PMC:7128678 / 14965-15650 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"459","span":{"begin":370,"end":371},"obj":"Gene"},{"id":"460","span":{"begin":299,"end":300},"obj":"Gene"},{"id":"461","span":{"begin":195,"end":196},"obj":"Gene"},{"id":"462","span":{"begin":86,"end":87},"obj":"Gene"},{"id":"463","span":{"begin":27,"end":37},"obj":"Species"},{"id":"464","span":{"begin":38,"end":43},"obj":"Gene"},{"id":"465","span":{"begin":658,"end":669},"obj":"Chemical"}],"attributes":[{"id":"A459","pred":"tao:has_database_id","subj":"459","obj":"Gene:43740568"},{"id":"A460","pred":"tao:has_database_id","subj":"460","obj":"Gene:43740568"},{"id":"A461","pred":"tao:has_database_id","subj":"461","obj":"Gene:43740568"},{"id":"A462","pred":"tao:has_database_id","subj":"462","obj":"Gene:43740568"},{"id":"A463","pred":"tao:has_database_id","subj":"463","obj":"Tax:2697049"},{"id":"A464","pred":"tao:has_database_id","subj":"464","obj":"Gene:43740568"},{"id":"A465","pred":"tao:has_database_id","subj":"465","obj":"MESH:D005732"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Structural features of the SARS-CoV-2 spike (S) protein. (a) Trimeric structure (each S protein has a distinct surface colour, ‘blue’, ‘yellow’ and ‘purple’). (b) Ribbon representation of ‘blue’ S protein in the trimer (α-helix, red; β-strand, blue; coil, grey). (c) Surface structure of the ‘blue’ S protein isolated from the trimer. (d) Ribbon structure of the ‘blue’ S protein. (e) Zoom on the N-terminal domain (NTD) of the ‘blue’ S protein. (f,g) Molecular model of a minimal NTD obtained with Hyperchem [ribbon in representation in (f), surface rendering in (g)]. (h) Highlighting of the amino acid residues of the NTD that could belong to a potential ganglioside-binding domain."}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T331","span":{"begin":27,"end":37},"obj":"SP_7"},{"id":"T332","span":{"begin":86,"end":95},"obj":"PG_1"},{"id":"T333","span":{"begin":195,"end":204},"obj":"PG_1"},{"id":"T334","span":{"begin":220,"end":227},"obj":"SO:0001117"},{"id":"T335","span":{"begin":299,"end":308},"obj":"PG_1"},{"id":"T336","span":{"begin":370,"end":379},"obj":"PG_1"},{"id":"T337","span":{"begin":408,"end":414},"obj":"SO:0000417"},{"id":"T338","span":{"begin":435,"end":444},"obj":"PG_1"},{"id":"T339","span":{"begin":658,"end":669},"obj":"CHEBI:28892;CHEBI:28892"},{"id":"T340","span":{"begin":678,"end":684},"obj":"SO:0000417"}],"text":"Structural features of the SARS-CoV-2 spike (S) protein. (a) Trimeric structure (each S protein has a distinct surface colour, ‘blue’, ‘yellow’ and ‘purple’). (b) Ribbon representation of ‘blue’ S protein in the trimer (α-helix, red; β-strand, blue; coil, grey). (c) Surface structure of the ‘blue’ S protein isolated from the trimer. (d) Ribbon structure of the ‘blue’ S protein. (e) Zoom on the N-terminal domain (NTD) of the ‘blue’ S protein. (f,g) Molecular model of a minimal NTD obtained with Hyperchem [ribbon in representation in (f), surface rendering in (g)]. (h) Highlighting of the amino acid residues of the NTD that could belong to a potential ganglioside-binding domain."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T70","span":{"begin":48,"end":55},"obj":"Body_part"},{"id":"T71","span":{"begin":88,"end":95},"obj":"Body_part"},{"id":"T72","span":{"begin":197,"end":204},"obj":"Body_part"},{"id":"T73","span":{"begin":222,"end":227},"obj":"Body_part"},{"id":"T74","span":{"begin":301,"end":308},"obj":"Body_part"},{"id":"T75","span":{"begin":372,"end":379},"obj":"Body_part"},{"id":"T76","span":{"begin":437,"end":444},"obj":"Body_part"},{"id":"T77","span":{"begin":594,"end":604},"obj":"Body_part"},{"id":"T78","span":{"begin":658,"end":669},"obj":"Body_part"}],"attributes":[{"id":"A70","pred":"fma_id","subj":"T70","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A71","pred":"fma_id","subj":"T71","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A72","pred":"fma_id","subj":"T72","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A73","pred":"fma_id","subj":"T73","obj":"http://purl.org/sig/ont/fma/fma60992"},{"id":"A74","pred":"fma_id","subj":"T74","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A75","pred":"fma_id","subj":"T75","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A76","pred":"fma_id","subj":"T76","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A77","pred":"fma_id","subj":"T77","obj":"http://purl.org/sig/ont/fma/fma82739"},{"id":"A78","pred":"fma_id","subj":"T78","obj":"http://purl.org/sig/ont/fma/fma82816"}],"text":"Structural features of the SARS-CoV-2 spike (S) protein. (a) Trimeric structure (each S protein has a distinct surface colour, ‘blue’, ‘yellow’ and ‘purple’). (b) Ribbon representation of ‘blue’ S protein in the trimer (α-helix, red; β-strand, blue; coil, grey). (c) Surface structure of the ‘blue’ S protein isolated from the trimer. (d) Ribbon structure of the ‘blue’ S protein. (e) Zoom on the N-terminal domain (NTD) of the ‘blue’ S protein. (f,g) Molecular model of a minimal NTD obtained with Hyperchem [ribbon in representation in (f), surface rendering in (g)]. (h) Highlighting of the amino acid residues of the NTD that could belong to a potential ganglioside-binding domain."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T7","span":{"begin":222,"end":227},"obj":"Body_part"},{"id":"T8","span":{"begin":267,"end":284},"obj":"Body_part"}],"attributes":[{"id":"A7","pred":"uberon_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/UBERON_0002488"},{"id":"A8","pred":"uberon_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/UBERON_0003102"}],"text":"Structural features of the SARS-CoV-2 spike (S) protein. (a) Trimeric structure (each S protein has a distinct surface colour, ‘blue’, ‘yellow’ and ‘purple’). (b) Ribbon representation of ‘blue’ S protein in the trimer (α-helix, red; β-strand, blue; coil, grey). (c) Surface structure of the ‘blue’ S protein isolated from the trimer. (d) Ribbon structure of the ‘blue’ S protein. (e) Zoom on the N-terminal domain (NTD) of the ‘blue’ S protein. (f,g) Molecular model of a minimal NTD obtained with Hyperchem [ribbon in representation in (f), surface rendering in (g)]. (h) Highlighting of the amino acid residues of the NTD that could belong to a potential ganglioside-binding domain."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T34","span":{"begin":27,"end":35},"obj":"Disease"},{"id":"T35","span":{"begin":416,"end":419},"obj":"Disease"},{"id":"T37","span":{"begin":481,"end":484},"obj":"Disease"},{"id":"T39","span":{"begin":621,"end":624},"obj":"Disease"}],"attributes":[{"id":"A34","pred":"mondo_id","subj":"T34","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A35","pred":"mondo_id","subj":"T35","obj":"http://purl.obolibrary.org/obo/MONDO_0008449"},{"id":"A36","pred":"mondo_id","subj":"T35","obj":"http://purl.obolibrary.org/obo/MONDO_0018075"},{"id":"A37","pred":"mondo_id","subj":"T37","obj":"http://purl.obolibrary.org/obo/MONDO_0008449"},{"id":"A38","pred":"mondo_id","subj":"T37","obj":"http://purl.obolibrary.org/obo/MONDO_0018075"},{"id":"A39","pred":"mondo_id","subj":"T39","obj":"http://purl.obolibrary.org/obo/MONDO_0008449"},{"id":"A40","pred":"mondo_id","subj":"T39","obj":"http://purl.obolibrary.org/obo/MONDO_0018075"}],"text":"Structural features of the SARS-CoV-2 spike (S) protein. (a) Trimeric structure (each S protein has a distinct surface colour, ‘blue’, ‘yellow’ and ‘purple’). (b) Ribbon representation of ‘blue’ S protein in the trimer (α-helix, red; β-strand, blue; coil, grey). (c) Surface structure of the ‘blue’ S protein isolated from the trimer. (d) Ribbon structure of the ‘blue’ S protein. (e) Zoom on the N-terminal domain (NTD) of the ‘blue’ S protein. (f,g) Molecular model of a minimal NTD obtained with Hyperchem [ribbon in representation in (f), surface rendering in (g)]. (h) Highlighting of the amino acid residues of the NTD that could belong to a potential ganglioside-binding domain."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T99","span":{"begin":58,"end":59},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T100","span":{"begin":96,"end":99},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T101","span":{"begin":100,"end":101},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T102","span":{"begin":160,"end":161},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T103","span":{"begin":471,"end":472},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T104","span":{"begin":594,"end":613},"obj":"http://purl.obolibrary.org/obo/CHEBI_33708"},{"id":"T105","span":{"begin":594,"end":613},"obj":"http://purl.obolibrary.org/obo/PR_000036907"},{"id":"T106","span":{"begin":646,"end":647},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"Structural features of the SARS-CoV-2 spike (S) protein. (a) Trimeric structure (each S protein has a distinct surface colour, ‘blue’, ‘yellow’ and ‘purple’). (b) Ribbon representation of ‘blue’ S protein in the trimer (α-helix, red; β-strand, blue; coil, grey). (c) Surface structure of the ‘blue’ S protein isolated from the trimer. (d) Ribbon structure of the ‘blue’ S protein. (e) Zoom on the N-terminal domain (NTD) of the ‘blue’ S protein. (f,g) Molecular model of a minimal NTD obtained with Hyperchem [ribbon in representation in (f), surface rendering in (g)]. (h) Highlighting of the amino acid residues of the NTD that could belong to a potential ganglioside-binding domain."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T281","span":{"begin":48,"end":55},"obj":"Chemical"},{"id":"T282","span":{"begin":88,"end":95},"obj":"Chemical"},{"id":"T283","span":{"begin":197,"end":204},"obj":"Chemical"},{"id":"T284","span":{"begin":301,"end":308},"obj":"Chemical"},{"id":"T285","span":{"begin":372,"end":379},"obj":"Chemical"},{"id":"T286","span":{"begin":437,"end":444},"obj":"Chemical"},{"id":"T287","span":{"begin":594,"end":604},"obj":"Chemical"},{"id":"T288","span":{"begin":594,"end":599},"obj":"Chemical"},{"id":"T289","span":{"begin":600,"end":604},"obj":"Chemical"},{"id":"T290","span":{"begin":658,"end":669},"obj":"Chemical"}],"attributes":[{"id":"A281","pred":"chebi_id","subj":"T281","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A282","pred":"chebi_id","subj":"T282","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A283","pred":"chebi_id","subj":"T283","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A284","pred":"chebi_id","subj":"T284","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A285","pred":"chebi_id","subj":"T285","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A286","pred":"chebi_id","subj":"T286","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A287","pred":"chebi_id","subj":"T287","obj":"http://purl.obolibrary.org/obo/CHEBI_33709"},{"id":"A288","pred":"chebi_id","subj":"T288","obj":"http://purl.obolibrary.org/obo/CHEBI_46882"},{"id":"A289","pred":"chebi_id","subj":"T289","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A290","pred":"chebi_id","subj":"T290","obj":"http://purl.obolibrary.org/obo/CHEBI_28892"}],"text":"Structural features of the SARS-CoV-2 spike (S) protein. (a) Trimeric structure (each S protein has a distinct surface colour, ‘blue’, ‘yellow’ and ‘purple’). (b) Ribbon representation of ‘blue’ S protein in the trimer (α-helix, red; β-strand, blue; coil, grey). (c) Surface structure of the ‘blue’ S protein isolated from the trimer. (d) Ribbon structure of the ‘blue’ S protein. (e) Zoom on the N-terminal domain (NTD) of the ‘blue’ S protein. (f,g) Molecular model of a minimal NTD obtained with Hyperchem [ribbon in representation in (f), surface rendering in (g)]. (h) Highlighting of the amino acid residues of the NTD that could belong to a potential ganglioside-binding domain."}