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PMC:7128678 / 13297-14484 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
349 1052-1065 Gene denotes CLQ-OH/CLQ-OH
350 35-46 Chemical denotes chloroquine MESH:D002738
351 57-75 Chemical denotes hydroxychloroquine MESH:D006886
352 77-83 Chemical denotes CLQ-OH
353 96-107 Chemical denotes ganglioside MESH:D005732
354 108-111 Chemical denotes GM1 MESH:D005677
355 152-155 Chemical denotes GM1 MESH:D005677
356 219-227 Chemical denotes ceramide MESH:D002518
357 321-332 Chemical denotes sialic-acid MESH:D019158
358 344-354 Chemical denotes saccharide MESH:D002241
359 405-417 Chemical denotes carbohydrate MESH:D002241
360 428-431 Chemical denotes GM1 MESH:D005677
361 460-475 Chemical denotes CLQ–ganglioside
362 627-635 Chemical denotes ceramide MESH:D002518
363 636-641 Chemical denotes sugar MESH:D000073893
364 664-672 Chemical denotes nitrogen MESH:D009584
365 716-727 Chemical denotes ganglioside MESH:D005732
366 770-773 Chemical denotes GM1 MESH:D005677
367 884-887 Chemical denotes GM1 MESH:D005677
368 915-918 Chemical denotes GM1 MESH:D005677
369 962-968 Chemical denotes CLQ-OH
370 1100-1106 Chemical denotes CLQ-OH
371 1126-1129 Chemical denotes GM1 MESH:D005677

LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T278 35-46 CHEBI:3638;DG_10;CHEBI:3638 denotes chloroquine
T279 57-75 CHEBI:5801;DG_20;CHEBI:5801 denotes hydroxychloroquine
T280 96-107 CHEBI:16856;CHEBI:16856 denotes ganglioside
T281 179-187 GO:0016020 denotes membrane
T282 219-227 CHEBI:17761;CHEBI:17761 denotes ceramide
T283 250-256 CHEBI:37527;CHEBI:37527 denotes acidic
T284 280-299 GO:0005615 denotes extracellular space
T285 321-332 CHEBI:26667;CHEBI:26667 denotes sialic-acid
T286 344-354 CHEBI:32111;CHEBI:32111 denotes saccharide
T287 405-417 CHEBI:16646;CHEBI:16646 denotes carbohydrate
T288 464-475 CHEBI:5386;CHEBI:5386 denotes ganglioside
T289 627-635 CHEBI:17761;CHEBI:17761 denotes ceramide
T290 673-678 CHEBI:33250;CHEBI:33250 denotes atoms
T291 697-703 CHEBI:37527;CHEBI:37527 denotes acidic
T292 716-727 CHEBI:5386;CHEBI:5386 denotes ganglioside
T293 774-783 GO:0032991 denotes complexed
T294 812-821 CHEBI:36357;CHEBI:36357 denotes molecules
T295 896-905 CHEBI:36357;CHEBI:36357 denotes molecules
T296 919-927 CHEBI:36357;CHEBI:36357 denotes molecule
T297 969-978 CHEBI:36357;CHEBI:36357 denotes molecules
T298 1107-1116 CHEBI:36357;CHEBI:36357 denotes molecules

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T59 96-107 Body_part denotes ganglioside http://purl.org/sig/ont/fma/fma82816
T60 280-299 Body_part denotes extracellular space http://purl.org/sig/ont/fma/fma70022
T61 405-417 Body_part denotes carbohydrate http://purl.org/sig/ont/fma/fma82737
T62 464-475 Body_part denotes ganglioside http://purl.org/sig/ont/fma/fma82816
T63 636-641 Body_part denotes sugar http://purl.org/sig/ont/fma/fma82737
T64 716-727 Body_part denotes ganglioside http://purl.org/sig/ont/fma/fma82816

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T6 394-397 Body_part denotes tip http://purl.obolibrary.org/obo/UBERON_2001840

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T89 166-167 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T90 179-187 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T91 374-375 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T92 434-435 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T93 534-535 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T94 642-650 http://purl.obolibrary.org/obo/UBERON_0007651 denotes junction

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T237 35-46 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T238 57-75 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T239 96-111 Chemical denotes ganglioside GM1 http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048
T241 96-107 Chemical denotes ganglioside http://purl.obolibrary.org/obo/CHEBI_28892
T242 108-111 Chemical denotes GM1 http://purl.obolibrary.org/obo/CHEBI_73110
T243 152-155 Chemical denotes GM1 http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110
T246 219-227 Chemical denotes ceramide http://purl.obolibrary.org/obo/CHEBI_17761|http://purl.obolibrary.org/obo/CHEBI_52639
T248 328-332 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T249 344-354 Chemical denotes saccharide http://purl.obolibrary.org/obo/CHEBI_16646
T250 405-417 Chemical denotes carbohydrate http://purl.obolibrary.org/obo/CHEBI_16646
T251 428-431 Chemical denotes GM1 http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110
T254 464-475 Chemical denotes ganglioside http://purl.obolibrary.org/obo/CHEBI_28892
T255 627-635 Chemical denotes ceramide http://purl.obolibrary.org/obo/CHEBI_17761|http://purl.obolibrary.org/obo/CHEBI_52639
T257 664-672 Chemical denotes nitrogen http://purl.obolibrary.org/obo/CHEBI_25555
T258 673-678 Chemical denotes atoms http://purl.obolibrary.org/obo/CHEBI_33250
T259 716-727 Chemical denotes ganglioside http://purl.obolibrary.org/obo/CHEBI_28892
T260 770-773 Chemical denotes GM1 http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110
T263 812-821 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T264 884-887 Chemical denotes GM1 http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110
T267 896-905 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T268 915-918 Chemical denotes GM1 http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110
T271 919-927 Chemical denotes molecule http://purl.obolibrary.org/obo/CHEBI_25367
T272 969-978 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T273 1107-1116 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T274 1126-1129 Chemical denotes GM1 http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110

LitCovid-PD-GlycoEpitope

Id Subject Object Predicate Lexical cue glyco_epitope_db_id
T8 108-111 GlycoEpitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T9 152-155 GlycoEpitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T10 428-431 GlycoEpitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T11 770-773 GlycoEpitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T12 884-887 GlycoEpitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T13 915-918 GlycoEpitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T14 1126-1129 GlycoEpitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T102 113-563 Sentence denotes The surface electrostatic potential of GM1 indicates a non-polar, membrane-embedded part corresponding to ceramide (white areas), and an acidic part protruding in the extracellular space corresponding to the sialic-acid-containing saccharide part (red areas). (a) CLQ bound to the tip of the carbohydrate moiety of GM1. (b) Molecular mechanism of CLQ–ganglioside interactions. (c) Molecular dynamics simulations revealed a second site of interaction.
T103 564-1079 Sentence denotes In this case, the aromatic cycles of CLQ are positioned at the ceramide–sugar junction, whereas the nitrogen atoms interact with the acidic part of the ganglioside (not illustrated). (d,e) Surface views of GM1 complexed with one (d) or two (e) CLQ molecules (both in blue), illustrating the geometric complementarity of GM1 and CLQ molecules. (f) One GM1 molecule can also accommodate two distinct CLQ-OH molecules simultaneously, after slight rearrangement allowing increased fit due to CLQ-OH/CLQ-OH interactions.
T104 1080-1187 Sentence denotes To improve clarity, CLQ-OH molecules bound to GM1 are represented in two distinct colours (blue and green).