad of mandatory amino acid residues such as (K,R)-Xn-(F,Y,W)-Xn-(K,R). The Xn intercalating segments, usually four to five residues, may contain any amino acid, but often Gly, Pro and/or Ser residues. The strict application of this algorithm did not allow the detection of any potential ganglioside-binding domain in this region of the NTD. However, an intriguing over-representation of aromatic and basic residues was found in the 129–158 segment: 129-KVCEFQFCNDPFLGVYYHKNNKSWMESEFR-158. This 30-amino acid stretch also contains Gly, Pro and/or Ser residues that are often found in ganglioside-binding motifs. These observations supported the notion that the tip of the NTD could display a large ganglioside-attachment interface."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T47","span":{"begin":84,"end":87},"obj":"Disease"},{"id":"T49","span":{"begin":538,"end":541},"obj":"Disease"},{"id":"T51","span":{"begin":873,"end":876},"obj":"Disease"}],"attributes":[{"id":"A47","pred":"mondo_id","subj":"T47","obj":"http://purl.obolibrary.org/obo/MONDO_0008449"},{"id":"A48","pred":"mondo_id","subj":"T47","obj":"http://purl.obolibrary.org/obo/MONDO_0018075"},{"id":"A49","pred":"mondo_id","subj":"T49","obj":"http://purl.obolibrary.org/obo/MONDO_0008449"},{"id":"A50","pred":"mondo_id","subj":"T49","obj":"http://purl.obolibrary.org/obo/MONDO_0018075"},{"id":"A51","pred":"mondo_id","subj":"T51","obj":"http://purl.obolibrary.org/obo/MONDO_0008449"},{"id":"A52","pred":"mondo_id","subj":"T51","obj":"http://purl.obolibrary.org/obo/MONDO_0018075"}],"text":"The amino acid sequence of the planar interfacial surface located at the tip of the NTD was analysed for the presence of consensus ganglioside-binding domains [20]. These motifs are constituted by a triad of mandatory amino acid residues such as (K,R)-Xn-(F,Y,W)-Xn-(K,R). The Xn intercalating segments, usually four to five residues, may contain any amino acid, but often Gly, Pro and/or Ser residues. The strict application of this algorithm did not allow the detection of any potential ganglioside-binding domain in this region of the NTD. However, an intriguing over-representation of aromatic and basic residues was found in the 129–158 segment: 129-KVCEFQFCNDPFLGVYYHKNNKSWMESEFR-158. This 30-amino acid stretch also contains Gly, Pro and/or Ser residues that are often found in ganglioside-binding motifs. These observations supported the notion that the tip of the NTD could display a large ganglioside-attachment interface."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T115","span":{"begin":197,"end":198},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T116","span":{"begin":218,"end":237},"obj":"http://purl.obolibrary.org/obo/CHEBI_33708"},{"id":"T117","span":{"begin":218,"end":237},"obj":"http://purl.obolibrary.org/obo/PR_000036907"},{"id":"T118","span":{"begin":891,"end":892},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"The amino acid sequence of the planar interfacial surface located at the tip of the NTD was analysed for the presence of consensus ganglioside-binding domains [20]. These motifs are constituted by a triad of mandatory amino acid residues such as (K,R)-Xn-(F,Y,W)-Xn-(K,R). The Xn intercalating segments, usually four to five residues, may contain any amino acid, but often Gly, Pro and/or Ser residues. The strict application of this algorithm did not allow the detection of any potential ganglioside-binding domain in this region of the NTD. However, an intriguing over-representation of aromatic and basic residues was found in the 129–158 segment: 129-KVCEFQFCNDPFLGVYYHKNNKSWMESEFR-158. This 30-amino acid stretch also contains Gly, Pro and/or Ser residues that are often found in ganglioside-binding motifs. These observations supported the notion that the tip of the NTD could display a large ganglioside-attachment interface."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T298","span":{"begin":4,"end":14},"obj":"Chemical"},{"id":"T299","span":{"begin":4,"end":9},"obj":"Chemical"},{"id":"T300","span":{"begin":10,"end":14},"obj":"Chemical"},{"id":"T301","span":{"begin":131,"end":142},"obj":"Chemical"},{"id":"T302","span":{"begin":218,"end":228},"obj":"Chemical"},{"id":"T303","span":{"begin":218,"end":223},"obj":"Chemical"},{"id":"T304","span":{"begin":224,"end":228},"obj":"Chemical"},{"id":"T305","span":{"begin":351,"end":361},"obj":"Chemical"},{"id":"T306","span":{"begin":351,"end":356},"obj":"Chemical"},{"id":"T307","span":{"begin":357,"end":361},"obj":"Chemical"},{"id":"T308","span":{"begin":373,"end":376},"obj":"Chemical"},{"id":"T309","span":{"begin":378,"end":381},"obj":"Chemical"},{"id":"T310","span":{"begin":389,"end":392},"obj":"Chemical"},{"id":"T312","span":{"begin":414,"end":425},"obj":"Chemical"},{"id":"T313","span":{"begin":489,"end":500},"obj":"Chemical"},{"id":"T314","span":{"begin":699,"end":709},"obj":"Chemical"},{"id":"T315","span":{"begin":699,"end":704},"obj":"Chemical"},{"id":"T316","span":{"begin":705,"end":709},"obj":"Chemical"},{"id":"T317","span":{"begin":732,"end":735},"obj":"Chemical"},{"id":"T318","span":{"begin":737,"end":740},"obj":"Chemical"},{"id":"T319","span":{"begin":748,"end":751},"obj":"Chemical"},{"id":"T321","span":{"begin":785,"end":796},"obj":"Chemical"},{"id":"T322","span":{"begin":899,"end":910},"obj":"Chemical"}],"attributes":[{"id":"A298","pred":"chebi_id","subj":"T298","obj":"http://purl.obolibrary.org/obo/CHEBI_33709"},{"id":"A299","pred":"chebi_id","subj":"T299","obj":"http://purl.obolibrary.org/obo/CHEBI_46882"},{"id":"A300","pred":"chebi_id","subj":"T300","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A301","pred":"chebi_id","subj":"T301","obj":"http://purl.obolibrary.org/obo/CHEBI_28892"},{"id":"A302","pred":"chebi_id","subj":"T302","obj":"http://purl.obolibrary.org/obo/CHEBI_33709"},{"id":"A303","pred":"chebi_id","subj":"T303","obj":"http://purl.obolibrary.org/obo/CHEBI_46882"},{"id":"A304","pred":"chebi_id","subj":"T304","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A305","pred":"chebi_id","subj":"T305","obj":"http://purl.obolibrary.org/obo/CHEBI_33709"},{"id":"A306","pred":"chebi_id","subj":"T306","obj":"http://purl.obolibrary.org/obo/CHEBI_46882"},{"id":"A307","pred":"chebi_id","subj":"T307","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A308","pred":"chebi_id","subj":"T308","obj":"http://purl.obolibrary.org/obo/CHEBI_15428"},{"id":"A309","pred":"chebi_id","subj":"T309","obj":"http://purl.obolibrary.org/obo/CHEBI_50342"},{"id":"A310","pred":"chebi_id","subj":"T310","obj":"http://purl.obolibrary.org/obo/CHEBI_17115"},{"id":"A311","pred":"chebi_id","subj":"T310","obj":"http://purl.obolibrary.org/obo/CHEBI_29999"},{"id":"A312","pred":"chebi_id","subj":"T312","obj":"http://purl.obolibrary.org/obo/CHEBI_33232"},{"id":"A313","pred":"chebi_id","subj":"T313","obj":"http://purl.obolibrary.org/obo/CHEBI_28892"},{"id":"A314","pred":"chebi_id","subj":"T314","obj":"http://purl.obolibrary.org/obo/CHEBI_33709"},{"id":"A315","pred":"chebi_id","subj":"T315","obj":"http://purl.obolibrary.org/obo/CHEBI_46882"},{"id":"A316","pred":"chebi_id","subj":"T316","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A317","pred":"chebi_id","subj":"T317","obj":"http://purl.obolibrary.org/obo/CHEBI_15428"},{"id":"A318","pred":"chebi_id","subj":"T318","obj":"http://purl.obolibrary.org/obo/CHEBI_50342"},{"id":"A319","pred":"chebi_id","subj":"T319","obj":"http://purl.obolibrary.org/obo/CHEBI_17115"},{"id":"A320","pred":"chebi_id","subj":"T319","obj":"http://purl.obolibrary.org/obo/CHEBI_29999"},{"id":"A321","pred":"chebi_id","subj":"T321","obj":"http://purl.obolibrary.org/obo/CHEBI_28892"},{"id":"A322","pred":"chebi_id","subj":"T322","obj":"http://purl.obolibrary.org/obo/CHEBI_28892"}],"text":"The amino acid sequence of the planar interfacial surface located at the tip of the NTD was analysed for the presence of consensus ganglioside-binding domains [20]. These motifs are constituted by a triad of mandatory amino acid residues such as (K,R)-Xn-(F,Y,W)-Xn-(K,R). The Xn intercalating segments, usually four to five residues, may contain any amino acid, but often Gly, Pro and/or Ser residues. The strict application of this algorithm did not allow the detection of any potential ganglioside-binding domain in this region of the NTD. However, an intriguing over-representation of aromatic and basic residues was found in the 129–158 segment: 129-KVCEFQFCNDPFLGVYYHKNNKSWMESEFR-158. This 30-amino acid stretch also contains Gly, Pro and/or Ser residues that are often found in ganglioside-binding motifs. These observations supported the notion that the tip of the NTD could display a large ganglioside-attachment interface."}

{"project":"LitCovid-sentences","denotations":[{"id":"T113","span":{"begin":0,"end":164},"obj":"Sentence"},{"id":"T114","span":{"begin":165,"end":272},"obj":"Sentence"},{"id":"T115","span":{"begin":273,"end":402},"obj":"Sentence"},{"id":"T116","span":{"begin":403,"end":542},"obj":"Sentence"},{"id":"T117","span":{"begin":543,"end":650},"obj":"Sentence"},{"id":"T118","span":{"begin":651,"end":690},"obj":"Sentence"},{"id":"T119","span":{"begin":691,"end":812},"obj":"Sentence"},{"id":"T120","span":{"begin":813,"end":932},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"The amino acid sequence of the planar interfacial surface located at the tip of the NTD was analysed for the presence of consensus ganglioside-binding domains [20]. These motifs are constituted by a triad of mandatory amino acid residues such as (K,R)-Xn-(F,Y,W)-Xn-(K,R). The Xn intercalating segments, usually four to five residues, may contain any amino acid, but often Gly, Pro and/or Ser residues. The strict application of this algorithm did not allow the detection of any potential ganglioside-binding domain in this region of the NTD. However, an intriguing over-representation of aromatic and basic residues was found in the 129–158 segment: 129-KVCEFQFCNDPFLGVYYHKNNKSWMESEFR-158. This 30-amino acid stretch also contains Gly, Pro and/or Ser residues that are often found in ganglioside-binding motifs. These observations supported the notion that the tip of the NTD could display a large ganglioside-attachment interface."}