PMC:7128678 / 13861-14376 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"349","span":{"begin":488,"end":501},"obj":"Gene"},{"id":"362","span":{"begin":63,"end":71},"obj":"Chemical"},{"id":"363","span":{"begin":72,"end":77},"obj":"Chemical"},{"id":"364","span":{"begin":100,"end":108},"obj":"Chemical"},{"id":"365","span":{"begin":152,"end":163},"obj":"Chemical"},{"id":"366","span":{"begin":206,"end":209},"obj":"Chemical"},{"id":"367","span":{"begin":320,"end":323},"obj":"Chemical"},{"id":"368","span":{"begin":351,"end":354},"obj":"Chemical"},{"id":"369","span":{"begin":398,"end":404},"obj":"Chemical"}],"attributes":[{"id":"A362","pred":"tao:has_database_id","subj":"362","obj":"MESH:D002518"},{"id":"A363","pred":"tao:has_database_id","subj":"363","obj":"MESH:D000073893"},{"id":"A364","pred":"tao:has_database_id","subj":"364","obj":"MESH:D009584"},{"id":"A365","pred":"tao:has_database_id","subj":"365","obj":"MESH:D005732"},{"id":"A366","pred":"tao:has_database_id","subj":"366","obj":"MESH:D005677"},{"id":"A367","pred":"tao:has_database_id","subj":"367","obj":"MESH:D005677"},{"id":"A368","pred":"tao:has_database_id","subj":"368","obj":"MESH:D005677"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"In this case, the aromatic cycles of CLQ are positioned at the ceramide–sugar junction, whereas the nitrogen atoms interact with the acidic part of the ganglioside (not illustrated). (d,e) Surface views of GM1 complexed with one (d) or two (e) CLQ molecules (both in blue), illustrating the geometric complementarity of GM1 and CLQ molecules. (f) One GM1 molecule can also accommodate two distinct CLQ-OH molecules simultaneously, after slight rearrangement allowing increased fit due to CLQ-OH/CLQ-OH interactions."}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T289","span":{"begin":63,"end":71},"obj":"CHEBI:17761;CHEBI:17761"},{"id":"T290","span":{"begin":109,"end":114},"obj":"CHEBI:33250;CHEBI:33250"},{"id":"T291","span":{"begin":133,"end":139},"obj":"CHEBI:37527;CHEBI:37527"},{"id":"T292","span":{"begin":152,"end":163},"obj":"CHEBI:5386;CHEBI:5386"},{"id":"T293","span":{"begin":210,"end":219},"obj":"GO:0032991"},{"id":"T294","span":{"begin":248,"end":257},"obj":"CHEBI:36357;CHEBI:36357"},{"id":"T295","span":{"begin":332,"end":341},"obj":"CHEBI:36357;CHEBI:36357"},{"id":"T296","span":{"begin":355,"end":363},"obj":"CHEBI:36357;CHEBI:36357"},{"id":"T297","span":{"begin":405,"end":414},"obj":"CHEBI:36357;CHEBI:36357"}],"text":"In this case, the aromatic cycles of CLQ are positioned at the ceramide–sugar junction, whereas the nitrogen atoms interact with the acidic part of the ganglioside (not illustrated). (d,e) Surface views of GM1 complexed with one (d) or two (e) CLQ molecules (both in blue), illustrating the geometric complementarity of GM1 and CLQ molecules. (f) One GM1 molecule can also accommodate two distinct CLQ-OH molecules simultaneously, after slight rearrangement allowing increased fit due to CLQ-OH/CLQ-OH interactions."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T63","span":{"begin":72,"end":77},"obj":"Body_part"},{"id":"T64","span":{"begin":152,"end":163},"obj":"Body_part"}],"attributes":[{"id":"A63","pred":"fma_id","subj":"T63","obj":"http://purl.org/sig/ont/fma/fma82737"},{"id":"A64","pred":"fma_id","subj":"T64","obj":"http://purl.org/sig/ont/fma/fma82816"}],"text":"In this case, the aromatic cycles of CLQ are positioned at the ceramide–sugar junction, whereas the nitrogen atoms interact with the acidic part of the ganglioside (not illustrated). (d,e) Surface views of GM1 complexed with one (d) or two (e) CLQ molecules (both in blue), illustrating the geometric complementarity of GM1 and CLQ molecules. (f) One GM1 molecule can also accommodate two distinct CLQ-OH molecules simultaneously, after slight rearrangement allowing increased fit due to CLQ-OH/CLQ-OH interactions."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T94","span":{"begin":78,"end":86},"obj":"http://purl.obolibrary.org/obo/UBERON_0007651"}],"text":"In this case, the aromatic cycles of CLQ are positioned at the ceramide–sugar junction, whereas the nitrogen atoms interact with the acidic part of the ganglioside (not illustrated). (d,e) Surface views of GM1 complexed with one (d) or two (e) CLQ molecules (both in blue), illustrating the geometric complementarity of GM1 and CLQ molecules. (f) One GM1 molecule can also accommodate two distinct CLQ-OH molecules simultaneously, after slight rearrangement allowing increased fit due to CLQ-OH/CLQ-OH interactions."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T255","span":{"begin":63,"end":71},"obj":"Chemical"},{"id":"T257","span":{"begin":100,"end":108},"obj":"Chemical"},{"id":"T258","span":{"begin":109,"end":114},"obj":"Chemical"},{"id":"T259","span":{"begin":152,"end":163},"obj":"Chemical"},{"id":"T260","span":{"begin":206,"end":209},"obj":"Chemical"},{"id":"T263","span":{"begin":248,"end":257},"obj":"Chemical"},{"id":"T264","span":{"begin":320,"end":323},"obj":"Chemical"},{"id":"T267","span":{"begin":332,"end":341},"obj":"Chemical"},{"id":"T268","span":{"begin":351,"end":354},"obj":"Chemical"},{"id":"T271","span":{"begin":355,"end":363},"obj":"Chemical"},{"id":"T272","span":{"begin":405,"end":414},"obj":"Chemical"}],"attributes":[{"id":"A255","pred":"chebi_id","subj":"T255","obj":"http://purl.obolibrary.org/obo/CHEBI_17761"},{"id":"A256","pred":"chebi_id","subj":"T255","obj":"http://purl.obolibrary.org/obo/CHEBI_52639"},{"id":"A257","pred":"chebi_id","subj":"T257","obj":"http://purl.obolibrary.org/obo/CHEBI_25555"},{"id":"A258","pred":"chebi_id","subj":"T258","obj":"http://purl.obolibrary.org/obo/CHEBI_33250"},{"id":"A259","pred":"chebi_id","subj":"T259","obj":"http://purl.obolibrary.org/obo/CHEBI_28892"},{"id":"A260","pred":"chebi_id","subj":"T260","obj":"http://purl.obolibrary.org/obo/CHEBI_18216"},{"id":"A261","pred":"chebi_id","subj":"T260","obj":"http://purl.obolibrary.org/obo/CHEBI_61048"},{"id":"A262","pred":"chebi_id","subj":"T260","obj":"http://purl.obolibrary.org/obo/CHEBI_73110"},{"id":"A263","pred":"chebi_id","subj":"T263","obj":"http://purl.obolibrary.org/obo/CHEBI_25367"},{"id":"A264","pred":"chebi_id","subj":"T264","obj":"http://purl.obolibrary.org/obo/CHEBI_18216"},{"id":"A265","pred":"chebi_id","subj":"T264","obj":"http://purl.obolibrary.org/obo/CHEBI_61048"},{"id":"A266","pred":"chebi_id","subj":"T264","obj":"http://purl.obolibrary.org/obo/CHEBI_73110"},{"id":"A267","pred":"chebi_id","subj":"T267","obj":"http://purl.obolibrary.org/obo/CHEBI_25367"},{"id":"A268","pred":"chebi_id","subj":"T268","obj":"http://purl.obolibrary.org/obo/CHEBI_18216"},{"id":"A269","pred":"chebi_id","subj":"T268","obj":"http://purl.obolibrary.org/obo/CHEBI_61048"},{"id":"A270","pred":"chebi_id","subj":"T268","obj":"http://purl.obolibrary.org/obo/CHEBI_73110"},{"id":"A271","pred":"chebi_id","subj":"T271","obj":"http://purl.obolibrary.org/obo/CHEBI_25367"},{"id":"A272","pred":"chebi_id","subj":"T272","obj":"http://purl.obolibrary.org/obo/CHEBI_25367"}],"text":"In this case, the aromatic cycles of CLQ are positioned at the ceramide–sugar junction, whereas the nitrogen atoms interact with the acidic part of the ganglioside (not illustrated). (d,e) Surface views of GM1 complexed with one (d) or two (e) CLQ molecules (both in blue), illustrating the geometric complementarity of GM1 and CLQ molecules. (f) One GM1 molecule can also accommodate two distinct CLQ-OH molecules simultaneously, after slight rearrangement allowing increased fit due to CLQ-OH/CLQ-OH interactions."}

{"project":"LitCovid-PD-GlycoEpitope","denotations":[{"id":"T11","span":{"begin":206,"end":209},"obj":"GlycoEpitope"},{"id":"T12","span":{"begin":320,"end":323},"obj":"GlycoEpitope"},{"id":"T13","span":{"begin":351,"end":354},"obj":"GlycoEpitope"}],"attributes":[{"id":"A11","pred":"glyco_epitope_db_id","subj":"T11","obj":"http://www.glycoepitope.jp/epitopes/EP0050"},{"id":"A12","pred":"glyco_epitope_db_id","subj":"T12","obj":"http://www.glycoepitope.jp/epitopes/EP0050"},{"id":"A13","pred":"glyco_epitope_db_id","subj":"T13","obj":"http://www.glycoepitope.jp/epitopes/EP0050"}],"text":"In this case, the aromatic cycles of CLQ are positioned at the ceramide–sugar junction, whereas the nitrogen atoms interact with the acidic part of the ganglioside (not illustrated). (d,e) Surface views of GM1 complexed with one (d) or two (e) CLQ molecules (both in blue), illustrating the geometric complementarity of GM1 and CLQ molecules. (f) One GM1 molecule can also accommodate two distinct CLQ-OH molecules simultaneously, after slight rearrangement allowing increased fit due to CLQ-OH/CLQ-OH interactions."}

{"project":"LitCovid-sentences","denotations":[{"id":"T103","span":{"begin":0,"end":515},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"In this case, the aromatic cycles of CLQ are positioned at the ceramide–sugar junction, whereas the nitrogen atoms interact with the acidic part of the ganglioside (not illustrated). (d,e) Surface views of GM1 complexed with one (d) or two (e) CLQ molecules (both in blue), illustrating the geometric complementarity of GM1 and CLQ molecules. (f) One GM1 molecule can also accommodate two distinct CLQ-OH molecules simultaneously, after slight rearrangement allowing increased fit due to CLQ-OH/CLQ-OH interactions."}